Top Senior IT Jobs in San Antonio, TX

Reposted 18 Days AgoSaved
Remote
San Antonio, TX
157K-185K Annually
Senior level
157K-185K Annually
Senior level
Biotech • Pharmaceutical
Responsible for IT support and administration for Commercial systems. Partners with business owners to ensure system performance, compliance, and operational excellence across various business functions.
Top Skills: CRMData WarehouseEdiMarketing TechnologiesMaster Data Management
Reposted 18 Days AgoSaved
Remote
San Antonio, TX
80K-95K Annually
Senior level
80K-95K Annually
Senior level
Artificial Intelligence • Professional Services • Software • Analytics
The IT Support Lead oversees L1/L2 IT support operations, leading a team, ensuring effective issue resolution, and managing IT support functions.
Top Skills: Ai ToolsAntivirusFirewallsFreshserviceGoogle WorkspaceIntuneJAMFmacOSMicrosoft 365Mobile Device ManagementNetworking (SwitchesOktaRoutersVpns)Wi-FiWindows
20 Days AgoSaved
Remote
San Antonio, TX
75K-90K Annually
Senior level
75K-90K Annually
Senior level
Information Technology • Legal Tech • Consulting
Lead and grow a product support team for a live digital court reporting product (Maggie). Supervise analysts, triage and lead incident response for P0/P1 events, coordinate escalations to IT and engineering, run on-call rotations, develop runbooks/KB/training, track support metrics, provision hardware kits, and hire and train support staff.
Top Skills: Audio/Video Capture ToolsBrowser DiagnosticsJira Service ManagementKqlmacOSServicenowSQLWi-FiWindowsZendesk
20 Days AgoSaved
In-Office or Remote
San Antonio, TX
126K-190K Annually
Senior level
126K-190K Annually
Senior level
Security • Software • Cybersecurity
Design, implement, and evolve enterprise IT architecture solutions across cloud/hybrid, SaaS, and on‑prem platforms. Lead cross-functional architecture initiatives, define integration approaches, support AI/automation enablement, ensure security and governance alignment, optimize performance and cost, mentor teams, and contribute to standards, vendor evaluations, and modernization efforts.
Top Skills: AIAPIsAurora PlatformAutomationCloudHybrid CloudIntegrationsSaaS
20 Days AgoSaved
Remote
San Antonio, TX
99K-156K Annually
Senior level
99K-156K Annually
Senior level
Software
Own and operate core corporate IT systems including identity, endpoints, cloud infrastructure, and automations. Administer AWS, ServiceNow, MDM, and SaaS integrations; build workflows, govern AI tools, handle Tier 3 incidents and on-call duties, and partner with Security, People, and Enterprise apps to ensure reliability, security, and compliance.
Top Skills: AtlassianAWSAzure Ad/Entra IdBashClaudeEc2EcsGeminiGleanGoogle WorkspaceIamIntuneJAMFJSONKolideMcpOktaOkta WorkflowsPowershellPythonRest ApisServalServicenowSlackVpcZapierZoom
Reposted 20 Days AgoSaved
Remote
San Antonio, TX
100K-152K Annually
Senior level
100K-152K Annually
Senior level
Healthtech
The role involves strategic sourcing for indirect goods and services, overseeing supplier relationships, driving cost savings, and developing procurement strategies while collaborating with cross-functional teams.
Top Skills: Sourcing Technology Solutions
21 Days AgoSaved
Remote
San Antonio, TX
120K-160K Annually
Senior level
120K-160K Annually
Senior level
Software • Design
Lead enterprise IT procurement strategy, governance, and operations across hardware, software, cloud, and services. Own vendor relationships, commercial negotiations, licensing and asset lifecycle, M&A procurement integration, and procurement process/tooling. Mentor and scale the procurement team, partner with Finance, Legal, and Security, and deliver executive reporting and cost-optimization initiatives.
Top Skills: AdobeAutodeskCloud PlatformsMicrosoftSaaS
22 Days AgoSaved
Remote
San Antonio, TX
Senior level
Senior level
Artificial Intelligence • Healthtech • Software • Automation
Act as the technical lead for field sales, manage evaluations, deliver on-site and remote demos, prepare SOWs/RFIs/RFPs, respond to security questionnaires, train sales teams, and support sales across U.S. and Canada while maintaining client relationships and achieving technical sales targets.
Top Skills: AIAsset TrackingCloud ComputingHosted IpHubspotManaged SecurityMS OfficeNetworkingTelecommunicationsVirtualization
22 Days AgoSaved
Remote
San Antonio, TX
Senior level
Senior level
Artificial Intelligence • Healthtech • Software • Automation
Sell radiology IT solutions by building strategic account plans, managing long technical sales cycles, maintaining a 3-5× quota pipeline, forecasting in Salesforce, partnering with marketing/inside sales, and representing the company at industry conferences.
Top Skills: Ai-Driven SolutionsMiller Heiman Blue SheetsMiller Heiman Strategic SellingPacsReporting WorkflowRisSalesforce
22 Days AgoSaved
Remote
San Antonio, TX
83K-167K Annually
Senior level
83K-167K Annually
Senior level
Blockchain • Financial Services • Cryptocurrency • Web3
Lead IT SOX controls testing for ITGCs (access, change, operations) across blockchain-native and enterprise systems. Build testing programs, validate remediation, perform root-cause analysis, report to Audit Committee, and collaborate with Engineering, Security, and external auditors to ensure SOX compliance and scalable audit processes.
Top Skills: Ai-Assisted Audit ToolsAi-Enabled WorkflowsAuditboardAWSBlockchainCi/CdCobitCosoData AnalyticsDigital Asset Custody SystemsGCPGitlabOff-Chain ProcessingOn-Chain ProcessingPcaobWorkiva
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22 Days AgoSaved
Remote or Hybrid
San Antonio, TX
170K-195K Annually
Senior level
170K-195K Annually
Senior level
Big Data • Cloud • Security • Software • Cybersecurity
Lead strategy and execution for enterprise infrastructure, cloud platforms, and systems reliability. Build and scale a high-performing IT operations team, drive automation and observability, manage incident and change processes, partner cross-functionally on security and architecture, and lead large-scale infrastructure transformation to ensure resilient, scalable services.
Top Skills: AutomationAWSAzureCloud-NativeConfiguration ManagementGCPIdentity SystemsInfrastructure-As-CodeLinuxMonitoringNetworkingObservabilitySite Reliability Engineering (Sre)Unix
23 Days AgoSaved
Remote
San Antonio, TX
Senior level
Senior level
Insurance
Lead information security governance, risk, and compliance programs. Manage cross-functional teams, SOC 2 Type II audits, regulatory engagements, enterprise data security and governance, incident communications, information security questionnaires, KPI/KRI reporting, and mentor junior staff to ensure regulatory and standards alignment.
Top Skills: GdprGrc PlatformsHipaaIso 27001Nist Sp 800-53PciSoc 2
23 Days AgoSaved
Remote
San Antonio, TX
110K-125K Annually
Senior level
110K-125K Annually
Senior level
Consulting
Support and enforce NIST/CMMC-aligned security controls; monitor SIEM/EDR and perform incident triage and response; manage Windows/AD environments; conduct vulnerability scanning and remediation; protect and classify FCI/CUI; support audits and control validation; maintain compliance documentation; collaborate with IT and business teams and communicate security risks to technical and non-technical stakeholders.
Top Skills: Active DirectoryCis ControlsCmmcCsfEdrFirewallsIdentity And Access ManagementIso 27001LinuxMultifactor AuthenticationNessusNist Sp 800-171Nist Sp 800-53SIEMTenableVulnerability ScanningWindows
Reposted 23 Days AgoSaved
Remote
San Antonio, TX
Senior level
Senior level
Aerospace
The Manager of IT Engineering leads IT operations including identity management, SaaS, endpoint management, and internal tooling. This role ensures service quality and scalability for a remote workforce.
Top Skills: Ai ToolingAtlassianBashGoogle WorkspaceIruIso 27001JAMFKandjiOktaPythonSlackSoc 2Zsh
24 Days AgoSaved
Remote
San Antonio, TX
117K-191K Annually
Senior level
117K-191K Annually
Senior level
Greentech • Renewable Energy
Lead IT procurement and contracting for Digital Services: run RFx/RFPs, draft and negotiate contracts, manage renewals, oversee software licensing and vendor relationships, maintain procurement records, resolve disputes, and mentor junior staff.
Reposted 24 Days AgoSaved
Remote
San Antonio, TX
70K-115K Annually
Senior level
70K-115K Annually
Senior level
Consulting
The IT Project Manager will oversee project planning, implementation, and client interactions while ensuring compliance with federal and state regulations in the public sector.
Top Skills: AccessMS OfficeSpssSQL
Reposted 24 Days AgoSaved
Remote
San Antonio, TX
88K-135K Annually
Senior level
88K-135K Annually
Senior level
Consulting
The IT Project Manager will lead public sector ERP migration projects, ensuring high-quality deliverables and strategic alignment while collaborating with various stakeholders.
Top Skills: AgileBusiness IntelligenceCloud-Based ErpData AnalysisData MigrationIv&VPeoplesoftSap S/4Hana RiseSoftware DevelopmentWaterfall
25 Days AgoSaved
Remote
San Antonio, TX
Senior level
Senior level
Information Technology • Software
Build end-to-end automation and AI agents across identity, endpoint, SaaS, and ITSM systems. Automate onboarding/offboarding, ticket triage, self-service flows, and integrations. Operate and govern Vertex AI agents, establish KPIs, mentor sysadmins, and maintain reliable, auditable automations with security and compliance controls.
Top Skills: BashCloud IdentityGoogle Cloud Vertex AiGoogle WorkspaceJira Service ManagementJSONLlm ApisMdmN8NOktaPrompt EngineeringPythonRagRest ApisTinesWebhooksWorkatoZapier
Reposted 25 Days AgoSaved
In-Office or Remote
San Antonio, TX
Senior level
Senior level
Retail • Sales
The IT Manager, Product Owner - Finance drives financial process transformations, prioritizes product backlogs, and manages stakeholder relationships to ensure high-quality delivery of financial systems solutions.
Top Skills: CertiniaCpqFinancialforcePower BISalesforceServicemaxSQLZuora
Reposted 25 Days AgoSaved
Remote
San Antonio, TX
92K-138K Annually
Senior level
92K-138K Annually
Senior level
Healthtech • Pharmaceutical
Serve as the primary IT–business liaison, owning executive relationships, technology strategy, vendor management, and prioritization of IT/AI initiatives. Drive modernization, cost/benefit analyses, budgeting, continuous improvement, and successful deployment of technology solutions across business units.
Top Skills: AIAutomationLims
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