Top Remote Python Jobs in San Diego, CA

Leads photonic integrated circuit test software architecture, infrastructure improvements, test-station automation, and hardware-control software development. Oversees software migration across LabVIEW, Python, MATLAB, C#, and C++, while leading a small software team and mentoring engineers. The role supports electrical and optical testing of InP-based transceiver PICs at wafer, die, and subassembly levels, including vision systems, probe positioning, calibration, and test software revision control.

The Full-Stack Engineer will enhance backend functionality, collaborate with teams, and maintain platform performance and security, requiring expertise in Python.

Build and maintain scalable, internationalized React interfaces for a SaaS platform. Implement localization in front-end components, manage localization files, coordinate translation workflows, and validate localized builds across languages and regions. Partner with engineering, design, vendors, and localization teams to resolve UI and internationalization issues, support localization QA, and ensure release readiness. The role requires strong front-end development, localization engineering, testing, communication, and independent project management skills.

Deploy and operate cloud-native AI infrastructure across AWS, GCP, and Azure, including Kubernetes, networking, identity, security, multi-region, and data residency configurations. Build infrastructure as code, CI/CD, GitOps, observability, and alerting while supporting research, ML, and GPU platforms. Partner with clients and internal engineering and science teams on enterprise deployments, compliance, reliability, cost, and production hardening.

Lead a small Infrastructure and Agentic Platform team while serving as a hands-on engineering manager. Own AWS infrastructure, data platforms, security, compliance, reliability, and AI-native software development workflows. Mentor engineers, guide hiring, define the roadmap, and build tools for planning, coding, testing, monitoring, and triage. The role requires balancing AI acceleration with engineering quality, cost, security, and operational reliability in a healthcare AI environment.

Build and maintain scalable AWS infrastructure using Terraform and AWS CDK. Design highly available cloud environments, automate operational workflows with TypeScript, implement policy-as-code guardrails, optimize cloud costs, and lead disaster recovery planning and testing. The role also involves CI/CD, Kubernetes, networking, identity platforms, cross-team consensus building, project ownership, communication, and mentoring junior engineers.

Build Python backend services and data-intensive systems supporting member identity, eligibility, billing, partner integrations, reporting, and analytics. Design APIs, asynchronous workflows, and data pipelines; validate, reconcile, retry, replay, and recover inconsistent external data. Improve production reliability, observability, testing, and performance while collaborating with Engineering, Product, and Operations. The role offers growth toward independent ownership of services and technical decisions.

Leads production delivery of intelligent, full-stack solutions across data pipelines, APIs, applications, infrastructure, and ML systems. Acts as the primary technical client contact, translates architecture into delivery decisions, manages technical risk, and leads a cross-functional squad of engineers and data scientists. The role combines hands-on engineering with mentoring, code reviews, architecture, product scoping, and client-site implementation in regulated and critical-infrastructure environments.

Own developer productivity across a large monorepo and the path to production. Improve build, test, deployment, and coverage workflows; enable teams to ship safely and quickly; support multi-cloud and multi-region expansion; and strengthen operational excellence. The role requires delivering framework-level improvements across teams while contributing to backend feature code and working directly with customers on complex scaling challenges.

Operates and supports customer cloud environments across Azure, AWS, GCP, and OCI. Responsibilities include monitoring, incident and request response, provisioning, access management, maintenance, troubleshooting, governance, documentation, customer communication, and ITSM execution. The role also uses scripting, automation, monitoring, and DevOps/SRE practices to improve operational consistency. Participation in after-hours and weekend on-call support is required.

Build and maintain production software implementing healthcare interoperability standards, including FHIR and HL7. Develop APIs, services, data pipelines, validation logic, data models, and automated tests while preserving clinical meaning and data quality. Collaborate with engineers, data scientists, healthcare professionals, product managers, and operations staff to deliver scalable healthcare solutions.

Design, build, deploy, and operationalize Palantir Foundry solutions for defense and security customers. Develop data pipelines, ontology models, operator applications, integrations, and custom widgets using real-time intelligence. Debug infrastructure, networking, and application layers across cloud, hybrid, restricted, disconnected, and on-premises environments. Partner with customer stakeholders, advise technical teams, and own solutions end to end. Travel to secure customer sites and operations centers approximately 25–75% of the time.

Designs large-scale data platforms and distributed systems, develops automated data pipelines, establishes architecture standards, and improves platform scalability, resiliency, performance, and cost efficiency. Partners with engineering, product, security, cloud, and architecture teams to modernize workflows and establish governance, security, and observability practices. Leads architecture reviews, resolves technical decisions, mentors technical staff, and communicates strategy and risk to senior leadership.

Own end-to-end delivery of complex software features for a virtual care platform. Design scalable systems, build AI-powered agents and workflows, enhance reliable mobile and web experiences, and translate clinical and user needs into technical solutions. Collaborate with product managers, designers, and clinical staff while focusing on patient impact, product quality, and engineering efficiency.

Design and build Seeq’s internal platform, including infrastructure, services, multi-tenant Kubernetes clusters, system interfaces, and secure deployment capabilities. Improve scalability, reliability, software delivery, and infrastructure cost and performance. Lead migrations, integrate security practices, architect distributed systems, collaborate cross-functionally, and mentor engineers while remaining hands-on at Staff or Principal scope.

Build production-grade test automation infrastructure across API, integration, end-to-end, contract, regression, load, and performance testing. Develop Playwright suites, integrate automated tests with GitHub Actions release gates, create AI-assisted test generation workflows, maintain coverage dashboards, reduce flakiness, and establish performance-testing frameworks. Partner with engineers and product managers to define coverage, acceptance criteria, performance thresholds, and quality standards across the organization.

Leads high-fidelity CFD analysis for missiles, interceptors, munitions, and other high-speed vehicles. Establishes CFD standards, develops meshes and automated HPC workflows, validates simulations against wind tunnel and flight-test data, and integrates aerodynamic databases into vehicle design, GNC, trajectory, and mission models. Mentors engineers, presents findings at design reviews, supports resource planning, and provides technical leadership across complete vehicle programs.

Owns the health, performance, capacity, lifecycle, migration, replication, and incident response for Dell storage platforms across multiple client environments. Responsibilities include storage networking, performance tuning, firmware upgrades, support case management, automation, root cause analysis, change management, documentation, and client reporting. The engineer leads storage-impacting incidents, collaborates with virtualization and data protection teams, mentors junior engineers, and provides capacity and best-practice guidance.

Operates and maintains enterprise virtualization platforms across multiple client environments. Responsibilities include VMware Cloud Foundation, NSX, ESXi, vCenter, vSAN, capacity planning, performance troubleshooting, lifecycle management, incident leadership, automation, migrations, root cause analysis, change management, documentation, and client communication. The role also supports KVM and Hyper-V environments, leads virtualization projects, and mentors junior engineers.

Own the managed services tooling ecosystem, building API, webhook, and email integrations across RMM, monitoring, backup, and ITSM platforms. Configure Jira Service Management, reduce alert noise, troubleshoot tooling failures, establish integration standards, evaluate new tools, and ensure customer-specific rollouts. Produce operational reporting, explain tooling to customers, and maintain auditable documentation within ITIL-aligned change management processes.

Leads architecture and development of highly available, distributed backend systems supporting Airbnb’s AirCover insurance platform. Owns policy, coverage, enrollment, regional rules, experimentation, and scalable multi-region capabilities. Partners with product, data science, legal, and engineering teams; analyzes conversion data; ensures auditability, privacy, reliability, and data integrity; mentors engineers; and applies emerging technologies such as LLMs where beneficial.

Build and operate scalable cloud, data, and AI infrastructure across AWS, GCP, and Azure. Develop Infrastructure as Code, CI/CD pipelines, self-service platforms, and secure containerized environments. Establish observability, monitoring, alerting, governance, compliance, and operational support practices. Drive platform architecture and technical standards, collaborate across teams, evaluate new technologies, document solutions, and mentor engineers. The role is fully remote with up to 10% travel.

Lead the Client Platform organization responsible for container image builds, software supply chain security, and over-the-air updates across customer environments. Manage engineering managers and approximately 10 engineers, establish engineering culture, drive architecture decisions, operate secure CI/CD pipelines, and own distributed update systems. Partner with security research, product management, and customer success to deliver the client-side roadmap.

Lead architecture and reliability for a high-scale alerting platform. Design rule-based, ML-driven, and correlated detection systems; own Kafka-based event delivery, webhook reliability, idempotency, and sustained-load performance. Transform security and network telemetry into topology and dependency models that support LLM-assisted investigation and remediation. Provide cross-team technical leadership, mentor engineers, and guide long-term platform strategy across multiple alerting teams.

Lead and deliver BSP-level embedded software for communication, networking, and video applications. Develop device drivers, kernel configs, and Yocto/PetaLinux build flows; integrate and debug FPGA SoCs with hardware using schematics and lab instruments; set architecture and provide technical leadership, mentor teams, and work with customers. Remote with ~20% travel.