Top Remote Python Jobs in San Diego, CA

The Senior Full Stack Engineer builds and ships features across frontend and backend systems, working with various frameworks and databases, while collaborating on technical specifications and improving developer experiences.

As a Database Reliability Engineer at ClickHouse, you'll improve reliability, manage escalation processes, support incident response, and enhance database performance while collaborating across teams.

The Integration Engineer will design and maintain healthcare data integrations, collaborating with teams to optimize performance and improve reliability using Python and various standards.

As a Software Engineer, you will design and build backend services for Relativity's generative AI platform, focusing on scalability and reliability in distributed systems.

The Senior Software Engineer will develop orchestration and autoscaling for the Lucenia search platform, working with cloud technologies and Kubernetes to manage services and mentor team members.

The Senior Solutions Engineer supports technical implementation and advisory for complex customer integrations, ensuring successful onboarding and troubleshooting while collaborating with cross-functional teams.

The Senior Data Infrastructure Engineer will enhance data infrastructure including pipelines, improve data governance, and facilitate collaboration across teams, ensuring scalable, AI-ready systems for analytics and applications.

As a Senior DevOps Engineer IV, you will lead cloud-native infrastructure design and management focusing on Kubernetes and AWS EKS, driving reliability, automation, and collaboration across teams while mentoring junior engineers.

The DevOps Engineer role focuses on integrating continuous delivery practices, maintaining CI/CD pipelines, collaborating with teams on infrastructure automation, and ensuring compliance standards.

As a Full Stack Software Engineer at Doxel, you will design and develop full-stack applications, collaborating cross-functionally to optimize user experiences and facilitate data processing for construction projects.

The Lead Software Engineer will design and develop full-stack applications for construction project management, ensuring intuitive data workflows and collaborating across teams to enhance user experience and performance.

Manage and maintain Linux servers across multi-cloud environments (AWS, Azure, OCI, GCP). Perform system updates, patching, automation (Bash/Python, Ansible/Puppet/Chef), monitoring, performance tuning, security hardening (DISA STIGs), backup/recovery, and provide Tier 2/3 support including on-call rotation.

Design and implement a shared Rust core used across desktop, mobile, and backend. Drive architecture decisions around CRDTs and distributed systems, integrate Rust components with frontend/mobile/backend teams, and improve performance, reliability, and maintainability.

Design, implement, and operate hybrid-cloud infrastructure and platform services. Automate infrastructure (IaC), manage Kubernetes (EKS and on-prem), provision distributed systems (Spark, Kafka, databases), build CI/CD pipelines, improve cloud governance/security, and collaborate with trading, development, and operations teams to maintain reliable production systems.

Build, enhance, and maintain backend services and REST APIs in Go; develop ETL pipelines in Python; design reliable PostgreSQL-backed APIs; use AWS services (S3, Lambda, Step Functions, Glue) for data processing; write well-tested, secure code; support operations and maintenance; participate in code reviews and cross-functional Agile collaboration.

Lead design, development, and implementation of complex software systems for life & annuity policy administration. Provide technical leadership, mentor engineers, architect scalable mainframe solutions, troubleshoot critical issues, and collaborate with stakeholders to meet performance, reliability, and security goals.

Design, build, operate, and evolve backend services and runtime infrastructure for cloud orchestration and job execution. Own distributed, asynchronous systems, APIs, workers, persistence, and service-to-service coordination. Improve reliability, observability, testing, and operational tooling; lead cross-team designs and mentor engineers.

Lead and build an R&D function to identify and validate new product opportunities across wallets and infrastructure. Independently prototype feasibility using code (Rust, TypeScript, Swift, Kotlin, Python), assess protocol and partner technology fit, produce handoff artifacts, and present recommendations to the CEO and leadership for further development.

Support implementation and optimization of pavement management systems, analyze pavement condition data (PCI, IRI, distress, structural), develop maintenance and rehabilitation strategies, prepare technical deliverables, manage projects and client coordination, and support pavement design, specifications, and QA/QC.

Build and deliver end-to-end product capabilities using Python and Next.js/TypeScript. Lead design, implementation, reliability, observability, CI/CD, and integrations. Champion AI-assisted development practices and agentic coding workflows, collaborate cross-functionally, and ensure production readiness and operational excellence.

Own and unify platform infrastructure, CI/CD, release automation, secrets and feature-flag systems, and observability. Ensure reliability, security, and compliance (PCI-DSS/SOC 2), contribute to codebase, and participate in on-call rotation while building developer self-service tooling.

Design, build, test, and maintain enterprise applications and integrations for VA healthcare modernization. Work in Agile teams to develop APIs, microservices, CI/CD pipelines, and DevSecOps practices, support legacy VistA/MUMPS systems, troubleshoot performance and integration issues, and ensure federal cybersecurity and compliance.

Lead SRE work to improve availability, reliability, observability, and security for a distributed SaaS platform. Build and maintain IaC (Terraform, CloudFormation), support CI/CD, manage containerized production environments (Kubernetes/EKS), run disaster recovery exercises, participate in on-call rotation, collaborate cross-functionally, and mentor teams while integrating tooling including AI into SRE workflows.

Lead backend architecture and implementation for a healthcare scheduling platform rebuild: build FastAPI service controllers and Pydantic schemas, port legacy Python services to FastAPI/SQLAlchemy, own PressW-side cloud infrastructure (EKS, networking, IAM, observability), coordinate migrations and translation layers, drive code quality and testing, and mentor mid-level engineers.

Lead frontend and mobile rebuild of a healthcare scheduling platform using Vite + React 19 and Expo/React Native with a shared TypeScript layer. Own identity and access migration to a modern IAM, implement push notifications, build a component library/design system, instrument analytics and session replay, enforce WCAG 2.1 AA accessibility and performance standards, mentor mid-level engineers, and contribute to hiring.