Top Remote Python Jobs in San Diego, CA

The Principal Software Engineer will define and build the Workflow Automation Engine, integrating AI with workflow processes, overseeing design and performance optimization, and leading engineering initiatives within the team.

Design and develop scalable software components, mentor junior engineers, collaborate with product teams, and integrate AI in workflows.

Design and develop scalable software components with a focus on performance. Collaborate with teams to create user experiences, integrate testing, and enhance product capabilities.

Lead architecture, modernization, and development of Group Insurance applications. Modernize mainframe monoliths into Java microservices and micro-frontends on cloud, mentor distributed Agile teams, collaborate with enterprise architecture, product owners and infrastructure, and enable test automation and integrations. Approximately 10% domestic travel.

Build and optimize backend data pipelines and calculations for 7M+ securities using Python/Django. Implement Airflow pipelines, pandas/Celery-based async calculations, database query tuning, caching, scalable data models, incident investigation, code reviews, and cross-team collaboration to ensure timely, accurate financial data.

Build, operate, and scale backend systems for card issuing and transaction processing. Break down projects, collaborate with product and cross-functional teams, write tested extensible code, support monitoring and on-call operations, and participate in team growth activities including interviews.

Lead technical strategy and execution for multi-quarter initiatives; build and maintain AI-driven systems; mentor and raise the technical bar across teams; collaborate cross-functionally; ensure data security and HIPAA-compliant practices; operate in an AWS + Kubernetes environment while introducing new technologies as system load grows.

Lead design, automation, and maintenance of cloud-based database infrastructure (primarily SQL Server and MySQL). Improve reliability with monitoring, HA/DR, automation, troubleshooting, on-call support, and mentoring of junior engineers while collaborating across teams.

Define and drive Payments technical strategy and architecture for rails, routing, and funds-flow systems. Lead large cross-team initiatives, ensure financial correctness, improve reliability and cost via observability, mentor senior engineers, and align stakeholders across product, risk, and regulatory teams.

Lead design and implementation of Affirm's Lakehouse Platform using Iceberg, Spark, Snowflake, and cloud storage. Drive platform roadmap, governance, access controls, performance and cost optimization, analytics engineering best practices, observability, and on-call readiness. Partner cross-functionally, mentor engineers, and build scalable, secure, self-service data infrastructure and semantic/agentic data tools.

Own performance observability and testing for a microservices-based AWS SaaS platform. Design and run load/stress tests, analyze logs and metrics, define KPIs and CI/CD performance gates, forecast capacity risks, and collaborate with platform, security, and product teams to prevent customer-facing performance issues.

Lead frontend-leaning full-stack implementation work for carrier and enterprise integrations: architect reusable UI and API layers, author RFCs, guide technical delivery, enforce testing and security best practices, and partner with cross-functional teams to scope and ship production integrations.

Lead and grow the Decision Advantage engineering team to design, build, and ship full-stack mission software. Partner with customers and product teams to deliver analytics, perception assessment, sentiment analysis, and warning systems. Drive technical practices, reusable services, and high-impact product outcomes while mentoring engineers and collaborating cross-functionally.

Design, build, and improve scalable backend systems that collect hard-to-access OSINT; build pipelines and ETL for messy data; collaborate with product and mission teams; mentor engineers and ensure reliable data delivery for DoD workflows.

Build and own Eve's marketing site and GTM engineering stack: integrate and optimize external tools, design AI agents for sales and marketing, implement webhooks and middleware to sync product/CRM data, and create programmatic campaigns and internal tools in partnership with Marketing, Sales, RevOps, and Product to drive growth and automation.

The Senior Python Engineer will develop and support MongoDB Python drivers, enhance library quality, and collaborate on product features.

The Senior IT Infrastructure Engineer will enhance automation and integration efforts while managing cloud services, CI/CD pipelines, and Kubernetes operations.

As a Senior Software Engineer in Trust & Safety, you'll analyze threats, design systems for abuse detection, and collaborate with teams to implement scalable defenses.

The Senior Software Engineer will design and build scalable AI/ML backend systems, develop data pipelines, and collaborate with cross-functional teams to implement ML-driven features while ensuring system performance and documentation.

As a Senior Software Engineer in ZT1, you will lead backend system development, manage projects, and influence product direction in a fast-paced, AI-centric environment.

Responsible for leading a team to improve developer productivity, managing projects, and ensuring high-quality code delivery while collaborating across teams.

Design and implement secure, scalable backend services for voice agents, integrate AI models and telephony, improve inference, debug concurrent systems, and collaborate with Product to deliver features end-to-end.

Lead the design and implementation of backend services for data cataloging and ML training systems, focusing on performance and scalability.

As a Solutions Architect at Deepgram, you'll engage with customers post-sales to resolve complex technical issues, create scalable solutions, and enhance support processes, using your engineering skills and experience in customer-focused roles.

The Marketing Backend Developer will build and maintain backend services and APIs for marketing operations, ensuring reliable data flow and system integrations, with a focus on performance and scalability.