Top Remote Python Jobs in San Diego, CA

Technical lead for public-facing gRPC APIs and SDKs powering provider search, ranking, and dynamic copay lookups. Own API design, versioning, ranking/steerage logic, and reliability at scale. Write and review code and designs, mentor engineers, drive technical direction, partner with product and partner engineering, and support production operations and scaling decisions.

Lead end-to-end delivery of 2-3 large SaaS customer implementations, triage cross-functional issues, build repeatable tooling and processes, mentor teammates, and feed implementation learnings into Product and Engineering while advancing AI-enabled workflows.

Lead and grow a DevOps team responsible for AWS/Azure infrastructure, CI/CD, reliability, observability, incident response, and FinOps. Set technical direction for IaC, pipelines, and service management while partnering with Product, Engineering, and Security and participating in on-call rotation.

Design, build, and maintain cross-platform mobile applications and end-to-end web features. Implement front-end interfaces, back-end services and RESTful APIs, optimize databases, write tests and documentation, perform code reviews, and collaborate with UX, QA, and DevOps to deliver high-quality, secure, and performant solutions.

Own architecture, development, and reliability of ecommerce web applications (Symfony storefront and Laravel back-office). Lead front-end JavaScript/CSS direction, optimize SQL schemas/queries, improve observability and incident response, reduce legacy technical debt, establish AI-assisted development workflows, mentor engineers, and drive end-to-end delivery of scalable customer-facing features.

Build and ship full‑stack product features on a Python/Flask backend and React frontend. Design REST/GraphQL APIs, work with SQLAlchemy and relational data models, integrate LLM/AI features, use async task queues (Celery), and collaborate with product, design, and engineers to deliver reliable, well-tested features end-to-end.

Design, build, and operate enterprise-scale multi-cloud infrastructure (primarily Azure, also AWS). Implement IaC (Terraform, ARM/Bicep, CloudFormation), CI/CD (GitHub Actions), monitoring, security/compliance, FinOps, automation scripting, and platform engineering to support reliability, performance, and AI/ML workloads.

The Lead Technology Engineer will lead IT systems implementation, ensure network security, manage integrations, and enhance operational efficiency through automation.

Design, build, and architect stablecoin and crypto infrastructure; integrate DEXs, DeFi protocols, and wallet providers; develop smart contract interactions; expand crypto product functionality and asset selection; collaborate cross-functionally; establish crypto development standards and ensure security and reliability for large-scale user experiences.

Lead backend development and operate services end-to-end: design, implement, deploy, monitor, and troubleshoot cloud-based back-end systems. Participate in on-call rotation, collaborate with frontend, CloudEng, and product teams, conduct code and security/privacy reviews, and mentor junior engineers.

Design, develop, test, and deploy features for the EverHealth platform. Troubleshoot and debug, review PRs, expand unit test coverage, participate in agile ceremonies, and maintain application performance and observability.

Lead modernization of internal platform tooling to 12-factor apps, delivering full-stack services (Go/Python + React/Vue), instrumenting observability (Grafana/Prometheus/Loki), driving Kubernetes-native GitOps (ArgoCD/GitLab CI), mentoring developers, and automating infrastructure with Ansible/Terraform on private/bare-metal clouds.

Own and administer the Redwood RunMyJobs platform, including scheduling, workflow orchestration, job dependencies, monitoring, troubleshooting, integrations, configuration, patching, and security. Develop automated batch workflows and support file transfers, APIs, CI/CD, cloud environments, and mainframe systems. Partner with architects, engineers, developers, and IT stakeholders to translate requirements into reliable automation solutions and improve operational processes.

Leads the design, development, testing, deployment, and maintenance of scalable full-stack web applications. Coordinates frontend and backend developers, translates requirements into technical plans, reviews code, mentors engineers, assigns tasks, monitors delivery, troubleshoots technical issues, and contributes to architecture decisions. Oversees APIs, databases, integrations, deployments, releases, security, performance, documentation, and application improvements while collaborating with product, design, and business teams.

The Software Quality Assurance Engineer will lead development activities, support feature completion, and drive non-functional requirements in a team focused on the 7750 Service Router.

The Prototype Engineer will integrate AI/ML capabilities into Higharc's products, develop tools for autonomous agents, and collaborate with research and product teams. Responsibilities include pushing prototypes to production and understanding homebuilding complexities.

Design, develop, and maintain scalable Python applications; collaborate with cross-functional teams to deliver features; ensure performance and quality; identify and fix bugs; maintain code quality and automation; lead and mentor team members using agile practices.

Lead design, implementation, and security of AWS cloud infrastructure and CI/CD automation. Drive cost optimization, observability, and IaC standards (Terraform/CDK). Mentor engineers, participate in on-call rotations, and collaborate with product and science teams to build scalable, reliable cloud-native systems.

Lead QA activities for government-facing web applications: design and execute manual and automated tests, develop test plans/cases, perform API and integration testing, manage defects, integrate tests into CI/CD, validate deployments, mentor junior QA, and collaborate with cross-functional teams to ensure high-quality releases.

Lead the technical vision and architecture for a domain, drive standards, run technical reviews, mentor engineers, plan and scope projects with product, build and ship code for hard problems, and evaluate AI tooling and production architecture to maintain reliable systems.

Build, enhance, and maintain backend services and REST APIs in Go; develop ETL pipelines in Python; design reliable PostgreSQL-backed APIs; use AWS services (S3, Lambda, Step Functions, Glue) for data processing; write well-tested, secure code; support operations and maintenance; participate in code reviews and cross-functional Agile collaboration.

Senior software engineer role to maintain and modernize CMS Hospital Quality Reporting systems using FHIR standards. Design and deliver medium-to-large features, automate CI/CD and testing, ensure compliance and data quality, integrate FHIR-based APIs and healthcare data formats, and reduce technical debt while collaborating with cross-functional teams and stakeholders.

Senior engineer responsible for maintaining and modernizing CMS Hospital Quality Reporting systems. Work includes designing and delivering features, FHIR-based API integration, test planning and automation, CI/CD and cloud deployments, performance and security testing, regulatory compliance, data validation, and cross-functional collaboration to improve healthcare quality reporting.

Lead and grow an engineering team building core VM and container platform capabilities for Azure. Drive technical strategy, execution, incident resolution, cross-team coordination, and scalable, secure platform innovations.

Designs and documents global LAN architectures for campus, engineering, warehouse, and manufacturing facilities. Tests and certifies Cisco network hardware, software, and firmware; provides advanced troubleshooting and installation support; develops SD-Access solutions; validates network resilience and failover; advises operations teams; and collaborates on network automation, monitoring, and infrastructure improvements.