Top Remote Python Jobs in San Diego, CA

Provides frontline support for high-availability cloud systems, monitors infrastructure, manages incidents, coordinates outage bridges, documents technical issues, and develops automation and AI agentic workflows. The role partners with development teams to improve detection and resolution, supports AWS technologies, databases, networks, CI/CD tools, and observability platforms. This is a Monday–Thursday overnight shift within a 24/7 command center and includes some holiday coverage.

Own frontend architecture for React and TypeScript applications supporting complex research and analytics workflows. Build performant, accessible interfaces; establish standards for performance, testing, accessibility, and CI quality gates; evolve shared component libraries and design systems; partner on API contracts; address technical debt; contribute to Django services; and mentor engineers while leading department-wide technical initiatives.

Build and improve AWS cloud infrastructure, CI/CD pipelines, Terraform-managed environments, and containerized applications on ECS Fargate. Lead architecture and deployment reviews, automate reliable application delivery, troubleshoot incidents, perform root cause analysis, and implement monitoring, logging, security, and compliance controls. Collaborate with application, IT, business, and vendor teams while modernizing legacy applications and developing platform engineering capabilities.

Build, secure, and operate an Azure Government AI platform supporting Azure AI Foundry and approved generative AI models. Configure AI projects, deployments, networking, identities, monitoring, cost controls, and integrations. Automate repeatable infrastructure and release processes, troubleshoot across cloud layers, and create operational documentation. The role requires strong Azure engineering, AI platform, security, networking, monitoring, and scripting experience, with responsibility for reliable developer experiences and governed AI usage.

Own product features from research and UX design through full-stack production delivery. Design user flows, wireframes, and reusable components while building responsive front-end experiences, APIs, back-end logic, and database solutions. Improve hiring marketplace workflows, dashboards, scheduling, messaging, and integrations. Use user feedback, analytics, funnel metrics, and A/B testing to guide iteration while ensuring performance, accessibility, and security.

Build and maintain full-stack systems for a global monitoring application supporting federal partners and satellite data access. Responsibilities include designing scalable backend services and frontend applications, improving architecture and infrastructure, integrating complex customer requirements, and owning mission-system quality and availability. The role requires collaboration across teams throughout the engineering lifecycle and experience with cloud infrastructure, observability, geospatial data, and complex integrations.

Design and implement scalable cloud infrastructure, monitor performance, automate processes, ensure security and compliance, and lead a DevOps team.

Build and maintain cloud and on-premises infrastructure, CI/CD pipelines, deployment automation, and infrastructure-as-code. Integrate DevSecOps practices, manage releases and rollbacks, and establish monitoring, logging, alerting, and observability. Collaborate with development, QA, and operations teams while supporting data-management processes and scalable systems across Azure and containerized environments.

The Quantitative Developer will assist with client onboarding, support, implement and maintain new functionality for portfolio compliance, and improve team documentation.

Drive the Continuous Integration team, ensuring build systems' reliability and scalability, and mentor CI engineers while improving developer productivity through automation and tooling.

Own cross-team, platform-level engineering initiatives end-to-end: architecture, migrations, observability, on-call, and customer outcomes. Drive AI-native tooling and agentic AI adoption, mentor senior engineers, and set technical standards across teams.

Architect and deliver high-scale NVIDIA GPU compute environments for enterprise AI workloads. Lead bare-metal provisioning, cluster management, operating-system hardening, scheduler and workload configuration, monitoring, performance validation, and day-two operations. Serve as a customer-facing technical authority, supporting presales discovery, architecture, bills of materials, estimation, and client workshops. Design repeatable AI infrastructure across DGX, HGX, MGX, NVL72, and Cisco AI POD platforms.

Architects and delivers high-performance AI networking fabrics using NVIDIA InfiniBand and Spectrum-X Ethernet. Designs lossless, automated, scalable network infrastructure for DGX and AI cloud environments; configures routing, QoS, RoCEv2, SHARP, telemetry, and DPU offload. Owns cabling, link validation, performance testing, infrastructure-as-code, and day-two operations. Provides technical leadership in client workshops, presales scoping, bills of materials, cost estimation, and integration with enterprise networks.

Design, build, and maintain scalable, highly available AWS cloud infrastructure for healthcare SaaS services. Develop Infrastructure-as-Code deployments and CI/CD pipelines across environments, manage Kubernetes and serverless workloads, and own monitoring, alerting, observability, disaster recovery, and backups. Strengthen cloud security through IAM, WAF, KMS, secrets management, certificates, and logging. Contribute to system reliability, documentation, and on-call support while collaborating on secure, cost-efficient infrastructure solutions.

Validate and characterize high-speed analog and mixed-signal IPs, test chips, and ASIC products. Develop automated lab scripts and 24/7 testing flows, configure devices, operate measurement equipment, analyze results, debug hardware, review PCB and package designs, document test procedures, support reliability and ATE testing, and collaborate with design and system teams.

Develops electrical, optical, and thermal test plans, algorithms, hardware, software, and automated production test solutions for photonic integrated circuits. Responsibilities include device characterization, instrument control, motion and vision systems, test station qualification, Gage R&R, SPC, documentation, data analysis, troubleshooting, and cross-functional project coordination.

Designs and manages AWS cloud infrastructure and Amazon EKS platforms using GitLab CI/CD and Infrastructure as Code. Builds ETL workflows and scalable data pipelines for analytics and AI workloads, supports MLOps/AIOps and FinOps capabilities, troubleshoots Linux systems, and improves platform performance, security, scalability, and availability.

Lead the architecture and evolution of managed Kubernetes and cloud-native services. Provide cross-team technical oversight, standardize platform practices, integrate open-source technologies, improve scale, performance, security, and operational efficiency, and mentor engineering teams. The role requires expertise in Kubernetes-based platforms, container runtimes, cloud-native architectures, and Go, Python, or Bash.

The Principal R&D Engineer will lead wireless technology projects, oversee system design, manage project schedules, engage with customers, and supervise a team of engineers.

Drive technical strategy and roadmap for Affirm's Online Storage platform. Design and build multi-region, highly available datastore solutions and control planes for hundreds of databases. Automate schema migrations, disaster recovery, sharding, and performance tuning. Collaborate with product, SRE, and infrastructure teams, own operations and on-call readiness, and mentor engineers while setting code and design standards.

Lead and set technical strategy for the Order Platform powering post-checkout flows (orders, captures, refunds, settlement). Design and ship highly available backend systems, own reliability/operational practices, mentor engineers, collaborate cross-functionally, and drive long-term technical decisions and execution plans.

Lead architecture and hands-on development of the end-to-end video pipeline (live ingest, transcoding, storage, playback, and developer SDKs). Mentor engineers, collaborate across mobile/web/ML/platform teams, own monitoring and on-call support, and help scale video streaming and VoD capabilities for millions of streams and clips.

Work across frontend and backend to design, build, and ship annotation and review features; implement ingestion, storage, user management, and annotation pipelines; integrate model inference into workflows; optimize performance for large images/videos; design APIs and collaborate with product, operations, and annotators.

Design and build scalable backend systems, data pipelines, and cloud infrastructure. Own CI/CD, containerization, databases, and reliability; collaborate with tech leads to deliver secure, production-grade solutions for startups in a fully remote environment.

Design, build, and operate internal developer platforms, CI/CD pipelines, developer environments, deployment workflows, and shared services. Create automation and custom tooling, prototype and productionize AI-assisted engineering workflows, strengthen cloud and container foundations (Kubernetes, IaC), instrument platforms with telemetry, and own platform projects end-to-end including rollout, adoption, and on-call.