Top Remote Python Jobs in San Diego, CA

Design, administer, and optimize databases for cloud-native platforms. Support production incidents, evaluate and improve schemas and replication, drive DB architecture choices across AWS/GCP, implement IaC (Terraform) and GitOps, and build repeatable database designs for availability, reliability, and performance.

Own and drive the architecture and roadmap of ClickUp's data platform. Build scalable, reliable data pipelines and AI/ML infrastructure using AWS serverless, Snowflake, dbt, and Terraform. Lead cross-team technical initiatives, optimize cloud costs, establish engineering standards (observability, testing, CI/CD), mentor senior engineers, and influence org-wide architecture decisions.

Build and maintain backend APIs and data pipelines that ingest and process large-scale construction data (360° video, schedules, IoT). Optimize storage and query performance using DuckDB and PostgreSQL, extend Airflow workflows, integrate Wasm for local computation, monitor data quality, and collaborate with frontend, CV, and ML teams to deploy production models and analytics.

Lead and coordinate high-severity production incidents for cloud-native services, drive root cause analysis and reliability improvements, own incident communications to stakeholders and customers, and mentor peers while maintaining incident playbooks and observability-driven diagnostics.

Lead design, implementation, and operation of Signifyd's GCP/Kubernetes cloud platform. Architect scalable, secure infrastructure, embed AI-driven automation, own SLOs and incident response, improve developer experience via CI/CD/GitOps tooling, mentor engineers, manage cloud capacity/FinOps, and build observability and security into the platform.

Own collaborative editing across React clients and Node services, including offline storage, queued mutations, realtime WebSocket synchronization, conflict resolution, and data persistence. Build agent-enabled editing experiences, investigate data-loss issues across environments, and collaborate with designers, backend engineers, and open-source contributors. The role requires production TypeScript experience across React and Node, rich-text editor frameworks, offline applications, WebSockets, and advanced Postgres skills.

Own end-to-end custom integrations for strategic customers, from technical discovery through production deployment. Build Python-based integrations against unfamiliar APIs and infrastructure, collaborate directly with customer engineers and stakeholders, diagnose issues remotely, and distinguish one-off requests from broader product gaps. The role requires independently delivering production code, communicating with both technical and executive audiences, and supporting deployments in cloud, self-hosted, regulated, and air-gapped environments.

Provide tier-2 technical support and administration for lottery platforms, troubleshoot availability and performance issues, support customer implementations, maintain monitoring and documentation, manage SLAs, and participate in 24x7 on-call rotation. Work primarily with Windows Server and SQL Server, plus some Ubuntu and Java/WildFly support.

Lead development of the production toolchain that compiles complex Python packages (e.g., NumPy, SciPy, PyTorch). Build and maintain build/release pipelines, create and review conda recipes, automate processes, mentor engineers, run incident response and postmortems, and advise leadership on technical tradeoffs. Partner with distribution and wheels teams and validate AI-assisted code where used.

Build and maintain internal developer platforms, tooling, and automation to improve engineering productivity. Implement AI-powered tooling and LLM/agent-driven workflows, create service catalogs and self-service infrastructure, partner with engineering teams to improve reliability, and reduce operational overhead through automation and improved developer experience.

Lead technical direction and architecture for a software team, write production code, mentor engineers through reviews and pairing, partner with product to align roadmap and technical plans, resolve technical risk and tech debt, and establish engineering standards and tooling.

Design, build, and scale embedded connectivity and security for distributed energy devices. Implement networking (Ethernet/Wi‑Fi/Thread/Zigbee/BLE), secure provisioning, OTA firmware pipelines, telemetry, and diagnostics. Support testing, certification, manufacturing validation, and cross-functional collaboration from prototype to deployment.

Design, build, and operate scalable, fault-tolerant distributed data infrastructure and platform tooling. Collaborate cross-functionally to architect high-impact systems, contribute to library and platform development, and improve deployment, control, and observability for large-scale data systems.

Design, build, and operate scalable, resilient distributed systems for Netflix's Open Connect CDN. Develop cloud services, steering algorithms, deployment automation, data pipelines, and operational tooling to optimize quality-of-experience, hardware utilization, and cost efficiency while enabling real-time adaptation and reliable production operations.

Design, build, and operate cloud-native, large-scale distributed data infrastructure (Spark, Presto/Trino, Druid, Iceberg). Improve performance, scalability, and reliability, collaborate cross-functionally, and contribute to open-source projects.

Design, build, and maintain tools and services for Active Directory and cloud identity platforms. Implement security policies and access controls, collaborate on Azure and Google Workspace deployments, automate integrations via APIs and CI/CD, maintain runbooks, participate in on-call rotation, and support AWS infrastructure for production systems.

Leads mission formulation and architecture for international space opportunities. Develops mission concepts, performs mission-level analyses, owns top-level budgets, defines requirements, evaluates spacecraft and constellation configurations, and guides engineering teams through design trade studies. Collaborates with customers, scientists, and engineering disciplines to create practical, cost-effective satellite missions. Requires regular international travel and occasional travel to the Mountain View facility.

Lead and grow a backend engineering team while staying hands-on: design and build Python/FastAPI services with Temporal and Postgres, own roadmap and delivery, set SLIs/SLOs, drive observability and reliability, run engineering rituals, hire and coach engineers, and improve quality with DevOps and AI tooling.

The Principal R&D Engineer will manage and participate in wireless technology projects, overseeing system design, development tasks, and team collaboration. Responsibilities include technical management, project leadership, and customer engagement, requiring advanced knowledge in wireless systems and communications.

Provide advanced application development, integration, and troubleshooting for DDC/BMS/BAS projects. Configure BACnet/Modbus gateways, develop control databases and interfaces, support commissioning and service teams, review portfolio standards, mentor junior engineers, and participate in customer technical meetings and project lifecycle documentation.

The Senior Full Stack Engineer will design and maintain features across backend and frontend systems, focusing on scalability and security while collaborating on production-grade solutions in a fast-paced environment.

The Production Engineer will design, build and maintain production infrastructure, ensuring reliability, observability, and automation while collaborating with engineering teams on distributed systems.

Lead design and scaling of a high-performance, data-intensive storage layer for network telemetry. Co-own multi-year roadmap, collaborate with product/support/sales, and solve challenging distributed storage and query-performance problems at large scale.

The Solution Architect will design and implement cloud-native solutions, collaborate on automation, and modernize applications while ensuring security compliance and delivering business insights.

The Platform Engineer will design and implement scalable compute infrastructure for autonomous vehicle simulation, utilizing cloud platforms and on-premises clusters, along with managing CI/CD pipelines and monitoring systems.