Top Remote Python Jobs in San Diego, CA

Design and implement PostgreSQL internals, indexing, query engine extensions, and storage-layer features to support large-scale document workloads on Azure. Profile distributed systems, tune performance, collaborate with open-source communities, conduct design/code reviews, and drive cross-team alignment for mission-critical database features.

Lead a cross-discipline engineering team to deliver production-ready, AI-enabled solutions across the full lifecycle. Coach engineers and data scientists, manage a portfolio of engagements, act as player‑coach on select projects, strengthen multidisciplinary practices, and champion responsible, hypervelocity AI engineering and reusable accelerators.

Design, develop, and maintain scalable Python applications and cloud-native solutions. Architect microservices, containerized deployments (Docker/Kubernetes), optimize cloud infrastructure, build CI/CD pipelines, integrate messaging systems, ensure security and high code quality, and mentor junior developers. Generative AI/ML experience is a plus.

Design and implement PostgreSQL internals and indexing strategies for large-scale document workloads. Extend query engine with BSON-aware operators and custom scan nodes, optimize index pruning, profile distributed system performance, collaborate with open-source communities, and lead design/code reviews.

Hands-on Principal engineer who designs, builds, and operates production-grade Azure solutions with strategic customers; develops an observability-focused Azure service, supports live production via on-call and incident response, creates reusable tooling and reference implementations, and drives platform improvements while mentoring field engineering teams.

Design and build scalable backend systems, data pipelines, and cloud infrastructure. Own CI/CD, containerization, databases, and reliability; collaborate with tech leads to deliver secure, production-grade solutions for startups in a fully remote environment.

Design, implement, and operate highly scalable Azure cloud services and full‑stack features for Compute Manager. Own design, coding, debugging, reliability, and on‑call operations as a DRI. Collaborate across teams to improve availability, performance, observability, and run distributed systems at hyperscale.

Design and deliver large-scale, resilient AI and Kubernetes infrastructure for hybrid environments. Implement, optimize, and maintain cloud-native, container orchestration solutions; integrate AI capabilities; participate in on-call rotations; mentor engineers and drive reliability, observability, and performance at scale.

Maintain and improve ETL/data pipelines and election readiness systems; process voter files, resolve pipeline errors, build integrations for disparate data sources, and improve reliability. Collaborate with product, engineering, and data teams to support campaigns and state parties, primarily using Airflow and the GCP ecosystem.

Design and implement scalable first-mile networking solutions for Microsoft 365 Substrate and COSMIC. Drive design, dependency identification, coding, optimization, debugging, and on-call monitoring. Analyze production telemetry to improve reliability, performance, and observability. Act as a DRI, lead design and release plans, and collaborate with stakeholders to meet product requirements at global scale.

Design, build, and own operator services that provision, repair, and manage bare-metal GPU servers. Implement secure, extensible code across firmware, imaging, DPU initialization, and network configuration. Operate and monitor GPU fleets at scale, serve on-call rotations to resolve incidents, and apply AI tools across the SDLC while driving automation, telemetry, and reliability improvements.

Leads the design, implementation, optimization, and support of highly scalable Azure Storage services. Responsibilities include end-to-end performance testing, benchmarking, automation, profiling, bottleneck and root-cause analysis across compute, storage, and networking layers, KPI definition, scaling recommendations, and operational incident response. The role collaborates across teams, drives project and release plans, supports reliable and secure services, and mentors engineers while participating in on-call responsibilities.

Design, build, and operate secure, compliant AWS environments using Terraform and automation. Build CI/CD pipelines, security automation, observability, and support containerized and serverless workloads. Contribute to ISO 27001/SOC 2 compliance, create developer tooling, and troubleshoot complex platform issues in a distributed team.

Remote software engineer contributing to technical design, developing and maintaining applications (primarily C# and SQL; Python/Golang/React optional), writing clean code, reducing technical debt, debugging and performing root-cause analysis, creating test plans/scripts, supporting releases, and mentoring teammates to ensure software quality and reliability.

Lead and coach multiple full‑stack engineering teams and Consultants in Training. Set technical direction for Capstone Projects, translate requirements into deliverables, drive architecture and system design, manage schedules and performance, and improve recruiting and delivery pipelines. Champion agile practices, quality, tooling, and continuous improvement while interfacing with clients and senior leadership to deliver enterprise-scale software and mentor consultants toward placement and career growth.

Coach, mentor, and train early-career software engineers; run lab sessions; support recruitment via technical interviews; guide project requirements, execution, and engineering best practices; assist Engineering Manager with planning, performance oversight, and integration of training materials and feedback.

The Senior Backend Engineer will lead AI-focused projects, optimize data pipelines, mentor juniors, and enhance customer support through innovative technologies.

The Staff Engineer will lead cross-functional teams, focus on AI development practices, ensure scalable engineering, and evolve system architecture at ParentSquare.

Lead and grow an engineering team, set technical vision, drive delivery of scalable secure systems, partner with product/design, establish engineering practices (Agile, CI/CD, TDD), mentor engineers, and promote innovation to advance Function's healthcare platform.

As a Gameplay Engineer, you'll design and refine networked gameplay systems, iterate on features, and collaborate with designers and back-end engineers.

The Engineering Leader will oversee the architecture and reliability of AI improvement products, focusing on backend systems, scalability, and technical leadership.

The Senior Backend Software Engineer will design and scale backend systems using Python and FastAPI, collaborate with researchers, optimize infrastructure, and implement testing and monitoring systems.

Design, implement, and maintain scalable, secure multi-cloud infrastructure (Azure and AWS) using IaC; build and optimize CI/CD pipelines; automate operations and database deployment; implement observability and security controls (HIPAA/SOC2); lead incident response and mentor engineers.

Develop scalable web applications using React and Next.js, implement backend solutions in Python, maintain DevOps practices, and collaborate with AI/ML teams to deploy applications.

The PHP Developer will design and architect web applications using the LAMP stack, collaborate with teams, optimize performance, ensure security, mentor junior developers, and conduct code reviews.