Top Remote Python Jobs in San Diego, CA

Build and scale backend data platforms and services for real-time loan origination and financial reporting. Lead quarterly delivery, guide engineers, define technical plans, collaborate with product and design partners, improve reliability and operational practices, monitor service metrics, participate in on-call support, uphold engineering quality standards, and mentor team members. The role requires developing highly available distributed systems and scalable data pipelines using technologies such as Python, Kotlin, AWS, MySQL, Kubernetes, Spark, and Airflow.

Leads the strategy, validation, and safety assurance of Level 3–4 autonomous driving behaviors powered by machine learning. Owns behavior-related safety cases, standards alignment, ODD and evaluation frameworks, safety metrics, launch-readiness assurance, and evidence assessment across simulation, closed-course, and public-road testing. Leads cross-functional technical collaboration and builds a high-performing AV behavior safety engineering team through hiring, coaching, and development.

Build and evolve SailPoint’s AWS-based internal migration platform through hands-on full-stack development, cloud infrastructure, AI agents, APIs, testing, CI/CD, observability, and security. The role uses Angular, FastAPI, Python, AWS CDK, and numerous AWS services. Responsibilities include architectural contributions, mentoring engineers, troubleshooting, stakeholder collaboration, and improving automation, reliability, developer productivity, and customer migration outcomes.

Lead reliability, scalability, and operational excellence of large-scale database platforms across cloud and on-prem. Build automation-first database infrastructure (Kubernetes operators, IaC, GitOps), drive monitoring/SLOs, incident leadership, performance and cost optimization, and partner with application teams on safe schema/migration practices. Mentor engineers and evaluate AI-assisted workflows to improve productivity and reliability.

Own the durability, recoverability, performance, and security of a production PostgreSQL/RDS fleet supporting a live trading platform. Lead replication, failover, backup and restore, disaster-recovery drills, data lifecycle management, access control, encryption, and database observability. Investigate engine-level performance issues including WAL contention, replica lag, bloat, and locking. Build infrastructure and AI-assisted operational tooling while documenting runbooks and reliability decisions.

Build and operate secure, scalable multi-cloud infrastructure across AWS, GCP, and networking platforms. Develop self-service tooling, infrastructure-as-code defaults, cloud guardrails, and standardized platform patterns. Lead cross-team infrastructure initiatives, technical investigations, and operational improvements while partnering with security, compute, routing, and other infrastructure teams.

Design, scale, and operate Runpod’s distributed storage platform across network volumes, local NVMe, and S3-compatible object storage. Tune storage and high-speed network performance, lead capacity expansions and migrations, write production automation and control-plane code, extend APIs, and build observability, dashboards, SLOs, and alerts. The role also participates in on-call operations, incident response, infrastructure-as-code practices, and long-term architecture decisions for petabyte-scale AI infrastructure.

Research and analyze vehicle network signals, OEM telematics data, wiring diagrams, and field logs to expand vehicle telemetry coverage. Capture and interpret vehicle network data using live debugging, log analysis, scraping, reverse engineering, and custom scripts. Validate solutions on vehicles and at customer locations, document findings, and collaborate with global engineering and product teams to support new telematics capabilities.

Lead enterprise B2B integration projects for strategic customers using APIs, webhooks, connectors, cloud services, and scalable integration architectures. Translate business requirements into technical designs, build and review code, manage complex projects, troubleshoot deployments, and advise customers and internal teams on integration best practices. Collaborate with product, sales, support, and developer ecosystem teams while supporting multiple customer engagements and improving professional services methodologies.

Lead Apollo’s Rep Experience engineering team building prospecting, account management, task orchestration, dashboards, and AI-driven recommendations. Responsibilities include technical decision-making, architecture, planning, coding mentorship, hiring, people management, on-call sustainability, estimation, process improvement, and cross-functional collaboration with Product, Design, GTM, and engineering leadership.

Lead technical strategy and execution for multi-quarter initiatives, build and maintain software systems using AI, mentor and elevate engineers, collaborate across disciplines, and protect user privacy and security. The role involves working in an AWS and Kubernetes environment with technologies including Python, TypeScript, React, Go, Airflow, dbt, and Claude Code.

Build scalable, API-first platform capabilities through manifest-driven development. Develop Java and Kotlin backend services and Python workers for third-party integrations, collaborate across engineering teams, participate in architecture reviews, and troubleshoot production systems using logs, metrics, and traces. The role requires expertise in highly scalable systems, object-oriented design, REST services, relational databases, responsive messaging, caching, and software quality practices.

Design and develop scalable, highly available software systems for NinjaOne’s IT Operations platform. Build Java and Kotlin applications, implement enterprise design patterns, optimize systems serving millions of endpoints, and contribute production code. Responsibilities include REST service development, relational database work, client-server messaging, caching, scalability improvements, and quality testing. The role collaborates with engineers to deliver reliable cloud services supporting worldwide operations.

Build and maintain scalable, internationalized React interfaces for a SaaS platform. Implement localization in front-end components, manage localization files, coordinate translation workflows, and validate localized builds across languages and regions. Partner with engineering, design, vendors, and localization teams to resolve UI and internationalization issues, support localization QA, and ensure release readiness. The role requires strong front-end development, localization engineering, testing, communication, and independent project management skills.

Design, develop, launch, and maintain scalable backend systems and APIs used by merchant and partner integrations. Collaborate with engineers and stakeholders, balance speed with system quality, debug code, conduct code reviews, and write tested, extensible software. The role requires experience with distributed systems, Python or Kotlin, AWS, MySQL, and Kubernetes, along with strong communication and ownership of professional growth.

Owns Bloom Credit’s production support and incident response function, including monitoring, incident coordination, root cause analysis, documentation, metrics, and preventive improvements. Supports client-facing Operations with onboarding, offboarding, and troubleshooting tasks while automating repetitive workflows using scripts. Partners with engineering, operations, and product teams to improve system reliability, reduce support overhead, and strengthen incident response processes.

Architects, deploys, and operates CrowdStrike’s data platform infrastructure and services. Responsibilities include administering Airflow and Superset, managing Terraform infrastructure, building CI/CD pipelines, implementing security and access controls, developing DBT data models, cataloging assets in OpenMetadata, writing Python automation, and mentoring engineers. The role requires cloud, container orchestration, SQL, data modeling, compliance, and AI technology expertise, along with eligibility for CJIS clearance.

Software Engineering Interns will build and ship high-impact software projects across product, infrastructure, customer experience, mobile, and security teams. Responsibilities include designing, developing, testing, and deploying features; collaborating with multidisciplinary teams; participating in agile development and prototyping; applying user-centered design; and learning through mentorship, technical talks, and feedback. The internship is virtual, full-time, and lasts 12 weeks during Summer 2027.

Owns and optimizes resilient, ultra-low-latency network and physical data-center infrastructure for institutional trading across cloud and on-premises environments. Designs routing, multicast, segmentation, firewall, VPN, telemetry, and automation systems. Leads production changes, incident response, failover testing, maintenance, and on-call support for 24/7 trading platforms. Mentors engineers and partners with SRE, product, and trading-system teams to improve reliability and developer velocity.

Develop and operate backend systems supporting post-transaction processing for Affirm Card. Break down projects, write tested and extensible code, collaborate with product and engineering teams, monitor system health, troubleshoot issues, participate in on-call support, and contribute to code reviews and team development.

Lead and mentor the software engineering team responsible for PSA Set Registry, a large-scale consumer web and mobile product. Drive architecture, development, delivery, code quality, release management, production troubleshooting, and technical strategy. Partner with product, design, and business teams to translate requirements into scalable solutions while promoting agile practices, collaboration, continuous learning, and an inclusive engineering culture.

Research intern supporting next-generation memory and system architecture development for AI and datacenter workloads. Responsibilities include characterizing AI training and inference workloads, building analytical and simulation performance models, evaluating memory and integration technologies, validating models against reference data, and producing performance, efficiency, and cost analyses. The intern will document findings, contribute to technical reports and invention disclosures, and help quantify architectural tradeoffs for future memory products.

Lead technical strategy, build and maintain software systems using AI, mentor early-career engineers, collaborate across disciplines, and protect user privacy and security. The role involves developing scalable systems on AWS and Kubernetes while working with healthcare data and adhering to HIPAA and data-security best practices.

Own and modernize Domino's Tempest scale-testing platform; build repeatable automated validation, sizing guidance, and cloud-scale test automation; partner with platform teams to enable multi-cloud scale testing and improve test reliability and reporting.

Own the reliability, performance, resilience, observability, and security of AWS and Kubernetes infrastructure supporting products and AI/ML workloads. Define SLOs, lead incident response and root-cause analysis, build Terraform automation, optimize cloud costs, reduce operational toil, and establish deployment standards that help engineers ship reliably. Participate in on-call rotations and maintain HIPAA-compliant infrastructure.