Top Senior IT Jobs in Indianapolis, IN

Design, deploy, and manage scalable, secure cloud infrastructure. Implement networking, VMs, IaC, and configuration management. Integrate Azure infrastructure into CI/CD pipelines, automate provisioning with DevOps/GitHub Actions, and enforce security/compliance with security teams. Provide Windows Server administration and support enterprise cloud initiatives.

Perform financial analyses for IT, develop Total Cost of Ownership and forecasting models, and recommend financial strategies. Support IT operations/governance, integrate financial checkpoints into governance, and apply Agile delivery principles to align services and outcomes.

Lead product strategy and delivery for FP&A planning platforms (Workday Adaptive/enterprise SaaS). Own roadmap, governance, release planning, and adoption. Partner with Engineering, Data, TPMs, and Finance stakeholders to define requirements, mitigate risks, evaluate AI/agentic automation, and measure outcomes for executive stakeholders.

Lead and continuously improve the global IT Compliance function for a CRO, ensuring IT governance, ISMS and ISO 27001 certification support, GxP computerised system compliance, audit readiness and vendor/third-party compliance oversight. Provide regulatory guidance, manage audit responses, run risk assessments, maintain compliance documentation, and drive remediation and continual improvement across IT and business stakeholders.

Manage operations and maintenance of Consumer Health S/4HANA ecosystems, including request and incident lifecycle, event management, application security, capacity and production transition, vendor escalations, and continuous service improvement to ensure rapid recovery and reliable service delivery.

Serve as Product Owner for Oracle/Cerner clinical solutions, partnering with stakeholders to define workflows, write user stories, manage backlogs, configure systems, support enterprise deployment and adoption, and provide SME through the product lifecycle. Requires risk mitigation, cross-team collaboration, and occasional travel.

Serve as strategic advisor to assess and optimize end-to-end hospital revenue cycle operations using Epic workflows. Lead performance improvement, analytics, change management, compliance, and operational initiatives to improve financial and patient financial experience.

Provide senior-level remote IT support and operations for a distributed workforce: troubleshoot macOS/Windows/Linux/mobile, manage onboarding/offboarding, administer identity (Rippling/Okta) and MDM, maintain asset inventory, build AI-driven automations (Console.com, Risotto, Unthread), support SOC 2/HIPAA/ISO compliance, write runbooks in Notion, and contribute to the IT roadmap while mentoring the team.

The Senior IT Program Manager leads program development and implementation, ensuring projects align with business needs and are delivered on time and budget. They manage stakeholder relationships and facilitate communication with senior leadership, oversee financial management, and develop risk management strategies.

Serve as first-line IT support for hardware, software, networking, and enterprise applications. Triage and resolve support tickets, manage onboarding/offboarding, administer Okta and endpoint management (Intune, Jamf), maintain device health and access controls, collaborate with Security and Engineering, document processes, and improve support workflows to ensure a secure, compliant, and user-friendly hybrid work environment.

The role involves designing and developing enterprise-grade software solutions, integrating AI tools, collaborating with teams, and maintaining documentation while enhancing productivity for Yahoo personnel.

The IT Systems Engineer III will improve Ophelia's IT systems through integration, automation, and security while managing IT projects, overseeing service providers, and ensuring compliance.

Provide administration, maintenance, development, and troubleshooting for Oracle IAM (OAM, OIG, OID, OIM) including provisioning, authentication, RBAC/ABAC controls, custom Java/REST integrations, BI Publisher reporting, and IAM continuous monitoring. Produce SOPs, coordinate with SMEs, and apply secure coding and audit practices to support production and non-production environments.

Lead on-site IT for a manufacturing/tech center, owning IT/OT alignment, cybersecurity, AI-driven digitalization, service delivery, site projects, vendor management, and local IT team development. Build prototypes with low-code/AI tools, ensure compliance and business continuity, and act as the primary IT business partner to site leadership.

Design and guide secure, scalable enterprise and cloud architectures (DNS, Azure, AWS, on-prem). Lead cloud migrations, implement monitoring, integrate hybrid environments, present technical briefings, and mentor staff while ensuring security and performance for a mission-focused government client.

Lead Data QA for the Enterprise Data Warehouse: define QA strategy, design and execute source-to-target validations, CDC and ETL checks, data masking verification, build quality dashboards and automations, mentor QA analysts, manage defects and release readiness, and collaborate with Data Engineering, BI, Product, and stakeholders to ensure data is accurate, complete, and audit-ready.

Provide white-glove IT support to the CEO, executive leadership, Board and assistants; manage HQ site IT operations, conference room AV, event and offsite board meeting tech, vendor relationships, procurement, and ServiceNow-based incident management. Ensure flawless exec device and meeting experiences and provide on-call/after-hours support.

Lead human-centered design and front-end engineering for the NIH Data Lakehouse: conduct user research and testing; create wireframes, prototypes, flows, and accessible interfaces; build scalable React/Next.js/TypeScript UI components; integrate with GraphQL and search services; contribute to design systems, component libraries, and platform-wide front-end best practices.

Senior IT leader partnering with Commercial leadership to define and deliver pharma commercial technology strategy, oversee Veeva and digital platforms, lead product launch technology readiness, manage vendors/agencies, ensure compliance and governance, and lead IT teams to deliver scalable, secure commercial applications and digital experiences.

The Lead IT Telecom Architect designs and optimizes Telecom and Contact Center architecture to meet business goals, ensuring security and performance. Responsibilities include strategy development, technology evaluation, system implementation oversight, and stakeholder collaboration.

Lead enterprise IT sourcing and software procurement for complex renewals and strategic sourcing initiatives. Drive savings, establish governance, create vendor strategies and KPIs, partner with IT and stakeholders, mentor procurement staff, and manage contract negotiations and renewals.

Design, modify, and program software for local, networked, cloud, or internet applications. Write code, test and debug, document installation and maintenance procedures, gather user requirements, implement enhancements, and perform related duties.

Lead and coordinate IT service delivery and integrations at the Indianapolis site, partnering with site leadership, vendors, and DT governance to manage demand, monitor performance, ensure compliance, support projects, drive continuous improvement, and provide hands-on AV support. Serve as primary DT liaison, manage budgets and service metrics, and travel to regional sites as needed.

Lead and mentor the Infrastructure team and deliver the enterprise infrastructure roadmap. Design and maintain resilient on-prem and cloud (Azure) network and server environments, oversee capacity planning, monitoring, backup/recovery, disaster recovery, vendor management, and infrastructure automation. Support ERP/Sage X3 infrastructure, collaborate with InfoSec on vulnerability remediation and OT teams for manufacturing environments, and manage infrastructure projects and on-call escalations.

Remote IT Manager responsible for analyzing, upgrading, and administering IT systems (networks, servers, email, backups), evaluating vendors and technologies, managing projects, tracking inventory, training staff, and providing technical support to improve operational efficiency.