Top Senior Machine Learning Jobs in Charleston, SC

Design, build, deploy, and operate production machine learning systems for personalization, recommendations, optimization, decisioning, experimentation, and measurement. Build reusable ML platforms, pipelines, and tooling; manage model monitoring, quality, drift detection, retraining, governance, and reliability. Partner with data scientists, engineers, and product teams to productionize models, make architectural decisions, and provide technical leadership through mentorship, reviews, and engineering standards.

Lead a consortium advancing AI-driven neurodegeneration research: set strategy, build partnerships, manage multidisciplinary executive team, oversee product development and deployment, secure funding, ensure ethical AI and scientific integrity, and scale the platform to broader biomedical domains.

Lead development of digital twin and simulation models for warehouse operations, deploy AI-driven decision systems, build forecasting and optimization models, validate experiments linking operational metrics to financial impact, and partner with engineers, operations, and external AI/academic partners to scale innovations across fulfillment networks.

The Business Development Director will lead strategic engagement with Google Cloud, focusing on partnership growth, go-to-market strategies, and revenue generation through cloud solutions.

Lead design and scaling of a unified fraud and risk platform. Own roadmap, fraud metrics, SQL-based analysis, A/B testing, real-time detection models, and cross-functional delivery to balance customer experience and risk mitigation.

Lead fraud detection and mitigation for a conversational BNPL product. Define fraud typologies, own repayment and chargeback analytics, manage fraud KPIs, design operational policies, collaborate on ML models and decisioning workflows, and coordinate SARs and compliance reporting.

Lead fraud detection and mitigation for a conversational BNPL product: define fraud typologies, analyze repayment/chargeback trends, own fraud KPIs, design policies, collaborate on ML models and decisioning workflows, and coordinate SARs with Compliance.

Lead fraud risk for a conversational lending product (SNPL): define first-party fraud typologies, analyze repayment and chargeback trends, own fraud KPIs, design automated/manual blocking policies, coordinate ML/rules with central Fraud and Data teams, and liaise with Compliance on SARs and loan abuse.

The AI Engineer will design and build production systems, focusing on LLM integration, system reliability, evaluation frameworks, and high-quality product features while maintaining strong engineering practices.

Lead product strategy and execution for multiple client digital products (web, mobile, AI). Act as primary client contact, define roadmaps and requirements, translate vision into user stories and designs, coordinate across design, engineering, PM, and QA, manage scope/prioritization, support sales and upsell opportunities, and ensure timely launches.

Lead end-to-end delivery of LOIS by owning the master program plan, coordinating cross-functional teams (engineering, product, design, ML, data, SRE, operations), resolving blockers and dependencies, establishing lightweight delivery infrastructure and tooling, partnering on release planning, and maintaining transparent status, risks, and accountability to deliver complex features to customers.

Drive new business and expand accounts by selling AI-driven services and software to engineering and manufacturing customers. Manage full sales cycle from prospecting to close, align solutions to measurable ROI, collaborate with technical and marketing teams, and meet revenue targets while attending industry events and maintaining CRM pipeline accuracy.

Design, optimize, and scale ClickUp's search infrastructure using OpenSearch/ElasticSearch. Improve relevance, speed, and real-time indexing; build vector/semantic search capabilities; create measurement frameworks; integrate search with AI and product features; troubleshoot at scale; and mentor junior engineers to maintain high search quality under heavy load.

Design, scale, and optimize ClickUp's search infrastructure using OpenSearch/Elasticsearch. Improve relevance, speed, and real-time indexing, build vector search capabilities, create evaluation frameworks, and collaborate with AI/backend/product teams to integrate and troubleshoot search at scale.

The Senior Backend Data Engineer will extend data ingestion and processing pipelines, build APIs and backend services, and provide technical leadership.

Lead Tekmetric's API product strategy and roadmap for the SaaS platform. Own API lifecycle (contracts, versioning, documentation), drive developer experience and adoption, identify integration opportunities, lead generative AI initiatives, perform user research and analytics-driven prioritization, collaborate across design/engineering/sales, train internal teams, and measure business impact.

Lead planning, execution, and optimization of cross-functional hardware and software projects for robot development, manufacturing, testing, upgrades, and deployments. Coordinate mechanical, electrical, embedded, systems, manufacturing, and operations teams, define scope and timelines, mitigate risks, implement process improvements, run sprints, and maintain project documentation and stakeholder communication.

Lead Woolpert's partner marketing for the Google relationship: develop and execute joint go-to-market plans, run integrated campaigns, enable sales, create partner collateral, measure KPIs, and coach one specialist to drive co-selling and pipeline growth for Digital Innovations.

Lead development of Vanta's business analytics function: build scalable product data assets, define measurement frameworks, use AI-assisted analytics, partner with cross-functional teams, and deliver executive-level recommendations to drive product and business decisions.

Lead and grow a global engineering team building endpoint visibility, prevention, and on-device ML across Windows, macOS, and Linux. Own roadmap and delivery, direct model development and telemetry, drive cross-platform protection parity, coordinate with product and partner teams, and represent the team externally through research and conferences.

Build and operate a secure Kubernetes-based AI/ML platform for government test and evaluation teams. Responsibilities include GPU scheduling, workload orchestration, infrastructure-as-code, GitOps, observability, capacity planning, upgrades, security hardening, compliance support, and operational documentation. The role involves restricted and disconnected environments, automated security tooling, collaboration with government and engineering stakeholders, technical leadership, and mentoring.

Lead statistical design and analysis for Phase I-IV clinical studies, develop protocols and SAPs, perform efficacy and exploratory analyses, run simulations, apply advanced methods (mixed models, longitudinal), oversee datasets (ADaM/CDISC), use R and SAS for analyses, and provide strategic statistical guidance to cross-functional teams supporting regulatory submissions.

Lead and grow a team of 5-7 enterprise sales reps in the Bay Area, recruit and develop sales leaders, build business plans, drive new-logo acquisition and account expansion, manage the sales cycle from lead generation to close, develop GTM strategy, and report to the VP of Sales. Role supports ambitious quarterly and annual goals and may require occasional work outside standard hours.

Lead the vision and execution of data product roadmap; translate business needs into epics and acceptance criteria; partner with data engineering and analytics; run agile ceremonies and manage backlog; champion data-as-a-product; scope and pilot AI/ML capabilities; present roadmaps and business cases to leadership.

Sell Fiddler’s AI observability platform to enterprise customers: prospect, navigate complex multi-stakeholder deals, demonstrate technical and business value for ML/AI solutions, close revenue, grow accounts, and collaborate cross-functionally. Travel as needed (10–25%).