Top Remote Python Jobs in San Diego, CA

Lead design and hands-on delivery of cloud-first solutions on Microsoft Azure and related platforms. Translate stakeholder requirements into architecture patterns, document designs, mentor teams, build POCs, migrate legacy apps, and apply AI responsibly to improve delivery and quality.

Lead design, analysis, manufacturing, and testing of rocket propulsion hardware and PPMS from concept to flight. Produce CAD and P&IDs, perform fluid network and systems modeling, develop and execute test plans, collaborate with vehicle, test, vendors, and procurement to meet engine requirements.

Lead design, architecture, and delivery of enterprise web, mobile, backend and cloud solutions. Provide technical and people leadership across Agile teams, enforce engineering best practices (CI/CD, DevSecOps, observability), mentor engineers, manage delivery risks, and drive platform modernization and production readiness.

Design, build, and maintain automated validation suites across web, mainframe, API, desktop, file, and email workflows. Develop and enhance automation frameworks using Java/Python/JavaScript and tooling (Selenium, Playwright, Cypress, REST Assured). Integrate LLM/GenAI capabilities for test generation, failure analysis, and data creation. Validate banking and payments functionality; collaborate in Agile/Scrum teams and apply test architecture best practices.

Lead development and optimization of web scraping pipelines to extract, clean, and store large-scale web data. Handle dynamic content, pagination, distributed scraping, database design with NoSQL, deploy jobs to cloud, and monitor systems for reliability and data quality. Support ML-based data cleaning and categorization.

The Growth Engineer will architect growth systems, automate processes, design experiments, optimize funnels, and collaborate cross-functionally to enhance customer acquisition and ensure alignment with commercial goals.

Lead backend technical strategy and hands-on implementation to migrate on-prem systems to Azure, decompose a .NET monolith into service-based architecture, define data models and API contracts, ship customer-facing features with CI/CD and observability, and mentor engineers across the cross-functional Platform team.

Lead architectural strategy and modernization for large-scale distributed systems. Design modular, extensible services, migrate legacy monoliths to microservices, optimize AWS infrastructure and costs, document and visualize systems, facilitate cross-functional design, mentor engineering teams, and scout emerging technologies.

Lead design, build, and scale GridUnity's cloud SaaS platform. Own end-to-end features, mentor engineers, drive architecture, improve scalability, reliability, security, and data practices while collaborating with product teams.

Design, build, and operate core cloud-native infrastructure services for NVIDIA DGX Cloud. Develop scalable, secure microservices and automation for provisioning and lifecycle management, integrate internal and external platforms, and implement observability and security to ensure reliable, global production operations.

Design, develop, and optimize system software and firmware for SoC-based O-RAN infrastructure. Implement power-management policies (DVFS, clock/power gating, thermal control), analyze RU/DU workloads, build performance and power models, create measurement and test tooling, validate on simulation/emulation and silicon, and influence SoC and platform architectures for 5G/6G deployments.

Operate and improve brokerage platform reliability: on-call incident response, define SLIs/SLOs, enhance observability, deploy infrastructure via GitOps, and own PostgreSQL performance, migrations, HA/DR, and mentoring.

Work on a DevOps/SRE platform team to build and maintain Kubernetes clusters, IaC, CI/CD pipelines, identity management, monitoring, certificate lifecycle, and security compliance. Troubleshoot deployments, support on-call incidents, document runbooks/ADRs, mentor junior engineers, and contribute to strategic platform planning and automation to ensure a reliable, secure, and scalable cloud platform.

Engineer and maintain cloud-based application deployments as as-a-code (AaC) using CI/CD pipelines. Configure, deploy, and troubleshoot tools like TeamWork Cloud, Cameo, and Cassandra; integrate applications with workflow/ticketing systems; develop integration interfaces (Python, PowerShell, Groovy); implement IDAM solutions; build test plans and documentation; and use DevOps tooling (Ansible, Terraform, Jenkins, GitLab). Active TS/SCI with CI poly and DoDD 8140 Security+ CE required.

As an Automation QA Engineer, you'll design and implement test frameworks for Oracle projects, focusing on automation testing for APIs and web interfaces, collaborating with development teams to identify and resolve defects.

Design, build, and operate bidirectional integrations between the Quadrivia AI platform and major US EHRs and healthcare systems. Implement HL7v2 and FHIR R4 interfaces, operate integration engines (InterSystems IRIS or equivalents), ensure secure connectivity and compliance (HIPAA/SOC2/HITRUST), guarantee data integrity and patient matching, coordinate parallel integration teams, set standards, mentor engineers, and support customer security reviews and go-lives.

The role involves developing and maintaining Oracle HCM integrations, ensuring the accuracy and security of data flows, and mentoring junior developers.

The Senior Oracle Payroll Integrations Developer will design, develop, and maintain integrations across payroll systems, ensuring data integrity and compliance while optimizing performance and scalability.

Design, automate, deploy, and operate large-scale software-defined storage and Kubernetes platforms in a private cloud. Build IaC and GitOps workflows (Ansible, Terraform, Helm, Git), implement CI/CD for infra, manage backups, monitoring, and observability, troubleshoot cross-domain issues, participate in on-call/incident response, and produce runbooks and documentation.

Design, implement, and operate large-scale DNS and multi-tenant Kubernetes infrastructure in private cloud. Automate provisioning with IaC (Ansible, Terraform/Pulumi, Python), build CI/CD and GitOps pipelines, implement monitoring/alerting (Prometheus/Loki/Grafana), harden for HA and DR, perform deep troubleshooting across storage, hypervisors and networking, participate in on-call incident response, and collaborate on change management with global teams.

Operate and lead data-center LAN infrastructure in a 24/7 SaaS environment. Own troubleshooting, incident response, and change management across Cisco Nexus, Palo Alto, and F5 platforms. Drive projects, architecture (VXLAN/EVPN), automation (Ansible, Terraform, Python), observability (Prometheus, Grafana, SolarWinds), and cloud networking (AWS, GCP). Mentor junior engineers, participate in on-call rotation, and define operational standards, reliability metrics (SLI/SLO), and preventive engineering.

Lead modernization of internal platform tooling to 12-factor apps, delivering full-stack services (Go/Python + React/Vue), instrumenting observability (Grafana/Prometheus/Loki), driving Kubernetes-native GitOps (ArgoCD/GitLab CI), mentoring developers, and automating infrastructure with Ansible/Terraform on private/bare-metal clouds.

Architect, implement, and operate a multi-tenant OpenStack private cloud. Automate provisioning with Ansible/Terraform/Pulumi, extend core OpenStack services, build CI/CD update pipelines, implement monitoring/observability, harden for HA and DR, perform deep troubleshooting, and participate in on-call incident response and upstream contributions.

Lead architecture and technical strategy across an infrastructure platform ecosystem. Drive hands-on architectural improvements to graph engine and backend services, reduce technical debt, establish standards, champion AI-first engineering practices, run architecture/code reviews and mentorship, and collaborate with product and leadership to ensure scalable, extensible systems.

Design, build, and maintain full‑stack features across frontend (TypeScript + React) and backend (Python, Node.js, or JVM languages). Own end-to-end development, testing, CI, databases, and cloud/distributed systems. Mentor engineers, participate in code reviews and pair programming, and work in an agile, remote team.