Top Remote Python Jobs in San Diego, CA

Own and evolve patient-facing clinical application surfaces, including a React widget, clinician portal, and Python service layer. Lead full-stack architecture, AI application integrations, encounter data flows, internal tooling, versioned shared components, and operational reliability. Partner with AI engineers on LLM-enabled workflows, maintain dependencies, protect consumers from breaking changes, and mentor junior engineers. The role requires durable ownership of rapidly built systems and delivery of critical healthcare technology.

Build, patch, customize, and test Linux userspace packages for Rocky Linux products. Remediate CVEs, improve package-building automation, develop automated system tests, and support deployments across servers, virtual machines, and cloud infrastructure. Collaborate on architecture, proofs of concept, documentation, capacity planning, and launch reviews while contributing to open-source development and CI/CD practices.

Leads end-to-end design, development, quality, and integration of complex software solutions and cloud services. Provides technical leadership for enterprise-wide projects, manages engineering processes, risks, dependencies, and delivery priorities, and writes code across the software ecosystem. Collaborates with multidisciplinary teams to deliver measurable, user-centric technology solutions, primarily supporting healthcare caregivers.

Lead full-stack software development across frontend and backend systems, delivering user-facing healthcare features from concept through iteration. Design APIs and application architecture, write technical specifications, improve testing and CI practices, collaborate with product, AI/ML, clinical, and UX teams, and guide cross-team technical decisions. The role involves React, Python, cloud infrastructure, databases, asynchronous workflows, and healthcare data technologies.

Lead architecture and development of scalable software solutions for the Seller Platform. Collaborate with product and business stakeholders, conduct code reviews, mentor engineers, research emerging technologies, and solve complex technical challenges. The role requires strong Java and Ruby experience, distributed systems expertise, software architecture knowledge, and proficiency with modern AI coding tools.

Designs, implements, and supports secure, highly available IBM MQ and MFT integration environments. Responsibilities include AWS cloud infrastructure, Terraform-based infrastructure automation, Python scripting, CI/CD collaboration, security, monitoring, logging, disaster recovery, troubleshooting, and optimization of enterprise messaging and cloud platforms.

Deploys, supports, and improves Managed Services Gateways across cloud and virtualization platforms. Administers Linux, Kubernetes (Rancher), VMware/Hyper-V, networking and firewalls; automates workflows; triages escalations; documents runbooks; coordinates with clients and teams; participates in on-call and lifecycle/security initiatives.

Designs and implements enterprise cloud and AI solutions for unstructured data workloads. Responsibilities include building ingestion pipelines, API integrations, document extraction and HITL workflows, tuning machine learning models, benchmarking performance, and ensuring security, availability, disaster recovery, and data isolation. The role also supports customer developers, leads technical proofs of concept, mentors engineering teams, develops reusable blueprints, and provides feedback to product engineering.

Owns delivery of backend money movement and card ledger systems, leading engineers through complex problems and ambiguity. Collaborates with product, design, analytics, and engineering stakeholders; defines scalable technical solutions; supports system availability, monitoring, on-call operations, code quality, and engineering standards. The role also includes mentoring and developing team talent while building highly available distributed systems for Affirm’s financial products.

Own and improve CI/CD, developer tooling, agent harnesses, Kubernetes infrastructure, observability, cost management, and incident-response practices. Build platform capabilities that reduce engineering toil and improve delivery speed for conversational AI products. Participate in an on-call rotation for core infrastructure and help shape reliable, scalable systems across a fully remote engineering organization.

Lead the architecture, development, and evolution of Keeper Commander, including Python and .NET SDKs, CLI tooling, APIs, and developer automation. Remain hands-on with coding, debugging, architecture, integrations, security, testing, and release engineering while mentoring a small team. Partner with Product, QA, and Security teams, support the open-source ecosystem, improve developer experience, and guide technical strategy for enterprise and DevOps integrations.

Develop and maintain Akamai’s custom Linux kernel for its cloud platform. Responsibilities include adding performance, reliability, and security features; porting modifications across kernel versions; debugging production and test issues; improving build and continuous-testing automation; collaborating with platform, application, hardware, and test teams; and contributing changes upstream to the Linux community.

Build and operate WISEcode’s food data lakehouse using Python, SQL, DuckLake, S3 Parquet, Postgres, and Prefect. Responsibilities include source ingestion, entity resolution, pipeline consolidation, data enrichment, downstream connectors, data quality reporting, configuration discipline, and architectural documentation. The role requires designing and shipping production lakehouse or warehouse systems, managing scalable API-driven pipelines, and collaborating closely with engineers in a fully remote environment.

Leads Clever’s engineering organization and technical strategy, overseeing architecture, execution, production systems, organizational design, recruiting, and leadership development. The role remains technically hands-on through architecture and code reviews, debugging, production support, and direct contribution. It also drives AI-assisted engineering, modernization of legacy systems, engineering productivity, and close collaboration with Product and executive leadership.

Develops high-speed analog ICs exceeding 100 Gbaud for optical networking products. Responsibilities span product definition, circuit design, layout, verification, bring-up, design validation, qualification, testing, characterization, and production ramp-up. The role collaborates with verification, CAD, product, test, operations, and reliability teams and supports system-level customers. Required expertise includes SiGe BiCMOS or CMOS analog design, high-frequency structures, device physics, RF wafer probing, laboratory equipment, and high-speed IC evaluation.

Administers and supports enterprise infrastructure, Windows and Linux environments, Azure, Microsoft 365, virtualization, identity services, PKI, backups, and core banking systems. Automates processes, manages access and security remediation, supports disaster recovery, investigates root causes, maintains technical documentation, and provides Tier 3 and on-call support. Coordinates infrastructure projects, change management, vendor engagements, audits, and lifecycle planning.

Build and maintain full-stack features across core financial platforms using Python, Django, PostgreSQL, and modern JavaScript or TypeScript frameworks. Design scalable systems, implement front-end interfaces and back-end APIs, write automated tests, optimize performance, resolve bugs, participate in code reviews, collaborate cross-functionally, and guide junior engineers while using AI-assisted development tools.

Define the technical vision and multi-quarter strategy for Coinbase’s FinHub financial infrastructure. Architect scalable ledger and money-movement primitives across fiat and crypto, ensuring double-entry accounting, idempotency, reconciliation, auditability, reliability, and safe failure recovery. Lead complex cross-team architectural initiatives, collaborate with finance, risk, compliance, and operations stakeholders, and mentor senior engineers while improving system design and operational excellence.

Design, build, and maintain pipeline and artist-facing tools across web, desktop, and Unreal surfaces. Develop Python integrations with Maya, Unreal, Nuke, Perforce, and AYON; build AI-assisted features; and own tools through production. Collaborate directly with artists and supervisors, manage work autonomously, and deliver responsive, maintainable, well-tested software.

Develop and optimize low-level embedded software and firmware for wireless communication systems. Integrate WiFi and 5G/LTE modules, support board bring-up, and validate hardware-software interactions. Optimize CPU, DSP, FPGA, and power performance; implement secure boot and OTA firmware updates; debug complex subsystem interactions; and collaborate with hardware and cross-functional teams. Maintain technical documentation and participate in code reviews.

Own the enterprise network strategy, architecture standards, governance, and modernization roadmap. Lead hybrid and multi-cloud connectivity, network security, resiliency, automation, observability, and lifecycle strategies across global environments. Evaluate technologies and vendors, develop executive business cases, guide major transformations, and mentor architects and senior engineers. The role requires influencing technical and business leaders while delivering secure, scalable, resilient, and cost-effective network capabilities.

Senior Software Engineer responsible for shaping and delivering a new fundraising product from discovery through production. The role involves full-stack development, architecture, prototyping, customer collaboration, production troubleshooting, reliability improvements, and mentoring. The engineer will work autonomously in an early-stage business unit, use customer feedback and data to guide decisions, and contribute across interfaces, backend services, integrations, infrastructure, and AI-enabled workflows.

Develop and maintain scalable Python/Django backend features for Cyware’s Cyber Fusion platform across commercial and AWS GovCloud environments. Design microservices, REST APIs, AI and RAG integrations, multi-tenant architectures, and secure identity systems. Ensure FedRAMP/GovRAMP compliance through secure coding, audit logging, RBAC, encryption, testing, and continuous monitoring. Collaborate with DevOps, GRC, Security, and engineering teams on CI/CD, code reviews, production support, and platform improvements.

Build, secure, and operate AWS and AWS GovCloud infrastructure across commercial and government environments. Own CI/CD pipelines, Kubernetes and GitOps deployments, infrastructure as code, environment segmentation, secrets management, monitoring, incident response, database migrations, and compliance automation. Support FedRAMP, GovRAMP, and IL5 authorization requirements, collaborate with Security/GRC on audits and continuous monitoring, and improve reliability, scalability, and engineering productivity.

Own and scale Bitsight’s SaaS cloud infrastructure, focusing on reliability, security, automation, and cost efficiency. Design complex systems, troubleshoot production issues, validate AI-assisted infrastructure automation, and improve delivery processes. Lead technical discussions, establish infrastructure best practices, mentor engineers, and collaborate across teams. The role requires strong Linux, scripting, containerization, cloud, infrastructure-as-code, networking, and observability expertise, with occasional off-shift production support.