Top Senior Machine Learning Jobs in Charleston, SC

Lead analytics partner to Community Support, driving data-driven roadmaps, scalable reporting and measurement, causal inference and experimentation, and improvements to agent/guest/host experiences via analytics, modeling, and stakeholder influence.

Design and implement scalable backend and distributed systems for a marketing intelligence platform. Build near-real-time ingestion and processing, scale an incrementality/experimentation product, integrate AI-powered workflows, improve data ingestion/exports and connection-state systems, and contribute frontend components to deliver end-to-end product experiences.

Lead a Big Data Engineering team to deliver production-grade ETL and data pipelines at scale. Own team execution, code quality, morale, and roadmap execution with product managers. Remove roadblocks, coach and develop engineers, promote engineering best practices, and enable data-driven and AI-powered product features (personalization, recommendations, search, ranking, matching).

Evaluate and strengthen AI model behavior on cybersecurity topics by writing expert prompts, annotating and grading model responses for accuracy and safety, and applying structured guidelines to classify sensitive content. Work part-time on AI safety tasks with emphasis on secure, responsible handling of dual-use information.

Lead manufacturing process improvements for precision optical production: analyze data, reduce cycle time and costs, design/qualify tooling and automation, apply Lean/Six Sigma and AI-enabled analytics, maintain process documentation, partner cross-functionally, drive CAPEX and continuous improvement projects, and train production staff.

Seeking a Senior Full Stack .NET Developer to work on a social good project, with strong skills in C#, AngularJS, design, and UX. Requires 5+ years of experience.

Lead a multidisciplinary team to design, deploy, and optimize ML-driven bidding systems and measurement for a nine-figure marketing budget. Drive experimentation, partner strategy, media-mix optimization, and end-to-end measurement while aligning Marketing, Analytics, Engineering, and Product to improve marketing ROI and scale performance.

The Senior Data Scientist will design and deploy time-series forecasting models, collaborate with stakeholders, and operationalize models in cloud environments, focusing on demand planning across various industries.

Senior BI Data Researcher will lead research and engineering across modern data systems: big data management, data cleaning, quality, metadata, search/discovery, information extraction, time-series and heterogeneous analytics, applied AI/ML, distributed processing, and query/storage optimization. Collaborates with research teams to build scalable tooling, ML models across diverse modalities (tabular, time series, text, audio, video), and edge-enabled architectures.

Drive Midwest SLED revenue by selling analytics-driven SaaS identity and fraud solutions. Build pipeline, manage full sales cycle, develop partnerships/channels, collaborate with product, forecast accurately, and travel up to 50% to close deals and ensure customer success.

Lead product vision and execution for tDesign, an internal platform for small-molecule drug discovery. Define roadmap, translate complex AI/ML and scientific needs into intuitive UX, integrate AI agents and automated workflows, coordinate cross-functional teams, and drive adoption and product impact metrics.

The Engineering Manager will lead teams in developing and managing Blackbaud's Data & AI platform, focusing on scalability, security, and cost-efficiency.

Serve as the technical lead in pre-sales for state, local, and education customers: run discovery, design POCs and workshops, deliver demos, map needs to Socure solutions, advise on fraud/risk/compliance, influence product, and mentor junior consultants.

Lead end-to-end deployments of AI for hotel revenue teams: integrate PMS/CRS/RMS, ship ML/optimization models and agentic workflows, validate recommendations with revenue managers, define metrics, drive adoption, and hire/mentor the forward deployed engineering team.

Lead strategy, roadmap, and lifecycle for payer analytics and automation products. Translate market, customer, regulatory, and data insights into product requirements, drive cross-functional delivery with Engineering and Data Science, support go-to-market and adoption, and measure product performance to inform investment and portfolio decisions. Build product practices and partner with stakeholders across sales, customer success, clinical, actuarial, and executive teams.

Lead Growth Engineering architecture and implementation: build Go-based data pipelines, audit/replace martech, create experimentation infrastructure, ship full-stack Go/TypeScript features, productionize ML, review team work, and apply AI-assisted development daily.

Design and deliver enterprise-grade Generative AI solutions on AWS using Bedrock and AgentCore. Architect LLM-based applications, RAG pipelines, agentic workflows, vector DB integrations, and APIs. Optimize models for performance, cost, and quality, ensure security and governance, lead teams, and troubleshoot production GenAI systems.

Lead complex enterprise sales of AI-powered SaaS solutions, build pipeline, manage 6–12 month high-six-figure deals, multi-thread across stakeholder teams, collaborate with marketing/product/customer success, and translate technical AI capabilities into business ROI.

Lead execution of Product Engineering AI and automation initiatives across photonics products. Build and deploy reusable AI/automation tools, transform engineering data into AI-ready systems, and drive cross-functional adoption to improve development, qualification, manufacturing, and reliability processes.

Set the technical direction for machine learning at Payabli by maturing production risk models and launching new models across the payments lifecycle. Establish experimentation, monitoring, drift detection, benchmarking, retraining, and incident-response foundations. Translate payments challenges into modeling opportunities, connect model performance to business outcomes, influence the ML roadmap, and mentor engineers while partnering with product, engineering, and risk operations.

Design, build, deploy, and operate production machine learning systems for personalization, recommendations, optimization, decisioning, experimentation, and measurement. Build reusable ML platforms, pipelines, and tooling; manage model monitoring, quality, drift detection, retraining, governance, and reliability. Partner with data scientists, engineers, and product teams to productionize models, make architectural decisions, and provide technical leadership through mentorship, reviews, and engineering standards.

Lead a consortium advancing AI-driven neurodegeneration research: set strategy, build partnerships, manage multidisciplinary executive team, oversee product development and deployment, secure funding, ensure ethical AI and scientific integrity, and scale the platform to broader biomedical domains.

Lead development of digital twin and simulation models for warehouse operations, deploy AI-driven decision systems, build forecasting and optimization models, validate experiments linking operational metrics to financial impact, and partner with engineers, operations, and external AI/academic partners to scale innovations across fulfillment networks.

The Business Development Director will lead strategic engagement with Google Cloud, focusing on partnership growth, go-to-market strategies, and revenue generation through cloud solutions.

Lead design and scaling of a unified fraud and risk platform. Own roadmap, fraud metrics, SQL-based analysis, A/B testing, real-time detection models, and cross-functional delivery to balance customer experience and risk mitigation.