Top Senior Data Science Jobs in Indianapolis, IN

Reposted One Month AgoSaved
In-Office or Remote
Indianapolis, IN
48K-170K Annually
Senior level
48K-170K Annually
Senior level
Agency • Information Technology
Build and scale production Generative AI applications: design multi-agent systems and LangGraph workflows, implement advanced RAG with vector DBs, integrate and fine-tune LLMs, deploy FastAPI async services in Docker, and optimize GenAI performance, cost, and monitoring.
Top Skills: Api SecurityAsync PythonCi/CdClaudeDockerEmbedding ModelsFastapiGeminiHugging FaceLangchainLanggraphLlamaLlamaindexLlm MonitoringLlm QuantizationLocal Model DeploymentModel Fine-TuningMulti-Agent SystemsOpenaiPostgresPrompt EngineeringPythonPyTorchTensorFlowVector DatabasesVector Search
Reposted One Month AgoSaved
In-Office or Remote
Indianapolis, IN
56K-196K Annually
Senior level
56K-196K Annually
Senior level
Agency • Information Technology
Design, build, and deploy production-ready generative AI applications: architect multi-agent workflows, implement advanced RAG with vector DBs, integrate/swap LLMs, fine-tune models, and deliver scalable FastAPI-based services with monitoring, CI/CD, and containerized deployment.
Top Skills: Async PythonCi/CdClaudeDockerEmbedding ModelsFastapiGeminiHugging FaceLangchainLanggraphLlamaLlamaindexLlm MonitoringMulti-Agent SystemsOpenaiPostgresPrompt EngineeringPythonPyTorchTensorFlowVector DatabasesVector Search
Reposted One Month AgoSaved
In-Office
Indianapolis, IN
126K-244K Annually
Senior level
126K-244K Annually
Senior level
Healthtech • Biotech • Pharmaceutical
The Data Scientist will lead the development of data products that enable AI-driven insights, ensuring compliance and optimizing processes across CMC workflows.
Top Skills: AirflowAws S3AzureDatabricksGlueLambdaMicrosoft FabricPythonRdsSQL
20 Days AgoSaved
In-Office
Indianapolis, IN
119K-144K Annually
Senior level
119K-144K Annually
Senior level
Other • Energy
Develop predictive and advanced analytics using large, complex datasets to evaluate electricity market operations, pricing, participant activity, supply and demand, and anomalies. Lead end-to-end data science projects, investigate market outcomes, and build scalable pipelines, dashboards, alerts, and decision-support tools. Partner with Digital Technology to implement solutions using machine learning, statistical analysis, cloud platforms, data engineering, and visualization technologies.
Top Skills: AWSAzureData WarehousingETLEviewsGCPGitNoSQLNumpyPlotlyPower BIPythonPyTorchRSASScikit-LearnSQLStreamlitTableauTensorFlowVBA
One Month AgoSaved
Remote
Indianapolis, IN
Senior level
Senior level
Software • Consulting • Cybersecurity • Defense
Design, train, fine-tune, deploy, and monitor Large Language Models for government mission applications. Collaborate with cross-functional teams, ensure data preprocessing and model performance, present findings to stakeholders, and mentor junior data scientists.
Top Skills: BertGptLarge Language ModelsNlpPythonPyTorchTensorFlowTransformers
12 Days AgoSaved
In-Office or Remote
Indianapolis, IN
125K-145K Annually
Senior level
125K-145K Annually
Senior level
Edtech
Lead experimentation and decision science initiatives from problem definition through recommendations. Design and analyze A/B tests, quasi-experiments, matched-market tests, and causal inference studies. Apply advanced statistics, regression, predictive modeling, machine learning, and big-data analysis using Python, R, SQL, and PySpark. Partner with stakeholders, communicate actionable findings, build reproducible workflows, and mentor analysts and junior data scientists.
Top Skills: PysparkPythonRSQL
13 Days AgoSaved
Remote
Indianapolis, IN
100K-132K Annually
Senior level
100K-132K Annually
Senior level
Healthtech • Social Impact
Build, validate, deploy, monitor, and maintain predictive models and analytical reports. Translate findings for technical and non-technical stakeholders, promote data literacy, deliver training, collaborate on data infrastructure, apply advanced statistical and machine learning methods, and support analytical requests across mental health and crisis care programs.
Top Skills: Amazon RedshiftAmazon SagemakerAWSDeployment PipelinesModel RegistriesPandasPythonRScikit-LearnSnowflakeTidyverseVersion Control
Reposted One Month AgoSaved
Remote
Indianapolis, IN
Senior level
Senior level
Logistics • Software
Senior individual contributor owning complex end-to-end ML problems for supply chain and consumer applications. Build and deploy predictive models (demand forecasting, delivery ETA, recommendations), embed with engineering teams, define MLOps standards, and advise leadership on data science strategy and investments.
Top Skills: Api EndpointsAWSAzureBigQueryDrift DetectionExperimentation FrameworksGCPGitGitMicroservicesModel VersioningPipeline OrchestrationPostgresPythonSQL
Reposted One Month AgoSaved
Remote
Indianapolis, IN
150K-195K Annually
Senior level
150K-195K Annually
Senior level
Software • Cryptocurrency • Web3
Partner with Marketing as the embedded data science lead to build marketing measurement, attribution, LTV/ROAS/CAC models, run experiments, analyze the full funnel, create forecasts and dashboards, and influence channel strategy and budget allocation.
Top Skills: Ad PlatformsAppsflyerGoogle AnalyticsLookerMmpPythonRSQLTableau
Reposted One Month AgoSaved
Remote
Indianapolis, IN
255K-298K Annually
Senior level
255K-298K Annually
Senior level
Consumer Web • Other • Social Media • Software
As the Staff Data Scientist, you will lead the data science function, driving strategy, mentoring peers, and shaping product direction through advanced analytics and experimentation.
Top Skills: PythonSQL
Reposted One Month AgoSaved
Remote
Indianapolis, IN
Senior level
Senior level
Big Data • Food • Mobile • Payments
Lead company-level measurement and causal strategy, define MAU×ARPU metrics and semantic mart, set scientific standards for experimentation and analysis, own strategic models (MMM, elasticity, forecasting), partner with engineering to productionize analytics, and raise org-wide scientific maturity through governance, templates, and upskilling.
Top Skills: DbtExperimentation PlatformsPythonSnowflakeSQL
13 Days AgoSaved
Remote
Indianapolis, IN
160K-200K Annually
Senior level
160K-200K Annually
Senior level
AdTech • Fintech • Marketing Tech
Build and deploy machine learning and experimentation systems for personalization, ranking, targeting, attribution, and causal measurement. Develop features and pipelines from transaction and behavioral data, design A/B tests, productionize models with engineering teams, and improve recommendation systems. Translate analytical results into business insights tied to conversion, retention, lift, and ROI while owning projects from problem framing through post-launch evaluation.
Top Skills: AirflowAPIsAWSDbtFeature StoresGCPPandasPythonPyTorchScikit-LearnSparkSQLXgboost
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Reposted One Month AgoSaved
Easy Apply
Remote
Indianapolis, IN
Easy Apply
180K-212K Annually
Senior level
180K-212K Annually
Senior level
Artificial Intelligence • Blockchain • Fintech • Financial Services • Cryptocurrency • NFT • Web3
Own and evolve revenue calibration models tying CX interactions to revenue, design causal inference and experimentation frameworks, build LLM-powered classification/NLP pipelines, productionize models with Analytics Engineers, define segmentation and behavioral signals, and ensure statistical rigor for executive reporting and regulatory defensibility.
Top Skills: A/B TestingCausal InferenceGeminiGenerative AiGleanLibrechatLlmMlNlp
15 Days AgoSaved
Remote
Indianapolis, IN
Senior level
Senior level
Artificial Intelligence • Big Data • Machine Learning
Lead end-to-end predictive analytics and machine learning initiatives, including forecasting, churn prediction, and risk modeling. Translate business needs into scalable ML solutions, build and deploy models on AWS SageMaker, develop production ML pipelines, and oversee monitoring, governance, explainability, and retraining. Collaborate with engineering and MLOps teams, communicate insights to stakeholders, and mentor junior data scientists while providing hands-on technical leadership.
Top Skills: Amazon SagemakerApache AirflowAWSAws LambdaAws Step FunctionsCi/CdGenerative AiInfrastructure As CodeKubeflowMlopsNumpyPandasPythonSagemaker PipelinesScikit-LearnXgboost
Reposted One Month AgoSaved
Remote
Indianapolis, IN
Senior level
Senior level
Machine Learning • Software
The Staff Data Scientist will lead the development and deployment of ML and GenAI systems to detect billing errors and fraud in healthcare payments, collaborating with cross-functional teams.
Top Skills: AIData ScienceMachine Learning
Reposted One Month AgoSaved
Remote
Indianapolis, IN
220K-290K Annually
Senior level
220K-290K Annually
Senior level
Information Technology • Software
Build and productionize ML models and data infrastructure to analyze millions of chaos engineering experiments, detect and explain failures, recommend automated remediation, and integrate AI-driven failure analysis into Gremlin's product using techniques like causal inference, graph ML, time-series modeling, and reinforcement learning.
Top Skills: Agentic AiCausal InferenceChaos EngineeringData PipelinesFeature StoresGraph MlMlopsModel MonitoringModel ServingReinforcement LearningSite Reliability EngineeringTime-Series Modeling
16 Days AgoSaved
Remote
Indianapolis, IN
Senior level
Senior level
Big Data • Food • Mobile • Payments
Develop and deploy predictive and causal models for personalization, retention, monetization, and product strategy. Design experimentation and measurement frameworks, analyze user and marketing behavior, quantify business impact, and translate complex findings into strategic decisions. Collaborate with Product, Engineering, Marketing, and Data Product teams to build scalable data solutions. Mentor peers, promote rigorous model validation and governance, and apply Python, SQL, Snowflake, dbt, Airflow, Spark, and AWS to production-ready data science initiatives.
Top Skills: AirflowAWSBayesian InferenceCausal InferenceCcpaDbtExperimentation FrameworksGdprMachine LearningPythonSnowflakeSparkSQL
17 Days AgoSaved
In-Office or Remote
Indianapolis, IN
Senior level
Senior level
Healthtech
Lead the design, development, deployment, and governance of advanced analytics, machine learning, and AI solutions using large healthcare datasets. Responsibilities include data preparation, statistical and predictive modeling, model monitoring, explainability, visualization, stakeholder communication, and translating findings into clinical and operational improvements. The role also mentors data professionals, advises leaders, manages initiative priorities and risks, and promotes responsible AI and Agile practices.
Top Skills: Advanced AnalyticsAgileArtificial IntelligenceData VisualizationDeep LearningFeature EngineeringGenerative AiMachine LearningNatural Language ProcessingOptimizationPredictive ModelingStatistical Modeling
One Month AgoSaved
Remote or Hybrid
Indianapolis, IN
Senior level
Senior level
Software
Design and deploy ML systems for enterprise search, recommendations, retrieval, and AI agents. Build scalable data/ML pipelines, evaluation frameworks, and metrics. Apply statistics, experimentation, and causal inference to guide product decisions. Collaborate cross-functionally, prototype LLM-based capabilities (embeddings, RAG), and mentor junior team members.
Top Skills: Agent Orchestration FrameworksEmbeddingsFoundation ModelsLlmsPythonRetrieval SystemsRetrieval-Augmented Generation (Rag)SQLVector Databases
One Month AgoSaved
Remote or Hybrid
Indianapolis, IN
179K-217K Annually
Senior level
179K-217K Annually
Senior level
Software
Lead design and deployment of ML systems for enterprise search, retrieval, recommendations, and AI agents. Build scalable data/ML pipelines, evaluation frameworks, and KPIs. Apply statistics, causal inference, experimentation, and analysis to guide product strategy. Prototype and productionize LLM-based features, mentor junior staff, and collaborate cross-functionally.
Top Skills: Agent Orchestration FrameworksEmbedding ModelsEmbeddingsFoundation ModelsLlmsPythonRetrieval SystemsRetrieval-Augmented Generation (Rag)SQLVector Databases
Reposted One Month AgoSaved
Remote
Indianapolis, IN
175K-234K Annually
Senior level
175K-234K Annually
Senior level
Information Technology • Other • Social Media
As a Senior Data Scientist, you'll optimize search relevance, retrieve content, analyze data, and collaborate with teams to enhance product strategies.
Top Skills: Ml ModelsNumpyPandasPythonScikit-LearnSQL
Reposted One Month AgoSaved
Remote
Indianapolis, IN
220K-250K Annually
Senior level
220K-250K Annually
Senior level
Events • Greentech • Logistics • Software • Transportation • Travel
Lead design and production deployment of ML models focused on pricing, availability, forecasting, and optimization. Build data infrastructure, governance, testing/monitoring, and dashboards. Partner with executives and cross-functional teams, mentor others, and establish scalable data-science practices and experimentation frameworks.
Top Skills: LlmsMachine LearningNlpPythonRSQL
Reposted 28 Days AgoSaved
In-Office or Remote
Indianapolis, IN
200K-250K Annually
Senior level
200K-250K Annually
Senior level
Software
Lead product data scientist shaping growth strategy, experimentation, and metrics. Build self-service analytics, size opportunities, design and analyze experiments with product and engineering, drive activation/engagement/monetization insights, and evolve the company's experimentation culture.
Top Skills: A/B TestingAi ToolsPythonRSQL
One Month AgoSaved
Remote
Indianapolis, IN
172K-280K Annually
Senior level
172K-280K Annually
Senior level
Artificial Intelligence • Consumer Web • Information Technology • Real Estate • Software • PropTech
Build and deploy end-to-end ML models for renter acquisition, supply optimization, ranking, personalization, and marketplace optimization. Lead technical projects from problem framing through experimentation, launch, monitoring, and iteration. Apply statistical methods, causal inference, and rigorous A/B testing. Partner cross-functionally, mentor other data scientists, and raise modeling and experimentation standards.
Top Skills: AirflowDbtGCPMlopsPythonPyTorchScikit-LearnSQLTensorFlowXgboost
20 Days AgoSaved
Remote
Indianapolis, IN
130K-150K Annually
Senior level
130K-150K Annually
Senior level
Information Technology • Consulting
Build production AI retrieval and knowledge systems for rare disease research at NIH. Model biomedical ontologies in PostgreSQL, develop semantic search, retrieval-augmented services, ranking, evaluation, and observability, and deliver user interfaces with Next.js, React, and TypeScript. Deploy and operate services in on-premises and HPC Kubernetes environments, including GPU inference. Collaborate with NIH staff, clinicians, and researchers, and contribute to scientific publications.
Top Skills: Ci/CdDockerFastapiFull-Text SearchGa4GhGitHelmHpoKubernetesLitellmLlm ApisMedcptMeshMondoNext.JsObo FoundryOllamaPgvectorPostgresPydanticPytestPythonReactStatefulsetsTypescriptUmlsVllm
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