Top Senior Machine Learning Jobs in St. Louis, MO

Reposted 22 Days AgoSaved
Remote
St. Louis, MO
200K-250K Annually
Senior level
200K-250K Annually
Senior level
Artificial Intelligence • eCommerce • Software
As a Senior MLOps Engineer, you will manage production ML systems, define lifecycle strategies, optimize ML pipelines, and collaborate with cross-functional teams to enhance ML operations.
Top Skills: AWSAzureCi/CdGCPPythonPyTorchTensorFlow
Reposted 22 Days AgoSaved
Remote
St. Louis, MO
Senior level
Senior level
Internet of Things
Build and productionize AI systems for logistics: multi-agent copilots, forecasting/optimization models, evaluation and observability, continuous learning loops, and operational reliability. Mentor engineers and make build-vs-rule tradeoffs while shipping high-impact ML services.
Top Skills: Amazon BedrockAnthropicAzure OpenaiBrowser AutomationDocument UnderstandingFastapiFeature StoresLangchainLanggraphMcpMlopsMulti-Agent OrchestrationOpenaiPythonRag (Retrieval-Augmented Generation)Streaming SystemsTool/Function-Calling
Reposted 23 Days AgoSaved
Remote
St. Louis, MO
150K-269K Annually
Senior level
150K-269K Annually
Senior level
Cloud • Information Technology • Insurance • Software • Analytics
The role involves defining and refining Guidewire's AI narrative, crafting audience-specific messages, leading competitive positioning, and creating technical marketing assets to convey the value of AI-driven solutions in the P&C insurance sector.
Top Skills: Agent StudioAIAPIsCloud PlatformsData GovernanceGenerative AiLlmopsMlMlopsOrchestration FrameworksSdksVector Stores
23 Days AgoSaved
Remote
St. Louis, MO
466K-750K Annually
Senior level
466K-750K Annually
Senior level
News + Entertainment
Lead ML initiatives to improve Sales productivity and automation: define roadmap, design and deploy production ML models and AI agents, build measurement pipelines with analytics engineers, iterate from performance and seller feedback, and act as senior technical partner across product, engineering, and Sales to drive measurable revenue impact.
Top Skills: PythonSQL
23 Days AgoSaved
Remote
St. Louis, MO
600K-1M Annually
Senior level
600K-1M Annually
Senior level
News + Entertainment
Lead ML technical strategy for Live Ads, designing and deploying forecasting, targeting, bidding, auction, and yield-optimization models. Build and evaluate large-scale production ML systems, create online/offline evaluation frameworks, partner with product to set objectives and trade-offs, and communicate results to stakeholders and leadership.
Top Skills: JavaPythonScala
23 Days AgoSaved
Remote
St. Louis, MO
600K-1M Annually
Senior level
600K-1M Annually
Senior level
News + Entertainment
Lead design and execution of a modernized, Python-native AI/ML platform for AIMS: define architecture, drive migration, build migration tooling, ensure scalability, observability, cost optimization, and reliability, prototype GenAI operational tooling, and set org-wide technical standards.
Top Skills: Batch ProcessingDistributed SystemsExperiment FrameworksFeature StoresGenaiJavaLlmsModel Serving PlatformsObservability/Monitoring SystemsPythonReal-Time ServingScalaTraining Pipelines
23 Days AgoSaved
Remote
St. Louis, MO
466K-750K Annually
Senior level
466K-750K Annually
Senior level
News + Entertainment
Design and execute ML research and end-to-end model development for generative and summary-generation systems. Lead rigorous experiments, translate findings for stakeholders, partner with engineers to deploy models, track state-of-the-art advances, and define roadmaps to improve promotional writing and discovery for members.
Top Skills: Deep LearningDiffusion ModelsLarge Language Models (Llms)Llm Post-Training ApproachesNatural Language Processing (Nlp)PythonPyTorchTensorFlow
24 Days AgoSaved
Remote
St. Louis, MO
219K-328K Annually
Senior level
219K-328K Annually
Senior level
Cloud • Legal Tech • Software
Lead a team of ML engineers to design, build, and productionize LLM/GenAI and agentic systems (retrieval, tool use, orchestration). Collaborate cross-functionally with MLOps, product, and data science, review code, mentor engineers, run technical evaluations and proofs-of-concept, and ensure reliable, safe ML deployments for a large SaaS product.
Top Skills: Agentic SystemsEvaluation FrameworksFine-Tuning Foundational ModelsGenaiLlmsMlopsPrompt DesignRag (Retrieval-Augmented Generation)RetrievalTool-Calling AgentsTraining Language ModelsUnstructured Data Preprocessing
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24 Days AgoSaved
Remote
St. Louis, MO
117K-187K Annually
Senior level
117K-187K Annually
Senior level
Edtech
Embed with strategic higher-education partners to design, build, and ship production AI and platform integrations (LLM/RAG, LTI) across Cengage products. Own end-to-end deployments, write production code, ensure compliance and accessibility, evaluate AI safety and outcomes, mentor FDEs, and translate field learnings into product roadmap contributions.
Top Skills: AgsApi GatewayAuroraAWSCaliperCloudwatchCoppaDeep LinkingEcsEksFerpaGraphQLJavaScriptLambdaLlm ApisLti 1.3Lti AdvantageMindtapNrpsPrompt EngineeringPythonRag (Retrieval-Augmented Generation)RdsRestS3SQLTool-Calling AgentsTypescriptWebassignXapi
Reposted 24 Days AgoSaved
Remote
St. Louis, MO
156K-229K Annually
Senior level
156K-229K Annually
Senior level
Productivity • Software • Conversational AI
The Machine Learning Engineer will develop and maintain scalable ML systems, collaborate across teams, and innovate solutions for real-time applications to enhance customer experiences.
Top Skills: AirflowAWSAzureDockerDynamoDBEmrFlinkGCPJavaKafkaKubeflowKubernetesMetaflowMlflowOpensearchPythonSagemakerSnowflakeSparkSQL
Reposted 24 Days AgoSaved
Remote
St. Louis, MO
130K-187K Annually
Senior level
130K-187K Annually
Senior level
Aerospace • Defense • Manufacturing
The job involves building responsive web dashboards, advanced data visualizations, and analytics tools for unmanned aircraft systems, requiring a deep understanding of UI/UX design and data presentation.
Top Skills: AngularCSSD3.JsFigmaGraphQLHTMLJavaScriptJestMobxNumpyPandasPlotlyPythonReactRechartsRestful ApisTypescriptVueWebglZustand
Reposted 24 Days AgoSaved
Remote
St. Louis, MO
248K-310K Annually
Senior level
248K-310K Annually
Senior level
Real Estate • Travel • PropTech
Responsible for fine-tuning state-of-the-art LLMs, optimizing models for deployment, and driving AI architectural decisions. Collaborate with cross-functional teams to develop impactful AI products.
Top Skills: PythonPyTorch
One Month AgoSaved
Remote
St. Louis, MO
Senior level
Senior level
Gaming • Machine Learning • News + Entertainment • Design • Conversational AI • Generative AI
Lead technical execution across backend, frontend, mobile, AI, and data. Translate ambiguous product goals into technical plans, unblock hard engineering problems, coordinate cross-domain work, raise engineering quality, define hiring needs and technical evaluation standards, and build internal AI workflows to foster an AI-native engineering culture.
Top Skills: Ai AgentsAi SystemsAndroidData InfrastructureData PipelinesExperimentationFlutterGoiOSLlm WorkflowsMachine LearningNext.JsPythonReactReact NativeRecommendation Systems
Reposted One Month AgoSaved
In-Office or Remote
St. Louis, MO
140K-180K Annually
Senior level
140K-180K Annually
Senior level
Artificial Intelligence • Legal Tech • Natural Language Processing • Generative AI
Lead technical pre-sales and enterprise rollouts by owning infrastructure strategy, PoCs, migrations (on‑prem to cloud), DMS/CRM integrations, InfoSec discussions, and stakeholder engagement with C-level sponsors to enable scalable deployments and upsell opportunities.
Top Skills: Cloud InfrastructureCRMDevsecopsDocument Management SystemsGenerative AiImanageLarge Language ModelsMachine LearningMicrosoft Word
Reposted 2 Months AgoSaved
Remote
St. Louis, MO
150K-165K Annually
Senior level
150K-165K Annually
Senior level
Healthtech
Lead program delivery for engineering teams at Arine, optimizing internal processes and ensuring timely execution of technical programs while facilitating Agile methodologies.
Top Skills: AgileAIConfluenceData ScienceJIRAMachine LearningSaaS
Senior level
Gaming • Software
The AI Director will oversee ML bot development and implementation, identify AI opportunities, educate teams, and prototype AI solutions.
Top Skills: C++PythonPyTorchTensorFlow
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