Top Senior Machine Learning Jobs in Indianapolis, IN

Lead research and development of generative AI and recommendation solutions for Netflix promotional assets and content discovery. Responsibilities include tracking LLM research, developing summarization and LLM-as-judge systems, training and evaluating models, optimizing generated content for audience impact, partnering with engineering teams, defining ML roadmaps, and communicating technical strategies to stakeholders.

Architects and rapidly deploys AI agent systems, BI and ML pipelines, and data governance solutions for strategic enterprise customers. Acts as a technical bridge between customers, Product, Engineering, and GTM teams; develops reusable solution patterns and internal tooling; influences platform roadmaps and delivery methodologies; conducts competitive analysis; and mentors field and customer technical teams.

Develop complex healthcare reports, ETL solutions, databases, and Power BI dashboards for LTSS and Dual Eligible programs. Analyze multidimensional data, ensure governance and accuracy, identify operational improvements, and deliver actionable insights to leadership. The role translates business requirements into scalable reporting solutions, collaborates with clinical, operational, data engineering, and IT teams, and leads testing, process automation, visualization, and large cross-functional data projects.

Drive go-to-market reporting, business intelligence, forecasting, dashboard development, and ad hoc analysis. The role standardizes forecasting processes, maintains analytical documentation, automates reporting and data pipelines using AI-assisted tools, and delivers actionable insights to Sales, Marketing, Engineering, Finance, and executive stakeholders.

Build and lead the organization-wide adoption of generative AI, agentic systems, and AI-assisted development. Design production automation agents, evaluate coding tools, modernize rules-based workflows with ML, and establish responsible AI guardrails. Partner with engineering, product, data, and clinical teams to identify high-impact opportunities, own the enablement roadmap, measure outcomes, and drive adoption through working software, documentation, and hands-on collaboration.

Leads business analysis for AI and automation initiatives, identifying adoption opportunities, developing business cases, gathering requirements, and aligning business needs with technical solutions. The role facilitates stakeholder workshops, supports solution design, testing, deployment, change management, governance, and benefits realization. It also advises executives, monitors outcomes, promotes business analysis standards, and mentors junior analysts.

Leads operational oversight, performance analysis, governance, and continuous improvement for AI-powered products and services. Develops performance frameworks, executive dashboards, business insights, risk and compliance reporting, and scalable AI operating models. Partners with AI engineers, product teams, and business leaders to optimize workflows, support automation, manage operational risks, and drive cross-functional operational excellence.

Leads the strategy, roadmap, development, launch, and optimization of AI-powered products. Defines product vision, requirements, priorities, success metrics, and adoption goals while coordinating engineering, AI, business, executive, and customer stakeholders. Evaluates emerging AI capabilities, supports responsible AI governance, manages product performance, and drives continuous improvement aligned with business objectives.

Own the technical systems that convert market signals into revenue pipeline. Build and maintain prediction models, multichannel campaign infrastructure, AI-driven personalization, call intelligence, and signal-to-task workflows. The role requires production coding, applied machine learning, API integrations, SQL, CRM and GTM stack expertise, and practical LLM usage. You will manage live revenue systems, improve attribution and data quality, and balance rapid experimentation with reliability.

Develop and maintain quantitative models for forecasting, pricing optimization, and risk assessment. Analyze mortgage business metrics to identify revenue, profitability, and operational improvement opportunities. Build performance measurement frameworks, dashboards, automated reports, and SQL-based analytics workflows. Use Python for statistical analysis, automation, and machine learning workflows. Validate and monitor model performance, recalibrating models as needed, while communicating actionable recommendations to business leaders.

Deploy onsite with strategic customers to understand security and risk workflows, then build AI-powered integrations, data pipelines, and production software. Translate security ratings into financial risk models, connect systems across cloud environments, rapidly prototype and harden solutions, and guide technical relationships through renewal and expansion. The role bridges customers, Product, Engineering, Customer Success, and Sales Engineering while feeding field insights into the product roadmap.

Own the strategy and roadmap for Constructor’s search quality and Product Discovery Engine. Drive measurable improvements in relevance, conversion, revenue per visit, and GMV across retail verticals. Partner with ML, data science, and engineering teams to productionize state-of-the-art retrieval, ranking, query understanding, personalization, and LLM capabilities. Establish evaluation frameworks, investigate quality issues, align multiple teams, and expand into chapter-wide product leadership.

Leads the full lifecycle of clinical NGS diagnostic algorithms for oncology and liquid biopsy applications. Responsibilities include algorithm design, analytical validation, design control, regulatory readiness, variant calling, QC metric development, probabilistic modeling, machine learning, and validation pipeline automation. The role serves as technical authority for algorithm changes, supports regulatory submissions, and develops solutions for low-input, fragmented, and ultra-low-frequency genomic variants.

Leads analytical and scientific strategy for Fetch’s Play and Rewarded Apps businesses. Develops predictive and machine learning models, experimentation frameworks, causal analyses, feature pipelines, and measurement systems using Python and SQL. Partners with Product, Marketing, Engineering, and business leaders to improve monetization, engagement, retention, personalization, and marketplace outcomes. Translates complex findings into strategic recommendations, mentors data scientists and analysts, and establishes analytical best practices.

Own the full machine learning lifecycle for search ranking and retrieval, including model training, deployment, serving, feature pipelines, evaluation frameworks, hybrid lexical-vector retrieval, large-scale embedding inference, query understanding, and permissions-aware multi-tenant search. Collaborate with infrastructure, AI, and backend teams to improve search relevance across ClickUp’s platform.

Leads the enterprise analytics organization, managing Analytics Engineers, Data Analysts, and BI Developers. Defines analytics strategy; delivers executive dashboards, KPI scorecards, operational reporting, semantic models, and self-service BI. Establishes data governance and metric standards, ensures data quality, partners with Engineering, Product, Finance, Operations, and executives, and translates business questions into actionable analytical solutions. Mentors analytics talent and drives prioritization, adoption, and measurable business outcomes.

Senior backend engineer responsible for setting technical direction, designing scalable distributed systems, building customer-facing web applications, mentoring engineers, and applying machine learning to large-scale healthcare data. The role requires Java, Scala, or Rust expertise, cloud systems experience, technical design leadership, cross-functional collaboration, and adoption of agentic engineering practices.

Provides strategic and hands-on biostatistical leadership across pharmaceutical discovery, translational, biomarker, and early research programs. Designs studies, analyzes complex biological datasets, develops advanced statistical methods and reproducible R workflows, and translates evidence into portfolio decisions. The role collaborates with quantitative and scientific functions, supports publications and external partnerships, mentors statisticians, and advances data-driven analytical practices.

Own the full enterprise sales cycle for Oversee’s leisure travel business, from prospecting through closing. Build relationships with OTAs, agencies, tour operators, and vacation providers; develop pipeline; identify target segments and use cases; refine positioning and sales strategy; lead complex stakeholder processes; and partner with Product and Engineering to convert market insights into a repeatable leisure sales motion.

Own AgentSee’s sales and go-to-market strategy as the first dedicated sales leader. Personally close early enterprise opportunities, refine the ideal customer profile, positioning, pricing, packaging, and sales process, and translate AI capabilities into measurable business value. Build repeatable sales operations and playbooks, provide market feedback to Product and Engineering, and eventually hire and lead the AgentSee sales organization.

Lead the vision, strategy, and end-to-end development of Zip’s Contract Orchestration product. Build AI capabilities for contract analysis, redlining, generation, routing, metadata extraction, and quality evaluation. Partner with customers, engineering, design, legal, procurement, finance, and suppliers to improve contract workflows, cycle times, visibility, and compliance. Own product quality, lifecycle strategy, user research, prioritization, and cross-functional alignment.

Own customer onboarding by prioritizing integration work, developing Python and SQL data pipelines, automating repetitive processes, and leading technical customer calls. Translate CRM and fundraising data into model-ready formats, manage onboarding risks, document processes, support CSMs, and train team members. The role serves as Dataro’s US technical customer representative while collaborating with engineering in Sydney.

Develops machine learning and deep learning models for biologicals discovery in crop health. The role integrates genomic, metabolomic, and phenotypic data to prioritize microbial and natural product candidates, applies modern AI methods, and partners with scientists across biology, chemistry, genomics, and data engineering. Responsibilities include framing research problems, defining evaluation strategies, interpreting model outputs, generating biological hypotheses, and advancing predictive solutions through integrated discovery pipelines.

Lead the strategic roadmap and full product lifecycle for Constant Contact’s AI Assistant. Drive adoption, engagement, customer value, competitive differentiation, and ROI by partnering with engineering, design, marketing, sales, and customer success. Define success metrics, guide AI product strategy, mentor product managers, and represent the vision across the company. The role requires deep understanding of AI/ML products, LLM capabilities, SMB workflows, data-driven decision-making, and strong executive communication.

Provides advanced internal IT support across identity, devices, software, SaaS, and workplace applications. The role resolves complex employee technology issues, manages support workflows, builds AI-assisted automations and self-service resources, analyzes support metrics, and improves onboarding, access, device, and software processes. It also coordinates with security, infrastructure, endpoint, identity, and enterprise systems teams while supporting distributed employees across time zones.