Top Remote Python Jobs in San Diego, CA

Reposted 4 Days AgoSaved
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Remote
Remote San Diego, CA
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175K-240K Annually
Senior level
175K-240K Annually
Senior level
Machine Learning • Security • Software • Analytics • Defense
Lead design, build, and deploy full-stack software for DoD/IC missions. Rapidly prototype MVPs, integrate systems and APIs, deliver high-performance frontends, collaborate with users, and deploy/test in secure operational environments.
Top Skills: APIsDevOpsPythonReactTypescript
Reposted 4 Days AgoSaved
Remote
Remote San Diego, CA
120K-135K Annually
Senior level
120K-135K Annually
Senior level
Fintech • Financial Services
Lead design and maintenance of automated end-to-end tests across internal and external systems, build AI/LLM evaluation frameworks, embed testing in CI/CD pipelines, promote shift-left quality practices, and transform manual processes into automation suites while collaborating with engineers and product managers.
Top Skills: APIsAWSCi/CdDatadogGenerative AiGitGoJIRAKatalon StudioLeapworkLlmLoad TestingMablPerformance TestingPlaywrightPostmanPythonReactRubySalesforceSpasTestsigmaTricentis ToscaTypescript
Reposted 4 Days AgoSaved
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Remote or Hybrid
Remote San Diego, CA
Easy Apply
187K-220K Annually
Senior level
187K-220K Annually
Senior level
Artificial Intelligence • Cloud • Computer Vision • Hardware • Internet of Things • Software
The role involves building core infrastructure for orchestrating intelligent agents, defining platform primitives, and ensuring systems scale and reliability. Collaboration with internal teams and end-to-end system ownership are essential.
Top Skills: GoPython
Reposted 5 Days AgoSaved
Remote
Remote San Diego, CA
253K-275K Annually
Senior level
253K-275K Annually
Senior level
Blockchain • Software • Cryptocurrency • Web3
Design, build, test, and deploy smart contracts and decentralized applications. Maintain blockchain integrations and backend services, optimize for security and gas efficiency, contribute to architecture and technical strategy, conduct code reviews, mentor junior engineers, and collaborate with product, frontend, and security teams.
Top Skills: AnchorAvalancheBnb ChainCi/CdCloud InfrastructureDaosDatabasesDefiEthereumEthers.JsFoundryGitGoHardhatNftsNode.jsPolygonPythonRustSmart ContractsSolanaSolidityTruffleTypescriptWallet IntegrationsWeb3.Js
5 Days AgoSaved
In-Office or Remote
Remote San Diego, CA
114K-213K Annually
Senior level
114K-213K Annually
Senior level
Blockchain • eCommerce • Fintech • Payments • Software • Financial Services • Cryptocurrency
Lead architecture and scaling of finance systems across Oracle Fusion and integrations. Drive AI-assisted development, design data models, build integrations (SQL/PLSQL, REST/SOAP), automate financial workflows, and translate accounting requirements into scalable technical solutions while partnering with business and data teams.
Top Skills: ClaudeCursorData LakeEnterprise LlmsGithub CopilotGoJavaJSONOracle BipOracle FahOracle FusionOracle GlOracle SlaPl/SqlPythonRestSoapSQLXML
Reposted 5 Days AgoSaved
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Remote
Remote San Diego, CA
Easy Apply
124K-155K Annually
Senior level
124K-155K Annually
Senior level
Digital Media • eCommerce • Information Technology • Marketing Tech • Pet • Retail • Social Media
The Lead Software Engineer in Test will own test automation strategy, design automation frameworks, integrate testing into CI/CD, and mentor QA engineers to enhance quality across engineering processes.
Top Skills: AppiumC#CypressGithub ActionsGitlab CiJavaJenkinsJestPlaywrightPythonRestassuredSeleniumTypescript
Reposted 5 Days AgoSaved
Remote
Remote San Diego, CA
203K-274K Annually
Expert/Leader
203K-274K Annually
Expert/Leader
Artificial Intelligence • Cloud • Consumer Web • Productivity • Software • App development • Data Privacy
As a Senior Infrastructure Engineer, you'll build scalable systems for a next-generation search platform, ensuring data integrity and user experience while collaborating with cross-functional teams.
Top Skills: C/C++ElasticsearchGoJavaPython
Reposted 5 Days AgoSaved
Remote
Remote San Diego, CA
193K-309K Annually
Senior level
193K-309K Annually
Senior level
Cloud • Fintech • Food • Information Technology • Software • Hospitality
The Staff Software Engineer will architect and code backend services and ML models, integrate systems, ensure quality, and mentor engineers in the AI & Strategy Engineering team.
Top Skills: AWSGoJavaLambdaLangchainLlmsMlPythonRag ArchitecturesSagemakerSalesforceSqs
Reposted 5 Days AgoSaved
Remote
Remote San Diego, CA
180K-245K Annually
Senior level
180K-245K Annually
Senior level
Artificial Intelligence • Machine Learning • Natural Language Processing • Software • Conversational AI
As a Billing & Analytics Software Engineer, you'll design and maintain the billing pipeline, integrate billing systems, and develop customer-facing analytics dashboards to support revenue recognition and operational observability.
Top Skills: GoKafkaMySQLNode.jsPostgresPub/SubPythonSqsTypescript
Reposted 5 Days AgoSaved
Remote
Remote San Diego, CA
125K-172K Annually
Senior level
125K-172K Annually
Senior level
Artificial Intelligence • Cloud • Information Technology • Machine Learning • Consulting • Generative AI • Big Data Analytics
As a Senior GenAI Solutions Architect, you will lead the design and implementation of generative AI applications on AWS, collaborating with clients to understand their needs and guiding project execution with a team of engineers.
Top Skills: AWSAws CdkCloudFormationGenaiJIRAMlPythonReactTerraform
Reposted 5 Days AgoSaved
Remote or Hybrid
Remote San Diego, CA
280K-385K Annually
Senior level
280K-385K Annually
Senior level
Automotive • Big Data • Information Technology • Robotics • Software • Transportation • Manufacturing
The Principal Developer Productivity Engineer will enhance GM's developer tools, mentor engineers, and drive system performance through observability and software engineering best practices.
Top Skills: C/C++DockerGoGrafanaIstioKubernetesNode.jsPrometheusPythonRustTerraform
Reposted 5 Days AgoSaved
Remote
Remote San Diego, CA
Senior level
Senior level
Edtech • Fintech • Payments • Social Impact • Financial Services • Big Data Analytics
Lead and mentor a team of software engineers while overseeing AI-powered product development, engineering delivery, and strategic planning within a financial technology company.
Top Skills: AWSCircleCIDockerGithub ActionsJavaScriptJenkinsKubernetesMongoDBMs Sql ServerMySQLNestjsNext.JsNode.jsPythonReact
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Reposted 5 Days AgoSaved
Remote
Remote San Diego, CA
150K-220K Annually
Senior level
150K-220K Annually
Senior level
Artificial Intelligence • Machine Learning • Natural Language Processing • Software • Conversational AI
The engineer will build and operate AI/ML infrastructure, managing services on AWS and bare metal, using tools like Kubernetes and Terraform.
Top Skills: AWSBashGoKubernetesPythonSlurmTerraform
Reposted 5 Days AgoSaved
Easy Apply
Remote or Hybrid
Remote San Diego, CA
Easy Apply
200K-250K Annually
Senior level
200K-250K Annually
Senior level
Artificial Intelligence • Machine Learning
Develop and manage high-performance back-end systems, design secure APIs, optimize performance in cloud environments, conduct testing, and manage ML model lifecycles.
Top Skills: SparkAWSAzureDockerGCPGoJavaKubeflowKubernetesMlflowPythonScala
Reposted 6 Days AgoSaved
Easy Apply
Remote
Remote San Diego, CA
Easy Apply
231K-260K Annually
Senior level
231K-260K Annually
Senior level
Big Data • Healthtech • HR Tech • Machine Learning • Software • Telehealth • Big Data Analytics
Lead technical strategy and execution for multi-quarter initiatives; build and maintain AI-driven systems; mentor and raise the technical bar across teams; collaborate cross-functionally; ensure data security and HIPAA-compliant practices; operate in an AWS + Kubernetes environment while introducing new technologies as system load grows.
Top Skills: AirflowAWSClaude CodeDbtGoKubernetesPythonReactTypescript
6 Days AgoSaved
In-Office or Remote
Remote San Diego, CA
142K-199K Annually
Senior level
142K-199K Annually
Senior level
Artificial Intelligence • Fintech • Information Technology • Logistics • Payments • Business Intelligence • Generative AI
Lead design, automation, and maintenance of cloud-based database infrastructure (primarily SQL Server and MySQL). Improve reliability with monitoring, HA/DR, automation, troubleshooting, on-call support, and mentoring of junior engineers while collaborating across teams.
Top Skills: AuroraAWSBashFailover ClusteringMySQLNew RelicOrchestratorPmmPythonRdsRubySQL ServerVividcortex
Reposted 6 Days AgoSaved
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Remote
Remote San Diego, CA
Easy Apply
195K-270K Annually
Senior level
195K-270K Annually
Senior level
Artificial Intelligence • Fintech • Machine Learning • Social Impact • Software
Lead the architectural design and development of a new consumer credit product, focusing on backend systems, distributed services, and integrating AI tools. Mentor team members and influence product direction through engineering insights.
Top Skills: APIsAvroC#DatabasesJavaKafkaKinesisKotlinProtobufPythonRubySqs
6 Days AgoSaved
Easy Apply
Remote
Remote San Diego, CA
Easy Apply
146K-225K Annually
Junior
146K-225K Annually
Junior
Big Data • Fintech • Mobile • Payments • Financial Services
Build, operate, and scale backend systems for card issuing and transaction processing. Break down projects, collaborate with product and cross-functional teams, write tested extensible code, support monitoring and on-call operations, and participate in team growth activities including interviews.
Top Skills: AWSKotlinKubernetesMySQLPython
Reposted 6 Days AgoSaved
Easy Apply
Remote
Remote San Diego, CA
Easy Apply
169K-240K Annually
Senior level
169K-240K Annually
Senior level
Big Data • Fintech • Mobile • Payments • Financial Services
As a Senior Software Engineer in ZT1, you will lead backend system development, manage projects, and influence product direction in a fast-paced, AI-centric environment.
Top Skills: AWSKotlinKubernetesMySQLPythonReactVue
Reposted 6 Days AgoSaved
Easy Apply
Remote
Remote San Diego, CA
Easy Apply
169K-240K Annually
Senior level
169K-240K Annually
Senior level
Big Data • Fintech • Mobile • Payments • Financial Services
Responsible for leading a team to improve developer productivity, managing projects, and ensuring high-quality code delivery while collaborating across teams.
Top Skills: AWSKotlinKubernetesMySQLPython
Reposted 7 Days AgoSaved
Remote
Remote San Diego, CA
111K-183K Annually
Mid level
111K-183K Annually
Mid level
Aerospace • Information Technology • Software • Cybersecurity • Design • Defense • Manufacturing
Design, develop, and execute automated test systems for aerospace applications, collaborating with engineering and quality teams to ensure compliance and performance.
Top Skills: C#C/C++GitJIRALabviewMatlabPythonSvnTeststand
Reposted 7 Days AgoSaved
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Remote or Hybrid
Remote San Diego, CA
Easy Apply
250K-300K Annually
Senior level
250K-300K Annually
Senior level
Legal Tech • Software • Generative AI
Build and own Eve's marketing site and GTM engineering stack: integrate and optimize external tools, design AI agents for sales and marketing, implement webhooks and middleware to sync product/CRM data, and create programmatic campaigns and internal tools in partnership with Marketing, Sales, RevOps, and Product to drive growth and automation.
Top Skills: Ai AgentsCRMCSSHTMLJavaScriptLlmsMarketing AutomationMiddlewarePythonSQLWebhooks
Reposted 7 Days AgoSaved
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Remote or Hybrid
Remote San Diego, CA
Easy Apply
126K-248K Annually
Senior level
126K-248K Annually
Senior level
Big Data • Cloud • Software • Database
The Senior Python Engineer will develop and support MongoDB Python drivers, enhance library quality, and collaborate on product features.
Top Skills: Ai/Ml FrameworksMongoDBPypiPython
Reposted 7 Days AgoSaved
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Remote
Remote San Diego, CA
Easy Apply
239K-275K Annually
Senior level
239K-275K Annually
Senior level
Big Data • Healthtech • HR Tech • Machine Learning • Software • Telehealth • Big Data Analytics
The Staff Security Engineer will lead technical security design, ensure data protection standards, mentor engineering teams, and improve security infrastructure.
Top Skills: AWSCyberhavenKubernetesPythonSnowflakeTerrraformWiz
Reposted 7 Days AgoSaved
Remote or Hybrid
Remote San Diego, CA
Senior level
Senior level
Fintech • Machine Learning • Software • Financial Services
The Data Center Engineer will manage physical servers and network hardware, ensuring their installation, maintenance, and troubleshooting, along with overseeing documentation and vendor coordination.
Top Skills: BashFiber OpticsLinuxNetwork CablingNetwork DevicesPythonServer HardwareStorage Systems
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