Top Senior IT Jobs in Charleston, SC

Build and deploy AI/ML solutions from prototype through production for CMS, including generative AI, LLMs, RAG, intelligent classification, knowledge management, agentic frameworks, and enterprise integrations. Evaluate AI coding tools, establish AI/ML roadmaps, scale adoption, mentor data scientists, and translate technical concepts for stakeholders and leadership.

Designs, implements, maintains, and evaluates environmental databases for CMS Unified Case Management. Builds and maintains ETL pipelines using AWS, Snowflake, and PostgreSQL; implements automated data validation; automates reporting pipelines; creates dashboards, tables, plots, maps, and documentation. Performs data analysis, develops recommendations, follows project specifications, and presents findings to stakeholders while applying Agile practices.

Leads the IT Strategic Governance and Delivery Office, overseeing project portfolios aligned with business goals. Manages planning and delivery of multiple IT initiatives, governance, budgets, timelines, quality, stakeholder relationships, process improvement, KPIs, and operational agreements. Drives cross-functional collaboration, continuous improvement, and strategic change while managing, coaching, and developing a team of six.

Owns and leads Regulatory IT systems supporting Global Regulatory Affairs and R&D. Responsibilities include maintaining technology roadmaps, managing system enhancements and implementations, overseeing vendors and releases, providing production support, delivering integrations, conducting data mapping and validation, and ensuring GxP, HIPAA, GDPR, and CCPA compliance. The role serves as the primary IT partner for regulatory business units, manages budgets, and coordinates cross-functional teams delivering regulated technology initiatives.

Leads infrastructure engineering strategy, modernization, project delivery, automation, and operational readiness across hybrid AWS, Azure, on-premises, networking, identity, Microsoft 365, and endpoint platforms. Establishes engineering standards, architecture patterns, security and resilience practices, Infrastructure as Code, CI/CD, monitoring, documentation, and support handoffs. Manages infrastructure projects, vendors, budgets, risks, and executive communications while leading, coaching, and developing an infrastructure engineering team.

Leads and develops the internal IT helpdesk and systems administration team, shifting operations from reactive support to proactive service delivery. Owns IT roadmaps, cross-functional projects, vendor relationships, authentication and access standards, disaster recovery, security improvements, and process automation. Establishes measurable KPIs and audit-ready onboarding and offboarding workflows while improving documentation, service levels, workload visibility, and operational accountability.

The IT Business Analyst gathers and translates business requirements into technical solutions, partners with stakeholders and product owners, manages backlogs and roadmaps, and supports project delivery. The role creates requirements and UAT documentation, tracks software development, coordinates production issue resolution, and administers Genesys Cloud contact center capabilities including routing, IVR, queues, reporting, dialers, and workflows. It also identifies process improvements and serves as a subject matter expert across supported products and programs.

Coordinates data platform incident response, triage, escalation, root cause analysis, problem management, post-incident reviews, and operational improvements. Maintains runbooks, documentation, metrics, dashboards, and stakeholder communications. Implements and monitors security controls, supports security incident response, vulnerability remediation, compliance audits, regulatory reporting, disaster recovery exercises, and cross-functional coordination across data, cloud, infrastructure, DevSecOps, application, and governance teams.

Plans, executes, and reports on information systems control assessments for federal financial systems. Evaluates cybersecurity, access, change management, and segregation-of-duties controls across SAP and non-SAP enterprise applications. Applies FFMIA, GAO, FISCAM, Federal Audit Manual, OMB Circular, and federal accounting requirements. Produces working papers, summary reports, detailed findings, and actionable recommendations while supporting DoD/DLA programs.

Leads complex IT systems audit and audit advisory engagements for government clients. Applies accounting principles, auditing standards, Federal Acquisition Regulations, OMB guidance, and FISCAM requirements. Provides technical direction, manages client relationships, oversees project execution, and ensures high-quality, timely, and budget-compliant deliverables. Requires DoD/DLA experience, project management capability, relevant certification, and an IT-II Non-Critical Sensitive designation or Tier 3 background investigation.

Lead enterprise IT portfolio governance and prioritization while managing the PMO delivery portfolio for Fixed-Site imaging. Establish intake, steering committees, portfolio standards, resource planning, and executive reporting. Oversee concurrent healthcare IT programs involving RIS/PACS, patient portals, interoperability, infrastructure, and applications. Manage scope, budgets, schedules, risks, vendors, stakeholder communications, and Agile or traditional delivery methods across a matrixed organization.

Lead and grow a product support team for a live digital court reporting product (Maggie). Supervise analysts, triage and lead incident response for P0/P1 events, coordinate escalations to IT and engineering, run on-call rotations, develop runbooks/KB/training, track support metrics, provision hardware kits, and hire and train support staff.

Lead and coordinate IT and security audits across cloud infrastructure, application security, IAM, vendor risk, and blockchain products; shape audit roadmap; produce executive- and Board-level reports; drive remediation and validate corrective actions; partner with technology leaders and mentor audit staff.

Lead end-to-end IT and security audits across cloud infrastructure, application security, IAM, vendor risk, and blockchain products. Plan and execute fieldwork, produce evidence-based reports for senior leaders and the Audit Committee, mentor junior auditors, validate remediation, and partner with Engineering and Security to improve controls while maintaining audit independence.

Coordinates testing for Epic applications and integrated healthcare systems, including test planning, user acceptance testing, defect management, upgrades, implementations, documentation, and compliance. Provides tier-2 application support, resolves complex system issues, supports optimization and enhancements, collaborates with stakeholders and vendors, facilitates governance meetings, and mentors junior analysts. The role also requires advanced AI literacy, healthcare operations knowledge, and independent leadership across application support and delivery initiatives.

Designs, deploys, and configures secure enterprise integrations across cloud, on-premises, and hybrid environments. Develops Zero Trust architectures, integration strategies, APIs, middleware, identity and access workflows, and authentication protocols. Integrates identity providers, security tools, ITSM systems, data stores, and enterprise services while embedding security controls and supporting compliance audits. Troubleshoots complex integration issues, documents workflows and dependencies, and provides technical leadership for federal, intelligence, and defense customers.

Drive sales growth for LG IT solutions across the Central Region through consultative selling, territory planning, account development, and partner collaboration. Build enterprise and commercial customer relationships, manage opportunities from discovery through close, coordinate pricing and forecasting, maintain Salesforce pipeline data, and achieve revenue and sales objectives. The role involves executive engagement, customer presentations, trade shows, and approximately 70–75% regional travel.

Supports modernization of a mission-critical court case management system by eliciting and decomposing requirements, managing user stories and acceptance criteria, facilitating Agile collaboration, and supporting testing. Conducts process and workflow analysis, develops wireframes and process models, performs user research and usability testing, maintains technical documentation, and delivers briefings to technical and non-technical stakeholders.

Lead and execute demand generation strategy for internal IT buyers: build GTM playbook, run integrated inbound/outbound campaigns, own pipeline metrics and reporting, partner with Sales/Rev Ops/Marketing to drive pipeline and revenue.

Administer and secure DOE’s Oracle Fusion Middleware environment, serving as the primary SME for WebCenter, Enterprise Manager, OID/OAM, and SSL/TLS encryption. Responsibilities include installation, configuration, patching, tuning, monitoring, identity and access management, certificate lifecycle management, compliance with NIST and FedRAMP controls, audit support, remediation, and backup support for broader Oracle technologies. The role also requires collaboration with program managers, security teams, and product SMEs.

Plans, prepares, executes, automates, and closes testing for Oracle E-Business Suite applications. Creates test plans, data, cases, and scripts; performs functional, API, regression, load, performance, and end-to-end testing; validates databases with SQL; evaluates testing tools; tracks defects through closure; and conducts root-cause analysis. Collaborates with technical and functional teams in an Agile environment to improve quality and reduce errors.

Develop, enhance, test, deploy, and support clinical applications within the IHS RPMS system. Analyze requirements, translate designs into code, troubleshoot complex software issues, address accessibility and security considerations, support testing and documentation, provide customer support, and report on technical findings and project progress while collaborating with multidisciplinary teams.

Lead the design, development, modernization, and governance of enterprise customer-data applications and integrations. Manage operational data stores, system dependencies, IAM integrations, security, compliance, DevOps practices, deployments, and production support. Define target-state architectures, guide technology modernization, oversee vendor teams, troubleshoot critical issues, and communicate technical strategies across business and technology teams while mentoring junior engineers.

Own day-to-day cybersecurity, identity and access hygiene, compliance readiness, and infrastructure security across a multi-site healthcare environment. Administer Microsoft security tools, MFA, Conditional Access, SIEM, email protection, patching, backups, firewalls, and network controls. Lead SOC 2 evidence collection, security reporting, remediation tracking, third-party access reviews, and audit preparation. Direct and verify outsourced IT and offshore resources, enforce SLAs, supervise network work, and communicate risks to nontechnical leaders.

Leads global Workday platform strategy, governance, roadmap, delivery, and operational excellence. Manages Workday technical teams and offshore resources across HCM, talent, recruiting, payroll, integrations, reporting, security, and related modules. Partners with HR, Payroll, and Technology leaders to prioritize investments, oversee enhancements and transformations, manage vendors, budgets, contracts, and business cases, and ensure privacy, compliance, stability, and measurable business value.