Top Remote Python Jobs in San Diego, CA

Design, build, and maintain cloud-hosted SaaS platforms and deployment artifacts. Own Helm charts, containers, IaC, CI/CD pipelines, and serverless components. Ensure scalable, secure Kubernetes/OpenShift deployments, monitor performance, troubleshoot production issues, and collaborate with platform, security, and infrastructure teams.

Create and maintain developer documentation, tutorials, API references, troubleshooting guides, and runnable examples for LanceDB. Build documentation designed for both developers and AI agents, validate AI-generated content, maintain documentation tooling, automate code and link checks, and collaborate with engineering, product, and open-source communities. The role requires strong Python skills, database and data workflow knowledge, technical writing expertise, and experience with Git-based development workflows.

Provides L2 technical support for a B2B SaaS platform by investigating escalated issues, reproducing problems, shipping bug fixes, and supporting L1 representatives. The role partners with Engineering, Product, Customer Success, and senior engineers, identifies recurring issues, improves visibility through metrics, documents findings, and writes knowledge-base content. The position works remotely on a 3 PM–11 PM ET weekday shift with alternating Saturday on-call coverage.

Design and develop physical layouts for silicon interposers used in NVIDIA products. Collaborate with package technical leads, signal integrity and technology engineers, and design teams to deliver package solutions. Conduct feasibility studies, floorplanning, custom layout, design-rule and netlist verification, and layout trade-off analysis. Resolve manufacturing, electrical, cost, and scheduling issues while using Cadence tools and verification flows such as DRC and LVS.

Own reliability, scalability, security, observability, and incident response for production applications across AWS and on-premises DoD environments. Build monitoring and alerting, define SLIs and SLOs, lead post-incident reviews, automate infrastructure with Terraform and Ansible, operate Kubernetes clusters, embed RMF and STIG controls, reduce operational toil, and support secure air-gapped deployments.

Designs and manages DevOps processes, automation, CI/CD pipelines, cloud environments, containerized infrastructure, observability, and release systems. Partners with development, QA, DataOps, architecture, support, and operations teams to improve reliability, security, scalability, and performance. Responsibilities include infrastructure provisioning, monitoring, troubleshooting, root-cause analysis, technical documentation, tool evaluation, production support, and continuous improvement.

Design and build backend services and APIs for identity resolution and platform integrations. Optimize event-driven pipelines processing billions of signals, deploy cloud-native services on AWS EKS and Kubernetes, and ensure reliability, observability, and scalability. Collaborate with engineering, product, and data teams to deliver identity solutions while mentoring junior engineers. The role requires expertise in backend or data engineering, distributed systems, streaming technologies, cloud deployment, data modeling, and high-throughput databases.

Own end-to-end full-stack product features using TypeScript, Node.js, React, Python, Kafka, and distributed systems. Design data models, backend services, event pipelines, interfaces, auditability, security controls, and AI agent experiences for a regulated fintech product. Operate production systems, collaborate with AI engineers, and help establish engineering practices on a small remote team.

Design and lead development of high-performance networking infrastructure for large-scale AI training and inference in Azure. Architect low-latency, low-jitter communication frameworks, optimize distributed systems, benchmark scalability, resolve complex networking issues, and improve reliability, observability, and performance. Mentor engineers, create technical designs, manage dependencies, and participate in on-call operations for critical services.

Build and deploy secure business automations and integrations across SaaS tools, internal systems, and APIs. Partner with stakeholders to identify high-impact workflow improvements, apply AI and agentic patterns where appropriate, and establish scalable engineering practices for documentation, testing, access controls, secrets management, logging, and maintenance. The role also helps shape automation infrastructure and team standards while collaborating with security and IT leadership.

Build and operate automation and tooling for large-scale NVIDIA GPU infrastructure. Responsibilities include bare-metal provisioning, hardware validation, firmware and software upgrades, cluster lifecycle management, BMC and Redfish integration, failure diagnosis, reliability engineering, incident response, and automated repair. The role works across hardware, networking, Linux, Kubernetes, data center operations, and partner teams to safely bring GPU capacity into production.

Manage BizTech production operations, including ticket queues, incident response, on-call troubleshooting, observability dashboards, and service-health reporting. Build automation and self-healing workflows using Python, Go, JavaScript, TypeScript, Bash, infrastructure-as-code, CI/CD, and AI-assisted tools. Develop LLM-powered triage, diagnostics, runbooks, and root-cause analysis to reduce recurring tickets and improve mean time to resolution. Partner with global stakeholders and support enterprise systems, data pipelines, monitoring, and identity integrations.

Own and improve Attentive's first-party data collection across the JS tag, Cloudflare Workers, and Java backend. Expand edge compute capabilities, build agentic AI systems to detect and fix data-quality issues, harden the event ingestion pipeline for reliability and observability, and lead technical direction on a small autonomous team while mentoring engineers.

Own Cresta’s web platform, CMS architecture, component system, analytics and GTM integrations, localization, SEO/AEO implementation, and engineering practices. Build tooling that enables marketers to work independently and develop, deploy, evaluate, and optimize AI agents for marketing use cases. Partner with brand, design, marketing operations, product, and engineering teams while providing technical leadership and owning projects end to end.

Early-career Software Engineer developing and maintaining Windows desktop fluid-flow simulation applications. Responsibilities span user interfaces, application logic, data models, integrations, testing, debugging, build automation, CI/CD, and modernization. The role involves collaboration with engineering, QA, product, and domain experts while contributing clean, maintainable code and participating in reviews, bug triage, and build pipeline rotations.

Own production operations and highly available cloud infrastructure for regulated government environments. Lead incident response, root-cause analysis, disaster recovery testing, compliance operationalization, audit readiness, vulnerability management, and continuous monitoring. Build automation, secure CI/CD pipelines, infrastructure-as-code, observability, and compliance tooling across Kubernetes, Linux, containers, and cloud platforms. Partner with security, compliance, and engineering teams to improve reliability, deployment safety, and regulatory sustainment.

Principal Engineer responsible for owning complex software initiatives from problem framing through architecture, implementation, deployment, production support, and continuous improvement. The role involves building web applications, services, APIs, MCP servers, data pipelines, and platform integrations; leading architecture and code reviews; improving security, reliability, and maintainability; mentoring engineers; and shaping technical strategy. The engineer will also use and improve AI-assisted development practices while maintaining human accountability for quality and operational outcomes.

Own backend and product delivery from scoping through production. Design customer-facing backend services, AI agent capabilities, APIs, data models, and system architecture for large unstructured datasets. Lead high-impact technical initiatives independently, maintain engineering quality, shape product direction with founders, and translate customer needs into dependable software. The role requires advanced Python, production-scale backend experience, system design expertise, and a product-minded approach.

Build scalable web applications, APIs, data pipelines, and data integrations for a cybersecurity platform. Responsibilities include architecting software for high-volume data environments, designing algorithms and data structures, optimizing storage and performance, maintaining coding standards, supporting analytics data systems, and collaborating across technical and non-technical teams throughout the product lifecycle.

Leads QA automation initiatives by developing and maintaining automated functional, regression, API, and integration test suites for Guidewire software and mobile applications. Improves CI/CD pipelines, performs root cause analysis, drives quality improvements, collaborates with developers and product owners, and mentors junior QA engineers.

Designs, develops, and deploys enterprise applications using Java, Spring Boot, microservices, REST APIs, cloud services, databases, DevOps tools, and Angular or React. The role also involves AI exposure with Python, LangChain, and LangGraph, along with application security, monitoring, performance, deployment, and collaboration with project teams. The position is onsite in McLean, Virginia.

Leads enterprise data integration strategy, tool selection, solution design, implementation, monitoring, and maintenance across on-premise and cloud systems. Collaborates with IT and business stakeholders to define integration requirements, ensure data integrity and governance compliance, troubleshoot issues, document architectures, and improve integration capabilities using APIs, middleware, ETL tools, databases, and cloud services.

Design, build, and optimize scalable backend services, APIs, and data pipelines. Integrate with third-party billing/commerce systems, maintain serverless/event-driven architectures on AWS, ensure security and performance, implement automated tests and CI/CD, mentor engineers, and drive architectural decisions.

Leads signal and power integrity for next-generation ASIC packaging, defining design rules, analyzing interposer, substrate, and PCB performance, and delivering high-volume package designs. Collaborates with layout teams, vendors, and system partners on advanced packaging and high-speed interfaces. Establishes design processes and tools, contributes to ASIC architecture reviews, mentors engineers, and drives technical improvements. Requires extensive high-speed ASIC tape-out, SerDes, SI/PI, electromagnetic analysis, and laboratory tool experience.

Build and maintain scalable backend systems and data pipelines for healthcare workflows. Collaborate cross-functionally to automate provider and patient workflows, prototype features, ship production-ready code, and ensure systems are maintainable and scalable.