Top Remote Staff Software Engineer Jobs

The Staff/Principal Software Engineer will work in a remote global team, addressing software engineering challenges while fostering collaboration and clear communication.

Lead architecture and implementation of motion planning, trajectory generation, and optimization for autonomous trucks. Provide multi-team technical leadership, design production-quality C++ planning software, integrate with controls and perception, validate via SiL/HiL/ViL, and support on-vehicle debugging, deployment, and performance optimization to deliver safe, reliable autonomy at scale.

The Lead Rust Software Engineer will design and build scalable applications, mentor teams on Rust, and contribute to complex product development.

Lead design and operation of the Synapse Everywhere external API platform: define API surface and guarantees, translate product and clinical requirements into contracts, own reliability and on-call incident response, provide technical mentorship and code reviews, and design scalable, secure cloud-native solutions (k8s, LLMs) with strong developer experience.

Build and operate identity verification, vetting (KYC/KYB), and access control systems; integrate identity vendors; create monitoring, dashboards, and enforcement tooling to detect misuse and account takeover; collaborate with policy, threat intelligence, enforcement, and go-to-market teams to ensure safe, scoped access to advanced AI capabilities.

Lead design and implementation of agentic AI/ML solutions and modern software (APIs, microservices, CI/CD, streaming) on cloud platforms. Bridge legacy IBMi AS400 systems with modern AI, train and fine-tune models, oversee lifecycle, mentor engineers, set technical direction, and improve automation and testing across claims adjudication systems.

Lead the validation and compliance of non-product software used in medical device development. Responsibilities include defining validation strategies, ensuring compliance with FDA and ISO standards, and cross-functional collaboration.

Lead design and development of satellite imaging payload and ADCS embedded software. Implement and maintain clean C/C++ and Python code on Embedded Linux, support requirements, tests, and releases, drive work in Jira, collaborate cross-functionally, and mentor engineers.

Design, build, and maintain full‑stack features across frontend (TypeScript + React) and backend (Python, Node.js, or JVM languages). Own end-to-end development, testing, CI, databases, and cloud/distributed systems. Mentor engineers, participate in code reviews and pair programming, and work in an agile, remote team.

This role requires shaping technical direction, leveraging AI tools for production systems, and making crucial decisions to align product intent with engineering realities.

Lead technical direction and hands-on development of an accelerator-agnostic inference runtime. Own architecture, performance, scheduling, memory management, validation (canary/shadow/rollback), and cross-accelerator abstractions. Drive integrations with compilers, build systems, and infra, mentor engineers, and coordinate prioritization across serving, scaling, and accelerator teams to ensure efficient, reliable inference at scale.

The role involves designing scalable distributed systems using Scala, enhancing feature stores for performance, and collaborating with ML engineers to resolve challenges.

Develop real-time graphics software for multi-sensor simulation in autonomous driving. Collaborate with experts to enhance rendering technology and improve simulation realism.

The Staff SDET will design and implement automated test frameworks using TypeScript, collaborate with developers, and enhance testing processes within CI/CD pipelines.

The Staff Software Development Engineer will lead and contribute to the development of CVS Health's digital platform, focus on customer-centric solutions, mentor junior developers, and ensure high-quality code delivery across projects.

Seeking a Staff Cloud Software Engineer to architect and manage scalable cloud systems on AWS, improve security, and mentor engineers.

As a Staff Software Engineer, you'll architect and build foundational platform services, focusing on data infrastructure, healthcare interoperability, and secure APIs while mentoring other engineers.

Lead design and delivery of AI-powered, data-driven workflows and foundations: build retrieval/evidence pipelines, durable job execution, monitoring/evaluation, data contracts, identity resolution, and reusable abstractions while partnering with product and engineering to measure adoption and impact.

Design and develop web applications, mentor teammates, shape architectural decisions, write clean code, conduct testing, and troubleshoot issues.

Lead and build high-throughput microservices and distributed systems, define multi-quarter technical roadmaps, ship data-driven features, mentor engineers, drive experimentation and A/B testing, ensure reliability/observability, partner with product and design, and champion AI tooling adoption across the team.

As an Engineer at Novel, you will develop NFT commerce solutions using Shopify plug-ins, collaborating in a dynamic startup environment.

As a Senior Software Engineer, you will build scalable distributed systems, improve developer experience, mentor peers, and lead incident responses.

Lead technical direction for the Growth team at Sanity.io, focusing on scalable solutions, mentoring engineers, and making data-informed architectural decisions.

We are looking for a Senior .NET Software Engineer to take ownership of features and drive architectural decisions while building AI-powered EMR software.

Mark43 is inviting applicants for their engineering team, without a specific role. They'll reach out if a match is found.