Top Remote Python Jobs in San Diego, CA

Own the reliability, availability, security, and observability of Tradeweb’s global AWS platform. Responsibilities include infrastructure-as-code automation, monitoring, SLO development, incident triage and resolution, performance analysis, architecture collaboration, and regular on-call support. The role requires cloud-native engineering, scripting, networking, Linux/Unix, security, and reliability expertise while contributing to an Agile engineering organization.

Own and improve Glydways’ Bazel monorepo infrastructure across C++, Python, and Go. Responsibilities include implementing remote caching and remote build execution, optimizing build and test performance, maintaining toolchains and dependencies, supporting embedded cross-compilation, improving CI/CD workflows with AWS and Buildkite, developing developer automation, monitoring build health, and participating in on-call support.

Build and maintain responsive web, PWA, and mobile app experiences; design secure APIs and third-party integrations; develop conversational AI and voice bots; implement targeted messaging, ad-tech, analytics, and A/B testing; and optimize performance, reliability, and uptime. The role requires full-stack development, marketing technology integration, cloud and DevOps fundamentals, and collaboration in a fast-paced startup environment.

Owns production reliability for a B2B SaaS platform, including SLOs, error budgets, observability, alerting, incident response, recovery exercises, performance and capacity engineering, load testing, disaster recovery, and production readiness. The role writes automation and production code, leads incidents, coaches engineering teams, and improves reliability across Kubernetes, Azure, databases, messaging, and service infrastructure.

Build and maintain full-stack features for Suwali, translating broad goals into practical plans and delivering work from exploration through deployment and follow-up. Collaborate with technical and non-technical colleagues, assess user feedback and data, communicate progress clearly, and contribute to product decisions. The role requires production engineering across frontend and backend systems, with potential future responsibility for managing and mentoring engineers.

Build full-stack applications for an AI-driven pipeline risk platform. Primary responsibilities include developing TypeScript and React interfaces, building TypeScript and Python APIs, designing asynchronous analytical workflows, integrating Databricks and Azure services, and enabling customer model deployment. The role also covers testing, security, performance optimization, database development, CI/CD, accessibility, API documentation, and collaboration with design, data science, product, QA, and engineering teams.

Develop and enhance the LEXSO security operations platform across frontend and backend systems. Build microservices, REST APIs, Kafka consumers, React interfaces, real-time visualizations, and integrations for cameras, sensors, drones, and other devices. Contribute to architecture, data modeling, CI/CD, testing, debugging, optimization, and Agile delivery while collaborating with distributed systems and automation specialists.

Own and re-architect Filevine’s end-to-end CI/CD systems across .NET, Python, and Svelte. Build internal developer tooling, improve testing and feedback cycles, enhance local development and onboarding, instrument DORA delivery metrics, and introduce AI-assisted development practices. The role includes infrastructure-as-code, containerization, mentorship, cross-team process improvement, and on-call ownership for delivered systems.

Own production reliability and infrastructure operations for the GrayKey cloud platform. Responsibilities include AWS monitoring, incident response, vulnerability remediation, networking, IAM and Okta administration, EKS and Argo CD operations, backups, recovery testing, Terraform changes, cost optimization, automation, documentation, and compliance support. The role requires independent work during Pacific and Mountain time-zone hours and involves less than 5% travel.

Build and maintain full-stack software using TypeScript, Go, and Python, including backend, frontend, and architectural development. Collaborate with developers, designers, product managers, and Department of Defense stakeholders to develop AI-powered solutions, take products from concept to launch, conduct code reviews, and support customers through travel when needed.

Develop, test, and ship features for patient-facing applications, booking systems, clinical operations tools, and internal platforms. Collaborate with senior engineers on implementation, code reviews, debugging, troubleshooting, and automation for scheduling and patient engagement workflows. Build foundational experience with mobile applications, healthcare data systems, APIs, databases, version control, and production software while contributing to a collaborative engineering team.

Design, build, and maintain scalable applications, APIs, mobile platforms, booking systems, clinical integrations, and healthcare data systems. Own features end to end, make architectural decisions, improve security and reliability, and contribute to cloud deployment, CI/CD, monitoring, and DevOps. Collaborate with clinical, operations, and patient experience teams to deliver secure digital tools that improve patient care and clinic efficiency.

Develop and optimize Firefox performance across Windows, Android, Linux, and macOS. Write code, tests, prototypes, and tooling; profile and diagnose bottlenecks; improve benchmarks; and lead performance initiatives. Collaborate across engineering teams, educate developers, drive projects to completion, own browser performance areas, and contribute to the team’s technical roadmap.

Build and ship customer-facing transaction features end to end, including APIs, data models, pipelines, integrations, and user interfaces. Collaborate with product and design teams, contribute high-quality code, drive technical discussions, identify risks, and deliver production systems using a modern Python stack.

Leads enterprise solution architecture across applications, infrastructure, data, integrations, and processes. Defines technology blueprints, architecture roadmaps, modernization strategies, governance standards, and transformation plans. Partners with executives, business leaders, product owners, and engineering teams to align technology investments with business objectives. Evaluates emerging technologies and vendors, guides complex programs, manages technical debt, develops business cases, and mentors architects while promoting architecture excellence.

Build and deliver AI-powered healthcare products using React, Node.js, Python, and modern full-stack technologies. Partner with customers, designers, researchers, and product teams to understand workflow needs, design intuitive AI experiences, and own features from ideation through deployment, optimization, and scaling. The role requires strong product instincts, end-to-end software engineering ownership, and experience building production-grade applications.

Build and operate scalable data pipelines, backend services, APIs, and infrastructure powering AI-driven healthcare applications. Design distributed data systems, ETL workflows, streaming platforms, and cloud-native architectures while partnering with AI, machine learning, and product teams. Own production reliability, observability, security, automation, and on-call support for business-critical systems.

Build and maintain large-scale healthcare data platform software using HL7/FHIR, Apache Spark, Python, Scala, Databricks, and cloud technologies. Shape technical roadmaps, architecture, and implementation approaches; collaborate with product and business stakeholders; maintain CI/CD and staging environments; and mentor junior engineers. The role requires deep healthcare data expertise, technical leadership, and experience with modern software engineering and integration practices.

Leads a team responsible for simulation-based verification and validation of autonomous trucks. Defines V&V strategy, scenario coverage, test campaigns, toolchain requirements, and safety-case evidence aligned with automotive standards. Partners with product, systems, safety, engineering, tools teams, and vendors to establish release criteria, identify testing gaps, analyze results, and report risks and progress to leadership. The role also involves team development, simulation scenario management, and advancing autonomous vehicle validation practices.

Build and maintain full-stack software supporting patient-centered healthcare products. Contribute to architecture, technical standards, code reviews, design discussions, and reliable implementation. Collaborate with product managers, designers, and stakeholders, while advocating for privacy, security, and access to care. Mentor engineers, document knowledge, identify technical improvements, and help shape project direction. The role requires backend, database, cloud, and AI development-tool experience in a fully remote environment.

Leads a team of 4–6 senior network engineers while providing hands-on support for complex customer environments. Oversees daily operations, escalations, incident and major incident management, root cause analysis, preventive measures, performance reviews, on-call scheduling, and workload distribution. Troubleshoots and optimizes Cisco, Nexus, Meraki, Palo Alto, Check Point, F5, and SAN technologies, while supporting monitoring, automation, patching, firmware updates, and hardware lifecycle management.

Owns Site Reliability Engineering for a customer-facing SaaS platform across Azure and Azure Government. Responsibilities include monitoring and observability, incident response, root cause analysis, reliability improvements, automation, infrastructure as code, CI/CD, performance optimization, disaster recovery, and operational security. The engineer will define and track SLIs, SLOs, and error budgets, lead post-incident reviews, reduce operational toil, and collaborate with development teams on scalable, reliable platform operations.

Own the architecture, performance, reliability, and technical direction of high-traffic backend services and public APIs supporting search, browse, autocomplete, and recommendations. Lead distributed-systems design, mentor engineers, drive cross-team projects, participate in on-call and incident response, and balance scalability, latency, cost, and API compatibility.

Build full-stack software, backend services, APIs, frontend experiences, and shared integration capabilities supporting AI initiatives across Keeper’s products. Integrate LLMs, agents, and tool-calling workflows into secure production environments while maintaining zero-knowledge principles. Troubleshoot cross-product systems, improve reliability and observability, contribute to architecture and code reviews, automate testing and CI/CD, and collaborate with AI, product, and engineering teams.

Design, develop, test, and maintain scalable platform software and services. Collaborate with architecture and cross-functional teams, implement platform features, participate in code reviews, document technical specifications, troubleshoot issues, and optimize performance and scalability. The role requires Go development, scripting, Kubernetes, cloud-native technologies, containerization, cloud networking, and CI/CD experience.