Top Remote Python Jobs in San Diego, CA

As a Staff Backend Engineer, you'll design and operate backend services, lead technical initiatives, ensure reliability, and mentor team members in a remote-first setup.

The Senior Full-Stack Engineer will manage client relationships, design integration solutions, and ensure seamless delivery and optimization of technical workflows, while leveraging AI for efficiency.

The Senior Infrastructure Engineer will improve system reliability and efficiency, develop standards and tooling, and collaborate with engineering teams to optimize workflows and cloud infrastructure.

Lead the Mapping Engineering team as a Staff Software Engineer, focusing on designing scalable distributed backend systems for autonomous vehicle mapping, collaborating with cross-functional teams, and mentoring engineers.

As a Senior Software Engineer at Babylist, you will develop systems for a high-volume marketplace, collaborating on advertising, commerce features, and infrastructure while leading projects and improving processes with AI-driven methodologies.

Build and ship full-stack features for customer-facing Console and Playground, plus internal tools. Design and maintain APIs and backend services, implement accessible performant frontends, translate product requirements into incremental work, and improve code quality through reviews and design discussions.

Build and operate backend services, APIs, and frontend experiences for the Power Packs product. Work across the full SDLC on backend systems, frontend React/NextJS apps, integrations, observability, and documentation while collaborating with Product and Engineering to deliver scalable, production-quality features.

The Senior Site Reliability Engineer will develop and support distributed storage services, ensuring reliability and operational safety, with a focus on automation and efficiency.

Lead architecture and implementation of Oracle Fusion financial systems, build integrations (SQL/PLSQL, REST/SOAP), embed AI-assisted development, automate financial workflows, and translate accounting requirements into scalable technical designs and documentation.

Design, implement, and maintain partner integration solutions; translate partner requirements into scalable technical implementations; troubleshoot and automate fixes; collaborate with product and engineering teams to improve tools and ensure successful partner onboarding and launches.

Build and operate ingestion, reconciliation, and reporting systems that reconcile card-network and partner settlement files against internal transactions. Deliver end-to-end features for traceability, accounting journals, tax and regulatory reporting, and compliance tooling while ensuring reliability, scalability, and data privacy.

Build and deliver full-stack features for a web-based broker platform, collaborate with product and design, manage technical debt, shape architecture for scalability, participate in code reviews, and adopt AI-powered developer tools.

Help improve reliability and stability of Webflow's production infrastructure: maintain monitoring and observability tooling, optimize Kubernetes workloads for scalability and fault tolerance, occasionally debug/fix Node/Python/Go application code, collaborate with Support/Partnerships/Sales, and participate in on-call and incident response processes.

Maintain and optimize SaaS production and demo environments, respond to and resolve incidents, manage Jira-based incident workflows, use Dynatrace and observability tools for troubleshooting, automate operational tasks, enforce security best practices, document runbooks in Confluence, participate in on-call rotation, and collaborate cross-team to improve reliability and performance.

Lead architecture and implementation of Redfin's cloud database and storage systems with focus on reliability, scalability, observability, security, and disaster recovery. Own incident response, root cause analysis, upgrades, backups, migrations, and mentor engineers; participate in on-call rotation and collaborate with cross-functional senior leaders.

Design, build and maintain scalable data pipelines and automated workflows using Python, Airflow, DBT and cloud warehouses. Partner with Analytics, Sales and Marketing to deliver curated marketing datasets, enforce data quality through validation and CI/CD, and support production deployment and monitoring of Enterprise Data Lake/ODS solutions.

Lead development of AI-assisted reliability tooling, own incident response end-to-end, improve observability and SLO/SLI frameworks, scale single-tenant SaaS operations, mentor engineers, and reduce recurring operational toil through engineering and automation.

The Quantitative Developer will assist with client onboarding, support, implement and maintain new functionality for portfolio compliance, and improve team documentation.

Manage a high-performing software engineering team, driving product roadmap and technical direction, while ensuring quality, performance, and innovation.

Drive the Continuous Integration team, ensuring build systems' reliability and scalability, and mentor CI engineers while improving developer productivity through automation and tooling.

Design, build, and operate enterprise-scale multi-cloud infrastructure (Azure primary, GCP, AWS exposure). Own landing zones, Terraform modules, production AKS/GKE Kubernetes, Vault secrets, hybrid networking, CI/CD pipelines, monitoring, DR, and automation (Ansible, Python/Bash). Mentor engineers, document runbooks, and collaborate with security, application teams, and leadership to ensure secure, reliable, cost-optimized cloud platforms.

Own cross-team, platform-level engineering initiatives end-to-end: architecture, migrations, observability, on-call, and customer outcomes. Drive AI-native tooling and agentic AI adoption, mentor senior engineers, and set technical standards across teams.

Automate cloud infrastructure as code, build developer tooling, administer Kubernetes and platform services, improve CI/CD and observability, collaborate with product teams, run on-call rotation and manage incident runbooks to ensure platform reliability and developer productivity.

Drive technical strategy and roadmap for Affirm's Online Storage platform. Design and build multi-region, highly available datastore solutions and control planes for hundreds of databases. Automate schema migrations, disaster recovery, sharding, and performance tuning. Collaborate with product, SRE, and infrastructure teams, own operations and on-call readiness, and mentor engineers while setting code and design standards.

Lead and set technical strategy for the Order Platform powering post-checkout flows (orders, captures, refunds, settlement). Design and ship highly available backend systems, own reliability/operational practices, mentor engineers, collaborate cross-functionally, and drive long-term technical decisions and execution plans.