Top Remote Python Jobs in San Diego, CA

Develop, test, and ship features for data platforms, pipelines, contributor tools, quality assurance systems, and client-facing infrastructure. Collaborate with senior engineers, participate in code reviews, debug issues, and improve automation supporting large-scale AI training data workflows. The role offers hands-on experience with production engineering, data systems, and AI-adjacent technologies in a fully remote environment.

Designs, develops, and maintains automated UI, API, integration, regression, performance, and security tests for enterprise applications including ServiceNow and Salesforce. Builds reusable frameworks, integrates testing into CI/CD pipelines, manages quality gates, validates data with SQL and APIs, diagnoses failures, supports test environments, and collaborates on defect root cause analysis. Provides QA automation standards, metrics, reporting, and technical mentorship.

Build and scale full-stack applications, backend services, APIs, infrastructure, and user experiences supporting millions of users. Design reliable, high-performance systems; partner with Product, Design, and Data; own projects through deployment and optimization; improve observability and developer productivity; and support AI adoption through automation and AI-powered workflows.

Staff Software Engineer leading architecture, hands-on development, and delivery of reliable frontend, backend, API, data, and production systems across multiple teams. The role drives multi-quarter initiatives, AI-enabled engineering practices, system scalability, security, observability, incident response, technical standards, mentorship, and alignment between technical investments and product outcomes.

Leads optical navigation engineering across lunar and interplanetary missions. Responsibilities include designing and testing optical navigation and camera systems, operational analysis, camera calibration, image processing, planetary terrain modeling, software architecture, flight software development, verification, risk mitigation, and mission support. The role coordinates multidisciplinary teams, manages multiple projects, mentors engineers, oversees schedules and budgets, and communicates technical results to stakeholders and executives.

Designs and analyzes interplanetary spacecraft trajectories and maneuvers for NASA and commercial missions. Responsibilities include high- and low-thrust optimization, trade studies, Monte Carlo analysis, operational maneuver planning, navigation tool development, visualization, technical reporting, and stakeholder coordination. The engineer supports missions in development and flight operations while collaborating with spacecraft, science, and mission teams.

Develops and validates ground-based and onboard optical navigation systems for lunar and interplanetary missions. Responsibilities include camera calibration, image processing, observation planning, terrain and shape modeling, simulation, flight software development, system verification, technical analysis, and mission partner coordination. The engineer also documents results, troubleshoots technical issues, manages configuration-controlled software, supports project planning, and provides operational support for deep-space missions.

Performs orbit determination, trajectory reconstruction, covariance analysis, tracking-data assessment, and navigation-product development for spacecraft missions. Configures estimation runs, evaluates residuals and solution behavior, maintains analysis scripts and workflows, troubleshoots issues, and prepares technical reports. Level III engineers lead complex analyses, improve methods and software reliability, guide engineers, coordinate mission teams and customers, and manage project priorities, schedules, and budgets.

Supports orbit determination solutions, trajectory reconstruction, covariance analysis, tracking-data assessment, navigation products, and spacecraft maneuver planning. The role includes configuring estimation runs, reviewing residuals, checking coordinate and time-system accuracy, maintaining Python scripts and workflows, troubleshooting analyses, documenting results, and communicating findings to mission teams. Level II engineers independently execute routine analyses and support deep-space navigation operations. A bachelor’s degree, U.S. citizenship, Python knowledge, and foundational astrodynamics or estimation expertise are required.

Designs, builds, and operates secure, scalable cloud infrastructure, deployment pipelines, and operational systems. Owns infrastructure architecture, provisioning, CI/CD, infrastructure-as-code, automation, observability, reliability, cost optimization, and incident response. Leads SRE practices, resolves complex production issues, supports distributed systems and microservices, and collaborates with Product and Engineering teams. Participates in on-call rotations and drives durable solutions that improve platform availability and performance.

Provides staff-level customer-facing technical support for complex multi-cloud networking and security issues. Serves as an escalation point, leading troubleshooting, packet analysis, root cause analysis, deployments, integrations, optimization, and upgrades. Collaborates with sales, solution engineering, and product engineering teams; identifies defects, validates fixes, and improves product quality. Develops technical documentation, runbooks, and troubleshooting guides while advising leadership on recurring customer issues.

Designs, deploys, and troubleshoots enterprise cloud and hybrid network infrastructure across Azure, OpenShift, corporate offices, and security platforms. Administers FortiGate, FortiSASE, Cisco Meraki, Cloudflare, DNS, load balancing, ingress controllers, and Kubernetes networking. Partners with application, security, and cloud teams on deployments and incident response, creates network documentation, manages monitoring and alerting, and performs changes under established procedures.

Lead the architecture, development, operation, and evolution of TetraScience’s multi-tenant Tetra Apps platform. Design containerized application runtimes, routing, identity, security, observability, deployment, and developer tooling. Guide sprint and quarterly planning, write architecture decisions, support production customers, and mentor engineers through technical leadership. Remain hands-on across TypeScript, Node.js, React, Python, AWS, infrastructure-as-code, and CI/CD while safely improving a live platform.

Leads financial systems engineering for a service-contract business. Owns reconciliation systems, invoicing logic, financial data models, revenue recognition controls, and audit reporting. Manages SQL and dbt models, automated validations, exception resolution, merchant configuration audits, and cross-functional escalations across Engineering, Finance, Accounting, and Revenue teams. Leads individual contributors and develops the team as business needs evolve.

Designs, builds, and optimizes NFS and distributed storage systems. Diagnoses performance and reliability issues across kernel-space and user-space I/O, file systems, storage media, networking, and platform layers. Develops Python automation for observability, testing, debugging, and operations. Requires deep hands-on expertise with NFS, distributed file systems, object storage, Kubernetes, and high-performance technologies including NVMe, SSDs, RDMA, and high-speed networking.

Build and maintain Python-based automation, services, test infrastructure, and performance analysis tooling for a distributed database system. Collaborate with internal stakeholders, improve developer tooling and reproducible testing, analyze system performance, and create documentation and runbooks. The role requires strong software fundamentals, systems thinking, Linux and CI experience, and the ability to learn new languages and systems quickly.

Lead the technical direction and delivery of three customer-facing threat intelligence products. Manage a team of senior engineers, own architecture and roadmaps, operate Laravel, Python, and data pipeline services in the cloud, and ensure production reliability through on-call, incident response, and post-incident improvements. Partner with Product Management on quarterly commitments, technical prioritization, team development, and cross-functional architecture decisions.

Build and operate multi-cloud infrastructure for MariaDB Cloud, designing application layers, APIs, cloud-native services, automation, and database-adjacent features. Own production capabilities end to end across AWS, Azure, and GCP using Terraform, Kubernetes, Docker, CI/CD, Python, and backend languages. Develop AI-enabled workflows involving vector databases, semantic search, RAG, and LLM agents while ensuring security, observability, scalability, and reliable deployment.

Maintain and support Java-based healthcare SaaS applications across multiple customer environments. Responsibilities include bug fixes, feature delivery, refactoring, deployments, security remediation, SQL and data migrations, code reviews, configuration improvements, and production support. The role requires a generalist software engineer comfortable with Java, Angular, SQL, REST APIs, enterprise applications, and customer-facing environments.

Designs electrical systems and performs design calculations for data centers, industrial buildings, offices, and other large commercial construction projects. Responsibilities include equipment selection, specifications, submittal and RFI reviews, change orders, record drawings, site observations, inspections, commissioning, and coordination with clients and external disciplines. The role also manages project priorities, budgets, deadlines, and may mentor junior staff.

Develop and maintain automated photonic mask-build workflows, PDK releases, parameterized cells, compact models, and physical verification infrastructure. Build CI/CD pipelines, regression suites, and automated QA for reliable mask releases. Partner with EDA vendors, process engineers, device designers, and architects to automate design workflows, investigate quality escapes, and improve manufacturing readiness.

Manage and maintain complex global network infrastructure, including F5 BIG-IP, Cisco, and HPE Aruba platforms. Investigate and resolve network outages, performance issues, and security incidents; perform upgrades, configuration changes, monitoring, and on-call support. Lead automation initiatives using Python and Ansible, maintain technical documentation, and collaborate with systems, security, and application teams. The role requires 5–7 years of experience and professional vendor certifications are preferred.

Develop algorithms and test methodologies for photonic integrated circuits, run engineering and prototype tests, analyze test data using JMP and Excel, create high-volume production test processes, and troubleshoot hardware and software integration. The role requires programming, test automation, statistical analysis, test instrument experience, and familiarity with optoelectronic devices. This is a full-time, four-month onsite cooperative role in Sunnyvale, California.

Build and optimize growth features, experimentation frameworks, personalization strategies, onboarding flows, and engagement loops for Pika’s AI creative platform. Analyze user data, run A/B tests, improve performance and reliability, and collaborate with product, marketing, design, and data teams to drive acquisition, activation, engagement, retention, referrals, and virality.

Build and ship full-stack features, including REST APIs, single-page applications, data models, cloud-based containerized services, and relational database solutions. Translate product requests into deliverable work, contribute to architectural decisions, review pull requests, and protect patient data by maintaining strict PHI-handling practices. Work in a trunk-based development environment with short-lived branches, frequent releases, and continuous collaboration.