Top Remote Staff Software Engineer Jobs

Develop and optimize high-performance C/C++ signal-processing pipelines for genomic instruments. Design multi-threaded Linux software, debug and profile performance, collaborate with bioinformatics and instrument teams, and provide technical leadership to deliver accurate, fast base-calling solutions.

Provide technical leadership and hands-on engineering across AI, data, backend, and frontend systems. Drive architecture, remove technical risks, set engineering standards, mentor senior engineers, and influence cross-team technical direction.

Lead design and architecture of scalable, multi-tenant microservices and event-driven systems. Collaborate across teams to define requirements, resolve complex production issues, drive AI-enabled innovation, set standards, perform code reviews, and ensure rigorous testing and reliability for healthcare-aligned solutions.

Lead technical direction and deliver collision-free motion planning for humanoid robots. Design, implement, test, and deploy trajectory optimization, MPC, and sample-based planners; architect modular planning systems integrated with perception, state estimation, and control; develop algorithms robust to uncertainty; and provide cross-team technical leadership and mentorship.

The Staff Software Engineer will lead technical initiatives, drive quality code, mentor engineers, and work on scalable systems in a high-impact team environment.

Lead design and implementation of the payment integrations platform (APIs, SDKs, embedded web), build scalable payment rails (ACH), drive technical roadmap, mentor engineers, collaborate cross-functionally, and improve operations via automation, tooling, and observability.

As a Staff Software Engineer, you'll enhance the release and configuration systems across environments, optimize release pipelines, and provide tooling for reliable deployment, ensuring consistency and scalability while collaborating with various engineering teams.

The role involves leading the development of a full-stack platform for biopharma, focusing on architecture, UX, backend services, and API integrations, while ensuring reliability and collaboration with cross-functional teams.

As a Staff Software Engineer, you will develop core banking experiences, craft user flows, build APIs, and integrate third-party software, ensuring high-quality, well-documented, and test-driven code.

The Sr Staff Software Engineer will build core banking experiences, craft user flows, robust APIs, and integrate with third-party software, requiring significant back-end development experience.

The Staff Software Engineer will develop user experiences and APIs for banking applications, focusing on code quality, system design, and team mentorship.

As a Senior Staff Software Engineer, you will lead the design and development of AI-powered products, mentor team members, and architect backend systems using Python and modern frameworks while ensuring code quality and optimizing performance.

As a Staff Software Engineer at Juniper Square, you'll lead architectural decisions and develop AI-powered systems, mentoring engineers and ensuring high-quality technical standards while collaborating with cross-functional teams.

The Staff Software Engineer will manage projects, collaborate across teams, contribute to technical direction, and enhance backend systems for an AI-powered healthcare platform.

As a Staff Software Engineer, you'll design and build backend services, lead system design efforts, mentor engineers, and ensure system quality and reliability.

The Staff Software Engineer will develop software solutions, mentor non-staff engineers, and enhance engineering processes while delivering high-quality products.

As a Staff Software Engineer, you'll lead technical execution across teams, design microservices, improve cloud deployments, and mentor engineers while focusing on architecture and delivery.

Senior staff engineer role owning platform and solution architecture across cloud infrastructure, Kubernetes, GitOps, CI/CD, observability, and data pipelines. Build reusable modules, improve developer experience, secure cloud patterns, troubleshoot production systems, mentor engineers, and partner with product and data teams to deliver scalable, reliable platform capabilities.

Join Docker's Agentic Platform team to build and operate AI-driven workflows, focusing on infrastructure, orchestration, and technical leadership. Role involves design, operation, and continuous improvement of agent execution runtime and cloud services.

Lead AI technical strategy, architect AI systems, set safety standards, mentor engineers, and evaluate AI models at Midi Health, a healthcare-focused company.

Lead architecture and implementation of Chainguard Repository: design, build, and operate high-availability backend services in Go that serve package registries and APIs; improve scalability, reliability, observability, and load testing; drive technical decisions, collaborate across teams, and mentor engineers.

Lead high-impact initiatives and architect enterprise-grade APIs while mentoring engineers. Collaborate across teams to influence technical strategy and scale platform architecture.

Lead architecture and roadmap for Twilio's Compliance Experiences platform, modernizing legacy systems into cloud-native microservices. Drive AI-augmented development, design high-availability APIs and data systems, mentor senior engineers, ensure regulatory-compliant developer experiences, and lead incident remediation and cross-team technical strategy.

Seeking a Staff Software Engineer to design and build cloud-deployed systems. Must have extensive programming and leadership experience in software engineering.

The Staff Software Engineer will build and maintain GoGuardian's Safety product suite, lead architectural decisions, mentor developers, and champion AI adoption in engineering workflows.