Top IT Jobs in San Luis Obispo, CA

Architects, implements, and operates secure, scalable Microsoft Azure solutions supporting generative AI and scientific research. Develops Terraform infrastructure, automation, and CI/CD pipelines; integrates compute, storage, networking, identity, security, monitoring, APIs, and AI services. Troubleshoots performance, reliability, security, and cost issues across application and infrastructure layers. Partners with developers, AI engineers, security teams, and customers to translate requirements into architecture, mentors engineers, evaluates tradeoffs, and supports compliance and authorization activities.

Executes Liquidia’s IT compliance program across SOX, GxP, and 21 CFR Part 11 requirements. Manages IT audits, control evidence, corrective actions, third-party risk assessments, infrastructure qualification, validated systems documentation, cybersecurity framework alignment, AI governance records, and external auditor coordination. Partners with Quality, Procurement, Legal, auditors, and IT stakeholders to maintain policies, assess compliance impacts, support validation activities, and mature the cybersecurity governance roadmap.

Lead strategic build-versus-buy engineering initiatives within Elastic’s IT organization. Design and deliver internal platforms using Elasticsearch, Kibana, Elastic ML, AI, and cloud technologies across developer productivity, FinOps, IT service management, and enterprise efficiency. Establish architecture and engineering standards, partner cross-functionally with IT, Security, Platform Engineering, Finance, and other teams, and validate Elastic products through internal production systems.

Maintain and improve cybersecurity across Azure Cloud and on-premises environments. Monitor and tune security alerts, manage vulnerability scanning and remediation, conduct threat intelligence analysis, support incident response, perform risk assessments and threat modeling, and implement security controls and configurations. The role also supports regulatory compliance, security documentation, cross-functional initiatives, and on-call response to security alerts.

Leads Docker’s global Information Technology organization, overseeing help desk services, application management, device lifecycle logistics, internal productivity tools, service metrics, SLAs, and continual improvement. Develops multi-year IT strategy and technology roadmaps, architects and optimizes the SaaS and cloud application ecosystem, manages technical debt, and partners with executives and technical leaders to support business growth. Builds a metrics-driven, customer-focused team and advances AI- and automation-first practices.

Supports network design and implementation at Air Force and Space Force bases. Assists with equipment and infrastructure installation, fiber-optic testing, troubleshooting, documentation, assessments, stakeholder coordination, and project communication. Works with senior engineers, government counterparts, vendors, and implementation teams to sustain wired network functionality. The position requires Secret clearance, U.S. citizenship, and extensive travel to field sites, primarily Eielson Air Force Base in Fairbanks, Alaska.

Leads the surveying, design, installation, and implementation of telecommunications rooms and infrastructure at Eielson Air Force Base. Develops rack, cabling, grounding, electrical, cooling, and equipment layouts; manages government, contractor, and subcontractor installation teams; coordinates facility upgrades and network, fiber, ISP, and OSP integration; ensures compliance with DoD, UFC, TIA/EIA, and I3A standards; and supports design reviews and customer briefings.

Leads FHIR-based digital quality measurement programs for CMS and federal stakeholders. Directs translation of traditional measures into computable digital measures, including specification authoring, CQL and value set management, feasibility review, testing, validation, and annual maintenance. Serves as the technical liaison for FHIR, QI-Core, interoperability, and quality reporting topics; mentors multidisciplinary teams and supports stakeholder engagement, technical strategy, and federal deliverables.

Provides senior technical leadership for IT support and operations in a remote healthcare technology environment. Owns complex escalations, incident resolution, root cause analysis, endpoint and identity administration, onboarding and offboarding, vendor escalations, documentation, automation, and reliability improvements. Coaches support staff, develops scalable processes, partners with Security, Compliance, Engineering, Product, and clinical teams, and communicates clearly during high-impact incidents affecting clinical workflows.

Manage and secure cloud and server infrastructure, including Windows Server, Azure, AWS, Azure Virtual Desktop, Active Directory, DNS, DHCP, and Office 365. Responsibilities include monitoring, troubleshooting, patching, automation, security and compliance, backup and disaster recovery, infrastructure migrations, ITIL service management, documentation, and user support. The administrator will participate in 24/7 on-call rotations and collaborate on infrastructure optimization and project initiatives.

Deploys, hardens, troubleshoots, and modernizes Windows and .NET applications across on-premises environments and AWS. Responsibilities include Terraform infrastructure, CI/CD pipelines, SQL Server and Amazon RDS administration, load balancing, WAF configuration, observability, certificate management, automation, migrations, incident response, documentation, and collaboration with application owners. The role is remote but requires weekly onsite availability in Rockville, Maryland, and may involve occasional after-hours maintenance or outage troubleshooting.

Design, develop, and maintain high-performance Scala/Java server-side applications and RESTful APIs. Work on distributed systems, ensure data integrity and security, write unit tests, optimize performance, participate in design reviews, and mentor junior engineers while supporting CMS mission requirements.

Administer Epic’s corporate identity, access, endpoints, applications, devices, and employee IT support. Manage onboarding and offboarding, access reviews, authentication and device standards, MDM provisioning, asset inventories, procedures, and audit evidence. Support SOC 2 or similar compliance activities, security reviews, and incident response while partnering with infrastructure and people operations. This is a fully remote, US-based role supporting a global engineering team.

Leads multidisciplinary distribution systems engineering teams supporting large-scale telecommunications and network infrastructure modernization. Responsibilities include supervising engineers, technicians, subcontractors, and agency labor; coordinating government stakeholders, base access, schedules, materials, and deployments; validating designs and engineering deliverables; leading reviews and planning; mitigating risks; and supporting program execution. The role requires extensive OSP/ISP, fiber optic, telecommunications room, Air Force and Space Force standards experience, an active Secret clearance, and extensive travel to Eielson Air Force Base.

Lead enterprise solution architecture and modernization of legacy IBM mainframe financial applications. Analyze current-state systems, design cloud-enabled future-state architectures, map business processes, and guide migrations involving COBOL, JCL, CICS, DB2, and VSAM. Provide technical leadership across integration, data migration, interoperability, documentation, testing, and deployment. Collaborate with financial agencies and development teams to implement modern solutions using Java, Spring Boot, APIs, microservices, databases, cloud platforms, and DevSecOps practices.

Lead administration of Microsoft 365, Google Workspace, SaaS applications, Azure identity, and cloud infrastructure in a fully cloud-based organization. Provide Level 2/3 service desk escalation, execute migrations and cybersecurity projects, establish IT service processes, manage assets and vendors, and support onboarding, offboarding, incident response, change management, and M&A initiatives. The role partners with IT leadership and may help build and manage a growing internal technical team.

The Senior Clinical Trials IT Business Analyst bridges Clinical Development and IT, optimizing clinical trial technologies and managing system implementations, validations, and stakeholder engagement.

Leads enterprise architecture for Biogen’s Veeva ecosystem across Development, Quality, Regulatory, Safety, and Commercial functions. Translates business needs into scalable Veeva configurations and integrations, governs target-state architecture and platform standards, reviews solution designs, and oversees implementation and release planning. Mentors configuration teams, drives cross-vault consistency, manages architecture governance, aligns with Veeva product roadmaps, and advises IT leadership on platform strategy, investments, regulatory compliance, and business objectives.

Leads the design, development, integration, deployment, and operation of large-scale Zero Trust security solutions for DoD environments. Creates system architecture blueprints, selects technologies, integrates distributed systems across on-premise and cloud environments, optimizes performance, ensures compliance with DoD requirements, and leads engineering teams. Diagnoses system issues, implements solutions, and produces architecture documentation while supporting installation, migration, and configuration activities across multiple client locations.

Leads the architecture, design, integration, deployment, and operation of large-scale Zero Trust security solutions for DoD environments. Creates system blueprints, selects technologies, integrates distributed systems across on-premises, cloud, and hybrid environments, optimizes performance, resolves system issues, and ensures compliance with DoD requirements. Leads engineering teams, supports installation and migration at multiple locations, and documents architecture and implementation decisions.

Sell radiology IT solutions by building strategic account plans, managing long technical sales cycles, maintaining a 3-5× quota pipeline, forecasting in Salesforce, partnering with marketing/inside sales, and representing the company at industry conferences.

Provide front-line technical support and customer service via phone and ticketing (ConnectWise), troubleshoot hardware/software (Windows/macOS, MS Office), escalate and document issues, perform occasional on-site client visits, and maintain service desk administration and timesheet reporting.

Leads business analysis for enterprise applications and reporting initiatives. Translates stakeholder needs into requirements and functional or technical specifications, partners with IT on scalable solutions, manages project scope and risks, maintains process documentation, supports UAT and change readiness, and drives process standardization. Establishes business analysis standards and best practices across a growing, multi-location organization.

The IT Manager, Product Owner - Finance drives financial process transformations, prioritizes product backlogs, and manages stakeholder relationships to ensure high-quality delivery of financial systems solutions.

Develop and maintain Digital Workplace tools, working closely with teams, performing testing, debugging, and technical research. Requires web development experience and familiarity with modern software architectures.