Top Remote Principal Software Engineer Jobs

Principal IC responsible for reliability, observability, and modernization of a .NET-based Platform Services portfolio on Azure. Own architecture, resilience patterns, shared libraries, and migration of legacy .NET services. Implement observability, event-driven messaging, and AI-first engineering practices while mentoring engineers and partnering with architecture teams.

Design and build secure, scalable enterprise clinical workflow systems for Butterfly Cloud. Solve distributed-systems challenges involving elasticity, reliability, performance, and automated validation. Lead system design, own business problems, guide developers through execution, and mentor engineers. The role may span frontend and backend layers and involve cloud architecture, observability, search, real-time applications, GraphQL, containerization, and healthcare data compliance.

Lead architecture and development of high-performance, scalable backend systems for Yahoo Mail using Java and C++. Set technical strategy, establish architectural standards, validate AI-generated code, mentor senior engineers, collaborate cross-functionally, and ensure reliability through automated logging, telemetry, and debugging workflows.

The Principal Software Engineer leads a team to develop full-stack real-time applications, integrates machine learning models, and influences software architecture in cloud environments while supporting healthcare analytics.

Lead technical direction for AI infrastructure, data platforms, shared software primitives, and agentic engineering practices. Build scalable, cloud-native services and secure MCP integrations while establishing AI quality gates, evaluation frameworks, responsible-AI controls, SLOs, and architectural standards. Guide modernization, build-versus-buy decisions, and high-stakes platform choices. Mentor senior engineers and influence technical norms across teams while balancing product delivery, partner needs, member trust, security, and operational quality.

Founding Principal Software Engineer building an AI-first platform for life sciences safety, regulatory, and clinical development. Own full feature lifecycle from design to production, drive technical solutions, mentor engineers, define engineering best practices, and contribute daily to production Python code using modern open-source tools (FastAPI, Pydantic, Git).

Founding member building an AI-driven life sciences SaaS platform. Own features end-to-end from design to production, contribute daily code, collaborate with product, perform expert code reviews, define engineering best practices, and mentor engineers to grow the team and deliver scalable, high-volume solutions.

Lead design, build, deploy, and support a new AI-driven enterprise SaaS platform. Own features end-to-end, drive technical designs, mentor engineers, enforce best practices, perform expert code reviews, and ship scalable production Python services with AI-assisted engineering workflows.

Architect and build AI-native production systems across a multi-language stack, design offline and online evaluation frameworks for LLMs, monitor live model behavior and drift, lead architecture reviews, mentor senior engineers, and prototype and ship AI capabilities while ensuring reliability and correctness in a regulated domain.

Lead technical strategy and architecture across teams, resolve cross-system issues, mentor engineers, participate in on-call rotations, build production-grade full‑stack software, and ensure scalability, reliability, security, and cost-efficiency of cloud systems.

The Principal Software Engineer at Snout will define architectural direction, build features across the stack, and enhance team effectiveness, ensuring quality and performance.

As a Principal Software Data Engineer, you'll lead the design, development, and optimization of large-scale data platforms and pipelines, ensuring data governance and driving innovation in a collaborative environment.

Lead full‑stack development and ownership of ZoomInfo's Mesh AI platform: build React frontends, backend APIs, cloud infrastructure, LLM integrations, orchestration workflows, developer SDKs, respond to incidents, ensure quality, and mentor engineers.

As a Principal Software Engineer, you'll develop software systems for NVIDIA's rack-scale infrastructure, defining software architecture, collaborating across teams, mentoring engineers, and ensuring high-quality technical decisions in complex environments.

Design and maintain backend systems, influence technical direction, ensure scalability and reliability, mentor engineers, and improve engineering practices.

Design and operate backend systems, influence technical direction, improve practices, and mentor engineers while ensuring software scalability and reliability.

Design and develop tools for verifying the correctness of smart contracts, extend verification algorithms, and collaborate with engineers on technical solutions.

Lead design, build, and scaling of Agentic AI and industry-specific solution accelerators on Genesys Cloud. Develop reusable multi-agent workflows, RAG-based knowledge orchestration, integrations with enterprise systems, prototypes, and production-grade AI applications. Provide technical leadership, mentor engineers, collaborate with product and industry SMEs, and deliver repeatable solution blueprints to accelerate deployment and time-to-value.

Lead architecture and delivery of enterprise AI data platform transformations. Design and implement scalable lakehouse, streaming, and real-time analytics solutions. Lead migrations from Databricks/Snowflake/Azure/AWS to Oracle AI Data Platform, optimize Spark workloads, build reusable accelerators, drive AI/ML data pipelines and governance, advise executives, influence product roadmap, and mentor senior engineers globally.

Lead end-to-end delivery of full-stack product and platform initiatives. Design and implement scalable frontend and backend systems, own production reliability and incidents, introduce pragmatic engineering practices, mentor engineers, and drive architecture and tooling decisions to balance speed and long-term maintainability.

Design, architect, and implement cloud-first full-stack software using Java/C# and JavaScript frameworks. Provide technical leadership, mentor engineers, improve architecture and performance, promote CI and automated testing, and support customer implementation and cloud platform operations.

Lead end-to-end feature development across frontend and backend for an enterprise data analytics platform. Design, implement, and maintain React UIs, backend services, APIs, databases, and distributed systems. Collaborate with Product, UX, and Engineering, mentor engineers, improve quality through testing/CI, and introduce new technologies including AI-assisted development.

Design and own CI/CD and configuration management for a large-scale, multi-cluster Kubernetes fleet. Define GitOps-driven, declarative reference architectures and templated production environments. Implement progressive delivery (canary, automated rollback), improve pipeline reliability and speed, evolve the Internal Developer Portal, embed AI tooling into delivery workflows, and partner with Cloud, Security, and Compliance while mentoring senior engineers.

Lead architecture and delivery of OCI's Key Management Service (KMS). Design and implement secure, scalable features integrating HSMs and encryption-at-rest. Drive distributed systems architecture, cross-team collaboration, operational readiness, and engineering best practices for production-grade cloud security services.

Lead architecture and implementation across the full stack, rework user and license management, and develop core runtime components for a code-first PCB design product. Drive technical direction, identify and fix technical debt, mentor engineers, perform code reviews, and build production-ready, high-performance systems involving computational geometry and advanced visualization.