Top Remote Python Jobs in Washington, DC

The Senior Python Engineer will develop and support MongoDB Python drivers, enhance library quality, and collaborate on product features.

Lead frontend-leaning full-stack implementation work for carrier and enterprise integrations: architect reusable UI and API layers, author RFCs, guide technical delivery, enforce testing and security best practices, and partner with cross-functional teams to scope and ship production integrations.

Define and drive Payments technical strategy and architecture for rails, routing, and funds-flow systems. Lead large cross-team initiatives, ensure financial correctness, improve reliability and cost via observability, mentor senior engineers, and align stakeholders across product, risk, and regulatory teams.

Build, operate, and scale backend systems for card issuing and transaction processing. Break down projects, collaborate with product and cross-functional teams, write tested extensible code, support monitoring and on-call operations, and participate in team growth activities including interviews.

Lead design and implementation of Affirm's Lakehouse Platform using Iceberg, Spark, Snowflake, and cloud storage. Drive platform roadmap, governance, access controls, performance and cost optimization, analytics engineering best practices, observability, and on-call readiness. Partner cross-functionally, mentor engineers, and build scalable, secure, self-service data infrastructure and semantic/agentic data tools.

Lead technical strategy and execution for multi-quarter initiatives; build and maintain AI-driven systems; mentor and raise the technical bar across teams; collaborate cross-functionally; ensure data security and HIPAA-compliant practices; operate in an AWS + Kubernetes environment while introducing new technologies as system load grows.

Design, build, and maintain Airflow-based automation pipelines and services to move files, run scheduled FTP jobs, validate and modify data, monitor application health, parse logs/emails, implement robust error handling and observability, and integrate API-driven systems to reduce manual operational work.

Lead and grow a backend/platform engineering team building API-driven systems and core services. Own technical direction, architecture, reliability, and integration with product, data science, and infrastructure. Hire and mentor engineers, contribute to code and architecture, support incident response, and ensure scalable, secure, production-ready backend APIs and platform tooling.

Lead architecture and engineering initiatives to design, build, and scale cloud-native, microservices-based applications on GCP. Guide stakeholders, author technical documentation, validate non-functional requirements, mentor engineers, drive POCs, and ensure security, accessibility, and data protection for consumer-facing healthcare solutions.

The Lead Architect will develop backend services, oversee integration with imaging facilities, set coding standards, mentor engineers, and ensure fault-tolerant systems while adhering to healthcare data standards.

Build and ship production-grade agentic AI developer tools and a coding harness to modernize legacy systems. Design integrations across source control, CI/CD, security scanners, and cloud services. Partner with customers and product teams to iterate on AI-native workflows, ensure cybersecurity compliance, and scale agentic systems for defense missions.

The Sr Staff AV Behavior Safety Engineer leads safety validation for GM's autonomous driving systems, influences launch decisions, and collaborates across teams for safety standards and performance metrics in AV behavior development.

Lead design, implementation, and security of AWS cloud infrastructure and CI/CD automation. Drive cost optimization, observability, and IaC standards (Terraform/CDK). Mentor engineers, participate in on-call rotations, and collaborate with product and science teams to build scalable, reliable cloud-native systems.

Perform CFD and 1D lumped-parameter fluid analyses for rocket engines, predict component and system performance, build transient and steady models, support testing and anomaly investigations, recommend design improvements, and mentor peers to grow propulsion fluid-analysis capabilities.

Senior technical owner of an existing NetSuite ERP: provide Tier 2/3 production support, triage and permanently resolve incidents, build and optimize SuiteScript 2.x and SuiteFlow customizations, maintain integrations (Deposco WMS, Salesforce via Jitterbit), manage SDF sandbox-to-production promotions, monitor performance, ensure release readiness, author runbooks, and operate under ITGC/SOX-adjacent change management with on-call responsibilities.

Own and implement platform initiatives to improve scalability, reliability, and developer experience. Automate infrastructure with IaC, operate Kubernetes and CI/CD pipelines, build developer tools, monitor platform resilience, participate in incident response, and influence architecture and processes as you grow.

Lead design and delivery of a reliability platform for production systems. Own quarterly goals, guide engineers through ambiguity, collaborate with PM/design/analytics, monitor and operate services (on-call), set quality and code standards, and mentor teammates. Integrate AI/LLM tooling to improve automation, debugging, and service health.

Lead delivery for the Batch Infrastructure team: design, build, and operate reliable, scalable compute platforms for scheduled and on-demand batch workloads. Collaborate with product/design/analytics, define technical plans, ensure availability (monitoring/on-call), set code and design standards, and mentor engineers to improve delivery and quality.

Design, build, and maintain distributed data platform components (messaging, DB, data warehouse), automate provisioning/backups, troubleshoot performance/reliability, participate in on-call rotation, mentor junior engineers, and contribute to the technical roadmap and platform improvements.

Ensure stability and resilience of Runpod's distributed AI platform by defining SLIs/SLOs, leading incident response, building observability and reliability tooling, automating operational workflows, and partnering with engineering teams to reduce toil and improve production readiness.

Build, operate, and extend data platform and application-layer services enabling secure, self-service data applications at scale. Implement provisioning, CI/CD, access control, integrations, observability, automation, and incident response while contributing to semantic layer and AI-ready tooling roadmaps.

Build and maintain scalable integration and end-to-end test automation frameworks, optimize CI pipelines and test execution, improve test stability and reporting, support engineering teams with triage and best practices, write technical specs/ADRs, participate in on-call rotation, and collaborate cross-functionally to evolve the company test strategy.

This internship role focuses on SRE skills, requiring collaboration and problem-solving in dynamic environments for Zscaler's Zero Trust Exchange team.

The Senior Software Engineer will lead and support a team in developing reliable and scalable backend systems, collaborating on product development, and improving infrastructure for secure communication between services.

Deploy, manage, validate, and optimize large-scale AI compute and HPC infrastructure in Linux environments. Serve as a technical liaison among NVIDIA, partners, and enterprise customers; lead planning through implementation, document handoffs, transfer knowledge, troubleshoot hardware and software, and provide feedback for product and architecture improvements. The role involves networking, system design, automation, benchmarking, cluster provisioning, and customer-site travel up to 30%.