Top Remote Python Jobs in San Diego, CA

Build and maintain end-to-end features across frontend (React/TypeScript) and backend (Python/FastAPI), design and consume RESTful APIs, write well-tested code, collaborate with product and customers, and iterate quickly based on feedback to support hospital supply chain workflows.

As a Senior Product Support Engineer, you'll provide escalation support for security products, focusing on performance, reliability, and security for customers using Akamai's Zero Trust platform.

Design, build, and operate large-scale distributed web-crawling and data ingestion systems. Improve throughput, reliability, observability, and data quality. Develop backend services for job orchestration and asynchronous workloads, partner with product teams to create data products, and mentor teammates on domain-specific acquisition techniques.

Lead backend-focused engineering to design and ship member- and care team-facing experiences. Own architecture end-to-end, set technical direction and quality standards, mentor engineers, and deliver scalable, secure APIs with CI/CD, cloud deployments, and GenAI/LLM-informed workflows.

Lead architecture and delivery of patient-facing pricing systems. Own data modeling, accuracy, and auditability. Ship features for pricing and cost-estimation, collaborate with product and engineering leaders, and mentor and grow the engineering team.

Embed with enterprise customers to design, integrate, and deploy production agentic AI workflows. Wire platform into data, identity, and internal systems, lead security and procurement reviews, drive adoption, and feed product improvements to accelerate future deployments.

Design, implement, and operate scalable AWS and Kubernetes infrastructure using Terraform and automation. Improve CI/CD, observability, security posture, and developer experience; troubleshoot production incidents, maintain runbooks, and support customer-managed deployments.

The Solution Engineer will design and implement data quality solutions, work directly with customers, and optimize integrations within their data ecosystems, utilizing Python and modern tools while communicating technical concepts effectively.

Develop secure, data-rich frontend features using React and TypeScript for a DoD mission-planning platform. Integrate UIs with backend APIs, support map-based and AI-enabled decision-support workflows, write unit/integration tests, participate in code reviews and security remediation, and collaborate with cross-functional teams with periodic onsite sprint planning in Laurel, MD.

Build, test, and integrate secure backend services and APIs for DoD mission-planning. Work on REST and gRPC services, asynchronous workflows, geospatial databases, containerized deployments, CI/CD, automated tests, and vulnerability remediation while collaborating with AI/ML, frontend, and cybersecurity teams.

Design and build full-stack applications that expose AI/ML insights. Develop backend services in Python, RESTful APIs, and containerized microservices. Build high-performance front-end interfaces with React/Vue/Angular. Implement cloud-native solutions on Google Cloud or Azure, manage relational and NoSQL databases, apply testing and CI/CD, and participate in Agile development and architecture sessions.

Design, build, and maintain automation and deployment frameworks. Create Python automation scripts, custom Dockerfiles, and Helm charts; deploy and manage Helm across multiple Kubernetes clusters. Maintain configuration-as-code repos, implement CI/CD (preferably GitLab CI/CD), apply GitOps/Kustomize practices, troubleshoot platform issues, and collaborate with development teams to ensure scalable, documented platform operations.

As a Software Engineer at Canonical, you will design, build, and ship software, improve packaging and distribution processes, and mentor colleagues while contributing to open source projects.

The Junior Ubuntu Software Engineer will design, build, and ship software, focusing on quality and resilience, while engaging with the open source community.

The Ubuntu Engineering Lead will oversee and mentor teams, drive the development and delivery of high-quality software, and contribute to community engagement while managing technical roadmaps and cultivating engineering talent.

Define high-level SoC subsystem and I/O architecture for LPU products, translate product requirements into architecture and IP specifications, build and validate functional/architectural models (C++, SystemC, Python), and drive tradeoffs across performance, power, reliability, and security while coordinating with IP, firmware, software, RTL, verification, and post-silicon teams.

The Geospatial (GIS) Solutions Architect-Engineer will design and implement geospatial solutions, leveraging ESRI tools, collaborating with stakeholders, and leading custom development efforts.

Build and operate scalable Kubernetes (EKS) infrastructure, develop Terraform infrastructure-as-code, maintain internal developer platform and tooling, support automation, security, and performance, and participate in 24x7 on-call rotations and incident escalation.

The Principal Software Engineer will lead the design and build-out of an AI Context Layer, ensuring high-quality data for AI systems, while managing access control and developer interfaces, and leading cross-team projects.

The role involves overseeing full-stack development, creating APIs, improving microservices, and collaborating with cross-functional teams to enhance mental health care interfaces.

As a Senior Site Reliability Engineer, you will design, develop, and maintain reliable infrastructure for Wikimedia's API services, ensuring performance and availability while driving reliability engineering practices and improving developer experience.

Deploy, upgrade, and maintain High-Speed Data infrastructure supporting DNS, DHCP, DOCSIS provisioning and related platforms. Perform Linux (CentOS/RHEL) administration, scripting/automation (Python, Bash, Ansible, Docker), vendor management, troubleshooting, LLD documentation, project work, training, and on-call support to ensure availability and security of HSD services.

Deploy, upgrade, and maintain High-Speed Data infrastructure (DNS, DHCP, DOCSIS). Administer CentOS/RHEL systems, automate with Python/Ansible/Shell, troubleshoot escalations, create LLDs, run upgrades, train teams, perform on-call duties, and ensure security and high availability.

Lead an engineering product team building account management, portfolio tracking, and wealth management platforms. Provide technical leadership and architecture guidance, manage schedules and vendors, mentor engineers, drive DevOps and observability practices, collaborate with product and stakeholders, and own operational readiness and incident escalation. Hands-on data engineering experience with AWS, Python, Lambda, and Postgres is valued.

As a Senior Systems Engineer II, you will lead stakeholder discussions, manage system requirements, support software services for cardiac health, and conduct compliance assessments while collaborating with cross-functional teams.