Top Remote Python Jobs in San Diego, CA

Design, build, test, and deploy smart contracts and decentralized applications. Maintain blockchain integrations and backend services, optimize for security and gas efficiency, contribute to architecture and technical strategy, conduct code reviews, mentor junior engineers, and collaborate with product, frontend, and security teams.

Operate and monitor MongoDB Atlas infrastructure, troubleshoot production incidents, automate monitoring and remediation, collaborate globally to reduce MTTR, participate in on-call rotations and second-shift weekend schedules, and support FedRAMP government environments.

Lead architecture and hands-on development of the end-to-end video pipeline (live ingest, transcoding, storage, playback, and developer SDKs). Mentor engineers, collaborate across mobile/web/ML/platform teams, own monitoring and on-call support, and help scale video streaming and VoD capabilities for millions of streams and clips.

Design, build, and operate internal developer platforms, CI/CD pipelines, developer environments, deployment workflows, and shared services. Create automation and custom tooling, prototype and productionize AI-assisted engineering workflows, strengthen cloud and container foundations (Kubernetes, IaC), instrument platforms with telemetry, and own platform projects end-to-end including rollout, adoption, and on-call.

The Senior Software Engineer will design, build, and maintain CI/CD pipelines, improve automation workflows, and mentor junior engineers in a security-focused development environment.

Build and own Eve's marketing site and GTM engineering stack: integrate and optimize external tools, design AI agents for sales and marketing, implement webhooks and middleware to sync product/CRM data, and create programmatic campaigns and internal tools in partnership with Marketing, Sales, RevOps, and Product to drive growth and automation.

The Senior Python Engineer will develop and support MongoDB Python drivers, enhance library quality, and collaborate on product features.

Lead frontend-leaning full-stack implementation work for carrier and enterprise integrations: architect reusable UI and API layers, author RFCs, guide technical delivery, enforce testing and security best practices, and partner with cross-functional teams to scope and ship production integrations.

Lead design, automation, and maintenance of cloud-based database infrastructure (primarily SQL Server and MySQL). Improve reliability with monitoring, HA/DR, automation, troubleshooting, on-call support, and mentoring of junior engineers while collaborating across teams.

Lead technical strategy and execution for multi-quarter initiatives; build and maintain AI-driven systems; mentor and raise the technical bar across teams; collaborate cross-functionally; ensure data security and HIPAA-compliant practices; operate in an AWS + Kubernetes environment while introducing new technologies as system load grows.

Define and drive Payments technical strategy and architecture for rails, routing, and funds-flow systems. Lead large cross-team initiatives, ensure financial correctness, improve reliability and cost via observability, mentor senior engineers, and align stakeholders across product, risk, and regulatory teams.

Build, operate, and scale backend systems for card issuing and transaction processing. Break down projects, collaborate with product and cross-functional teams, write tested extensible code, support monitoring and on-call operations, and participate in team growth activities including interviews.

Lead design and implementation of Affirm's Lakehouse Platform using Iceberg, Spark, Snowflake, and cloud storage. Drive platform roadmap, governance, access controls, performance and cost optimization, analytics engineering best practices, observability, and on-call readiness. Partner cross-functionally, mentor engineers, and build scalable, secure, self-service data infrastructure and semantic/agentic data tools.

Design, develop, and maintain Python-based web applications and integrations. Collaborate in an Agile team, participate in code reviews and scrum ceremonies, work with stakeholders to translate workflows into tickets, troubleshoot production issues, and optimize database queries and application performance. Use Flask/Django, relational and NoSQL databases, web services, and containerization.

Design, build, and maintain Airflow-based automation pipelines and services to move files, run scheduled FTP jobs, validate and modify data, monitor application health, parse logs/emails, implement robust error handling and observability, and integrate API-driven systems to reduce manual operational work.

Lead and grow a backend/platform engineering team building API-driven systems and core services. Own technical direction, architecture, reliability, and integration with product, data science, and infrastructure. Hire and mentor engineers, contribute to code and architecture, support incident response, and ensure scalable, secure, production-ready backend APIs and platform tooling.

The Lead Architect will develop backend services, oversee integration with imaging facilities, set coding standards, mentor engineers, and ensure fault-tolerant systems while adhering to healthcare data standards.

Build and ship production-grade agentic AI developer tools and a coding harness to modernize legacy systems. Design integrations across source control, CI/CD, security scanners, and cloud services. Partner with customers and product teams to iterate on AI-native workflows, ensure cybersecurity compliance, and scale agentic systems for defense missions.

Lead design and build of scalable AWS cloud-based backend services and APIs powering web and mobile customer experiences. Own end-to-end feature delivery, improve grading and authentication workflows for scale and reliability, leverage AI tools to accelerate development, and provide technical leadership and mentorship across teams.

The Sr Staff AV Behavior Safety Engineer leads safety validation for GM's autonomous driving systems, influences launch decisions, and collaborates across teams for safety standards and performance metrics in AV behavior development.

Perform CFD and 1D lumped-parameter fluid analyses for rocket engines, predict component and system performance, build transient and steady models, support testing and anomaly investigations, recommend design improvements, and mentor peers to grow propulsion fluid-analysis capabilities.

Senior technical owner of an existing NetSuite ERP: provide Tier 2/3 production support, triage and permanently resolve incidents, build and optimize SuiteScript 2.x and SuiteFlow customizations, maintain integrations (Deposco WMS, Salesforce via Jitterbit), manage SDF sandbox-to-production promotions, monitor performance, ensure release readiness, author runbooks, and operate under ITGC/SOX-adjacent change management with on-call responsibilities.

Own and implement platform initiatives to improve scalability, reliability, and developer experience. Automate infrastructure with IaC, operate Kubernetes and CI/CD pipelines, build developer tools, monitor platform resilience, participate in incident response, and influence architecture and processes as you grow.

Lead design and delivery of a reliability platform for production systems. Own quarterly goals, guide engineers through ambiguity, collaborate with PM/design/analytics, monitor and operate services (on-call), set quality and code standards, and mentor teammates. Integrate AI/LLM tooling to improve automation, debugging, and service health.

Lead delivery for the Batch Infrastructure team: design, build, and operate reliable, scalable compute platforms for scheduled and on-demand batch workloads. Collaborate with product/design/analytics, define technical plans, ensure availability (monitoring/on-call), set code and design standards, and mentor engineers to improve delivery and quality.