Top Senior C# Jobs in San Diego, CA

Integrates biological protocols with prototype instrumentation, troubleshooting hardware, software, consumables, workflows, and assays. Designs hardware experiments, transfers molecular and cell biology protocols, gathers engineering requirements, and develops automation, data-analysis, instrument-control, and AI-assisted tooling. Collaborates with engineering and scientific teams to detect drift, classify failures, and optimize workflows. Requires hands-on instrumentation development, wet-lab familiarity, Python scripting, data analysis, and AI tool experience. Travel up to 20%.

Leads architecture, development, governance, and delivery of enterprise OutSystems applications across O11 and ODC. Builds full-stack web and mobile solutions, integrations, and custom C#/.NET extensions; establishes coding and security standards; mentors developers; manages deployments and performance; and collaborates on CI/CD, DevOps, Agile delivery, and compliance in a regulated banking environment.

Lead technical direction and multi-quarter delivery for a platform modernization effort. Architect TypeScript, Java, PHP, and cloud systems; guide monolith decomposition, distributed services, databases, observability, security, and operational excellence. Mentor engineers, coordinate stakeholders, establish engineering standards, and lead responsible adoption of AI-assisted development across the organization.

Designs, develops, tests, troubleshoots, documents, and maintains software applications throughout the project lifecycle. Responsibilities include coding, database and system administration, performance testing, debugging, software upgrades, requirements documentation, user support, vendor coordination, and collaboration with analysts, administrators, and engineers. The role also provides guidance to junior development staff and supports cross-departmental projects.

Own web compatibility triage and incident response across DuckDuckGo browsers on Mac, Windows, iOS, and Android. Debug complex web applications and third-party code, distinguish site, browser, and privacy-related issues, reverse-engineer obfuscated code, build durable cross-platform fixes, and develop automation and LLM agent tooling to reproduce and triage breakage. Lead ambiguous projects independently and communicate with technical and non-technical stakeholders.

Staff Software Engineer leading hands-on full-stack development across C#/.NET services, Angular interfaces, databases, and AWS-hosted applications. Builds healthcare data integrations using HL7, FHIR, and X12 EDI; modernizes legacy systems; improves performance; applies secure coding and HIPAA practices; supports production incidents; reviews code; mentors engineers; and collaborates with product and QA teams.

Develops and maintains secure, accessible, responsive WordPress websites and web applications for Military OneSource. Responsibilities include PHP and JavaScript development, CMS customization, REST API integrations, UX/UI implementation, Section 508 and WCAG compliance, accessibility testing, production troubleshooting, performance optimization, Agile delivery, Git workflows, and collaboration with cybersecurity and DevSecOps teams in a Federal environment.

Lead architecture and hands-on development of scalable backend systems and APIs supporting real-time applications at massive scale. Own the full engineering lifecycle, establish standards for reliability and testing, troubleshoot production issues, influence technical roadmaps, collaborate cross-functionally, and mentor engineers. The role requires deep backend development, distributed cloud systems, system design, automated testing, and technical leadership experience.

Develop scalable C++ software that defines and enforces endpoint behavior across millions of managed Windows endpoints. Responsibilities include implementing features, improving platform performance, shipping production code, designing new systems, writing architecture documents, defining subsystem contracts, and collaborating with server, UI, product, and design teams. The role requires deep Windows systems and kernel-driver expertise, with preferred experience in WHQL, minifilter or WFP drivers, macOS Endpoint Security, and Linux kernel development.

Design, build, deploy, and operate scalable backend platform services and shared libraries. Contribute to architecture, reliability, developer experience, continuous delivery, monitoring, alerting, and incident response. Investigate production issues, implement lasting fixes, participate in technical reviews, mentor engineers, and collaborate cross-functionally to deliver business value. The role also encourages thoughtful use of AI tools to improve productivity.

Leads end-to-end design, development, quality, and integration of complex software solutions and cloud services. Provides technical leadership for enterprise-wide projects, manages engineering processes, risks, dependencies, and delivery priorities, and writes code across the software ecosystem. Collaborates with multidisciplinary teams to deliver measurable, user-centric technology solutions, primarily supporting healthcare caregivers.

Own end-to-end technical delivery for enterprise SitecoreAI and XM Cloud implementations. Lead discovery, architecture, development, QA, releases, client communication, and project delivery. Guide headless Next.js teams using React and TypeScript on Vercel or Netlify, ensure accessibility, SEO, performance, and security standards, and mentor developers. Support estimates, proposals, account growth, reusable solutions, and AI-assisted engineering practices.

Develop, test, deploy, maintain, and optimize software solutions using Microsoft technologies and Azure cloud services. Collaborate with business stakeholders, architects, security, infrastructure, product, and support teams throughout the software development lifecycle. Modernize legacy applications, build REST APIs, implement automated testing, ensure PCI and HIPAA compliance, document systems, manage releases, and support production troubleshooting, monitoring, performance, and reliability.

The Senior Software Engineer designs and develops software applications, optimizes APIs and databases, collaborates with teams, and ensures code quality through various testing practices.

Designs, develops, and leads scalable healthcare software solutions involving transaction processing, interoperability standards, integrations, and data platforms. Provides hands-on engineering, architectural leadership, quality ownership, risk management, technical mentorship, and cross-functional collaboration. The role requires building high-performance cloud-based SaaS solutions using microservices and serverless architectures, while guiding engineering strategy and ensuring secure, reliable delivery.

Build and scale full-stack applications using Ruby on Rails, React, PostgreSQL, Docker, Kubernetes, and Terraform. Design APIs, data architectures, synchronization systems, infrastructure, and CI/CD pipelines for secure, reliable operation in disconnected and low-bandwidth environments. Collaborate across engineering, business development, and mission teams while supporting critical defense and public safety operations.

Develop and ship features for mobile games across Unity/C# clients and Go backend services. Collaborate with Product, Design, and Art, troubleshoot live-product issues, improve code quality, maintain build and content pipelines, conduct testing and code reviews, support releases, and investigate regressions. The role requires ownership from implementation through production with limited supervision.

Build and scale reliable software systems supporting donor platforms, cash payments, and rapid-response programs. Own features end to end from architecture through deployment and monitoring, improve CI/CD and testing, troubleshoot production issues, and collaborate with product, operations, and data teams. The role also contributes to technical roadmaps and sustainable engineering practices in a mission-driven, fully remote organization.

Executes systems engineering across R&D platforms, hybrid cloud, SaaS, HPC, containers, integrations, data pipelines, observability, and AI architectures. Coordinates Enterprise IT, vendors, cybersecurity, compliance, and scientific stakeholders to deliver secure, scalable, validated, and supportable solutions. Develops technical documentation, deployment plans, runbooks, monitoring, lifecycle artifacts, risk logs, and operational handoffs. Implements RAG, vector database, AI gateway, agentic workflow, and multimodal integration patterns while supporting cloud migration, change management, governance, and technical issue resolution.

Leads a software development team and manages an enterprise application portfolio for a digital banking platform. Responsibilities include architecting requirements and solutions, developing and integrating APIs, improving security and performance, supporting continuous integration and code quality, refactoring code, collaborating with IT leadership and development managers, and driving development capability improvements. The role requires hands-on full-stack .NET expertise, technical leadership, Agile experience, and financial services knowledge.

Designs, develops, and executes comprehensive testing for C# thick-client, web, cloud, bioinformatics, and hardware-integrated software. Responsibilities include functional, regression, integration, and performance testing; defect tracking in Azure DevOps; test automation; pull request reviews; cross-functional collaboration; and improving QA processes. The role also ensures software quality standards and industry compliance.

Designs and directs development of scalable software systems using AI-assisted engineering practices. Owns architecture, APIs, data models, testing strategy, security, reliability, observability, deployment, and production operations. Decomposes work for AI agents, validates generated code and tests, leads incident response, and coaches engineers on effective AI-enabled development. Requires full-stack experience, modern server-side development, event-driven systems, cloud infrastructure, regulated-data security, and production use of agentic AI.

Drive technical direction and architecture across teams for enterprise retail software. Improve platform reliability and performance, scope customer-facing features, mentor engineers, de-risk large work, and embed AI-native practices (LLMs/agents) into engineering workflows.

Develop and support high-volume, mission-critical web applications across the full software development lifecycle. Build with TypeScript, JavaScript, Next.js, and SQL; deploy and operate applications in Microsoft Azure; use AI-assisted development tools; troubleshoot complex technical issues; make architectural decisions; and mentor other engineers. The role requires multi-tier system development, database optimization, Agile collaboration, and proactive delivery of reliable, high-quality software.

Develop and deliver high-volume enterprise applications across the full software development lifecycle. Design, code, test, debug, optimize SQL solutions, troubleshoot complex issues, contribute to scalable architecture, collaborate with technical and business stakeholders, and mentor other developers. Work independently while participating in Agile development and production implementation.