Top Remote Python Jobs in San Diego, CA

Lead and mentor engineering teams to deliver high-quality, AI-driven software, ensuring accountability and continuous improvement in development processes.

The Research Engineer will develop automated security analysis solutions for mobile applications and conduct research to identify security issues.

Lead development and maintenance of large-scale distributed systems and software platforms; design, test, deploy, and optimize applications used by physicians and patients; manage EDI analysts; collaborate with cross-functional teams to deliver technical solutions, monitor reliability, and drive system scalability and performance.

Perform manual and automated testing across web, mobile, APIs, backend services, and blockchain integrations. Build and maintain Python-based test frameworks, investigate issues across distributed systems, analyze logs/metrics/network traffic, contribute to release validation and automation, and collaborate with product, engineering, and DevOps. Use AI tools to accelerate testing, support incident analysis, and proactively improve testing coverage and product reliability.

Lead design, build, and maintenance of scalable, secure blockchain participation and custody infrastructure. Improve automation, monitoring, incident response, and observability; debug distributed protocols; inform leadership strategy; scope product opportunities; and support on-call reliability and deployment automation.

Build and maintain end-to-end product features across frontend, backend, and databases. Design APIs, authentication, data models, integrations, and AI-assisted workflows. Ship production-ready SaaS components, debug across the stack, improve reliability and performance, and collaborate on product and architecture decisions in an early-stage startup.

Design, implement, and manage scalable AWS infrastructure (EC2, S3, RDS, VPC, EKS) using IaC (Terraform/CloudFormation), automation, containerization (Docker, Kubernetes), and CI/CD (GitHub Actions). Enforce cloud security (IAM, encryption, network segmentation), monitor and optimize performance/cost, troubleshoot infrastructure and deployment issues, and collaborate with development teams. Support VA project requirements, undergo background checks, and complete fingerprinting.

Develop and maintain high-performance, scalable web applications using React/Next.js and TypeScript. Collaborate across design, product, and engineering, provide technical feedback, use GraphQL/REST, manage complex client state, and support backend Python and AWS infrastructure. Emphasize scalability, performance, security, and CI/CD containerized deployments while adopting AI-driven automation and agentic workflows.

Lead a hands-on engineering team building shared backend and cloud platform services. Architect, code, and ship high-volume REST APIs and reusable libraries, drive secure SDLC and CI/CD, mentor engineers, and promote AI-augmented delivery practices.

Build information-rich legal data visualizations using JavaScript, React, D3, and SVG. Use Python and Pyramid to retrieve and prepare data. Design for accessibility and usability, integrate new legal content with subject-matter experts, collaborate with frontend/back-end and NLP engineers, and participate in code reviews. Provide a portfolio of reviewable code samples.

Lead design, reliability, and evolution of hybrid-cloud and workplace infrastructure. Own domain architecture, drive migrations and reliability improvements, define SLIs/SLOs, automate with IaC, mentor engineers, collaborate across IT/SRE/Security, and maintain operational documentation and runbooks.

Lead design, reliability, and evolution of hybrid-cloud and workplace infrastructure. Architect scalable systems, drive complex migrations and performance improvements, improve reliability through monitoring and automation, collaborate across teams, mentor engineers, and maintain documentation and runbooks.

Lead design and delivery of end-to-end integrations between C2, communications, and commercial systems. Build backend services, APIs, SDKs, and front-end interfaces. Mentor engineers, shape integration architecture, engage open-source developer community, and own implementation, deployment, validation, and support for production integration solutions.

Owner of full-stack features and platform reliability: build scalable web applications, optimize PostgreSQL performance, maintain asynchronous infrastructure (Celery), migrate frontend to server-side HTMX, ship revenue-driving features, ensure observability and SLO-driven reliability, collaborate cross-functionally, write testable code, and participate in architecture and code reviews.

Lead enterprise cloud architecture engagements, define target-state AWS architecture and roadmaps, establish standards and governance, design scalable multi-account and hybrid infrastructures, implement IaC (Terraform/CloudFormation), build automation and CI/CD pipelines, mentor client teams, optimize cost/performance/security, and lead architecture reviews and workshops.

Lead and execute enterprise-scale VMware-to-AWS datacenter migrations using AWS migration tools (MGN, CloudEndure, HCX). Perform assessments, dependency mapping, wave-based migration planning, build AWS landing zones, implement hybrid connectivity, automate workflows with Terraform/CloudFormation and scripting, and provide client guidance, post-migration validation, and hypercare for large migration factories (200–500 VMs).

Design, build, test, and deploy production software for an agentic chatbot platform across intake, orchestration, retrieval, answer generation, caching, and integrations. Deliver clean code, participate in sprint work, review merge requests, collaborate with product and architecture, mentor junior engineers, and contribute to design and delivery decisions to solve conversational AI problems within a benefits ecosystem.

Serve as the highest technical escalation for complex, high-severity incidents across edge hardware, networking, AI inference, and cloud infrastructure. Diagnose root causes at code, configuration, and infra levels, drive permanent fixes with Engineering, lead technical bridges with enterprise stakeholders, define troubleshooting frameworks and documentation, conduct post-incident reviews, and participate in on-call rotations.

The Software Engineer will manage data collection, operate cloud infrastructure, and collaborate with scientists to enhance AI models at Speechify.

As a Staff Software Engineer, you'll architect and build foundational platform services, focusing on data infrastructure, healthcare interoperability, and secure APIs while mentoring other engineers.

As a Senior Software Engineer, you will develop new products and improve engineering infrastructure while taking ownership of product deliverables and enhancing technical architecture.

As a Software Engineer - Backend, you will develop products and manage engineering infrastructure, focusing on system design, security, and code quality.

The Product Support Engineer will handle customer environments, resolve Hadoop and Spark issues, and ensure optimal performance during migrations and upgrades.

The Senior Principal Energy Storage DevSecOps Solutions Engineer will design and operate backend services, write production code in Python, and manage cloud infrastructure in AWS, emphasizing automated workflows and CI/CD pipelines.

The role involves developing and managing backend systems and cloud infrastructure for energy storage operations, ensuring reliability and scalability through Python and AWS. Responsibilities include coding, infrastructure management, CI/CD pipeline development, and incident response leadership.