Top Remote Python Jobs in San Diego, CA

Lead full-stack development for secure, scalable mission planning and command-and-control software supporting space communications programs. Build frontend interfaces and backend services, design APIs, translate mockups into applications, conduct code reviews, improve quality and security, and mentor junior engineers. Work with modern web frameworks, containerized microservices, and highly secure government environments while owning technical problems end to end.

Build and ship production software across the frontend and backend, working closely with founders, customers, and product teams. Develop AI-powered features and systems involving web scraping, unstructured data, PDF parsing, and cloud infrastructure. Translate real-world real estate and financing problems into technical solutions, make high-impact decisions, and own shipped code. The internship may convert to a full-time role.

Build and maintain Java backend services, REST APIs, and full-stack web application features. Develop frontend functionality, use Python for supporting work, and apply AI coding tools such as Claude Code for development, testing, and debugging. Collaborate on design decisions and code reviews, troubleshoot issues, and support application deployment and maintenance across cloud environments.

Build and maintain responsive web experiences, PWAs, and native-feeling mobile apps; design secure APIs and third-party integrations; develop conversational AI bots and support automation; implement ad-tech, segmentation, push notifications, analytics, and A/B testing; and optimize performance, reliability, and uptime. The role requires full-stack development, cloud and DevOps fundamentals, and collaboration in a fast-paced startup.

Designs and maintains automated test frameworks for web, API, and mobile applications. Performs functional, regression, integration, and end-to-end testing; validates APIs, databases, and integrations; integrates tests into CI/CD pipelines; manages defects; collaborates with development and product teams in Agile ceremonies; and provides quality metrics and reporting.

Owns and optimizes resilient, ultra-low-latency network and physical data-center infrastructure for institutional trading across cloud and on-premises environments. Designs routing, multicast, segmentation, firewall, VPN, telemetry, and automation systems. Leads production changes, incident response, failover testing, maintenance, and on-call support for 24/7 trading platforms. Mentors engineers and partners with SRE, product, and trading-system teams to improve reliability and developer velocity.

Lead technical direction and multi-quarter delivery for a platform modernization effort. Architect TypeScript, Java, PHP, and cloud systems; guide monolith decomposition, distributed services, databases, observability, security, and operational excellence. Mentor engineers, coordinate stakeholders, establish engineering standards, and lead responsible adoption of AI-assisted development across the organization.

Lead and mentor the software engineering team responsible for PSA Set Registry, a large-scale consumer web and mobile product. Drive architecture, development, delivery, code quality, release management, production troubleshooting, and technical strategy. Partner with product, design, and business teams to translate requirements into scalable solutions while promoting agile practices, collaboration, continuous learning, and an inclusive engineering culture.

Design and operate scalable, secure, highly available AWS infrastructure for a revenue management platform. Build infrastructure automation, CI/CD tooling, monitoring, and developer tools; advise on architecture, improve reliability and security, troubleshoot 24/7 incidents, lead root cause analyses, support AI-enabled DevOps workflows, and mentor engineers. The role participates in a weekly on-call rotation and is remote in the US or Canada.

Own the enterprise architecture vision for scalable, high-performance, cost-efficient multi-tenant SaaS systems. Lead AWS cloud optimization, distributed data and AI infrastructure, architectural governance, and Architecture Review Council activities. Guide engineering teams on microservices, event-driven systems, automation, and cloud-native practices while driving GenAI adoption across the software lifecycle. Build prototypes, establish architectural standards, optimize total cost of ownership, and mentor technical leaders.

Designs, operates, and improves AWS and Azure cloud infrastructure supporting customer-facing higher education products. Owns Kubernetes platforms, infrastructure as code, deployment automation, CI/CD, monitoring, security, reliability, disaster recovery, and cost optimization. Troubleshoots complex infrastructure and application issues, leads incidents, participates in on-call rotations, mentors engineers, contributes to technical standards, and partners across Development and Information Security on modernization and production readiness.

Build and own healthcare product surfaces end to end, from user discovery and interface design through API development, deployment, measurement, and migration from Salesforce or Athena. Work across React/TypeScript and Python/FastAPI on AWS, apply AI agents and LLM features, collaborate directly with clinicians and coordinators, and ensure rigorous handling of PHI, access control, and HIPAA-sensitive workflows.

Own web compatibility triage and incident response across DuckDuckGo browsers on Mac, Windows, iOS, and Android. Debug complex web applications and third-party code, distinguish site, browser, and privacy-related issues, reverse-engineer obfuscated code, build durable cross-platform fixes, and develop automation and LLM agent tooling to reproduce and triage breakage. Lead ambiguous projects independently and communicate with technical and non-technical stakeholders.

Lead architecture and roadmap for a company-wide data lakehouse platform. Build platform-as-product components (SDKs, CLIs, control planes), optimize distributed compute/storage, prototype performance R&D, ensure compliance-by-design (lineage, PII masking, access control), enable real-time AI data ingestion, drive engineering standards, and mentor cross-functional teams.

Forward Deployed Engineer embedded with strategic customers to design and operate large-scale data infrastructure, troubleshoot distributed systems and networking issues, develop automation and APIs, and translate deployment challenges into product improvements. The role requires deep expertise in storage, Linux internals, high-performance networking, Python and C/C++, plus customer-facing communication and up to 25% travel.

Design, build, and scale backend services, APIs, and workflow systems supporting healthcare claims identification and recovery. Integrate AI/ML models, legal datasets, and transactional data while developing fault-tolerant Temporal workflows. Maintain AWS infrastructure and secure deployment pipelines using Python, TypeScript, PostgreSQL, Redis, and related technologies. Collaborate with product, business, and data science teams to deliver reliable, secure, high-performance systems in a regulated startup environment.

The Principal QA Architect owns the strategy, architecture, delivery, and adoption of enterprise QA technology solutions. Responsibilities include designing automation frameworks, AI-enabled testing capabilities, reporting, observability, test data solutions, CI/CD quality gates, and integrated platforms. The role remains hands-on with software development, prototyping, integrations, and troubleshooting while providing technical leadership, mentoring, roadmap ownership, stakeholder influence, and outcome measurement across QA and software delivery teams.

Administer identity, Google Workspace, email security, endpoint management, networking, SaaS applications, and cloud IAM for a distributed organization. Serve as the US escalation point for IT Support, manage onboarding and offboarding, conduct access audits, support acquisitions and platform consolidations, automate recurring tasks with scripts and APIs, coordinate security-provider activities, and maintain infrastructure documentation and runbooks. The role owns the New York office network and infrastructure projects end to end.

Own and evolve high-scale backend and data-layer services. Design, build, test, and operate distributed backend services and APIs, improve reliability/latency/scale, take end-to-end ownership from design through production support, participate in on-call and incident response, and mentor peers while partnering with Product and SRE teams.

Lead technical direction for Elastic’s core billing platform across cloud providers. Design and operate scalable billing systems, data pipelines, APIs, and PostgreSQL architecture. Improve reliability, observability, incident response, deployment, and CI/CD practices. Partner with SRE, Cloud Infrastructure, Product, Design, and Finance teams, guide architecture and roadmap decisions, review technical work, mentor engineers, and participate in on-call rotations.

Develop and deploy a cloud-ready PostgreSQL/PostGIS database, Python REST APIs, ETL workflows, React interfaces, dashboards, and GIS visualization tools for the USGS Volcano Hazards Program. Ensure accessibility, security compliance, documentation, testing, and interoperability across volcano observatories. Collaborate with government stakeholders, support federal certification activities, and participate in up to three onsite visits during the 12-month engagement.

Own and modernize Domino's Tempest scale-testing platform; build repeatable automated validation, sizing guidance, and cloud-scale test automation; partner with platform teams to enable multi-cloud scale testing and improve test reliability and reporting.

Provides senior technical leadership for enterprise systems and telecom architecture. Establishes standards, approves designs, evaluates vendor solutions, develops technology roadmaps and capital plans, oversees testing and operational readiness, and guides complex projects across their lifecycle. Serves as a subject matter expert and liaison among engineering, product, program, capacity, leadership, and vendor teams while ensuring highly available, scalable, secure, and reliable network infrastructure.

Administers and supports enterprise middleware platforms, including WebSphere, WebLogic, Apache, Tomcat, IIS, and Portal. Performs security remediation, vulnerability management, patching, compliance validation, certificate and identity integration, server administration, performance monitoring, JVM tuning, troubleshooting, and incident response. Develops Shell, Python, and JACL automation for deployments, configuration, certificate management, reporting, and health checks while supporting CI/CD, change management, documentation, audits, and production operations.

Deploy and integrate Shield AIs Hivemind autonomy software with customers worldwide. Provide on-site technical support, training, debugging, and documentation. Collaborate with sales and product engineering to support pre- and post-sales activities and improve autonomy products.