Top Senior IT Jobs in San Antonio, TX

Reposted 11 Hours AgoSaved
Remote
San Antonio, TX
70K-115K Annually
Senior level
70K-115K Annually
Senior level
Consulting
The IT Project Manager will oversee project planning, implementation, and client interactions while ensuring compliance with federal and state regulations in the public sector.
Top Skills: AccessMS OfficeSpssSQL
Reposted 11 Hours AgoSaved
Remote
San Antonio, TX
88K-135K Annually
Senior level
88K-135K Annually
Senior level
Consulting
The IT Project Manager will lead public sector ERP migration projects, ensuring high-quality deliverables and strategic alignment while collaborating with various stakeholders.
Top Skills: AgileBusiness IntelligenceCloud-Based ErpData AnalysisData MigrationIv&VPeoplesoftSap S/4Hana RiseSoftware DevelopmentWaterfall
Reposted 11 Hours AgoSaved
Remote
San Antonio, TX
92K-138K Annually
Senior level
92K-138K Annually
Senior level
Healthtech • Pharmaceutical
Serve as the primary IT–business liaison, owning executive relationships, technology strategy, vendor management, and prioritization of IT/AI initiatives. Drive modernization, cost/benefit analyses, budgeting, continuous improvement, and successful deployment of technology solutions across business units.
Top Skills: AIAutomationLims
YesterdaySaved
Remote
San Antonio, TX
Senior level
Senior level
Cloud • Information Technology • Consulting
Lead delivery and oversight of internal and client projects, ensuring on-time, on-budget completion. Manage resources, risks, scope, finances, stakeholders, vendor relationships, project documentation, performance tracking, and reporting. Apply project management methodologies (Agile/Waterfall) and leverage AI platforms to increase efficiency.
Top Skills: Ai PlatformsAzureMS OfficeMicrosoft ProjectSmartsheet
YesterdaySaved
Remote or Hybrid
San Antonio, TX
138K-190K Annually
Senior level
138K-190K Annually
Senior level
Artificial Intelligence • Healthtech • Social Impact • Telehealth
Build and maintain internal platforms, automations, and integrations to scale IT operations. Own identity, access, lifecycle automation, endpoint trust, SaaS provisioning, and operational reporting. Develop scripts and services (Python, Bash), partner with Security and Engineering for secure AI, Zero Trust, HIPAA and SOC 2 compliance, and apply DevOps/SRE/ITIL practices for monitoring and incident response.
Top Skills: AWSBashCi/CdGitGitGithub ActionsGoogle WorkspaceIamIpaasJamf ProJSONLambdaLinuxMicrosoft 365Microsoft IntuneOktaOkta WorkflowsPythonRest ApisWebhooksWorkato
YesterdaySaved
Remote
San Antonio, TX
Senior level
Senior level
Other
Lead and deliver complex cross-functional IT projects using Agile, predictive, and hybrid methods. Create schedules, manage budgets, risks, changes, and stakeholders; mentor PM staff and ensure projects meet scope, schedule, and cost baselines.
Top Skills: AgileHybridPredictiveProject Management SoftwareSoftware Development Life Cycle
YesterdaySaved
Remote
San Antonio, TX
84K-143K Annually
Senior level
84K-143K Annually
Senior level
Healthtech • Pharmaceutical
Owners product vision and roadmap for clinical IT solutions; define business value, perform build vs buy, manage releases, vendors, demand, cross-functional delivery, ROI, KPIs, and product lifecycle/migration.
Top Skills: AgileCotsSaaS
Reposted YesterdaySaved
Remote
San Antonio, TX
68K-80K Annually
Senior level
68K-80K Annually
Senior level
Social Impact
The Project & IT Budget Analyst manages project coordination and IT budget oversight, supporting strategic initiatives and ensuring financial accuracy.
Top Skills: MS OfficeSmartsheet
Reposted YesterdaySaved
Remote
San Antonio, TX
Senior level
Senior level
Healthtech
The Senior IT Project Manager oversees the delivery of technology and business transformation projects, supports PMO standards, manages project risks, and mentors junior managers.
Top Skills: JIRAMs ProjectServicenow PpmSmartsheet
Reposted YesterdaySaved
In-Office or Remote
San Antonio, TX
Senior level
Senior level
Healthtech • Information Technology
The Senior IT Risk and Compliance Analyst manages vendor risk, ensures compliance with regulations, documents controls, and supports risk mitigation efforts across IT teams.
Top Skills: Audit MethodologiesCobitIso27001Iso27002NistServicenow Irm
Reposted YesterdaySaved
Remote
San Antonio, TX
130K-156K Annually
Senior level
130K-156K Annually
Senior level
Fintech • Professional Services • Software • Financial Services
The IT Systems Engineer will manage IT operations, support M&A integrations, and optimize Microsoft cloud systems, ensuring reliability and security.
Top Skills: Active DirectoryAzureCloud-Based PlatformsEndpoint ManagerEntra IdIntuneLan/Wan InfrastructureMicrosoft 365Microsoft Defender Xdr
2 Days AgoSaved
Remote
San Antonio, TX
Senior level
Senior level
Artificial Intelligence • Information Technology
Lead and grow the IT Engineering team while hands-on securing endpoints, offices, networks, and SaaS tools. Implement automation-first workflows (scripting, IaC), manage MDM and identity systems, support office buildouts, ensure SOC 2/ISO 27001 compliance, mentor engineers, and collaborate with Security and Operations.
Top Skills: BashCisco MerakiFirewallsFleetGoogle WorkspaceIso 27001JAMFKandjiOidcOktaOsqueryPythonSAMLSantaScimSoc 2TerraformUbiquitiVpnsZero Trust
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2 Days AgoSaved
Remote
San Antonio, TX
59K-89K Annually
Senior level
59K-89K Annually
Senior level
Healthtech
Lead clinical applications initiatives by translating business needs into technical requirements, managing project portfolios, and delivering AI-enabled and Epic EHR solutions. Drive change management, mentor IT analysts, create process maps, measure project benefits, mitigate risks, and coordinate cross-functional stakeholders to improve clinical workflows and system usability.
Top Skills: AIEpic Ehr
Reposted 2 Days AgoSaved
In-Office or Remote
San Antonio, TX
133K-259K Annually
Senior level
133K-259K Annually
Senior level
Semiconductor • Manufacturing
The M&A Lead Integration Architect will strategize and implement integration plans for acquired entities, collaborating with various teams to ensure seamless transitions and alignment with business goals.
Top Skills: CRMErpHris
Reposted 2 Days AgoSaved
Remote
San Antonio, TX
95K-130K Annually
Senior level
95K-130K Annually
Senior level
Industrial • Manufacturing
The LN Support Analyst III provides support for LN Finance, ensuring effective implementation, end-user training, and process mapping while resolving user issues and documenting solutions.
Top Skills: AcpAcrCost AccountingDatabase ManagementErp LnLn Finance
Reposted 2 Days AgoSaved
Remote
San Antonio, TX
150K-180K Annually
Senior level
150K-180K Annually
Senior level
Greentech
Lead the Global IT department, managing endpoint operations, software procurement, identity management, and IT team development. Drive proactive IT automation and ensure operational excellence across remote teams.
Top Skills: BashCrowdstrikeDatadogGoogle WorkspaceJAMFMicrosoft IntuneOktaPowershellPythonTerraform
Reposted 2 Days AgoSaved
Remote
San Antonio, TX
133K-178K Annually
Senior level
133K-178K Annually
Senior level
Biotech
As Senior Manager of IT Commercial Data Management, you will lead data initiatives, manage product ownership, and develop data governance strategies in collaboration with stakeholders, ensuring high data quality and analytics capabilities.
Top Skills: Active BatchControl MGoogle AnalyticsInformaticaPythonSalesforceSnowflakeSQLVeeva Crm
Reposted 2 Days AgoSaved
Remote
San Antonio, TX
111K-166K Annually
Senior level
111K-166K Annually
Senior level
Energy • Utilities
The Senior Procurement Manager will oversee IT sourcing and software procurement, manage renewals, drive savings, and mentor team members in procurement practices.
Top Skills: Contract ManagementIt SourcingProject ManagementRoi AnalysisSoftware ProcurementSpreadsheets
Reposted 2 Days AgoSaved
Remote
San Antonio, TX
50K-100K Annually
Senior level
50K-100K Annually
Senior level
Insurance
The IT Business Partner will align IT services with business objectives, identify technology improvements, and support governance processes. Strong background in IT service delivery and business analysis is required, along with relationship-building skills.
Top Skills: Business AnalysisIt Service Management
3 Days AgoSaved
Remote
San Antonio, TX
149K-248K Annually
Senior level
149K-248K Annually
Senior level
Consulting
Lead and deliver major ServiceNow implementations aligned to ITIL v4 and CSDM. Translate business requirements into technical designs, oversee architecture and development, ensure quality assurance and security, coordinate stakeholders, supervise project teams, and recommend improvements to optimize service delivery and scalability.
Top Skills: AgileCmdbIrmItil V4ItomItsmSafeScrumSdlcServicenowServicenow Csdm
3 Days AgoSaved
In-Office or Remote
San Antonio, TX
148K-268K Annually
Senior level
148K-268K Annually
Senior level
Consumer Web • Digital Media • Information Technology • News + Entertainment • On-Demand
Lead design and development of customer profile operational data stores and integration pathways. Drive architecture, security, compliance, DevOps and CI/CD practices, mentor engineers, govern vendor delivery, troubleshoot production, and align technical solutions to business outcomes across cross-functional teams.
Top Skills: AWSAzureCi/CdData NetworkingDevOpsIamIvrJ2EeJavaMockitoMongoDBOauthOraclePl/SqlPostmanRestSafeSoapSoapui
3 Days AgoSaved
In-Office or Remote
San Antonio, TX
Senior level
Senior level
Events • Gaming • News + Entertainment • Other
Lead end-to-end IT sourcing for hardware, software, SaaS, and security services. Develop sourcing strategies, run RFx and negotiations, draft and manage contracts, perform market and TCO analysis, mitigate risks, manage supplier performance, and align cross-functional stakeholders to optimize cost, performance, and vendor portfolios.
Top Skills: Collaboration ToolsContract Management SoftwareEnterprise SecurityNetworking HardwareProductivity SoftwareSaaS
3 Days AgoSaved
Remote
San Antonio, TX
108K-205K Annually
Senior level
108K-205K Annually
Senior level
Aerospace • Defense
Design and document resilient, secure IT infrastructure for classified environments across compute, storage, virtualization, and archival systems. Advise engineering and support teams, lead technical meetings, support proposals and reviews, and ensure compliance with RMF/NIST/DoD frameworks and identity/access controls.
Top Skills: Active DirectoryAnsibleCloudContainerizationHyper VIcdLinuxMfaNasNetappNistPkiRed HatRmfSanVMwareWindows
4 Days AgoSaved
Remote
San Antonio, TX
72K-130K Annually
Senior level
72K-130K Annually
Senior level
Appliances • Industrial • Manufacturing
Lead IT sourcing for applications, software, cloud services and consulting. Develop sourcing strategies, run RFP/RFI, manage vendor relationships and performance, negotiate contracts, analyze spend for cost savings, ensure regulatory compliance (medical device, data privacy), and collaborate with IT, Finance, Legal and business stakeholders to deliver required IT resources.
Top Skills: Cloud InfrastructureCoupaCybersecurityEqmsGdprGxpHipaaIso 13485Iso/Iec 27001ItilNetworkingNistOraclePlmQmsSaaSSAP
4 Days AgoSaved
Remote
San Antonio, TX
Senior level
Senior level
Logistics • Manufacturing
Manage multi-site IT support operations for a manufacturing organization: lead L1/L2 teams, resolve hardware/software issues, oversee infrastructure, enforce cybersecurity, coordinate vendors, manage imaging and deployments, document systems, and align IT with production goals.
Top Skills: BackupsHandheld DevicesIncident ResponseNetworkingPatch ManagementPc ImagingPrintersTicketing SystemsWindowsWorkstations
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