Top Remote Python Jobs in San Diego, CA

Lead architecture and hands-on implementation of a full-stack platform and production AI systems (LLM integration, RAG, agentic workflows). Ship user-facing features across frontend, backend, data pipelines, infrastructure, testing, and monitoring. Set technical direction, tooling, and engineering practices while partnering with product and program teams.

Lead design and delivery of scalable, secure full‑stack features and services. Build maintainable front-end and backend code, implement integrations and data models, enable cloud-native CI/CD workflows, use containers and IaC, and act as a technical leader influencing architecture and delivery across teams while leveraging AI-assisted tools.

Design and deliver end-to-end full stack healthcare applications across UI, API, and data layers. Build secure, testable, cloud-native services, implement integrations and IaC, support CI/CD and monitoring, leverage AI-assisted tools, and mentor engineers while partnering with cross-functional teams.

Design, implement, and secure scalable cloud infrastructure across AWS and OCI; manage CI/CD (GitHub Actions), Kubernetes and ECS clusters (including GPU workloads); integrate observability (Datadog, Grafana, OpenTelemetry, Sentry); enforce security and compliance (SOC2, ISO 27001); handle DevOps/SRE intake, vulnerability response, and migrations from EKS to OKE.

The Senior Site Reliability Engineer is responsible for architecting reliability strategies, implementing SRE frameworks, mentoring engineers, and ensuring system resilience and performance in government systems.

Design, build, and maintain backend services in TypeScript for millions of users; develop full‑stack features with React/React Native; participate in code reviews; provide technical leadership, mentorship, and architecture guidance; collaborate with PM and design; use monitoring/metrics and Agile practices to deliver scalable, user-focused products.

As a Data Engineer, you will build and maintain ETL pipelines, develop data transformation processes, design data warehouses, and lead improvements in data architecture.

Architect and build large-scale cloud-distributed backend systems and data pipelines. Design and maintain REST/gRPC APIs and scalable microservices on AWS using Kubernetes. Lead technical decisions, mentor junior engineers, ensure reliability, observability, security, and support both legacy and new cloud architectures for high-scale connectivity services.

The Back End Engineer will develop and maintain backend services and REST APIs for Healthcare.gov tools, ensuring performance, reliability and security while collaborating with cross-functional teams.

Lead and grow the Database Reliability team to ensure highly available, scalable databases. Mentor engineers, shape incident response and capacity planning, collaborate with infrastructure/product/security, drive best practices for Postgres and CockroachDB, hire and scale the team, and own monitoring, cost optimisation, and performance tuning across environments.

The Senior Software Engineer will design and build scalable data solutions, manage backend systems, and enhance performance leveraging Golang and Python. Responsibilities include optimizing ETL processes and collaborating with teams to meet evolving customer needs.

Design, build and maintain Microsoft Cloud applications using Power Apps/Pages and Azure services. Implement Entra ID authentication, Azure Functions/App Services, Logic Apps and Blob storage. Create Azure Data Factory pipelines and APIs (REST/GraphQL), integrate external services and LLM data pipelines, and ensure performance, security, and scalability while collaborating with customers to turn requirements into streamlined apps.

Design, develop, and maintain scalable enterprise backend services, microservices, REST APIs, and integration layers. Build cloud-native applications, implement automated testing, support CI/CD, troubleshoot production issues, optimize performance, and contribute to architecture decisions. Review code, mentor junior developers, document APIs and operations, and collaborate with product, architecture, DevOps, QA, and global business teams.

As a DevOps Engineer II, you will build and scale a SaaS platform, manage infrastructure-as-code, develop data pipelines, and enhance team productivity while collaborating across teams.

Design, build, and maintain software applications; collaborate with engineers, analysts, and stakeholders; resolve bugs and production issues; write scalable, testable code; perform testing and debugging; produce technical documentation; mentor peers; participate in on-call rotation; leverage the team's data ecosystem to inform application design and improvements.

Designs, deploys, integrates, monitors, maintains, and troubleshoots storage and IT infrastructure, including SAN, NAS, object storage, VMware, networking, backups, and disaster recovery systems. Implements automation, security controls, patches, and system upgrades while maintaining documentation and compliance. Collaborates with cross-functional teams, participates in incident response and recovery planning, supports system rollouts, and mentors junior engineers. Requires occasional after-hours work and on-call availability for critical incidents.

Designs, configures, and maintains IT systems for performance, availability, scalability, and security. Monitors system health, automates administration, troubleshoots complex issues, supports incident response and disaster recovery, ensures compliance, documents configurations, and mentors junior engineers.

Own and improve platform reliability, availability, and performance for Filevines systems. Build AWS infrastructure with Terraform, develop CI/CD pipelines, monitoring, and automation, define SLOs/SLIs/error budgets, lead incident response, mentor engineers, and participate in a 24/7 on-call rotation to support highly available, low-latency production systems.

Join as a full-stack software engineer to design, develop, and maintain web applications and services. Collaborate cross-functionally, write clean code, perform code reviews, debug issues, and stay current with industry trends.

Design, configure, and optimize Azure DevOps organizations and CI/CD pipelines. Implement process templates, Portfolio++ for portfolio visibility, integrate with third-party tools, support sprint and capacity planning, troubleshoot pipelines, and create runbooks and adoption guidance for client teams.

The Software Integration Engineer will develop migration services, enhance file processing products, and collaborate with teams to optimize high-throughput services on the VGS platform.

The role involves deploying AI networking solutions in data centers, driving architectural decisions, troubleshooting network issues, and collaborating on customer projects for NVIDIA's technology solutions.

Design and optimize custom SRAM circuits for performance, area, power, functionality, and robustness across advanced semiconductor processes. Collaborate with mask designers on dense pitch-matched layouts, verify electrical integrity, and improve design automation, data collection, and analysis flows. The role supports custom memory development for NVIDIA processing chips and requires strong SRAM design expertise, circuit design experience, and familiarity with semiconductor design and verification tools.

Build an internal web tool to browse and validate healthcare event data flowing through AWS cloud pipelines. Write SQL queries and views over large datasets, identify incomplete fields and schema mismatches, and surface data gaps. The internship provides experience with AWS architecture, CI/CD deployment, healthcare data, Agile workflows, large-scale data pipelines, and engineering automation.

Support and improve internal technology infrastructure by troubleshooting applications, servers, networks, and databases; building automations and integrations; managing SQL, cloud infrastructure, DevOps processes, CI/CD pipelines, deployments, and version control; improving system reliability and scalability; collaborating with teams; documenting procedures; and applying security best practices.