Top Senior HR Jobs in St. Louis, MO

One Month AgoSaved
In-Office
St. Louis, MO
Senior level
Senior level
Other
Leads the full HR function, including recruiting, development, performance management, compensation, benefits, employee relations, compliance, and HR operations. Coaches managers, oversees the HR team, advises on employment law and workplace matters, manages benefits and compensation programs, and ensures consistent policies, documentation, reporting, and risk-management practices across a frontline distribution organization.
One Month AgoSaved
Hybrid
St. Louis, MO
Senior level
Senior level
Retail
Owns multi-state HR compliance across federal, state, and local requirements. Responsibilities include maintaining compliance calendars, monitoring regulatory changes, managing I-9/E-Verify, ADA accommodations, EEO-1 reporting, workers’ compensation, OSHA records, unemployment claims, labor posters, audits, remediation, and compliance training. Partners with HRIS, Payroll, Benefits, field leadership, and Legal to maintain audit-ready processes and escalate risks.
Top Skills: E-VerifyHrisUkg Pro
One Month AgoSaved
Remote
St. Louis, MO
Senior level
Senior level
Information Technology • Software
Serve as a strategic HR advisor across multiple software companies and countries. Lead employee relations investigations, performance management, workforce planning, organizational design, manager coaching, people analytics, compliance guidance, and HR program development. Support M&A integration by harmonizing people practices across acquired entities, reinforcing culture, and managing cross-entity HR initiatives. Partner with senior leaders, legal counsel, Total Rewards, and Payroll in a fast-paced, multi-entity environment.
Top Skills: HrisSaaS
Reposted One Month AgoSaved
Remote
St. Louis, MO
90-150 Hourly
Senior level
90-150 Hourly
Senior level
Professional Services • Consulting
Lead client engagements on benefits strategy, plan design, open enrollment, and administration. Stabilize operations, manage carriers/brokers, execute transitions and platform migrations, ensure compliance, advise on cost optimization and multi-state/global expansion, and expand client relationships.
Top Skills: DeelGustoHrisJustworksPaylocityPeo EnvironmentsRemote.ComRippling
One Month AgoSaved
Remote
St. Louis, MO
Senior level
Senior level
Biotech
Partners with senior leaders and employees on HR strategy, employee relations, employment-law compliance, workforce planning, talent acquisition, compensation, benefits, engagement, succession planning, onboarding, training, and performance management. Leads change initiatives, investigations, calibration discussions, and people programs while promoting an ethical, inclusive, and high-performing workplace.
Top Skills: Human Resources Information Systems (Hris)Microsoft Office Suite
One Month AgoSaved
Remote
St. Louis, MO
165K-180K Annually
Senior level
165K-180K Annually
Senior level
Social Impact
Leads the global HR Partner team and serves as a strategic HR advisor to executives and internal clients. Responsibilities include workforce planning, organizational design, talent management, employee relations, compensation, DEI, policy interpretation, investigations, performance management, HR analytics, and organization-wide HR initiatives. The role manages team performance, partners with senior leaders, ensures legal and regulatory compliance, and travels to NRDC offices up to 20% annually.
Top Skills: HrisExcelMS OfficeMicrosoft PowerpointMicrosoft Word
One Month AgoSaved
Remote
St. Louis, MO
Senior level
Senior level
Cloud • Information Technology • Security • Virtual Reality • Cybersecurity
Performs broad HR generalist duties including onboarding, offboarding, benefits and leave administration, employee relations, performance management, compensation, HRIS administration, policy implementation, employment law compliance, reporting, and employee investigations. Partners with managers and employees, supports training and organizational initiatives, maintains personnel records, and develops HR programs and solutions.
Top Skills: Applicant Tracking SystemsHrisIcimsMicrosoft Office SuiteSharepointUkg Pro
One Month AgoSaved
Remote
St. Louis, MO
Senior level
Senior level
Software • Transportation
Serves as a strategic HR consultant to management and employees across U.S. and Mexico operations. Oversees employee lifecycle activities including recruiting, talent management, compensation, succession planning, employee relations, compliance, training, and organizational change. Advises leaders, investigates workplace issues, supports workforce planning and HRIS initiatives, develops policies and job descriptions, and leads engagement and retention efforts. Requires regular travel between the United States and Mexico, with occasional domestic and international travel.
Top Skills: HrisExcelMS OfficeMicrosoft OutlookMicrosoft PowerpointMicrosoft WordWorkday
2 Months AgoSaved
In-Office
St. Louis, MO
70K-80K Annually
Senior level
70K-80K Annually
Senior level
Cannabis • Retail • Biotech • Pharmaceutical
Owns employee relations investigations, corrective action, separations, unemployment claims, leave administration, ADA accommodations, and HR compliance across a multi-site workforce. The manager coaches supervisors, prepares investigation findings, represents the company in unemployment hearings, supports hiring panels, and helps develop manager training. This role partners with the Director of Human Resources to build scalable HR processes across corporate, retail, cultivation, manufacturing, distribution, and compliance teams.
One Month AgoSaved
Remote
St. Louis, MO
50-75 Hourly
Senior level
50-75 Hourly
Senior level
Agency • HR Tech
Own end-to-end multi-state payroll, HRIS administration, compliance, reporting, integrations, and HR operations for clients. Lead HRIS and payroll implementations, system configurations, workflow automation, change management, employee lifecycle processes, and stakeholder workshops. Advise clients on employment law compliance, maintain data integrity and audit readiness, resolve payroll issues, and optimize people processes across varied organizations.
Top Skills: AdpDayforceHibobPaylocityRipplingUkgWorkday
Reposted 2 Months AgoSaved
Easy Apply
Remote
St. Louis, MO
Easy Apply
176K-207K Annually
Senior level
176K-207K Annually
Senior level
Artificial Intelligence • Blockchain • Fintech • Financial Services • Cryptocurrency • NFT • Web3
Partner with functional leaders to translate business strategy into people strategy. Own org design, performance management, compensation, talent development, engagement, and retention. Provide coaching on career pathing, change management, and sensitive employee issues. Use people data to generate insights and recommendations, build compliant HR policies, manage global employee relations, and collaborate with People Team COEs to deliver cohesive people programs at scale.
Top Skills: Generative AiMachine Learning
2 Months AgoSaved
Hybrid
St. Louis, MO
187K-329K Annually
Senior level
187K-329K Annually
Senior level
Artificial Intelligence • Edtech • Information Technology • Biotech
Lead strategy and operations for employee benefits across health, retirement, leave, and voluntary programs. Oversee a 15-person team, vendor management, compliance (ERISA/ACA/HIPAA/COBRA), budgeting, analytics, communications, and governance. Serve as senior advisor, drive benefit design and implementation, and ensure high-quality service delivery and workforce engagement.
Top Skills: AIWorkday Hris
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Reposted 2 Months AgoSaved
Remote
St. Louis, MO
Senior level
Senior level
Agency • Healthtech • Professional Services • Pharmaceutical
Provide HR generalist support for headquarters and remote employees, focusing on employee relations, investigations, performance management, FMLA/ADA/workers' comp administration, HRIS recordkeeping, legal compliance, policy development, and manager consultation. Handle employee inquiries on benefits and 401(k), maintain records, and assist with trainings and documentation to ensure regulatory and corporate compliance.
Reposted 2 Months AgoSaved
Remote
St. Louis, MO
Senior level
Senior level
Agency • Healthtech • Professional Services • Pharmaceutical
Provide administrative and operational HR support including onboarding/offboarding, recruitment administration, HRIS records maintenance, reporting, training documentation, compliance assistance, and responding to routine employee inquiries while handling confidential information and managing multiple priorities in a fully remote environment.
Top Skills: HrisExcelMicrosoft OutlookMicrosoft PowerpointMicrosoft Word
Reposted 2 Months AgoSaved
Remote
St. Louis, MO
Senior level
Senior level
Information Technology
The Head of HR strategically leads all HR functions, fostering a positive workplace culture while managing talent acquisition, employee relations, and compliance.
Top Skills: Hr Software
Reposted 2 Months AgoSaved
Remote or Hybrid
St. Louis, MO
Senior level
Senior level
Information Technology • Consulting
Assist higher education clients in enhancing HR operations as an HR leader. Responsibilities include oversight of projects, training, and aligning HR processes.
Top Skills: BannerEllucian ColleagueHigher Education ErpJenzabarWorkday
Reposted 2 Months AgoSaved
Remote
St. Louis, MO
80K-100K Hourly
Senior level
80K-100K Hourly
Senior level
Social Impact
Lead HR strategy and operations: employee relations, conflict resolution, performance management, onboarding, pay equity audits, training, policy compliance, and HR reporting. Partner with executive leadership and board to align HR with organizational goals and maintain confidential personnel records.
Reposted 2 Months AgoSaved
Remote
St. Louis, MO
Senior level
Senior level
Professional Services • Consulting
Conscious Talent seeks experienced people leaders to shape HR strategies, build inclusive cultures, and support organizational growth, integrating personal development values in their work.
Reposted 2 Months AgoSaved
Remote
St. Louis, MO
Senior level
Senior level
Social Impact
The HR Business Partner collaborates with management to improve employee focus and productivity, aligning HR strategies with company goals and overseeing HR functions.
Top Skills: Human Resource Information SystemsMicrosoft Office Suite
Reposted 2 Months AgoSaved
Remote
St. Louis, MO
Senior level
Senior level
Social Impact
The Human Resources Manager oversees HR operations, manages hiring and onboarding, and collaborates with the team on employee relations and compliance.
Top Skills: Human Resource Information SystemsMicrosoft Office Suite
Reposted 2 Months AgoSaved
Remote
St. Louis, MO
Senior level
Senior level
Cloud • Software
Lead HR Generalist responsible for global HR initiatives, regional talent development, performance management, and employee relations within the Americas, ensuring compliance and supporting high-performance teams.
Reposted 2 Months AgoSaved
Remote
St. Louis, MO
Senior level
Senior level
Fintech • Payments • Financial Services
As an HR and Payroll Specialist, you will manage payroll and HR operations, ensuring compliance and efficiency across multiple countries, primarily the US and Canada. Responsibilities include processing payroll, overseeing HR administrative tasks, and managing benefits administration while maintaining legal compliance.
Top Skills: Adp Workforce NowBamboohrDayforceGoogle SheetsGustoInsperityPayslipWorkday
Reposted 2 Months AgoSaved
Remote or Hybrid
St. Louis, MO
Senior level
Senior level
Information Technology • Consulting
The HR Consultant/Interim CHRO role involves leading HR transformation, implementing HR strategies, and advising on finance projects in higher education settings.
Top Skills: AtsBenefitsFinance ErpHcmPayroll
Reposted 2 Months AgoSaved
In-Office or Remote
St. Louis, MO
Senior level
Senior level
Travel • Hospitality
The HR Manager will lead the onboard HR team, provide expert advice on HR policies, manage employee relations, and ensure compliance with regulations while promoting a positive work culture.
Top Skills: Database ProgramsExcelPowerPointWord
Reposted 2 Months AgoSaved
Remote
St. Louis, MO
Senior level
Senior level
Logistics • Other
Serve as HR Business Partner for multi-site service center operations, leading employee relations, investigations, safety culture (Zero Harm), workforce planning, engagement, compliance, and HR program execution. Coach leaders, support talent lifecycle, manage high-risk ER cases, and partner with legal and HR centers of excellence to drive consistent people practices across distributed frontline teams.
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