Top Remote Python Jobs in San Diego, CA

Design, build, and maintain scalable AWS and Azure infrastructure using Infrastructure-as-Code. Develop automation, deployment pipelines, and production release processes. Contribute code to cloud services, manage networking and IAM, ensure availability and security, and respond to incidents while collaborating on observability and security practices.

Design, implement, and optimize high-performance backend systems in Rust for an xOT security platform. Participate across the development lifecycle—debugging, testing, and performance tuning—while integrating relational and NoSQL data stores, microservices, third-party devices, and AI tools. Provide technical leadership, code review feedback, and promote secure, reliable, observable distributed systems.

Design and develop backend services and APIs for identity resolution, optimize event-driven systems, and enhance system reliability. Mentor engineers and influence architectural decisions.

As a Lead Software Engineer, you'll design and develop GenAI platforms, integrate LLMs, mentor engineers, and solve technical challenges for scalable solutions.

Lead reliability, scalability, and operational excellence of large-scale database platforms across cloud and on-prem. Build automation-first database infrastructure (Kubernetes operators, IaC, GitOps), drive monitoring/SLOs, incident leadership, performance and cost optimization, and partner with application teams on safe schema/migration practices. Mentor engineers and evaluate AI-assisted workflows to improve productivity and reliability.

Lead architecture and scaling of finance systems across Oracle Fusion and integrations. Drive AI-assisted development, design data models, build integrations (SQL/PLSQL, REST/SOAP), automate financial workflows, and translate accounting requirements into scalable technical solutions while partnering with business and data teams.

Design, build, and operate high-throughput, fault-tolerant ledger and settlement systems of record. Develop durable ledgering APIs, settlement orchestration, and treasury automation. Ensure data contract integrity for downstream finance, run production systems to SLOs, debug multi-layer issues, lead and mentor engineers, and use AI tooling to reduce operational toil.

Build and operate the Power Packs customer experience and backend services. Design data foundations, APIs, and integrations across platform services. Troubleshoot distributed systems, contribute full-stack plumbing as needed, improve observability and documentation, and collaborate with Product and partner teams to deliver scalable, multi-tenant marketplace capabilities.

Design and implement CIAM backend services for authentication and authorization. Integrate identity systems, manage secure flows, and automate infrastructure.

Lead architecture and delivery of large-scale React and React Native frontends. Define frontend strategy and best practices, build shared component libraries and design systems, optimize performance and accessibility, collaborate with product/design/backend teams, mentor junior engineers, and resolve complex frontend and cross-stack issues.

Lead development of guidance, navigation, and control (GNC) systems from concept to flight-ready software. Design and simulate algorithms, translate requirements into embedded implementations, support HIL and flight test, analyze test data, coordinate across vehicle design, avionics, structures and testing, and document results while mitigating technical risk.

The software engineer will build full-stack features for Kora's voice AI agent, integrating data, refining prompts, and expanding multi-modal capabilities while mentoring peers and ensuring technical quality.

Operate and maintain AWS-hosted MERN applications and large-scale data workflows. Manage serverless and Spark-based pipelines, perform incident response and on-call duties, engineer automation to eliminate operational toil, ensure HIPAA/SOC2/HITRUST compliance, build observability and lead blameless post-mortems.

Lead design and delivery of full-stack, AI-powered products and platform capabilities. Own technically complex, mission-critical areas end-to-end, partner with product and customer teams, scale data ingestion and APIs, and mentor engineers to raise engineering quality and velocity.

Design, deploy, and operate multi-vendor, multi-region hybrid cloud data center networks. Drive automation-first deployments using IaC and scripting, improve deployment quality/velocity, integrate automation into capacity workflows, build visibility/tools, maintain production reliability, and participate in 24x7 on-call rotations.

Senior SRE owning availability, automation, and observability for CI/CD platform services. Build and operate infrastructure, run on-call, lead incident response, mentor engineers, drive design/capacity planning, integrate AI-assisted workflows, and improve cross-team reliability.

Lead a global network engineering team to design, scale, and operate large-scale IP and optical backbone and hybrid cloud connectivity. Own technical roadmap, cloud connectivity strategy, automation, vendor relationships, hardware/software integration, testing, tooling, DDoS mitigation, operational excellence, and participate in 24x7 on-call rotations while ensuring compliance in regulated environments.

Lead the developer experience roadmap and own multi-language SDKs and the code-generation pipeline. Design CI, release automation, observability, and tooling (CLI, starter repos). Improve cross-language parity, docs, and developer onboarding; remove systemic friction and represent DX to Product, Engineering, and Partnerships.

Lead technical strategy and execution for a backend ledger team building highly available, audit-grade financial systems. Drive architecture, reliability, monitoring, on-call practices, code quality, cross-functional collaboration, and mentoring to ensure accurate, scalable ledger operations.

As a Billing & Analytics Software Engineer, you'll design and maintain the billing pipeline, integrate billing systems, and develop customer-facing analytics dashboards to support revenue recognition and operational observability.

Lead the development of healthcare applications and data systems, focusing on audience intelligence and compliance. Design scalable data pipelines, APIs, and reporting systems while ensuring high data quality and security in regulated environments.

The engineer will build and operate AI/ML infrastructure, managing services on AWS and bare metal, using tools like Kubernetes and Terraform.

Lead the entire engineering organization: set technical vision, architecture, and operating model; recruit and develop managers; own delivery, reliability, security (SOC 2), budgeting, and metrics; improve velocity while reducing technical debt; partner with product and execs to drive roadmap and org-scale decisions.

Design and implement backend and real-time features in the GitLab monolith for portfolio planning at scale. Optimize PostgreSQL performance, evolve APIs (GraphQL/REST), build capacity planning and work-item hierarchies, create proofs of concept, maintain automated tests, support safe rollouts with feature flags and observability, mentor contributors, and participate in on-call and production troubleshooting.

Design and build agent-powered mission consoles, collaborate with stakeholders to improve user workflows, and maintain agentic workflows for mission outcomes.