Top Remote Python Jobs in San Diego, CA

Architect and refine scalable cloud infrastructure software for enterprise and internet-scale environments. Responsibilities include developing robust software, designing systems supporting 1,000+ nodes, optimizing performance, and collaborating with distributed technical teams in agile environments.

Develop, modernize, operate, and maintain mission-critical software for CNMOC. Responsibilities include architecture, coding, testing, debugging, ETL/ELT pipeline development, data integration, cloud and container operations, translating customer needs into user stories, sprint delivery, technical communication, and mentoring developers. The role also supports geospatial systems, databases, DevSecOps practices, Agile ceremonies, and customer issue escalation.

Advise enterprise customers on designing, securing, administering, and deploying Databricks environments on Microsoft Azure. Architect scalable cloud infrastructure, networking, identity, disaster recovery, observability, and infrastructure-as-code solutions. Support pre-sales activities through proof-of-concept architectures and technical content, while sharing expertise through training, tutorials, hackathons, conferences, and open-source contributions.

Lead a global network engineering team to design, scale, and operate large-scale IP and optical backbone and hybrid cloud connectivity. Own technical roadmap, cloud connectivity strategy, automation, vendor relationships, hardware/software integration, testing, tooling, DDoS mitigation, operational excellence, and participate in 24x7 on-call rotations while ensuring compliance in regulated environments.

Lead technical strategy and execution for a backend ledger team building highly available, audit-grade financial systems. Drive architecture, reliability, monitoring, on-call practices, code quality, cross-functional collaboration, and mentoring to ensure accurate, scalable ledger operations.

As a Billing & Analytics Software Engineer, you'll design and maintain the billing pipeline, integrate billing systems, and develop customer-facing analytics dashboards to support revenue recognition and operational observability.

Lead the development of healthcare applications and data systems, focusing on audience intelligence and compliance. Design scalable data pipelines, APIs, and reporting systems while ensuring high data quality and security in regulated environments.

Lead the entire engineering organization: set technical vision, architecture, and operating model; recruit and develop managers; own delivery, reliability, security (SOC 2), budgeting, and metrics; improve velocity while reducing technical debt; partner with product and execs to drive roadmap and org-scale decisions.

Design, build, and maintain Python backend services and internal APIs for high-traffic hosting platforms. Administer Linux production systems, optimize MySQL queries and schemas, troubleshoot incidents, and participate in on-call rotation. Collaborate with senior engineers and cross-functional teams to deliver tested features, modernize legacy Perl systems, and contribute to technical design decisions. Apply AI responsibly throughout development, debugging, testing, and code review.

Provides technical leadership for Bluehost’s large-scale hosting platform. Sets architecture standards, designs Python and MySQL backend systems on Linux, modernizes Perl and cPanel integrations, and drives reliability engineering practices. Leads complex incident root-cause analysis, establishes AI-augmented delivery standards, mentors senior engineers, and shapes multi-quarter technical roadmaps across the organization.

Lead backend architecture for large-scale cloud-native e-commerce, loyalty, identity, payment, and customer engagement platforms. Define scalable APIs, event-driven systems, microservices, integrations, data architectures, AWS infrastructure, observability, security, and resiliency standards. Guide modernization, governance, technical roadmaps, architecture reviews, and cross-functional delivery while mentoring engineering teams and aligning platforms with QSR digital ordering and omnichannel customer experiences.

Designs, develops, and supports enterprise automation solutions using Microsoft Power Platform, scripting, APIs, cloud services, and secure authentication. The role integrates cloud and on-premises systems, builds reusable workflows, monitors performance, resolves issues, documents solutions, and ensures governance and compliance. The engineer collaborates with infrastructure, security, application development, and business stakeholders to improve operational efficiency and service delivery.

Build and scale robotics simulation and sim-to-real workflows for NVIDIA partners. Develop solutions involving robot rigging, physics, rendering, sensor simulation, synthetic data, GPU computing, and learned policies. Lead technical evaluations, proofs of concept, workshops, and reference implementations; diagnose performance and integration issues; validate hybrid physics and neural approaches; and collaborate with research, engineering, product, and customers to guide platform adoption and roadmaps.

Own the architecture and development of critical backend and cloud platform domains. Design scalable, secure, multi-tenant distributed systems on AWS, including event-driven services, APIs, data models, and AI/ML infrastructure. Lead major initiatives from design through release, align cross-functional stakeholders, establish engineering standards, mentor engineers, and drive reliability, observability, security, and cost-efficiency improvements.

Build and own enterprise platform components end to end, integrating with customer infrastructure and self-managed Kubernetes environments. Develop observability, improve reliability and availability, debug distributed systems, address security vulnerabilities, and deliver production software for enterprise users. Collaborate with product and technical leads, mentor engineers, and maintain hands-on ownership across design, implementation, deployment, and production operations.

Develop and operate SpiceDB and AuthZed’s open-source authorization ecosystem. Design, implement, test, deploy, and optimize distributed systems involving databases, cloud infrastructure, query planning, scalability, reliability, and performance. Participate in production operations and on-call rotations, troubleshoot complex issues, collaborate with users and contributors, mentor engineers, and contribute to technical documentation and industry discussions.

Leads the architecture, reliability, scaling, and evolution of hybrid-cloud, data center, networking, and workplace infrastructure. Designs and implements complex systems, drives migrations and automation, improves monitoring and operational practices, participates in incident analysis, and provides technical direction across teams. The role remains hands-on while mentoring engineers, documenting systems, and establishing infrastructure standards. Core technologies include VMware, Cisco UCS, load balancers, Linux/Unix, networking, Infrastructure as Code, and Python.

Own Alkira’s global platform infrastructure, including Kubernetes clusters, CI/CD systems, shared databases and storage, service lifecycle, disaster recovery, Terraform modules, observability, and production tooling in Go or Python. Drive architectural decisions, cost reduction, reliability, security, and multi-team platform adoption while mentoring engineers and participating in on-call support.

Build core digital banking experiences for bank administrators and customers, including user flows, robust APIs, and third-party integrations. Design and implement scalable backend services using microservice architecture and domain-driven design. Write clean, documented, tested code with strong error handling, logging, and performance considerations. Contribute to system design, architectural decisions, code reviews, and technical guidance within an Agile Scrum environment.

Designs and commissions automated robotic, CNC, and tooling cells from concept through production handoff. Responsibilities include PLC, robot, HMI, motion-control, electrical-panel, industrial-network, machine-vision, sensor, and safety-device integration. The engineer performs floor commissioning, risk assessments, root-cause analysis, and customer run-offs while collaborating with manufacturing, tooling, software, and program-management teams. The role also mentors engineers and technicians and develops reusable controls libraries and standards.

Paid technology internship providing exposure to enterprise systems, data management, infrastructure, digital technologies, security, networking, web technologies, and business applications. Interns may contribute across areas including enterprise architecture, corporate systems, quality and vendor management, retirement services, wealth management, and employee benefits. The role seeks students with technical coursework, analytical ability, communication skills, collaboration, and eagerness to learn.

Architect and prototype scalable solutions for Twilio’s emerging technologies experimentation team. Lead AI, machine learning, and LLM-driven initiatives; guide technical direction; mentor engineers across the US and India; align prototypes with business goals; and ensure enterprise architecture, scalability, extensibility, and production readiness. The role requires extensive architecture or principal engineering experience, cloud expertise across AWS and Azure, full-stack development knowledge, database expertise, and strong technical leadership.

Modernize legacy SAS data-processing systems by translating logic into scalable, high-performance Python solutions. Build and optimize large-scale data pipelines using formats including SAS, Parquet, JSON, and SQL. Integrate PostgreSQL, implement parallel processing, automated testing, data validation, and quality assurance, and maintain well-documented code. Collaborate with IT specialists and stakeholders to validate requirements, troubleshoot issues, and deliver cloud-native modernization solutions.

Design, build, and operate scalable APIs and event-driven backend services using TypeScript, Node.js, Python, Kafka, and PostgreSQL. Develop infrastructure as code and CI/CD pipelines, troubleshoot production systems, and participate in on-call support. Provide technical leadership through architecture reviews, API and event standards, code reviews, mentoring, and cross-team guidance. Help improve engineering quality, reliability, scalability, development tooling, and adoption of AI-assisted development practices.

Develop and lead implementation of mathematical optimization models for supply chain applications. Investigate heuristics and optimization techniques, translate real-world problems into software, and design comprehensive testing strategies. Build robust C++ software, automated functional, regression, and performance tests, and collaborate with agile teams. Apply AI and other tools to accelerate development while maintaining architectural consistency, security, and code quality. Review AI-generated code for correctness, integration risks, and edge cases.