Top Software Engineer Jobs in San Luis Obispo, CA

Lead and deliver quarterly goals for a backend team; guide engineers through ambiguous problems; collaborate with product, design, and analytics; identify and resolve project and technical issues; ensure operational availability and on-call readiness; set code and design quality standards; and mentor and develop team members.

Sets technical direction for Helix’s Experience platform and broader engineering organization. Designs and implements distributed, full-stack genomic software systems focused on patient and provider experiences. Leads complex projects from scoping through production, advances AI-assisted engineering practices, establishes quality and delivery standards, mentors technical leaders, and drives cross-functional collaboration with product, design, research, scientific, and business teams.

Design and implement PostgreSQL internals and indexing/query features for large-scale document workloads, extend query engine with BSON-aware operators and custom scan nodes, tune index pruning and storage, profile distributed systems for performance, collaborate with open-source DocumentDB/PostgreSQL communities, and participate in design/code reviews.

Design and implement PostgreSQL internals, indexing, query engine extensions, and storage-layer features to support large-scale document workloads on Azure. Profile distributed systems, tune performance, collaborate with open-source communities, conduct design/code reviews, and drive cross-team alignment for mission-critical database features.

Build and own scalable payments infrastructure for card issuing, transaction processing, and settlement. Design reliable integrations with Stripe, banking partners, and internal platforms using .NET, C#, Azure, DDD, CQRS, and event-driven architectures. Improve system reliability, observability, performance, security, and compliance while mentoring engineers and contributing to technical direction. Apply AI-assisted development across coding, testing, debugging, and engineering workflows.

The Senior Backend Software Engineer will design and scale backend systems using Python and FastAPI, collaborate with researchers, optimize infrastructure, and implement testing and monitoring systems.

Develop scalable web applications using React and Next.js, implement backend solutions in Python, maintain DevOps practices, and collaborate with AI/ML teams to deploy applications.

Lead the development of analytics infrastructure for clinical AI/ML products, focusing on product performance monitoring, data management, and cross-functional collaboration.

Design and build enterprise LLM-serving infrastructure on Kubernetes, including GPU scheduling, scaling, model lifecycle management, Helm packaging, offline deployments, platform integrations, and production observability. Contribute across a multi-service Go codebase, create design documentation, participate in reviews, and help guide engineering direction within an autonomous remote-first team.

The Senior Bilingual Software Engineer will align U.S. teams with the Platform Core team in Japan, focusing on high-impact problems and maximizing platform leverage through clear communication and collaboration.

Design, build, and maintain scalable real-time and historical data pipelines and libraries; implement APIs, data quality checks, monitoring, and performance-optimized workflows; collaborate with autonomy, platform, and front-end teams to support fleet data analysis and visualization.

The Backend Software Engineer will develop and maintain backend systems for data processing related to coffee farming, utilizing Python and PostgreSQL. Responsibilities include feature development, problem-solving, and adapting systems to regulatory changes while ensuring system resilience.

Develop and enhance software solutions for mineral exploration, collaborating with geologists and data scientists, and driving insights from data systems.

Join Galaxy Ventures' Talent Network for Software Engineer roles. Connect with crypto portfolio companies for career opportunities and networking events.

The Mid-level Software Developer will design, develop, and enhance software applications, focusing on data integration and cloud environments, particularly using Python and SQL.

Build, modernize, deploy, and operate CMG’s marketing platform across current and legacy .NET systems. Develop APIs, integrations, background jobs, and loan-data workflows; troubleshoot issues across application code, SQL Server, vendor APIs, and Azure; and improve testing, CI/CD, deployment safety, and architecture. Work hands-on with coding agents, structured requirements, acceptance validation, and production ownership while migrating legacy applications toward modern services and internal APIs.

Join Supabase as a Software Engineer to own the Terraform provider, improving reliability, driving technical strategy, and creating documentation for seamless IaC workflows.

The Software Engineer, Backend Engineer will develop, automate, and maintain core functionalities for Rescale customers, focusing on backend systems and cloud services.

Design, build, and maintain scalable end-to-end systems and APIs/SDKs for an enterprise custody platform. Work full-stack across databases, cloud deployments, CI/CD, and security; troubleshoot issues, integrate emerging technologies, and mentor junior engineers.

Design, develop, and maintain scalable web applications using .NET backend and Angular/React frontend. Collaborate on requirements, implement RESTful APIs, optimize performance, debug, maintain documentation, support end-users, and work within CI/CD and DevOps workflows.

Design, develop, customize and integrate Microsoft Dynamics 365 CRM/CE solutions. Build entities, forms, workflows, plugins, reports and dashboards using CRM SDK, C#, JavaScript, ASP.NET and SQL. Troubleshoot issues, estimate implementation approaches, collaborate with stakeholders, document solutions, and mentor junior developers. Banking domain experience preferred.

The Software Engineer, Platform will design and develop backend APIs, ensure scalability, collaborate on B2B solutions, and support cross-functional teams.

The Web3 / Full-stack Software Engineer will design, develop, and deploy software solutions for staking products, collaborating with engineers and UX designers to enhance UI and ensure security of blockchain networks.

Design, build, and operate Airbnb’s global service mesh and network infrastructure. Responsibilities include defining mesh capabilities, improving routing, security, resilience, and failover, establishing SLOs, leading incident and change management, mentoring engineers, coordinating cross-functional infrastructure initiatives, and optimizing capacity, reliability, and cost for large-scale distributed systems.

Build and maintain secure, full-stack cybersecurity and compliance applications for cloud and on-premise environments. Develop APIs, integrations, data ingestion and normalization, risk analytics, relationship models, role-based access, CI/CD pipelines, and containerized deployments. Support post-quantum cryptography and compliance workflows while troubleshooting production issues and applying DevSecOps practices. Collaborate across engineering, cloud, cybersecurity, and compliance teams in a highly regulated, ambiguous product environment.