Top Remote Python Jobs in San Diego, CA

Lead design, build, and deploy full-stack software for DoD/IC missions. Rapidly prototype MVPs, integrate systems and APIs, deliver high-performance frontends, collaborate with users, and deploy/test in secure operational environments.

Lead design and maintenance of automated end-to-end tests across internal and external systems, build AI/LLM evaluation frameworks, embed testing in CI/CD pipelines, promote shift-left quality practices, and transform manual processes into automation suites while collaborating with engineers and product managers.

The role involves building core infrastructure for orchestrating intelligent agents, defining platform primitives, and ensuring systems scale and reliability. Collaboration with internal teams and end-to-end system ownership are essential.

Design, build, test, and deploy smart contracts and decentralized applications. Maintain blockchain integrations and backend services, optimize for security and gas efficiency, contribute to architecture and technical strategy, conduct code reviews, mentor junior engineers, and collaborate with product, frontend, and security teams.

Lead architecture and scaling of finance systems across Oracle Fusion and integrations. Drive AI-assisted development, design data models, build integrations (SQL/PLSQL, REST/SOAP), automate financial workflows, and translate accounting requirements into scalable technical solutions while partnering with business and data teams.

The Lead Software Engineer in Test will own test automation strategy, design automation frameworks, integrate testing into CI/CD, and mentor QA engineers to enhance quality across engineering processes.

As a Senior Infrastructure Engineer, you'll build scalable systems for a next-generation search platform, ensuring data integrity and user experience while collaborating with cross-functional teams.

The Staff Software Engineer will architect and code backend services and ML models, integrate systems, ensure quality, and mentor engineers in the AI & Strategy Engineering team.

As a Billing & Analytics Software Engineer, you'll design and maintain the billing pipeline, integrate billing systems, and develop customer-facing analytics dashboards to support revenue recognition and operational observability.

As a Senior GenAI Solutions Architect, you will lead the design and implementation of generative AI applications on AWS, collaborating with clients to understand their needs and guiding project execution with a team of engineers.

The Principal Developer Productivity Engineer will enhance GM's developer tools, mentor engineers, and drive system performance through observability and software engineering best practices.

Lead and mentor a team of software engineers while overseeing AI-powered product development, engineering delivery, and strategic planning within a financial technology company.

The engineer will build and operate AI/ML infrastructure, managing services on AWS and bare metal, using tools like Kubernetes and Terraform.

Develop and manage high-performance back-end systems, design secure APIs, optimize performance in cloud environments, conduct testing, and manage ML model lifecycles.

Lead technical strategy and execution for multi-quarter initiatives; build and maintain AI-driven systems; mentor and raise the technical bar across teams; collaborate cross-functionally; ensure data security and HIPAA-compliant practices; operate in an AWS + Kubernetes environment while introducing new technologies as system load grows.

Lead design, automation, and maintenance of cloud-based database infrastructure (primarily SQL Server and MySQL). Improve reliability with monitoring, HA/DR, automation, troubleshooting, on-call support, and mentoring of junior engineers while collaborating across teams.

Lead the architectural design and development of a new consumer credit product, focusing on backend systems, distributed services, and integrating AI tools. Mentor team members and influence product direction through engineering insights.

Build, operate, and scale backend systems for card issuing and transaction processing. Break down projects, collaborate with product and cross-functional teams, write tested extensible code, support monitoring and on-call operations, and participate in team growth activities including interviews.

As a Senior Software Engineer in ZT1, you will lead backend system development, manage projects, and influence product direction in a fast-paced, AI-centric environment.

Responsible for leading a team to improve developer productivity, managing projects, and ensuring high-quality code delivery while collaborating across teams.

Design, develop, and execute automated test systems for aerospace applications, collaborating with engineering and quality teams to ensure compliance and performance.

Build and own Eve's marketing site and GTM engineering stack: integrate and optimize external tools, design AI agents for sales and marketing, implement webhooks and middleware to sync product/CRM data, and create programmatic campaigns and internal tools in partnership with Marketing, Sales, RevOps, and Product to drive growth and automation.

The Senior Python Engineer will develop and support MongoDB Python drivers, enhance library quality, and collaborate on product features.

The Staff Security Engineer will lead technical security design, ensure data protection standards, mentor engineering teams, and improve security infrastructure.

The Data Center Engineer will manage physical servers and network hardware, ensuring their installation, maintenance, and troubleshooting, along with overseeing documentation and vendor coordination.