Top Senior IT Jobs in Charleston, SC

Owns the strategy and execution of eDiscovery and information governance programs across business functions and enterprise platforms. Partners with engineering teams to improve EDRM capabilities, translates regulatory requirements into system controls, manages roadmaps, dependencies, risks, and audit documentation, and validates compliance tooling through comprehensive testing. The role also identifies automation opportunities, responsibly applies generative AI and workflow tools, and drives organizational adoption.

Lead architecture and delivery of IT automations and integrations across platforms (n8n, Airflow, Temporal, Jira). Act as technical DRI for complex automation projects, partner with Security and IAM, build reusable frameworks and documentation, establish engineering standards and code review practices, and mentor peers.

Own IT-specific Sarbanes-Oxley (SOX) compliance for ITGCs and ITACs. Assess SOX readiness for systems and process changes, maintain control documentation, coordinate walkthroughs and remediation, liaise with internal/external auditors, review SOC reports, oversee testing programs, and identify automation and AI opportunities to strengthen controls and reporting.

Own and automate end-to-end employee lifecycle and shared IT infrastructure using infrastructure-as-code and SRE practices. Manage ITSM platform and AI-driven virtual agents, build integrations (Okta, Workday, JAMF, Google Workspace, Slack, Zoom, GitLab), instrument metrics, ensure reliability and compliance, and mentor support engineers.

The Lead Technical Support Engineer resolves complex technical issues, provides mentorship, collaborates with teams, and improves support systems.

Lead enterprise cloud architecture, governance, and infrastructure enablement. Define reusable IaC patterns (Terraform), cloud networking (Transit Gateway, multi-account VPCs), and migration/data center exit strategies. Build architecture review processes, drive adoption of cloud-native practices (Kubernetes, CI/CD), and translate technical decisions for stakeholders while coordinating security and compliance.

Lead and execute remote technical implementations for dental practices from signing through go-live. Configure PMS integrations, set up remote access and network configurations, manage AWS-hosted Windows VMs/ETL, handle support volume, liaise with MSPs, and improve onboarding processes and automation while partnering with cross-functional teams.

Leads healthcare claims processing for the World Trade Center Health Program, supervising processors, resolving complex claims, enforcing QA and regulatory compliance, monitoring production metrics, improving claim workflows, and coordinating with providers and federal representatives. The role requires expertise in claims platforms, CMS-1500 and UB-04 forms, ICD-10/CPT coding, reimbursement methodologies, team management, and advanced Excel.

Designs scalable, secure, and supportable technology solutions for customer implementations and enterprise initiatives. Translates business requirements into architectures spanning applications, integrations, infrastructure, cloud, data, and security. Leads solution design, technical decisions, implementation planning, cost estimation, stakeholder presentations, and risk mitigation. Develops architecture standards, governance processes, reference architectures, and reusable patterns while advising business and technology leaders on modernization and best practices.

Lead SAP S/4HANA data migration activities: extract, map, transform, load, validate, and reconcile master and transactional data using BODS, Migration Cockpit, LSMW/BDC and HANA SQL. Support mock loads, cutover execution, defect remediation, and collaborate with functional owners to cleanse and correct source data.

Build and operate internal software, platform services, developer tooling, Kubernetes infrastructure, and reproducible Nix environments. Develop Go and Rust automation, improve CI/CD and reliability, support Linux systems, networking, identity, endpoints, and SaaS platforms, and resolve ambiguous technical problems independently. Partner across engineering, security, operations, and business teams while mentoring engineers and shaping technical direction.

Manages core business systems including NetSuite, HubSpot, Microsoft 365, and related SaaS tools. Oversees user access, permissions, integrations, data quality, reporting, security, and vendor relationships. Builds workflow automations using low-code tools, evaluates practical AI applications, supports staff technology adoption, maintains IT policies and continuity plans, and troubleshoots system issues across a remote organization.

The Senior Test Engineer designs and executes manual and automated testing for front-end applications, back-end data, reporting, ETL processes, APIs, and workflows. Responsibilities include creating test plans and cases, performing functional, regression, performance, and non-functional testing, automating tests, documenting defects, conducting root-cause analysis, supporting UAT, and collaborating with Agile/SAFe teams and stakeholders. The role also provides requirements analysis, test estimates, defect reporting, and customer support for a CMS case management system.

Design, develop, and maintain secure integrations across NetSuite, Coupa, Leapfin, and other enterprise systems. Build iPaaS workflows, custom connectors, webhook and event-driven automations, bulk synchronization processes, monitoring, error handling, and retry mechanisms. Translate finance requirements into technical specifications and data mappings, support implementation projects, document architectures, and maintain audit readiness. Apply AI-powered tooling to automate finance operations while ensuring compliance, security, and reliable handling of sensitive financial data.

Lead cross-functional IT systems and tools integration across the M&A lifecycle, including pre-close planning, Day 1 readiness, post-close migration, application rationalization, identity and access, infrastructure, security, data, and collaboration technology. Manage milestones, dependencies, risks, decisions, cutover plans, dashboards, and executive reporting while coordinating IT and business stakeholders. Improve repeatable integration practices and use Microsoft 365 and AI-enabled tools to strengthen program visibility, automation, and execution.

Administer and secure enterprise IT and OT environments across sites, supporting Windows Server, virtualization, networking, cloud (Azure/M365), PLC/SCADA integrations, backups, DR, segmentation and Zero Trust initiatives. Provide Tier 2/3 escalation, network/OT troubleshooting, monitoring, documentation, compliance support, and collaborate with infrastructure, security, and manufacturing teams to maintain production uptime.

Engineer and operate enterprise EDR/XDR protections across hundreds of thousands of Windows, macOS, Linux, server, container, and multi-cloud workloads. Responsibilities include behavioral defense, allowlisting, phased deployments, threat investigation, host forensics, live remediation, SOC escalation support, attack simulation, and continuous measurement of endpoint coverage and control efficacy. The role also partners with application owners and IT operations to minimize business disruption while automating security policies and fleet-wide remediation.

Designs and delivers AI/ML-powered cybersecurity and fraud-detection solutions using large, disparate datasets. Develops analytics in Azure Databricks with Python, SQL, and R; integrates large language models, computer vision, and advanced analytics into secure environments. Analyzes system and process gaps, recommends remediation, investigates stakeholder requests, and communicates insights. Directs data science, data engineering, and business intelligence teams while managing multiple technology, cyber, risk, and analytics engagements.

Leads major IT service delivery and ServiceNow implementation projects, including architecture, technical design, development oversight, quality assurance, testing, security, scalability, and maintainability. Translates business requirements into technical solutions, advises clients, coordinates government and contractor stakeholders, supervises project teams, facilitates UAT and training, and recommends improvements. Requires ServiceNow expertise across multiple modules, IT consulting experience, Agile and SDLC knowledge, strong communication, and analytical skills.

Lead a remote analytics team to deliver dashboards, data products, and decision-support tools. Oversee project plans, stakeholder engagement, data platform modernization, ETL/automation, Tableau/Power BI deployments, statistical modeling, QA, metadata, and staff mentoring to support federal social service programs.

Designs, implements, and supports secure, scalable AWS and Azure infrastructure. Develops reusable Terraform and Ansible automation, CI/CD capabilities, and cloud infrastructure services. Configures cloud compute, storage, networking, databases, identity, security, monitoring, and backup solutions. Troubleshoots infrastructure and hosting issues, maintains technical and compliance documentation, and collaborates with customers and engineering teams using Agile and DevOps practices.

Leads complex CMS IT programs supporting ACA and NSA capabilities. Manages contract performance, distributed technical teams, concurrent projects, schedules, risks, resources, governance, Agile delivery, cloud platforms, data governance, KPIs, executive communications, and modernization initiatives. Serves as the primary technical liaison for CMS stakeholders, oversees personnel and subcontractors, drives operational improvements, and applies AI/ML-enabled optimization.

Leads business analysis and product ownership for CMS’s Unified Case Management system. Gathers requirements, defines scope, analyzes technical and business processes, supports data and reporting solutions, and participates in a SAFe scrum team. Drives process improvement, estimates deliverables, resolves complex issues, coordinates stakeholders, documents projects, manages customer expectations, and coaches less experienced professionals. The role is fully remote and supports investigative capabilities addressing healthcare fraud, waste, and abuse.

Administer AWS-hosted PostgreSQL databases, managing monitoring, backups, restores, snapshots, security, maintenance, and performance tuning. Support database migrations, releases, troubleshooting, and data quality remediation. Build Python and SQL data pipelines, automation, CDC and streaming workflows using AWS services and Kafka technologies. Enable near-real-time data movement to reporting platforms, data lakes, Snowflake, and Databricks while collaborating with application, DevOps, QA, analytics, and business teams.

Build and deploy AI/ML solutions from prototype through production for CMS, including generative AI, LLMs, RAG, intelligent classification, knowledge management, agentic frameworks, and enterprise integrations. Evaluate AI coding tools, establish AI/ML roadmaps, scale adoption, mentor data scientists, and translate technical concepts for stakeholders and leadership.