Top Remote Python Jobs in Washington, DC

The Site Reliability Engineer will provision and manage Kubernetes clusters, build automation tools, debug customer issues, and improve infrastructure reliability.

As a Software Engineer in AI Infrastructure, you will design and develop core platform components, build APIs and services, enhance performance, and automate tooling while collaborating across teams and improving system reliability.

Lead verification of custom ASIC/SoC from block to full-chip: develop verification plans, build SystemVerilog/UVM testbenches, run constrained-random and directed tests, use SVA and formal methods, manage regressions and CI, drive coverage closure, support post-silicon bring-up, and influence DV methodology across cross-functional teams.

Design, implement, and maintain Plume's core blockchain node and validator software; develop scalable, secure protocol features across the full crypto/DeFi stack; tackle distributed-systems and networking challenges; integrate backend services and on-chain UX; and iterate on protocol design to improve performance and reliability.

Build and operate services and tooling to automate network lifecycle, ensure safe network changes, develop scalable observability and telemetry, integrate network source-of-truth via APIs, and collaborate with network engineers and SREs to deliver production-grade automation and reliability.

Build and operate Nebius's network infrastructure: define SLIs/SLOs, improve site and inter-site reliability, lead incident response and postmortems, develop observability and alerting, automate change workflows, and collaborate with network and platform teams to embed operability.

Design, administer, and optimize databases for cloud-native platforms. Support production incidents, evaluate and improve schemas and replication, drive DB architecture choices across AWS/GCP, implement IaC (Terraform) and GitOps, and build repeatable database designs for availability, reliability, and performance.

Lead and coordinate high-severity production incidents for cloud-native services, drive root cause analysis and reliability improvements, own incident communications to stakeholders and customers, and mentor peers while maintaining incident playbooks and observability-driven diagnostics.

Lead design, implementation, and operation of Signifyd's GCP/Kubernetes cloud platform. Architect scalable, secure infrastructure, embed AI-driven automation, own SLOs and incident response, improve developer experience via CI/CD/GitOps tooling, mentor engineers, manage cloud capacity/FinOps, and build observability and security into the platform.

Own collaborative editing across React clients and Node services, including offline storage, queued mutations, realtime WebSocket synchronization, conflict resolution, and data persistence. Build agent-enabled editing experiences, investigate data-loss issues across environments, and collaborate with designers, backend engineers, and open-source contributors. The role requires production TypeScript experience across React and Node, rich-text editor frameworks, offline applications, WebSockets, and advanced Postgres skills.

Own end-to-end custom integrations for strategic customers, from technical discovery through production deployment. Build Python-based integrations against unfamiliar APIs and infrastructure, collaborate directly with customer engineers and stakeholders, diagnose issues remotely, and distinguish one-off requests from broader product gaps. The role requires independently delivering production code, communicating with both technical and executive audiences, and supporting deployments in cloud, self-hosted, regulated, and air-gapped environments.

The Senior Enterprise Architect leads the design and implementation of network and cloud architectures, ensuring alignment with organizational goals and industry practices. Responsibilities include defining architecture frameworks, advising on cloud adoption, ensuring security compliance, and managing cross-functional teams.

Provide tier-2 technical support and administration for lottery platforms, troubleshoot availability and performance issues, support customer implementations, maintain monitoring and documentation, manage SLAs, and participate in 24x7 on-call rotation. Work primarily with Windows Server and SQL Server, plus some Ubuntu and Java/WildFly support.

Lead development of the production toolchain that compiles complex Python packages (e.g., NumPy, SciPy, PyTorch). Build and maintain build/release pipelines, create and review conda recipes, automate processes, mentor engineers, run incident response and postmortems, and advise leadership on technical tradeoffs. Partner with distribution and wheels teams and validate AI-assisted code where used.

Build and maintain internal developer platforms, tooling, and automation to improve engineering productivity. Implement AI-powered tooling and LLM/agent-driven workflows, create service catalogs and self-service infrastructure, partner with engineering teams to improve reliability, and reduce operational overhead through automation and improved developer experience.

Lead technical direction and architecture for a software team, write production code, mentor engineers through reviews and pairing, partner with product to align roadmap and technical plans, resolve technical risk and tech debt, and establish engineering standards and tooling.

Design, build, and scale embedded connectivity and security for distributed energy devices. Implement networking (Ethernet/Wi‑Fi/Thread/Zigbee/BLE), secure provisioning, OTA firmware pipelines, telemetry, and diagnostics. Support testing, certification, manufacturing validation, and cross-functional collaboration from prototype to deployment.

Lead and grow a backend engineering team while staying hands-on: design and build Python/FastAPI services with Temporal and Postgres, own roadmap and delivery, set SLIs/SLOs, drive observability and reliability, run engineering rituals, hire and coach engineers, and improve quality with DevOps and AI tooling.

Provide advanced application development, integration, and troubleshooting for DDC/BMS/BAS projects. Configure BACnet/Modbus gateways, develop control databases and interfaces, support commissioning and service teams, review portfolio standards, mentor junior engineers, and participate in customer technical meetings and project lifecycle documentation.

The Senior Full Stack Engineer will design and maintain features across backend and frontend systems, focusing on scalability and security while collaborating on production-grade solutions in a fast-paced environment.

The Production Engineer will design, build and maintain production infrastructure, ensuring reliability, observability, and automation while collaborating with engineering teams on distributed systems.

Lead design and scaling of a high-performance, data-intensive storage layer for network telemetry. Co-own multi-year roadmap, collaborate with product/support/sales, and solve challenging distributed storage and query-performance problems at large scale.

The Solution Architect will design and implement cloud-native solutions, collaborate on automation, and modernize applications while ensuring security compliance and delivering business insights.

The Platform Engineer will design and implement scalable compute infrastructure for autonomous vehicle simulation, utilizing cloud platforms and on-premises clusters, along with managing CI/CD pipelines and monitoring systems.

The Principal Engineer will guide architectural strategy, solve complex technical challenges, mentor engineers, and ensure compliance with healthcare standards.