Top Remote Python Jobs in San Diego, CA

Build scalable data processing and exploration pipelines, ML infrastructure, and cloud-based applications. Write, test, instrument, and deploy software in Kubernetes environments while contributing to distributed systems and data-driven products. The role focuses on Python, big data technologies, containerization, and systems supporting marketplace intelligence.

Lead modernization of a 30-year-old Store Management System by reverse engineering EZC file-based platforms, migrating data and applications to PostgreSQL, and developing enterprise C/C++ software. Responsibilities include architecture, systems integration, APIs, ETL, performance optimization, troubleshooting, documentation, and maintaining business continuity. The role also applies AI-assisted development tools for code analysis, documentation, testing, and modernization while mentoring teams and supporting legacy and modern environments.

Lead architecture and development of secure, high-scale Python and FastAPI payment infrastructure for AI-agent transactions. Design APIs for tokenization, mandates, authentication, attestation, and cryptogram workflows; own security, reliability, observability, testing, Kubernetes provisioning, and production operations. Drive technical initiatives, design reviews, and cross-functional collaboration with product, security, infrastructure, platform, and card-network partners while applying AI-assisted engineering practices.

Serves as the strategic architect and technical lead for enterprise observability, APM, telemetry, and SRE ecosystems. Designs unified monitoring across hybrid cloud, Kubernetes, and legacy environments; establishes SLOs, SLIs, error budgets, and incident-response practices; leads automation using Ansible, Terraform, Python, and GitOps; and develops secure, scalable telemetry pipelines. The role also leads FOAK implementations, monitoring migrations, vendor transitions, knowledge-transfer programs, major incident escalations, operational handoffs, and engineering-team mentoring.

Leads major technical initiatives while designing enterprise identity systems, authorization models, and scalable multi-tenant SaaS architecture. Builds platform components with .NET/C# on AWS, improves data pipelines, resolves complex production issues, and shapes the technical roadmap. Mentors engineers, drives architecture and reviews, coordinates across teams, and supports security, compliance, automation, and continuous platform improvement.

Build full-stack Django applications with a frontend focus, creating intuitive, interactive, and performant data visualizations for complex healthcare pricing data. Collaborate with product and engineering teams to define user experiences, prioritize features, write scalable code, test and debug systems, improve existing functionality, and translate user requirements into technical solutions.

Design and scale reliable spine-leaf data center networks supporting GPU clusters and AI workloads. Build Ethernet fabrics using EVPN/VXLAN and BGP, optimize traffic, support RoCE/RDMA, and manage backbone, WAN, DCI, and edge connectivity. Develop network automation and Infrastructure-as-Code solutions, improve observability and telemetry, troubleshoot distributed performance issues, and collaborate with compute, storage, platform, and operations teams. The role requires hands-on Cumulus NOS expertise and experience with large-scale, high-performance infrastructure.

Build and maintain a React/TypeScript operations portal and Supabase/PostgreSQL backend for autonomous aircraft medical logistics. Improve aircraft allocation, mission generation, telemetry ingestion, live dashboards, reliability, testing, logging, and observability. Integrate Python services with ArduPilot aircraft and simulations while collaborating with autonomy and simulation engineers to mature real-flight and digital-twin systems.

Supports the design, prototyping, assembly, testing, repair, simulation, and flight testing of autonomous aircraft. Interns may work across airframe and mechanical design, avionics, controls, manufacturing, and data review while owning a project that improves aircraft development.

Owns block- and system-level verification for ASIC and FPGA designs, including test planning, UVM and formal environments, assertions, constrained-random testing, behavioral models, coverage closure, regression automation, and debugging. The role leads multiple verification projects, collaborates with designers and architects, reports progress, and advises external clients on verification strategy. Work is fully remote with possible domestic and international travel.

Design, deploy, enhance, and support secure custom government network platforms and cloud services. Manage CI/CD pipelines, build systems, testing frameworks, distributed databases, and storage ecosystems. Lead technical initiatives, code reviews, security patching, Agile SDLC releases, and system performance improvements. Collaborate with Operations, Engineering, and SRE teams to troubleshoot complex issues and deliver resilient application delivery networks.

Serves as a customer-dedicated Resident Engineer and technical expert for HPE data center networking products. Designs and troubleshoots networks, provides break/fix support, advises on Junos configurations, tests and certifies Junos software and hardware, develops Python automation, reviews designs, supports cross-organizational projects, drives technology innovation, manages technical relationships, and mentors junior engineers.

Develops, tests, documents, enhances, and maintains software solutions using Appian and related technologies. The role includes application development, process modeling, system integration, security remediation, performance improvement, user story analysis, technical documentation, and collaboration within an Agile software development team.

Develops, tests, documents, enhances, and maintains software solutions using Appian and related technologies. Designs integrations with external systems, resolves technical issues, remediates security vulnerabilities, improves performance, participates in requirements analysis and Agile development processes, and documents standards. The role also contributes to planning, mentors other engineers, collaborates with team members, and stays current with software development practices and technologies.

Lead the DevOps team’s technical vision and roadmap for WWE 2K. Design and improve CI/CD pipelines, infrastructure, deployment automation, developer tooling, and environments across Windows and Linux. Ensure reliability, scalability, observability, and performance while establishing deployment and operational standards. Collaborate across studios and disciplines, improve workflows and documentation, and provide technical leadership in a distributed, multi-team game development environment.

Lead customer migrations from self-managed GitLab to GitLab Dedicated using GitLab Geo. Plan replication, cutovers, network connectivity, and post-migration validation while debugging synchronization issues. Build repeatable automation, runbooks, and infrastructure validation using Terraform, Ansible, Kubernetes, and cloud platforms. Manage multiple customer engagements, advise stakeholders, communicate technical plans, and collaborate with Professional Services, Product, and Engineering teams.

Provide technical leadership for structural and/or thermal-fluids analysis of aerospace vehicles and propulsion systems. Perform FEA, fatigue, fracture, thermal-stress, CFD, and 1D fluid modeling; validate models against test data; support loads development, anomaly investigations, and nonconforming hardware disposition. Collaborate with design, systems, manufacturing, and test teams while improving analysis methods, mentoring engineers, and supporting safety-critical aerospace systems.

Maintains and secures enterprise end-user computing environments across Windows, macOS, Android, and iOS. Responsibilities include endpoint configuration, vulnerability patching, software packaging, virtual desktop administration, policy management, troubleshooting, documentation, hardware standards, automation, root cause analysis, vendor coordination, and support rotation participation.

Develop and operate Arista’s FedRAMP CloudVision SaaS platform at scale. Responsibilities include improving reliability, scalability, observability, autoscaling, disaster recovery, capacity planning, CI/CD, network architecture, cost optimization, and cloud application security. The role develops and manages Kubernetes-native services, distributed databases, and automation using technologies such as GCP, GKE, Go, Python, Ansible, Pulumi, and Bash. Participation in a FedRAMP on-call rotation is required.

Build and operate secure, scalable Azure infrastructure and AI platform capabilities using Terraform, MCP servers, LLMOps/GenAIOps, Docker, Kubernetes, and GitHub Actions. Own CI/CD, observability, reliability, security, compliance, incident response, and production support for platform and AI workloads. Partner on AI platform roadmap development, reusable engineering patterns, tooling adoption, documentation, and Agile delivery while participating in on-call rotations.

Design, build, operate, and maintain high-scale distributed telemetry systems for Grafana Mimir. Deliver features from concept through production, improve reliability and performance, review code and designs, manage releases, collaborate across the squad, contribute to open-source projects, and participate in follow-the-sun on-call rotations. The role involves cloud software development, microservices, observability, DevOps practices, and database query optimization.

Own end-to-end software integration across firmware, BSP, drivers, GPU software, services, and release systems. Lead system-level debugging of boot failures, crashes, resets, power transitions, performance regressions, and update issues. Analyze logs, traces, crash dumps, and hardware diagnostics to identify root causes, automate failure classification, integrate partner software, and coordinate cross-functional resolution across firmware, kernel, hardware, architecture, and OS teams.

Leads the architecture, development, and evolution of enterprise BI and analytics solutions for healthcare coding and clinical data products. Designs data, semantic, cloud, and distributed-system architectures; builds scalable data pipelines and embedded analytics; establishes engineering standards and governance; evaluates technologies and mentors development teams. The role requires extensive software engineering and architecture experience across AWS or Azure, analytics platforms, data modeling, ETL, security, reliability, and large-scale data processing.

Designs and operates enterprise observability, monitoring, telemetry, and automation solutions across infrastructure, applications, IoT platforms, and cloud environments. Responsibilities include managing Grafana and Instana ecosystems, dashboards, alerts, telemetry pipelines, incidents, RCA, databases, and platform health. Automates provisioning, monitoring deployment, remediation, and operational workflows using Python, PowerShell, Bash, Ansible, and Puppet. Supports 24x7 operations, major incidents, ITIL processes, service onboarding, documentation, and cross-functional reliability initiatives.

Own and improve Snowflake platform operations across development, test, and production environments. Responsibilities include security and access governance, reliability engineering, monitoring, incident response, recovery procedures, consumption and cost optimization, change management, automated testing, and controlled releases. The role partners with Data Engineering, Security, Identity, AWS, and commercial technology teams while documenting processes and building reusable automation.