Top Remote Python Jobs in San Diego, CA

Lead backend engineering strategy for Affirm’s international Identity team. Design and launch highly available distributed systems supporting KYC, user lifecycle management, and identity decisioning. Drive technical planning, cross-functional collaboration, operational excellence, monitoring, testing, and on-call readiness. Establish engineering quality standards, influence architecture, mentor team members, and deliver scalable systems using Python or Kotlin, AWS, MySQL, Spark, and Kubernetes.

Develop state estimation and navigation algorithms for autonomous systems operating in GPS-denied environments. Build production-grade C++ software for embedded Linux robotic platforms, create modeling and simulation tools, and implement comprehensive testing and validation. Collaborate on roadmap planning and agile execution while improving benchmarking and performance-analysis pipelines. The role requires professional C++ expertise, state estimation algorithm experience, sensor-fusion familiarity, and the ability to deploy reliable autonomy software.

Own platform reliability, observability, incident response, scaling, capacity planning, and deployment automation. Monitor system health, debug and resolve incidents, build logging and monitoring tools, improve CI/CD pipelines, develop self-service automation, and strengthen high-availability delivery systems. The role requires clear incident communication, post-incident learning, and collaboration across engineering teams in secure, high-side environments.

Provide engineering support for the design, implementation, and testing of SCADA systems for high voltage projects, ensuring compliance and effective communication on-site.

Design and implement FPGA code for satellite digital payloads, including DSP algorithms, software-defined radio signal processing, embedded systems, and processor or peripheral interfaces. Responsibilities include developing custom IP, improving DSP and interface reliability, integrating vendor IP cores, supporting communications architecture, and participating in spacecraft design studies. The engineer will work across simulation, synthesis, place and route, timing closure, and hardware testing.

Designs, builds, and operates secure, highly available AWS cloud platforms and production workloads. Responsibilities include cloud architecture, infrastructure as code, automation, Kubernetes or ECS operations, CI/CD, security, observability, troubleshooting, cost optimization, and collaboration with application, security, and SRE teams.

Conduct aerodynamic and fluid-dynamics analyses for an AI training project. Build geometries, computational domains, meshes, boundary conditions, and solver-ready CFD cases; run command-line simulations; automate workflows with Python; perform parameter sweeps and postprocessing; and validate numerical and physical results. Diagnose convergence issues and communicate modeling assumptions and engineering trade-offs. Requires an aerospace or mechanical engineering background with aerodynamics expertise and practical CFD and Python experience.

Architect, scale, and secure AWS infrastructure using IaC and automation. Build self-service templates, maintain FedRAMP-ready configurations, support incident response, optimize performance with Datadog, and mentor junior engineers.

Senior Software Engineer responsible for designing, building, and scaling high-volume pharmacy and prescription-processing services. The role includes improving automation, inventory optimization, billing and clinical workflows, predictive systems, and pharmacist tooling. Responsibilities include architecting maintainable platforms, solving complex healthcare and e-commerce problems, mentoring engineers, driving technical strategy, and maintaining production quality and resilience.

Senior engineer responsible for designing, building, and operating scalable data ingestion, processing, storage, and member-facing membership application. Drive architecture decisions, mentor engineers, build data pipelines, APIs, and ensure reliability, observability, CI/CD, and documentation while partnering with product and analytics stakeholders.

Design and own NodeZero’s over-the-air update infrastructure across thousands of customer deployments. Responsibilities include delivery protocols, version negotiation, rollout orchestration, health verification, rollback, fleet state management, constrained-environment delivery, reliability, incident response, architecture, production coding, and mentoring engineers. The role requires secure, highly reliable distributed systems that operate across air-gapped and customer-managed Kubernetes environments.

Lead the Data Streaming engineering sub-team responsible for reliable, scalable ingestion, normalization, and routing of cybersecurity telemetry. Manage and grow a 6–7 engineer team, establish SLOs and on-call processes, maintain schemas and data contracts, improve pipeline reliability and scalability, and collaborate with Security Research, Database Platform, and Asset Inventory teams. The role requires hands-on expertise with streaming architectures, cloud-native operations, data quality, and pipeline observability.

Staff Engineer responsible for database architecture, performance, reliability, migrations, and operational standards across PostgreSQL, graph, and time-series data stores. The role involves writing production code, analyzing query performance, designing failover and migration systems, mentoring engineers, and guiding database practices across teams. Candidates need deep PostgreSQL expertise, experience with graph and analytical databases, cloud or Kubernetes operations, and proficiency in Go or Python.

Lead a 6–7 person engineering team responsible for building, shipping, and maintaining production-grade integrations with security platforms such as CrowdStrike, SentinelOne, Splunk, and ServiceNow. Own the integration product roadmap, API contracts, reliability, compatibility, certification pipeline, and upstream change management. Partner with customer success, security research, and partnerships teams while hiring and developing engineers. The role requires hands-on technical expertise in Go or Python, enterprise authentication, event-driven architectures, AWS serverless services, and security data normalization.

Own the architecture and operation of NodeZero’s container image build, signing, scanning, CI/CD, and over-the-air delivery systems. Establish standards for reproducible builds, artifact versioning, release gating, rollout, rollback, and security. Write code, design systems, respond to operational incidents, make cross-team technical decisions, and mentor engineers. The role requires deep container, Kubernetes, release engineering, and secure software supply chain expertise.

Lead the architecture and implementation of a shared partner-integration framework connecting NodeZero with security and ITSM platforms. Build complex production integrations, define reliability and observability standards, advise on API patterns, respond to incidents, create architecture documentation, and mentor engineers. The role requires hands-on software development in Go or Python, expertise in distributed systems and API integrations, and experience with cloud-native environments such as Kubernetes and AWS.

Senior DevOps Engineer responsible for infrastructure automation, monitoring, reliability, secure Linux administration, CI/CD, infrastructure as code, cloud and networking strategy, and zero-touch provisioning. The role includes incident response, capacity planning, observability, documentation, on-call support, technical leadership, mentoring, and researching technologies across cloud, virtualization, and hardware platforms.

Build and scale backend or full-stack services supporting prescription intake, processing, fulfillment, inventory optimization, billing, benefits, and clinical workflows. Design resilient, maintainable, high-throughput systems; integrate automation, LLMs, predictive models, and service-oriented architectures; optimize pharmacy and supply chain operations; troubleshoot production issues; establish engineering best practices; and mentor other engineers.

Lead the design, development, and implementation of resilient pricing tools using Python and cloud technologies. Improve automation, deployment reliability, testing, documentation, and technical standards. Coordinate complex projects, research new development practices, identify technical blockers, and mentor junior developers. Collaborate with stakeholders while developing expertise in insurance pricing and supporting applications built with technologies such as Streamlit, Flask, Docker, Kubernetes, and cloud compute.

Deploys, configures, integrates, and operates Databricks and enterprise cloud data infrastructure for HUD. Automates infrastructure through IaC, scripting, APIs, and CI/CD; configures security, identity, access, compute, storage, and Unity Catalog. Supports data pipelines and Databricks applications, troubleshoots platform and integration issues, documents procedures, collaborates with cloud, cybersecurity, DevSecOps, and application teams, and provides technical leadership.

Designs, deploys, and operates high-performance InfiniBand and RoCE networking fabrics for GPU clusters, customer connectivity, and multi-site WAN infrastructure. Manages routing, switching, BGP peering, VLAN/VRF/VPC architectures, automation, monitoring, troubleshooting, documentation, capacity planning, and security audits. Requires deep data center or service provider networking expertise, advanced routing knowledge, and hands-on experience with Arista, NVIDIA, or Cisco platforms.

Administer enterprise database environments supporting high availability, replication, disaster recovery, security, performance, retention, and hybrid-cloud operations. Lead SQL Server infrastructure while supporting Oracle, MySQL, PostgreSQL, and NoSQL platforms. Design zero-downtime upgrades, migrations, failover testing, and modernization roadmaps. Develop automation using Terraform, Ansible, scripting, and CI/CD pipelines; establish operational standards; lead outage response; and mentor distributed operations teams.

The Integration Engineer will lead client onboarding for fraud and compliance products, manage integrations, analyze requirements, and support clients throughout the process.

Lead client onboarding and end-to-end integrations for fraud and compliance products. Translate technical and business requirements into scalable solutions, manage implementation timelines and risks, support customers, maintain API and SDK documentation, analyze SQL and JSON data, build internal automation tools, and provide product feedback to internal teams.

Build and operate enterprise Amazon Connect contact centers and AI agents. Implement generative AI (Bedrock/Claude), serverless backends, CDK IaC, observability, testing, and integrations with CRMs and analytics. Own delivery from code to production, mentor engineers, and support customer-facing technical workstreams.