Top Remote Python Jobs in San Diego, CA

Design and implement functional GPU architecture models and simulation platforms. Develop tools, tests, and validation infrastructure, collaborate with architecture and engineering teams, and apply AI/ML to improve simulation and analysis workflows.

As a Senior Software Engineer, you will lead frontend development, define architecture, optimize performance, and collaborate across teams to create user-friendly logistics applications.

The Senior Product Engineer will design and build AI-driven, full-stack financial workflows, oversee architecture, and mentor engineers while ensuring high-quality, reliable systems.

Design, build, and own AWS infrastructure and automation for a 24/7 SaaS platform. Implement scalable, secure, highly available systems, partner with developers to improve reliability and performance, maintain critical infrastructure, build tooling and processes to reduce toil, participate in weekly on-call rotation and lead RCA and durable fixes.

Lead end-to-end platform engineering projects to build and operate a multi-tenant data lakehouse and scalable compute infrastructure, partner with cross-functional teams, improve reliability/observability, support platform users, and drive platform usability and ML/analytics enablement.

Conduct audits of AWS infrastructure and Python/Django applications, provide recommendations for scalability and security, and implement high-availability solutions.

The ERP Project Technical Lead manages and oversees the technical development team, ensures project scope is tracked, facilitates communication between functional and technical teams, and enforces development standards.

Lead technical initiatives and oversee product delivery, translating requirements into scalable software designs while collaborating with cross-functional teams.

The Senior Software Engineer will develop features, maintain quality, review code, and collaborate on product design for the EnrollWise platform, focusing on back-end and some front-end work.

Develop and enhance features for EnrollWise, contribute to a scalable software architecture, review code, collaborate on design and technical feasibility, and maintain software quality.

Lead design and implementation of the Libraries Platform: services, pipelines, and package index to build, verify, and serve secure reproducible libraries. Automate artifact creation, CVE remediation, SBOM/provenance generation, AI-assisted patching, and operate registry/mirroring, CI/CD integrations, reliability, observability, and incident response while mentoring engineers.

Senior engineer responsible for designing, building, and operating scalable data ingestion, processing, storage, and member-facing membership application. Drive architecture decisions, mentor engineers, build data pipelines, APIs, and ensure reliability, observability, CI/CD, and documentation while partnering with product and analytics stakeholders.

Design, build, and maintain Shopify POS applications and custom UI extensions. Integrate POS frontends with server-side logic and third-party services, test on POS hardware, troubleshoot live retail issues, and maintain observability, security, and CI/CD practices while collaborating with product and client teams.

Manage and evolve enterprise-scale API Gateway integration platforms, implement IAC and AWS-based infrastructure, ensure observability and reliability, mentor engineers, lead platform enhancements, drive SRE practices (SLOs/SLIs), perform debugging/testing, and produce operational documentation.

As an AWS Solution Architect, you'll design and implement Amazon Connect solutions, improve customer processes, lead technical teams, and educate clients on AWS value.

The Software Development Manager will lead a team to develop new products, oversee project management, and enhance software solutions while ensuring timely delivery and team performance.

As a Senior DevOps / Platform Reliability Engineer, you will manage CI/CD pipelines, automate infrastructure, operate Kubernetes, and enhance observability while ensuring security and compliance for enterprise systems.

The role involves evaluating techniques for fault-tolerant quantum computing, assessing hardware performance, and conducting documentation and reporting for DARPA's QBI team.

Lead architecture, delivery, and operation of large distributed telemetry databases. Define technical strategy, SLOs/SLIs, and reliability practices; drive performance, cost, and observability improvements; lead incident response and cross-team projects; mentor engineers; and represent engineering to stakeholders.

The Application Developer will design, develop, and maintain geospatial applications, focusing on user interfaces, workflows, and APIs for efficient geospatial data access and processing.

Build and operate the platform: manage EKS/Kubernetes, implement GitOps (ArgoCD), maintain CI/CD (GitHub Actions), define SLIs/SLOs, lead incident response/on-call and post-mortems, design observability (Datadog, Sentry, CloudWatch, Grafana), automate infra with IaC (Terraform/CloudFormation/Crossplane), write Python tooling, and shape platform architecture and self-service workflows.

Define the architectural foundation for processing unstructured data for LLM applications. Oversee the core platform's development and mentor engineering teams.

You will develop and maintain components of the LLVM based toolchain, collaborating with the community while ensuring platform-specific optimizations and tests.

Design, build, and operate distributed, data-intensive backend systems and pipelines. Own production data infrastructure (streaming, batch, analytical stores), debug production incidents, participate in on-call rotations, partner with product and frontend teams, write/review architecture and code, and improve observability, reliability, and deployment practices.

The Staff Engineer will build data-driven experimentation systems, lead statistical engine design, ensure correctness in A/B testing, and mentor team members while collaborating cross-functionally.