Top Charleston, SC Startups (10,000+)

Want to feel truly valued at work? Check out Q2! Our unique company culture and super-hero employees, are what sets us apart. We know how to get it done and still have fun! Q2 builds the leading mobile banking software platform serving Credit Unions, Banks (large and small), Community Banks and Financial Institutions. Our mission is to build stronger and...

Sage is an innovative, one-of-a-kind operations management system that transforms how senior living communities deliver care. Unlike traditional nurse call systems, Sage offers a comprehensive platform that provides real-time insights into care delivery and operational efficiency. Our technology empowers caregivers with the tools and data they need to provide personalized care while boosting productivity. By leveraging real-time staffing data and...

PrizePicks is the fastest-growing sports company in North America according to the 2022 Inc. 5000 rankings and the largest independent skill-based fantasy sports operator in North America. PrizePicks was also awarded a Best Places to work certification in 2025. The company was recognized as the Fantasy Sports Business of the Year Award by the Fantasy Sports & Gaming Association and...

Superblocks is reimagining software development for a billion builders. Our mission is to help every team build, deploy, and manage AI-powered software with full control and flexibility. From startups to Fortune 500s, companies are rethinking how they build powerful software with Superblocks.

As the foundation for secure markets, OCC is a customer-driven organization that delivers world-class Risk Management, Clearing, and Settlement Services for a sophisticated mix of financial products that includes standard options, stock loans, and futures contracts.

SOPHiA GENETICS (Nasdaq: SOPH) is a healthcare technology company dedicated to establishing the practice of data-driven medicine as the standard of care and for life sciences research. It is the creator of the SOPHiA DDM™ Platform, a cloud-based SaaS platform capable of analyzing data and generating insights from complex multimodal data sets and different diagnostic modalities. The SOPHiA DDM™ Platform...

Vetcove is a Y Combinator and venture-backed growth stage company with notable investors in Silicon Valley and NYC. Our mission is to provide veterinary hospitals and nonprofits with technology that helps them succeed through our eCommerce and mobile platforms. Our community includes more than 17,000 veterinary hospitals and nonprofits whose staff collectively deliver care to tens of millions of animals...

Sysco LABS is a technology-focused division within Sysco, dedicated to reimagining foodservice through innovation. Sysco LABS uses customer and market intelligence, data-driven insights and agile technology development to rethink the entire foodservice ecosystem.

Gogo Business Aviation is the world’s leading provider of broadband connectivity services for the business aviation market. We offer a customizable suite of smart cabin systems for highly integrated connectivity, inflight entertainment, and voice solutions – innovations that help people in the air stay fully connected to their work, life and entertainment on the ground. Gogo created the inflight connectivity...

CertifID helps to create a world without wire fraud. Started after our co-founder was hit by fraud – we’re the only company dedicated to fighting fraud for the real estate industry with an identity verification SaaS platform, insurance, and proven recovery services. CertifID helps safeguard billions of dollars every month from fraud and provides peace of mind with direct insurance...

Founded by The Allstate Corporation in 2016, Arity is a mobility data and analytics company focused on improving transportation. We collect and analyze trillions of miles of driving data, using predictive analytics to build solutions with a single goal in mind: to make transportation smarter, safer and more useful for everyone.

Since 2004, EZ Texting has provided 230,000+ growing businesses and organizations with an effortless way to start text marketing — and powerful features and integrations to keep conversations going. EZ Texting is a recognized leader in text message marketing for small and medium-sized businesses and organizations, setting the standard for professional texting. Our messaging solutions allow everyone to easily and effectively...

At GoHealth, advancing health equity starts with the intentional, data-driven application of proprietary technology, beneficiary and Medicare-expert insight, and an unwavering commitment to creating positive, health-focused impacts. With our determined drive to help Medicare consumers find a plan that fits their budget and needs, we believe in hiring risk-takers, innovators, and collaborators within our industry to create individualized, simplified healthcare...

https://www.youtube.com/@northslope-technologies At Northslope, we believe that purpose-built AI products in the hands of business operators create far more value than slide decks or off-the-shelf software. That’s why we partner with ambitious organizations to transform entire industries through Palantir’s Foundry and AIP platforms—delivering powerful, measurable outcomes in weeks, not years. We operate more like a product startup than a traditional services firm. Our...

Pie is transforming small business insurance. Our team of seasoned technology and insurance experts are on a mission to empower small businesses to thrive by making insurance affordable and as easy as pie.

Tildei is an AI that learns your brand inside and out to power high-impact marketing and commerce experiences. Tildei works by creating a customized Brand Knowledge Graph, and then activating it across channels (social, SMS, Web, Reddit etc). The agents are designed for marketing and commerce, but further to drive meaningful actions for your brand and your customers (think: shopping cart...

Flatfile, the pioneer of AI-assisted data exchange, provides companies and their software development teams with the easiest, fastest, and safest way to build the ideal data file import experience for their users. Hundreds of companies such as AstraZeneca, Square or Sage rely on Flatfile’s extensible, API-first platform to create enterprise-scale, intelligent, file-based data import solutions, increase developer productivity, reduce cost...

At Toro TMS, we are on a mission to deliver technology that drives lasting improvements for the trucking industry. Our dedicated team has built an easy-to-use, modern end-to-end TMS specifically designed for bulk haulers. From load management and dispatch, to accounting and driver payroll, we provide a single software solution to help our customers move more loads.

Cloudflare, Inc. (NYSE: NET) is the leading connectivity cloud company on a mission to help build a better Internet. It empowers organizations to make their employees, applications and networks faster and more secure everywhere, while reducing complexity and cost. Cloudflare’s connectivity cloud delivers the most full-featured, unified platform of cloud-native products and developer tools, so any organization can gain the...

Riskified (NYSE:RSKD) empowers businesses to unleash ecommerce growth by outsmarting risk. Many of the world’s biggest brands and publicly traded companies selling online rely on Riskified for guaranteed protection against chargebacks, to fight fraud and policy abuse at scale, and to improve customer retention. Developed and managed by the largest team of ecommerce risk analysts, data scientists and researchers, Riskified’s...