Top Senior Software Engineer Jobs in Louisville, KY

One Month AgoSaved
Remote
Louisville, KY
205K-316K Annually
Senior level
205K-316K Annually
Senior level
Artificial Intelligence • Enterprise Web • Software • Design • Generative AI
Lead the technical vision and architecture for backend systems supporting experimentation, personalization, analytics, and conversion optimization. Design and operate high-throughput distributed systems and APIs, build data infrastructure, and productionize AI/ML capabilities. Drive complex multi-team initiatives, influence engineering strategy, establish technical standards and operational excellence, and mentor senior engineers. Partner with product, data science, ML, and engineering teams to translate business needs into scalable solutions.
Top Skills: Ai/MlAPIsDistributed SystemsGoJavaPythonReal-Time Data Infrastructure
16 Days AgoSaved
Remote
Louisville, KY
156K-224K Annually
Senior level
156K-224K Annually
Senior level
Healthtech
Designs and delivers complex cross-system integrations, APIs, automation workflows, and reusable engineering solutions. Diagnoses root causes, improves reliability, documents risks and runbooks, participates in on-call support, and partners with commercial, product, and engineering stakeholders. The role also mentors engineers and non-engineers, guides technical trade-offs, scopes ambiguous problems, and delivers measurable operational improvements.
Top Skills: APIsN8NPostgresReactRuby On RailsTinesVue
16 Days AgoSaved
Remote
Louisville, KY
175K-225K Annually
Senior level
175K-225K Annually
Senior level
AdTech • eCommerce • Marketing Tech
Owns Shopify checkout and post-purchase extensions, experimentation reporting, and revenue-critical APIs across PHP, TypeScript, MySQL, BigQuery, and Google Cloud. Designs secure REST services, investigates production issues, participates in on-call, and maintains unit and end-to-end testing without a separate QA handoff. The role requires Staff-level technical ownership, system-wide architectural judgment, AI-assisted development, mentoring, and collaboration in a remote, high-autonomy environment.
Top Skills: AngularjsAnthropic Claude CodeBigQueryBitbucketBunCloud SqlCodeigniter 4ConfluenceFigmaGitGkeGCPGraphQLJIRAMySQLNext.JsOwasp Top 10Php 8PreactReactRedisRest ApisRustSentryShopify Checkout ExtensibilityShopify Ui ExtensionsSlackTypescriptUnleashVueWebassembly
16 Days AgoSaved
Remote
Louisville, KY
Senior level
Senior level
Software
Design and develop Rust and Go control-plane microservices, Kubernetes operators, reconciliation engines, and APIs for bare-metal AI infrastructure. Integrate datacenter networking systems, DPUs, network operating systems, and hardware-management platforms. Build observability with OpenTelemetry, troubleshoot distributed systems, and maintain rigorous testing practices. The role requires expertise in datacenter networking protocols, Linux networking, Kubernetes, provisioning, security, virtualization, and high-performance interconnects, along with architectural documentation and open-source collaboration.
Top Skills: AxumBgpBiosBluefield DpuCalicoCiliumController-RuntimeCumulus LinuxDpdkDpfEvpnGoGrpcHost-Based NetworkingInfinibandInitramfsIpmiIpxeJwtKeycloakKmsKube-RsKubernetesKubernetes OperatorsKubevirtKvmL3VniLinuxLinux NetlinkMp-BgpNmx-MNvidia DocaNvlinkNvueOauth2OpentelemetryOvsPkiPostgresProtobufPxeRbacRedfishRestRocev2RustSecure BootSonicSpiffe/SvidSQLSqlxSystemdTlsTokioTonicTpmUefiVaultVxlanX.509
Reposted One Month AgoSaved
Remote
Louisville, KY
160K-190K Annually
Senior level
160K-190K Annually
Senior level
Artificial Intelligence • Cloud • Healthtech • Software
Join Archy as a Senior Platform Software Engineer to enhance dental practice management through a scalable SaaS solution, focusing on cloud infrastructure, CI/CD pipelines, and AI integration.
Top Skills: AWSAzureDockerGCPJava Spring BootKubernetes
One Month AgoSaved
Remote
Louisville, KY
Senior level
Senior level
Biotech
Leads the Bioinformatics Software Engineering team and owns engineering strategy, architecture, delivery, modernization, and production support for clinical genomics platforms. Oversees software engineers, bioinformatics workflows, data integration, automation, quality systems, release governance, reliability, and regulatory compliance. Partners with clinical, laboratory, scientific, quality, product, operations, and executive stakeholders to convert research methods into validated production workflows. Guides AI-enabled engineering initiatives while ensuring privacy, traceability, clinical-grade quality, and operational resilience.
Top Skills: Agentic AiAPIsCi/CdCloud PlatformsContainerizationData LakesData WarehousesDatabasesDockerGitHpcKubernetesLarge Language ModelsLinuxMicroservicesMonitoring And Observability ToolsNextflowWorkflow Orchestration
Reposted One Month AgoSaved
Easy Apply
Remote or Hybrid
Louisville, KY
Easy Apply
162K-290K Annually
Senior level
162K-290K Annually
Senior level
Artificial Intelligence • Cloud • Computer Vision • Hardware • Internet of Things • Software
The Staff Software Engineer will shape technical direction, build developer platforms, and design AI agents, enhancing developer productivity and collaboration across teams.
Top Skills: Ai Coding ToolsCi/CdGoPythonTypescript
Reposted One Month AgoSaved
Remote
Louisville, KY
Senior level
Senior level
Artificial Intelligence • Machine Learning • Software • Defense
As a Senior Software Engineer, you will design and build a cutting-edge identity search platform and implement AI systems for defense applications, working closely with cross-functional teams to enhance user workflows and support national security.
Top Skills: AWSElasticsearchNode.jsOpensearchPostgresReactTailwindTypescript
Reposted One Month AgoSaved
Easy Apply
Remote
Louisville, KY
Easy Apply
200K-275K Annually
Senior level
200K-275K Annually
Senior level
Big Data • Fintech • Mobile • Payments • Financial Services
The Staff Software Engineer will lead technical strategy, ensure system availability, and develop backend systems at scale, collaborating across teams to drive capacity modeling and operational quality.
Top Skills: AuroradbAWSDynamoDBElasticcacheKotlinKubernetesMySQLPythonSpark
Reposted One Month AgoSaved
Remote or Hybrid
Louisville, KY
185K-185K Annually
Senior level
185K-185K Annually
Senior level
eCommerce • Legal Tech • Professional Services • Software • Data Privacy
As a Senior Software Engineer, you will design and maintain systems, mentor team members, and improve both code quality and team practices.
Top Skills: ActiverecordAngularAWSCloudwatchEc2EcsElasticsearchJavaScriptRdsReactRubyRuby On RailsS3SequelSQLVpcVue
16 Days AgoSaved
Remote
Louisville, KY
160K-200K Annually
Senior level
160K-200K Annually
Senior level
Fintech • Software
Lead development and reliability of real-time and batch payment-processing systems across authorization, clearing, settlement, disputes, and card-network integrations. Build scalable, secure, low-latency services using Java, Python, Kotlin, and AWS; improve network peering infrastructure, failover, and capacity. Own initiatives from planning through launch, participate in on-call rotations, reduce technical debt, and drive cross-functional engineering improvements and strategic planning.
Top Skills: American ExpressAWSJavaKotlinMastercardPythonVisa
16 Days AgoSaved
In-Office or Remote
Louisville, KY
185K-225K Annually
Senior level
185K-225K Annually
Senior level
Information Technology • Logistics
Own and develop Curri’s React Native driver applications across iOS and Android. Lead mobile features from problem definition through deployment and measurement, build offline-first capabilities, background geolocation, and push notifications, and debug native modules and production issues. Collaborate directly with drivers, operations, Product, and Design while contributing to full-stack work and AI-assisted development.
Top Skills: AndroidiOSJavaScriptReact NativeTypescript
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17 Days AgoSaved
Remote
Louisville, KY
80K-128K Annually
Senior level
80K-128K Annually
Senior level
Aerospace • Information Technology • Security • Cybersecurity • Defense
Lead architecture updates and REST API integration for a federal environmental consultation platform. Implement cloud data integration, species display functionality, consultation logic, interoperability fixes, demo environment support, production deployments, and operational documentation. The role requires backend development, federal application integration, accessibility compliance, Git-based development, FedRAMP deployment knowledge, and the ability to obtain Public Trust clearance.
Top Skills: DatabricksFedrampGitJavaPostmanPythonRest ApisSection 508SoapuiWcag 2.0
17 Days AgoSaved
Remote
Louisville, KY
80K-128K Annually
Senior level
80K-128K Annually
Senior level
Aerospace • Information Technology • Security • Cybersecurity • Defense
Lead development of decision logic engines and regulatory consultation workflows for a federal Endangered Species Act platform. Implement species routing, agency-specific templates, REST integrations, testing, defect resolution, documentation, and approved updates. Maintain code review and version-control standards while supporting government acceptance and production feedback.
Top Skills: AWSDatabricksDelta LakeJavaPythonRest ApisVersion Control Systems
17 Days AgoSaved
Remote
Louisville, KY
140K-227K Annually
Senior level
140K-227K Annually
Senior level
Enterprise Web • Greentech • Information Technology • Software • Energy
Build and maintain backend computation engines for solar and electrical design. Develop simulation and optimization systems for PV and battery storage layouts, component selection, and electrical configuration. Translate physical models into reliable, scalable software, shape computation infrastructure, write tested code, mentor teammates, collaborate cross-functionally, and own services through production and on-call support.
Top Skills: APIsBatch ProcessingC++Cloud-Native Compute InfrastructureData PipelinesDistributed ProcessingMicroservicesOptimizationPythonRubySimulation
Reposted One Month AgoSaved
In-Office or Remote
Louisville, KY
Senior level
Senior level
Biotech • Consulting • Agriculture
Modernize and maintain a large-scale React Native mobile app with offline-first architecture, BLE device integrations, data synchronization, and performance improvements. Influence architecture, mentor developers, collaborate across teams, and occasionally visit customer farms to understand workflows.
Top Skills: AndroidBluetooth Low Energy (Ble)Ci/CdGitGitflowiOSJIRAReact Native
Reposted One Month AgoSaved
Remote
Louisville, KY
388K-558K Annually
Senior level
388K-558K Annually
Senior level
News + Entertainment
Build full-stack features and infrastructure analytics products to improve Netflix's cloud and AI efficiency. Design frontends (React/TypeScript), backend services/APIs (GraphQL/Node), shape data models, collaborate with analytics and data engineers, and own product direction from design through implementation.
Top Skills: GraphQLNode.jsReactSQLTypescript
Reposted One Month AgoSaved
Remote
Louisville, KY
Senior level
Senior level
Food
Modernize and evolve a large-scale React Native mobile app with offline-first architecture, BLE device integrations, local data storage and sync. Improve performance, reliability, and scalability, influence architecture, mentor developers, collaborate cross-functionally, and occasionally visit farms to understand user workflows.
Top Skills: AndroidBluetooth Low Energy (Ble)Ci/CdGitGitflowiOSJIRALocal DatabasesMobile SynchronizationOffline-First ArchitectureReact Native
17 Days AgoSaved
Remote
Louisville, KY
Senior level
Senior level
Healthtech
Designs and maintains Java and Spring Boot microservices for a secure, cloud-native foundation platform. Builds authentication and identity integrations using SAML, OAuth 2.0, OIDC, JWT, and RBAC; develops AWS infrastructure and resilient distributed systems; supports CI/CD, production operations, and on-call response. Provides technical leadership through architecture, code reviews, mentoring, and cross-functional collaboration while maintaining compliance with confidentiality, HIPAA, and regulatory requirements.
Top Skills: Api GatewayAWSAws CloudformationAws LambdaAws Secrets ManagerCi/CdCircuit BreakersDatadogEcsGitHipaaJavaJwtMicroservicesOauth 2.0OidcRbacSAMLSnsSpring BootSqs
17 Days AgoSaved
In-Office or Remote
Louisville, KY
105K-260K Annually
Senior level
105K-260K Annually
Senior level
Artificial Intelligence • Information Technology • Software
Own HUD’s production infrastructure and backend platform systems, focusing on reliability, scalability, performance, cost, deployment safety, and developer experience. Build AWS infrastructure with Terraform and Kubernetes, improve CI/CD and observability, design resilient services and asynchronous systems, manage incidents, and develop internal automation and tooling. The role supports high-availability AI, marketplace, and data-heavy workloads.
Top Skills: Amazon Ec2Amazon EcrAmazon EksAmazon S3AWSAws CodebuildAws IamCi/CdDockerHelmKubernetesLoad BalancersNetworkingObservabilitySecrets ManagementTerraform
17 Days AgoSaved
Remote
Louisville, KY
Senior level
Senior level
Healthtech • Telehealth
Develop and launch scalable web and mobile healthcare applications, APIs, integrations, and cloud infrastructure. Contribute to the technical roadmap, observability, security, compliance, and AI/ML infrastructure. Partner with the founding team and data science leadership to incorporate LLMs, support HIPAA and SOC 2 requirements, and build reliable products for patients and enterprise healthcare customers.
Top Skills: Ai/MlAmazon AwsArqAws LambdaDockerFastapiGitGCPGoogle Cloud FunctionsLlmsNumpyPostgresPythonReactReact NativeRedisScipy
17 Days AgoSaved
Remote
Louisville, KY
156K-208K Annually
Senior level
156K-208K Annually
Senior level
Marketing Tech • Software
Leads development of scalable backend systems and applications for the Mindbody ecosystem. Responsibilities include designing APIs and microservices, owning complex technical projects, collaborating with Product, Design, and QA, promoting engineering best practices, mentoring engineers, conducting code reviews and interviews, and leading incident postmortems. The role requires strong software architecture experience, large-scale SaaS development, cloud and database expertise, and effective cross-functional leadership.
Top Skills: .NetAWSC#Ci/CdClaude CodeCodexCursorDynamoDBJavaJavaScriptKibanaKotlinMcpsMicroservicesMongoDBNew RelicPostgresPythonReactRedisRubySQL
17 Days AgoSaved
Remote
Louisville, KY
80K-128K Annually
Senior level
80K-128K Annually
Senior level
Aerospace • Information Technology • Security • Cybersecurity • Defense
Senior Software Engineer responsible for compliance validation, defect remediation, production migration support, monitoring, and operational documentation for a federal ESA Section 7 data integration platform. The role validates decision logic and consultation routing, develops migration runbooks and rollback procedures, resolves critical application defects, supports post-deployment operations, incorporates user feedback, and enforces code review and version control practices.
Top Skills: AWSDatabricksDelta LakeJavaPythonRest Apis
Reposted 17 Days AgoSaved
In-Office or Remote
Louisville, KY
143K-304K Annually
Senior level
143K-304K Annually
Senior level
Software • Quantum Computing • Metaverse • Infrastructure as a Service (IaaS)
Lead design and build of production-ready cloud and AI systems, prioritize security and reliability, ship solutions quickly using modern engineering practices, collaborate with cross-functional teams, mentor engineers, drive customer adoption, and deliver reusable assets and end-to-end complex deliveries.
Top Skills: Automated TestingAzure MlCC#C++Ci/CdJavaJavaScriptLlmsObservabilityOpenaiPrompt EngineeringPythonRetrieval-Augmented Generation (Rag)
One Month AgoSaved
Easy Apply
Remote
Louisville, KY
Easy Apply
186K-219K Annually
Senior level
186K-219K Annually
Senior level
Artificial Intelligence • Blockchain • Fintech • Financial Services • Cryptocurrency • NFT • Web3
Design, build, and scale highly available backend and frontend systems powering Coinbase trading experiences for millions of users. Architect extensible support for multiple trading types and assets, evolve critical production infrastructure, partner with product and design, and promote engineering quality through code reviews, mentorship, and knowledge sharing.
Top Skills: Generative AiGoJavaMongoDBRedis
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