Top Remote Python Jobs in San Diego, CA

Build and maintain backend APIs and data pipelines that ingest and process large-scale construction data (360° video, schedules, IoT). Optimize storage and query performance using DuckDB and PostgreSQL, extend Airflow workflows, integrate Wasm for local computation, monitor data quality, and collaborate with frontend, CV, and ML teams to deploy production models and analytics.

Lead and coordinate high-severity production incidents for cloud-native services, drive root cause analysis and reliability improvements, own incident communications to stakeholders and customers, and mentor peers while maintaining incident playbooks and observability-driven diagnostics.

Leads the architecture, design, implementation, testing, and delivery of backend software for Slate’s digital customer experience. Owns code quality, system reliability, functional and integration testing, and technical decision-making. Collaborates with UX and product teams, leads code and design reviews, simplifies complex solutions, and mentors engineers while supporting career development.

Design and build distributed storage systems optimized for AI and machine learning workloads at hyperscale. Lead architecture, development, testing, deployment, scalability, performance, security, and efficiency initiatives for zettabyte-scale Azure storage. Collaborate with AI researchers and cloud infrastructure teams, mentor engineers, evaluate emerging technologies, and solve complex problems involving availability, durability, replication, high-performance I/O, metadata, indexing, caching, and data placement.

Lead large-scale NVIDIA AI datacenter deployments, integrating GPU, networking, and storage systems. Troubleshoot complex hardware and deployment issues, guide customer and cloud partner architectures, support sales engagements, and drive adoption of NVIDIA solutions. Collaborate with customer engineers, architects, decision-makers, OEM partners, and internal teams to validate, deploy, scale, and optimize enterprise AI infrastructure.

Lead test architect for end-to-end integration testing of a complex genomics product portfolio. Design contract-first validations (OpenAPI/Avro), build resilient API and event-driven test frameworks, embed LLM-driven test generation and log analysis into CI/CD, mentor SQEs, enforce staging guardrails, and run chaos/resiliency experiments across distributed microservices.

Own and evolve Quansight's multi-cloud infrastructure, lead client infrastructure engagements end-to-end, build observability and CI/CD systems, mentor teammates, and dedicate substantial time to contributing and maintaining open-source infrastructure projects.

Designs, maintains, and modernizes production system integrations and customer-hosted Linux infrastructure. Responsibilities include data interfaces, monitoring, troubleshooting, releases, backups, disaster recovery, security, migrations, CI/CD adoption, documentation, customer coordination, and on-call support. The role works with legacy systems in healthcare environments under HIPAA requirements and uses Claude Code for scripting and code review. It requires strong Linux administration, Bash scripting, Git, build and release management, secure data transfer, and production systems experience.

Lead technical strategy and architecture for Azure Storage geo-replication, data protection, failover orchestration, and business continuity. Drive cross-team delivery, operational excellence, telemetry, automation, AI-assisted operations, and represent the team in executive and customer engagements.

Lead and grow a distributed software engineering team building Azure Kubernetes Service infrastructure. Define architecture, drive design reviews, ensure security, reliability, observability, CI/CD, and operations at scale. Guide implementation, incident response, and continuous improvement while coaching engineers and aligning stakeholders across Azure product teams.

Lead investigation and mitigation of complex distributed storage issues for Azure Managed Disks. Design algorithms for load distribution, monitor system behavior, debug performance and availability problems, collaborate across teams, mentor engineers, act as on-call DRI, and improve observability and reliability at hyperscale.

Design and deliver large-scale, cloud-native and AI-enabled Kubernetes/AKS solutions. Implement, optimize, and maintain Kubernetes components and container orchestration across Azure, on-prem, and edge. Integrate AI capabilities, participate in on-call rotations, mentor engineers, and collaborate cross-functionally to improve reliability, observability, performance, and operational consistency at scale.

Define technical visions and architecture for products, platforms, and enterprise systems. Evaluate emerging technologies, lead proofs of concept, and design scalable cloud-native, distributed, and hybrid solutions. Establish engineering standards, assess technical risks, conduct architecture reviews, and guide modernization initiatives. Collaborate with customers and stakeholders, support engineering teams through complex decisions, mentor technical leaders, and contribute to product roadmaps, DevOps practices, and technology strategy.

Develop and enhance core banking applications through requirements analysis, coding, testing, debugging, documentation, deployment, and production support. Partner with business and technical stakeholders to deliver scalable solutions, improve processes, automate workflows, and enhance user experience. Participate in code reviews, technology roadmap discussions, continuous improvement initiatives, and an on-call rotation for troubleshooting critical production systems.

Manage the full deployment lifecycle for retail locations, coordinating installation, network setup, configurations, and troubleshooting, while building automation and ensuring quality.

Build and own robot autonomy systems spanning task, behavior, path, and trajectory planning. Design long-horizon behavior architectures with recovery and operator handoff, coordinate multiple robots, integrate LLM/VLM reasoning safely, and define interfaces between learned policies and classical planners. Evaluate performance through simulation, log replay, regression testing, and real-robot field operation while collaborating across perception, controls, simulation, and platform teams.

Lead design, implementation, and operation of Signifyd's GCP/Kubernetes cloud platform. Architect scalable, secure infrastructure, embed AI-driven automation, own SLOs and incident response, improve developer experience via CI/CD/GitOps tooling, mentor engineers, manage cloud capacity/FinOps, and build observability and security into the platform.

Leads operational support, incident management, troubleshooting, and reliability improvements for Snowflake and cloud-based data and AI platforms. Monitors ETL/ELT pipelines, performs root-cause analysis, develops automation, maintains runbooks, and advises clients on performance and operational strategy. Collaborates with engineering, analytics, architecture, and client teams while mentoring peers and supporting distributed 24/7 production environments.

Build and operate distributed, event-driven backend services for Stacklet’s cloud governance platform. Responsibilities include developing GraphQL APIs, policy execution pipelines, cloud asset and cost data stores, and scalable multi-cloud systems. The role requires designing for reliability, observability, retries, idempotency, and eventual consistency; managing PostgreSQL schemas and migrations; and using AWS serverless services, infrastructure as code, CI/CD, and automated testing. The engineer will also lead backend initiatives, mentor teammates, and contribute to architectural decisions.

Architect and deliver complex distributed systems using Azure cloud-native technologies, microservices, APIs, and event-driven patterns. Lead architecture reviews, reliability initiatives, performance optimization, incident response, and root-cause analysis. Drive adoption of AI-assisted development tools while maintaining security and code quality. Collaborate across engineering, DevOps, QA, and product teams, and mentor engineers on technical design, development practices, and AI-enabled workflows.

Build and maintain full-stack donor-facing giving forms, payment flows, recurring giving, memberships, and administrative tools. Own projects from architecture through production support, ensuring reliability, accessibility, performance, and data integrity. Collaborate with product managers, designers, and engineers; mentor junior engineers; contribute to technical standards, security monitoring, hiring, and rotational on-call support. Potentially serve as a Tech Lead for roadmap implementation and technical decision-making.

Design and build developer platforms, backend tooling, SDKs, test infrastructure, reusable components, evaluation frameworks, and AI-assisted engineering workflows. Own architecture across distributed systems, observability, governance, reliability, and developer productivity. Influence technical strategy across teams, establish engineering standards, mentor senior engineers, and drive multi-quarter platform investments. The role is hands-on and focused on enabling backend, mobile, ML, and web teams to deliver reliable software faster.

Leads Azure, AWS, and hybrid cloud deployment, migration, modernization, networking, security, automation, governance, backup, and disaster recovery projects. Designs highly available cloud architectures, implements Infrastructure as Code, supports virtual desktop environments, assesses customer readiness, and develops migration roadmaps. Provides technical leadership, mentoring, escalation support, architecture review participation, and customer advisory services.

Own the architecture and long-term direction of Polymarket’s intelligence-fusion platform. Design detection and correlation methods, ingest on-chain and OSINT data, improve data pipelines, automate investigation workflows, and build auditable tooling with analysts and investigators. The role requires deep experience in data or detection engineering, entity resolution, data fusion, scoring, corroboration, and scalable scheduled and event-driven systems. Experience with fraud, trust and safety, investigations, blockchain, or crypto data is advantageous.

Own collaborative editing across React clients and Node services, including offline storage, queued mutations, realtime WebSocket synchronization, conflict resolution, and data persistence. Build agent-enabled editing experiences, investigate data-loss issues across environments, and collaborate with designers, backend engineers, and open-source contributors. The role requires production TypeScript experience across React and Node, rich-text editor frameworks, offline applications, WebSockets, and advanced Postgres skills.