Top Remote Python Jobs in San Diego, CA

Leads and develops a DevOps platform team responsible for AWS-based developer platforms, CI/CD pipelines, Terraform, EKS, service onboarding, connectivity, secrets, observability integration, and environment promotion. Drives automation, AI-assisted DevOps workflows, platform reliability, security controls, incident response, compliance readiness, and cross-functional delivery. The role combines direct people leadership with hands-on technical oversight of scalable, self-service engineering infrastructure.

Tests, validates, and troubleshoots next-generation cloud server hardware for performance, power, reliability, and quality. Develops test scripts, documents results, identifies defects, recommends improvements, and resolves hardware issues across engineering and manufacturing environments. Requires hands-on embedded systems debugging, Linux and scripting experience, and knowledge of server architecture, firmware, operating systems, networking, storage, and hardware acceleration technologies.

Own reliability and security of CI/CD and production services: define SLI/SLOs, lead incident response and postmortems, build observability (Datadog), operate Kubernetes and IaC (Terraform), harden pipelines with SAST/DAST/SCA and policy-as-code, and coach teams on reliability and operational best practices.

Develops, tests, enhances, and troubleshoots software and database products. Collaborates with senior developers, project managers, and stakeholders throughout design, development, deployment, and code review. Writes unit tests, fixes defects, prototypes features, documents technical decisions, and participates in Agile sprints. The role requires strong programming skills, a bachelor's degree, and the ability to obtain and maintain an active Secret clearance.

Own and accelerate ELSA’s B2B Dashboard during a three-month contract. Build production-ready full-stack features across Go, Python, and Vue.js; shape product requirements; make UI/UX decisions; improve APIs and user experiences; use AI development tools; and collaborate with product, design, business, and engineering stakeholders to deliver high-impact improvements autonomously.

The Staff Software Engineer will shape technical direction, build developer platforms, and design AI agents, enhancing developer productivity and collaboration across teams.

Design, build, and operate scalable, secure data platform infrastructure for ingesting, processing, cataloging, and accessing petabytes of data. Improve Spark/Databricks reliability and developer experience, build ingestion/replication systems, develop internal libraries and tooling (Go/Python), and collaborate with cross-functional teams to support analytics, ML, and customer-facing data products.

Lead Salesforce and billing platform engineering with an emphasis on AI-driven automation. Build scalable Salesforce solutions (Apex, Flow, LWC), pilot LLM/agent workflows, modernize CI/CD and test automation, support Quote-to-Cash and billing processes, collaborate across product and finance, drive technical debt reduction, and mentor junior engineers.

Design, build, and run secure production infrastructure across cloud-native and air-gapped deployments. Own end-to-end platform outcomes, harden the artifact pipeline for signed releases, embed with teams to advise on security and deployment best practices, and partner with GRC on STIGs, CVE remediation, and audit readiness for classified environments.

Build, operate, and secure cloud-native and edge infrastructure including Kubernetes, artifact pipelines, application streaming, and air-gapped appliances. Partner with product, GRC, and mission owners to design, deploy, and harden systems, remediate vulnerabilities, support audits (IL5/IL6/JWICS), and ensure trusted artifact delivery across environments.

The Staff Software Engineer will lead technical strategy, ensure system availability, and develop backend systems at scale, collaborating across teams to drive capacity modeling and operational quality.

Lead cross-pod technical direction and system design for high-scale backend services, embed AI-native development practices, collaborate with product and design, mentor engineers, and drive ambiguous initiatives from design through production.

Develop and maintain Kubernetes runtime environments, support developers, resolve critical issues, and participate in on-call rotations for production systems.

Lead development and reliability of real-time and batch payment-processing systems across authorization, clearing, settlement, disputes, and card-network integrations. Build scalable, secure, low-latency services using Java, Python, Kotlin, and AWS; improve network peering infrastructure, failover, and capacity. Own initiatives from planning through launch, participate in on-call rotations, reduce technical debt, and drive cross-functional engineering improvements and strategic planning.

Develop production tools, desktop applications, DCC integrations, and real-time workflow systems for Lightspeed Studios. Partner with artists and engineers to improve content pipelines, usability, reliability, performance, and automation. Build Python and Qt/PySide solutions, integrate applications such as Maya and Houdini with Unreal Engine, and explore agentic AI for content creation. The role requires extensive tools or pipeline engineering experience in games, VFX, animation, or real-time production.

Build and maintain backend computation engines for solar and electrical design. Develop simulation and optimization systems for PV and battery storage layouts, component selection, and electrical configuration. Translate physical models into reliable, scalable software, shape computation infrastructure, write tested code, mentor teammates, collaborate cross-functionally, and own services through production and on-call support.

As a Mojo Libraries Engineer, you'll design and implement libraries for Mojo, focusing on performance and integration with AI systems, collaborating with multiple teams to optimize algorithms and deliver high business impact.

Lead technical vision and architecture for the Mojo compiler backend: IR lowering, optimization passes, and code generation across CPUs, GPUs, and AI accelerators. Drive MLIR/LLVM initiatives, expand debugging and profiling tooling (LLDB/GDB, LSP, profilers), mentor engineers, collaborate with cross-functional teams, and engage with the open-source community to shape developer tooling and compiler strategy.

Build, test, release, and maintain native Android and iOS applications across a portfolio of consumer mobile products. Use Kotlin, Swift, modern mobile frameworks, automated testing, analytics, experimentation, and AI coding agents to deliver high-quality software. Collaborate with product, design, marketing, operations, and engineering teams, measure user impact, manage app-store releases, and adapt across codebases and product pods.

Support technical integrations between Sentrycs C-UAS technology and partner C2 or system-of-systems platforms. Configure, test, validate, and troubleshoot REST APIs and software interfaces; collaborate with Product, Engineering, and Customer Success teams; document requirements, configurations, issues, and resolutions; support technology partners; and drive integration problems through resolution. The role requires developing deep API and integration expertise while working with globally distributed teams.

Build and maintain 3D pipeline integrations, plugins, exporters, and platform connections across DCC tools and SaaS destinations. Own integrations from scoping through deployment, documentation, release, and support. Ensure asset fidelity across formats, materials, textures, scene scaling, and color spaces while troubleshooting complex multi-system pipelines. Collaborate with internal engineering teams, external platform vendors, and customers to resolve integration constraints and extend the shared integration framework.

Build and automate cloud cost optimization and governance across AWS and GCP. Analyze billing and usage, identify and implement savings, maintain cost attribution, create reporting and anomaly detection, and write Python, Terraform, and Lambda automation. Partner with Engineering, Finance, Product, and leadership on architecture tradeoffs, forecasting, budgeting, and cost accountability.

Develop and launch scalable web and mobile healthcare applications, APIs, integrations, and cloud infrastructure. Contribute to the technical roadmap, observability, security, compliance, and AI/ML infrastructure. Partner with the founding team and data science leadership to incorporate LLMs, support HIPAA and SOC 2 requirements, and build reliable products for patients and enterprise healthcare customers.

Architect, build, and support reliable network infrastructure and automation for Akamai’s distributed cloud platform. Develop Bash and Python tooling, establish deployment standards, define SLOs, mentor engineers, and troubleshoot complex network issues. The role requires expertise in large-scale distributed systems, TCP/IP, BGP, Linux networking, configuration management, CI/CD, and open-source networking software, with participation in on-call rotations.

Leads architecture for cloud networking, security, DPU, and NIC solutions. Designs end-to-end systems spanning applications and hardware, researches technologies, develops proof-of-concept prototypes, writes architecture specifications, and collaborates with global software, hardware, product, engineering, and customer teams. Requires strong C, Python, Linux, networking, cloud, system architecture, and software development experience, with DPDK, OVS, OVN, container, Kubernetes, and data center expertise preferred.