Top Senior Machine Learning Jobs in St. Louis, MO

The Staff Product Manager will define product strategy, lead the product lifecycle, collaborate across teams, and drive innovation in claims processing software.

The Director of System Safety oversees safety functions for autonomous vehicles, managing safety cases, deployment plans, and regulatory relationships while leading a multi-disciplinary safety team.

Lead development of time-series and econometric models (ARIMA, VAR, state-space, WLS, panel data) and Bayesian probabilistic frameworks. Use causal inference and stochastic processes to produce actionable insights, work with large datasets on Databricks, communicate results to stakeholders, and mentor junior team members.

Own a product area of the Content Authoring Platform end-to-end: set vision and roadmap, run continuous discovery, define and measure outcomes, partner with engineering and design to deliver features, evaluate and apply AI capabilities prudently, mentor peers, and communicate strategy and trade-offs to stakeholders.

Lead client-facing full-stack Java development, mentor teams, design solutions, promote engineering best practices (Agile, DevOps, CI/CD, TDD), and deliver enterprise software using modern cloud, container, and JS frameworks.

Own end-to-end analysis of payments, chargebacks, and user lifecycle to identify drivers of net loss. Deep-dive into fraud cases, design and evaluate A/B experiments and risk-rule changes, build monitoring dashboards, partner with Risk, Payments, and Product to convert insights into mitigations, and run ad-hoc analyses of emerging loss trends.

The Senior Technical Architect will lead AI SDLC transformations, create architectural solutions, mentor teams, and drive innovation in regulated industries.

Design and implement scalable backend and distributed systems for a marketing intelligence platform. Build near-real-time ingestion and processing, scale an incrementality/experimentation product, integrate AI-powered workflows, improve data ingestion/exports and connection-state systems, and contribute frontend components to deliver end-to-end product experiences.

Lead a Big Data Engineering team to deliver production-grade ETL and data pipelines at scale. Own team execution, code quality, morale, and roadmap execution with product managers. Remove roadblocks, coach and develop engineers, promote engineering best practices, and enable data-driven and AI-powered product features (personalization, recommendations, search, ranking, matching).

Seeking a Senior Full Stack .NET Developer to work on a social good project, with strong skills in C#, AngularJS, design, and UX. Requires 5+ years of experience.

The Senior Data Scientist will design and deploy time-series forecasting models, collaborate with stakeholders, and operationalize models in cloud environments, focusing on demand planning across various industries.

Drive Midwest SLED revenue by selling analytics-driven SaaS identity and fraud solutions. Build pipeline, manage full sales cycle, develop partnerships/channels, collaborate with product, forecast accurately, and travel up to 50% to close deals and ensure customer success.

Lead execution of Product Engineering AI and automation initiatives across photonics products. Build and deploy reusable AI/automation tools, transform engineering data into AI-ready systems, and drive cross-functional adoption to improve development, qualification, manufacturing, and reliability processes.

Set the technical direction for machine learning at Payabli by maturing production risk models and launching new models across the payments lifecycle. Establish experimentation, monitoring, drift detection, benchmarking, retraining, and incident-response foundations. Translate payments challenges into modeling opportunities, connect model performance to business outcomes, influence the ML roadmap, and mentor engineers while partnering with product, engineering, and risk operations.

Lead a consortium advancing AI-driven neurodegeneration research: set strategy, build partnerships, manage multidisciplinary executive team, oversee product development and deployment, secure funding, ensure ethical AI and scientific integrity, and scale the platform to broader biomedical domains.

Work with enterprise customers to identify high-value tabular ML use cases, design production-grade architectures, prototype solutions, lead deployments, coordinate cross-functional teams, and codify reusable deployment patterns to scale adoption of the NEXUS tabular foundation model.

The AI Engineer will design and build production systems, focusing on LLM integration, system reliability, evaluation frameworks, and high-quality product features while maintaining strong engineering practices.

Lead end-to-end delivery of LOIS by owning the master program plan, coordinating cross-functional teams (engineering, product, design, ML, data, SRE, operations), resolving blockers and dependencies, establishing lightweight delivery infrastructure and tooling, partnering on release planning, and maintaining transparent status, risks, and accountability to deliver complex features to customers.

Lead Tekmetric's API product strategy and roadmap for the SaaS platform. Own API lifecycle (contracts, versioning, documentation), drive developer experience and adoption, identify integration opportunities, lead generative AI initiatives, perform user research and analytics-driven prioritization, collaborate across design/engineering/sales, train internal teams, and measure business impact.

Lead development of Vanta's business analytics function: build scalable product data assets, define measurement frameworks, use AI-assisted analytics, partner with cross-functional teams, and deliver executive-level recommendations to drive product and business decisions.

Lead the vision and execution of data product roadmap; translate business needs into epics and acceptance criteria; partner with data engineering and analytics; run agile ceremonies and manage backlog; champion data-as-a-product; scope and pilot AI/ML capabilities; present roadmaps and business cases to leadership.

Design, build, and operate core AI capabilities and reusable model integrations for an enterprise platform. Integrate foundation models into production, optimize performance and reliability, prototype new techniques, and support scalable backend services and distributed AI systems in collaboration with cross-functional teams.

Lead and mature Omada's enterprise privacy program, manage HIPAA compliance and incident response, embed privacy-by-design across products, conduct privacy risk assessments and vendor due diligence, advise on consumer privacy and AI governance, support interoperability/HIE participation, and deliver privacy training and guidance across the business.

The Staff Machine Learning Engineer will lead ML systems development for personalization and ranking, design architectures, and mentor team members, ensuring reliable operations at scale.

The Machine Learning Engineer will work on unstructured data classification and clustering, utilizing their expertise in AI systems and various programming languages.