Top Senior Machine Learning Jobs in Indianapolis, IN

Senior backend engineer responsible for setting technical direction, designing scalable distributed systems, building customer-facing web applications, mentoring engineers, and applying machine learning to large-scale healthcare data. The role requires Java, Scala, or Rust expertise, cloud systems experience, technical design leadership, cross-functional collaboration, and adoption of agentic engineering practices.

Provides strategic and hands-on biostatistical leadership across pharmaceutical discovery, translational, biomarker, and early research programs. Designs studies, analyzes complex biological datasets, develops advanced statistical methods and reproducible R workflows, and translates evidence into portfolio decisions. The role collaborates with quantitative and scientific functions, supports publications and external partnerships, mentors statisticians, and advances data-driven analytical practices.

Lead the vision, strategy, and end-to-end development of Zip’s Contract Orchestration product. Build AI capabilities for contract analysis, redlining, generation, routing, metadata extraction, and quality evaluation. Partner with customers, engineering, design, legal, procurement, finance, and suppliers to improve contract workflows, cycle times, visibility, and compliance. Own product quality, lifecycle strategy, user research, prioritization, and cross-functional alignment.

Own the full enterprise sales cycle for Oversee’s leisure travel business, from prospecting through closing. Build relationships with OTAs, agencies, tour operators, and vacation providers; develop pipeline; identify target segments and use cases; refine positioning and sales strategy; lead complex stakeholder processes; and partner with Product and Engineering to convert market insights into a repeatable leisure sales motion.

Own AgentSee’s sales and go-to-market strategy as the first dedicated sales leader. Personally close early enterprise opportunities, refine the ideal customer profile, positioning, pricing, packaging, and sales process, and translate AI capabilities into measurable business value. Build repeatable sales operations and playbooks, provide market feedback to Product and Engineering, and eventually hire and lead the AgentSee sales organization.

Own customer onboarding by prioritizing integration work, developing Python and SQL data pipelines, automating repetitive processes, and leading technical customer calls. Translate CRM and fundraising data into model-ready formats, manage onboarding risks, document processes, support CSMs, and train team members. The role serves as Dataro’s US technical customer representative while collaborating with engineering in Sydney.

Develops machine learning and deep learning models for biologicals discovery in crop health. The role integrates genomic, metabolomic, and phenotypic data to prioritize microbial and natural product candidates, applies modern AI methods, and partners with scientists across biology, chemistry, genomics, and data engineering. Responsibilities include framing research problems, defining evaluation strategies, interpreting model outputs, generating biological hypotheses, and advancing predictive solutions through integrated discovery pipelines.

Lead the strategic roadmap and full product lifecycle for Constant Contact’s AI Assistant. Drive adoption, engagement, customer value, competitive differentiation, and ROI by partnering with engineering, design, marketing, sales, and customer success. Define success metrics, guide AI product strategy, mentor product managers, and represent the vision across the company. The role requires deep understanding of AI/ML products, LLM capabilities, SMB workflows, data-driven decision-making, and strong executive communication.

Own clinical quality for member-facing AI products by partnering with product, engineering, and clinical teams. Design clinical AI evaluations, define quality thresholds and rubrics, assess accuracy, omissions, hallucinations, medication-safety risks, and translate clinical reasoning into prompts and decision logic. Monitor evolving evidence and standards of care, validate product launches, and communicate findings to technical and clinical audiences.

Manage post-sales relationships with a portfolio of customers, primarily financial institutions, to drive adoption and business outcomes from BioCatch’s behavioral biometric solution. Responsibilities include strategic consulting, project coordination, risk and escalation management, customer presentations, quarterly business reviews, roadmap feedback, stakeholder communication, team coaching, statements of work, and identifying expansion opportunities with account managers.

Lead design and implementation of Headway's insurance systems (eligibility, pricing, matching, claims). Build data-intensive, ML-powered platforms and automation, mentor engineers, write high-impact code, and improve accuracy and reliability across state and payer complexity to scale insurance-covered therapy.

Leads business analysis, advanced analytics, KPI development, data modeling, reporting automation, and AI/ML initiatives supporting global data-center construction and operational excellence. Builds datasets, dashboards, performance metrics, forecasts, and scenario models; translates complex findings for executives; aligns technology solutions with business needs; and promotes data governance, documentation, process improvement, and analytics maturity across cross-functional teams.

Build and lead Polymarket’s fraud operations function, including investigation workflows, SOPs, case routing, escalation paths, SLAs, QA processes, and reporting. Manage Fraud Analysts and BPO partners, oversee performance and capacity, investigate fraud typologies, identify process bottlenecks, and partner with Product, Engineering, Data Science, Compliance, and Fraud Strategy to improve detection, automation, and prevention.

Design, deploy, and manage machine learning models supporting client acquisition, retention, and reactivation. Develop Next Best Action, CRM, paid media, and personalization solutions using LLMs and traditional ML. Design and interpret experiments, analyze large-scale datasets, communicate recommendations to stakeholders, and collaborate with product, design, and engineering teams on product and infrastructure roadmaps.

Own end-to-end client relationships for a book of B2B SaaS customers: drive adoption, engagement, retention, and expansion of AI-powered contract drafting tools. Lead onboarding, training, large-scale rollouts, and translate customer feedback into product improvements while designing scalable CS processes and tracking health metrics to demonstrate value.

Own global GTM enablement for a Databricks product area, creating scalable technical content, competitive narratives, demos, labs, AI-powered tools, and learning programs for Solutions Architects and partner technical sellers. Partner with Product and Engineering to translate roadmaps into field-ready assets, establish feedback loops, measure field readiness and deal outcomes, and support selected customer-facing engagements. Build enablement programs from scratch while remaining hands-on with data and AI platforms.

Develop and optimize digital marketing campaigns for Karius’s metagenomic testing portfolio across provider and patient audiences. The role drives lead generation, customer acquisition, pipeline influence, and attributable revenue; develops healthcare and scientific content; builds KPI and measurement frameworks; analyzes customer behavior and market trends; and presents performance recommendations to senior stakeholders. Collaboration with internal teams, agencies, commercial operations, sales enablement, and branding partners is central.

Leads market research, competitive intelligence, forecasting, and commercial opportunity assessments supporting product launches and market expansion. Partners cross-functionally with Product, Commercial, Medical Affairs, Customer Success, UX, and Engineering to gather customer insights, define launch KPIs, develop go-to-market strategies, create sales enablement materials, and communicate actionable recommendations to leadership. Oversees research projects, vendors, budgets, data analysis, competitive monitoring, and pre- and post-launch performance evaluation.

Design, productionize, and scale machine learning and optimization models, pipelines, libraries, and deployment platforms. Partner with data scientists, engineers, product managers, and business stakeholders to deliver ML capabilities, personalization systems, and reusable end-to-end workflows. Establish ML engineering best practices, troubleshoot data pipelines, mentor junior professionals, and help define BetterHelp’s ML platform strategy.

Manage enterprise metadata, business glossaries, data catalogs, and end-to-end data lineage for a federal case management modernization program. Configure governance and metadata platforms, integrate data sources and pipelines, establish standards and workflows, monitor metadata quality, support compliant data sharing, develop governance metrics, document procedures, and train data stewards and business users.

Own customer outcomes from discovery through production deployment. Build decision systems using ontologies, reasoning, graph analytics, optimization, and machine learning over enterprise data. Write Python, SQL, and PyRel; debug unfamiliar systems; tune performance; harden deployments; document reusable solutions; and upstream platform improvements. Lead technical workshops and proofs of concept while partnering closely with customers, Product, and Engineering.

Drive new-logo sales and revenue growth for Wonderlic’s talent assessment and employee development solutions. Identify and prospect target clients, build relationships with HR and recruiting decision-makers, manage opportunities through the full sales cycle, close new business, and transition customers to Customer Success. Maintain expertise in products, market trends, and competitive conditions while providing strategic insights. The role requires B2B SaaS and HR technology sales experience, quota achievement, pipeline generation, and experience selling to SMB, mid-market, and enterprise buyers.

Own strategic partnerships with CPG customers, driving measurable outcomes, platform adoption, user expansion, and retention. Analyze usage data and business context to identify risks and opportunities, develop success plans, lead executive and operational relationships, and advocate for customers internally. Collaborate with product, sales, marketing, and support teams while contributing to repeatable playbooks, thought leadership, and customer best practices.

Conduct applied research on scalable optimization and resource-allocation algorithms for large communication networks. Apply machine learning, reinforcement learning, integer optimization, graph-based methods, and metaheuristics to improve solution quality and efficiency. Collaborate with software engineers to integrate algorithms into production aerospace networking systems, evaluate performance at realistic scale, publish research, support patent applications, and document novel methods.

Manage the operational integrity of an automated group health insurance underwriting workflow. Review and approve RFPs, validate broker and external data, correct errors, monitor funnel and risk metrics, analyze quote-to-bind performance, triage inquiries, coordinate with sales and health plan operations, and maintain underwriting dashboards and reporting.