Top Remote Python Jobs in San Diego, CA

Build realistic simulation environments, tools, and infrastructure for autonomous boats, drones, ground vehicles, and multi-agent systems. Develop configurable scenarios, sensor models, agent behaviors, closed-loop SIL and HIL workflows, replay and regression testing, and automated scenario evaluation. Integrate simulations with autonomy stacks, mission software, command-and-control systems, and data pipelines. Improve simulation scalability, fidelity, debugging, and developer workflows while helping engineering teams reproduce field failures and validate systems before deployment.

Supports client integrations, DevOps monitoring, ERP and practice management system transitions, and technical escalations. Builds and customizes Boomi processes, validates data flows, monitors integration health, investigates alerts, performs root-cause analysis, and resolves synchronization issues across APIs, databases, ERP, PMS, and SaaS environments. Communicates with client technical teams during incidents and migrations, coordinates fixes, documents recurring issues, and improves integration performance and reliability.

Own reliability, performance, scalability, and operational standards across on-premises, private-cloud, and AWS environments. Build infrastructure-as-code, deployment automation, monitoring, alerting, and observability tooling; define SLOs, SLIs, error budgets, and readiness standards. Lead incident response, root-cause analysis, disaster-recovery readiness, release coordination, and preventive automation. Mentor engineers, coach teams on operational practices, coordinate on-call coverage, and ensure infrastructure meets security and compliance requirements.

Leads API and UI automation testing by designing Playwright frameworks, building REST test suites, and validating backend functionality with Python. Integrates regression testing through Selenium Grid and Jenkins, reviews AI-generated automation scripts, creates Devin Playbooks, and supports test strategy, defect resolution, sprint activities, and SDLC quality. Mentors junior automation engineers in traditional and AI-assisted quality engineering practices.

Owns end-to-end delivery of production data platforms for utility clients, including discovery, architecture, ingestion, transformation, orchestration, governance, quality, deployment, and handover. Uses Databricks, Spark, Python, SQL, and AWS to modernize legacy systems, integrate utility data sources, build observable pipelines, and deliver operator-facing applications. Leads client engagements, manages scope and timelines, supports migrations, and contributes reusable engineering frameworks and reference architectures.

Designs, builds, and scales automation for secure hybrid infrastructure. Responsibilities include CI/CD, infrastructure as code, cloud architecture, configuration management, monitoring, logging, security, network operations, containerization, and self-healing systems. The role maintains mission-critical production environments, develops performance metrics, resolves root causes, and collaborates cross-functionally to improve reliability and operational efficiency.

Senior Software Engineer responsible for compliance validation, defect remediation, production migration support, monitoring, and operational documentation for a federal ESA Section 7 data integration platform. The role validates decision logic and consultation routing, develops migration runbooks and rollback procedures, resolves critical application defects, supports post-deployment operations, incorporates user feedback, and enforces code review and version control practices.

Designs, builds, and optimizes CI/CD pipelines across legacy mainframe and AWS environments. Automates workloads, integrates testing, maintains APIs, supports application integration, troubleshoots deployment issues, and improves DevOps processes. The role also supports software developers in an Agile/Scrum environment and contributes to modernization efforts bridging z/OS systems with cloud platforms.

Leads end-to-end customer engagements integrating software with government data systems. Designs and builds custom workflows, translates ambiguous requirements into technical plans, debugs production issues in constrained environments, documents decisions, reviews code, mentors engineers, and makes delivery trade-offs. Requires customer-facing software engineering experience, data integration expertise, and willingness to travel to U.S. military installations.

Integrate the company platform with government data and systems, onboard imperfect data, configure workflows, support releases, resolve customer issues, and build production software. The engineer owns workstreams end to end, collaborates directly with customers, supports deployments in constrained government environments, travels to military installations, and feeds field insights back into product development.

Build and own automation systems that eliminate friction across engineering, operations, and compliance. Responsibilities include regulatory workflow automation, CI/CD and developer productivity tooling, AI- and LLM-enabled internal workflows, system integrations, and reliable production software with testing, observability, auditability, and failure handling.

Build and lead UpDoc’s software quality engineering function for regulated, safety-critical healthcare technology. Own risk-based testing, traceability, verification evidence, automated test frameworks, CI/CD integration, defect management, release readiness, and failure investigation across web applications, APIs, integrations, and clinical workflows. Partner with Engineering, Clinical, Product, and Quality/Regulatory teams while establishing scalable quality processes and mentoring a growing team.

Build and maintain Python backend services, APIs, healthcare integrations, and reliable platform infrastructure. Collaborate with product, frontend, engineering, and clinical teams to define functionality, ensure safety, troubleshoot production issues, and deliver projects end to end. Contribute to DevOps, CI/CD, observability, testing, code review, and technical architecture for an AI-powered healthcare platform.

Build and maintain reliable integrations between UpDoc and healthcare systems, EHRs, and external APIs. Own integration projects from discovery and architecture through deployment, monitoring, troubleshooting, and maintenance. Develop Python APIs and backend services using FastAPI and Pydantic, implement healthcare interoperability standards, handle failures and data integrity, and create automated tests. Collaborate with healthcare technology stakeholders while supporting security, HIPAA, SOC 2, observability, and clinical reliability requirements.

Design, develop, deploy, and maintain scalable cloud applications and client-installed agents using C# and .NET. Own platform integrations, troubleshoot production issues, optimize performance and costs, improve testing and automation, and uphold software security and quality. Collaborate with product, architecture, UX, support, and customers; contribute to technical and architectural decisions; and mentor engineers. The role also requires polyglot development across integrations and familiarity with cloud security, PAM, Azure, CI/CD, and automation practices.

Build and operate Danaher’s enterprise data platform automation and reliability layer. Responsibilities include Infrastructure-as-Code, CI/CD, self-service developer enablement, data platform provisioning, observability, SLOs, auto-remediation, FinOps, compliance guardrails, and event-driven operations across Snowflake, Azure, Matillion, dbt, and Airflow. The role also develops AI-driven operators and copilots using Azure AI Foundry, Anthropic Claude, and related agent frameworks.

Design, build, and operate secure cloud-native and edge infrastructure for classified and commercial environments. Own end-to-end platform outcomes, harden artifact pipelines for signed builds across cloud and air-gapped deployments, embed with product teams to advise on secure deployments, and support compliance/audit activities (STIGs, CVE remediation) to enable operation in IL5/IL6/JWICS environments.

Lead and deliver quarterly goals for a backend team; guide engineers through ambiguous problems; collaborate with product, design, and analytics; identify and resolve project and technical issues; ensure operational availability and on-call readiness; set code and design quality standards; and mentor and develop team members.

Lead design and delivery of enterprise-grade integrations between Samsara and customer systems. Own architecture, implementation, mentorship, cross-functional coordination, troubleshooting, automation, and customer-facing technical enablement for complex B2B integrations.

Sets technical direction for Helix’s Experience platform and broader engineering organization. Designs and implements distributed, full-stack genomic software systems focused on patient and provider experiences. Leads complex projects from scoping through production, advances AI-assisted engineering practices, establishes quality and delivery standards, mentors technical leaders, and drives cross-functional collaboration with product, design, research, scientific, and business teams.

Design, automate, and maintain scalable infrastructure and SRE tooling. Manage Kubernetes clusters, CI/CD, monitoring, and incident response. Improve processes, reduce toil via automation, and collaborate with engineering and data teams to support domestic and international workloads.

Lead engineering ownership of an acquired consumer VPN product from due diligence through integration, stabilization, and growth. Manage and coach engineers while remaining hands-on with Kotlin, Swift, Go, architecture, operations, security, and production incidents. Establish testing, CI/CD, infrastructure, documentation, and compliance practices; partner with product, corporate development, marketing, and operations; and create a repeatable engineering playbook for future acquisitions.

Lead a backend engineering team responsible for Benepass Core Services, including ledger, decisioning, authentication, integrations, and money movement systems. Manage and develop 4–6 engineers, oversee hiring and performance, guide project execution, and maintain delivery accountability. Provide technical leadership through design reviews, prototyping, debugging, and operational incident management. Partner cross-functionally, uphold reliability and correctness standards, and model effective daily use of AI in engineering and management workflows.

Build and operate Conduit’s control plane services for provisioning, updating, repairing, and retiring customer infrastructure. Design reconciliation-based lifecycle systems, schema-driven APIs, usage metering, internal tooling, and integrations with billing and partner systems. Own contracts, versioning, reliability, asynchronous workflows, and cross-functional coordination. Participate in on-call support while improving platform maintainability and automation.

Engineering Manager leading a 4–6 person backend team responsible for core fintech services, including ledgers, decisioning, integrations, authentication, and directories. The role combines people management, hiring, coaching, execution ownership, technical design reviews, production debugging, reliability, and delivery accountability. The manager must remain technically credible in Python/Django systems, uphold high-integrity engineering standards, and use AI extensively for coding, planning, debugging, communication, and team effectiveness.