Top Senior Python Jobs in Louisville, KY

Reposted 18 Days AgoSaved
Easy Apply
Remote or Hybrid
Louisville, KY
Easy Apply
126K-248K Annually
Senior level
126K-248K Annually
Senior level
Big Data • Cloud • Software • Database
The Senior Python Engineer will develop and support MongoDB Python drivers, enhance library quality, and collaborate on product features.
Top Skills: Ai/Ml FrameworksMongoDBPypiPython
An Hour AgoSaved
Remote
Louisville, KY
100-200 Hourly
Senior level
100-200 Hourly
Senior level
HR Tech • Other • Professional Services
Evaluate AI coding-agent interactions for usefulness, correctness, engineering judgment, reasoning quality, and user trust. Provide rigorous, opinionated feedback distinguishing response quality levels and help define best practices for tools such as OpenAI Codex, Claude Code, and Cursor. This contract role requires strong software engineering expertise, familiarity with AI-assisted development workflows, and the ability to assess code and explanations without deeply reviewing or executing every line.
Top Skills: Claude CodeCursorJavaScriptOpenai CodexPythonTypescript
An Hour AgoSaved
Remote
Louisville, KY
Senior level
Senior level
Big Data • Blockchain • Software • Business Intelligence • App development • Big Data Analytics • Automation
Design, build, and maintain scalable full-stack web applications using React, Python, Node.js, and C#. Develop cloud-native AWS solutions with event-driven and serverless architectures, manage relational and NoSQL data stores, write automated tests, maintain infrastructure as code, and contribute to CI/CD pipelines. Collaborate with cross-functional engineering teams on architecture, security, performance, and end-to-end feature delivery in an agile environment.
Top Skills: Aws Application Load BalancerAws CloudfrontAws DynamodbAws EcsAws EventbridgeAws LambdaAws SqsC#Ci/CdEvent-Driven ArchitectureGitlab Ci/CdInfrastructure As CodeJestNode.jsNosql DatabasesPlaywrightPostgresPythonReactRelational DatabasesServerless ArchitectureSQLTerraform
An Hour AgoSaved
Remote
Louisville, KY
Senior level
Senior level
Big Data • Blockchain • Software • Business Intelligence • App development • Big Data Analytics • Automation
Develop and maintain end-to-end applications using Python, Node.js, C#, and React. Build scalable backend services, frontend features, APIs, cloud-native AWS solutions, automated tests, infrastructure as code, and CI/CD pipelines. Collaborate with cross-functional engineering teams in an agile, remote environment while contributing to architecture and reliable product delivery for US clients.
Top Skills: Aws Application Load BalancerAws CloudfrontAws DynamodbAws EcsAws EventbridgeAws LambdaAws SqsC#Gitlab Ci/CdJestNode.jsPlaywrightPostgresPythonReactSQLTerraform
YesterdaySaved
In-Office or Remote
Louisville, KY
42K-147K Annually
Senior level
42K-147K Annually
Senior level
Agency • Information Technology
Design, develop, test, and maintain scalable Python applications, backend services, REST APIs, microservices, and integrations. Work with databases, asynchronous processing, cloud platforms, containers, CI/CD, security, observability, and distributed systems. Troubleshoot production issues, optimize performance, create automated tests, participate in code reviews and architecture decisions, and collaborate with product, DevOps, QA, and engineering teams.
Top Skills: AsyncioAWSAzureCi/CdDevOpsDjangoDockerDynamoDBFastapiFlaskGCPGenerative AiGitKafkaKubernetesLangchainLanggraphLlmsMicroservicesMongoDBMySQLOpenai SdkOraclePostgresPytestPythonPython 3.XRabbitMQRedisRest ApisSQLSqsUnittest
YesterdaySaved
Remote
Louisville, KY
200K-225K Annually
Senior level
200K-225K Annually
Senior level
Artificial Intelligence • Computer Vision • Machine Learning • Analytics
Develop open source SDKs, enterprise APIs, UIs, and backend systems supporting large-scale computer vision datasets. Build scalable, maintainable, performant, and well-tested software for unstructured data and AI workflows. Contribute to enterprise deployments across customer clouds and on-premises environments, while improving tooling, automation, engineering practices, and open source community initiatives in a remote-first team.
Top Skills: DocumentdbElasticsearchMongoDBPythonTypescript
Reposted 2 Days AgoSaved
Remote or Hybrid
Louisville, KY
Senior level
Senior level
Digital Media • Social Media • Software • Design
Design, develop, and maintain scalable Python applications; collaborate with cross-functional teams to deliver features; ensure performance and quality; identify and fix bugs; maintain code quality and automation; lead and mentor team members using agile practices.
Top Skills: Python
Reposted 2 Days AgoSaved
Remote
Louisville, KY
1M-2M Annually
Senior level
1M-2M Annually
Senior level
Agency • Information Technology • Software • App development
Design, develop, and maintain scalable Python applications and cloud-native solutions. Architect microservices, containerized deployments (Docker/Kubernetes), optimize cloud infrastructure, build CI/CD pipelines, integrate messaging systems, ensure security and high code quality, and mentor junior developers. Generative AI/ML experience is a plus.
Top Skills: AWSAzureAzure PipelinesCi/CdCosmosdbDjangoDockerFastapiFlaskGenerative AiGitlab CiGCPHugging FaceJenkinsKafkaKubernetesPythonPyTorchRabbitMQRdsRest ApisServerlessTensorFlowWebsockets
Reposted 2 Days AgoSaved
Remote
Louisville, KY
Senior level
Senior level
Artificial Intelligence • Information Technology • Professional Services • Software
The Senior Full Stack Developer will design, develop, test, and debug software solutions, collaborating with teams and optimizing applications. Responsibilities include user interaction design, back-end functionality, and ensuring software scalability and security.
Top Skills: CSSDjangoDockerFastapiFlaskGitGnu/LinuxHTMLJavaScriptMongoDBMySQLNode.jsOraclePostgresPythonReactSvnVue
Reposted 2 Days AgoSaved
In-Office or Remote
Louisville, KY
135K-155K Annually
Senior level
135K-155K Annually
Senior level
Machine Learning • Other
The Backend Software Engineer will develop and maintain backend systems for data processing related to coffee farming, utilizing Python and PostgreSQL. Responsibilities include feature development, problem-solving, and adapting systems to regulatory changes while ensuring system resilience.
Top Skills: AWSCi/CdDockerPostgresPostgresql/PostgisPythonTerraform
Reposted 4 Days AgoSaved
Remote
Louisville, KY
Senior level
Senior level
Artificial Intelligence • Information Technology • Machine Learning • Software • Analytics • Consulting • Financial Services
Lead Software Engineer responsible for designing, developing, testing, and maintaining a distributed processing application using Python and Java. Collaborate with product owners, data coaches, analysts, DBAs, and Agile teams to meet backend/frontend requirements, implement cloud and big-data solutions (Spark/Hadoop), and ensure program standards and reliable delivery.
Top Skills: SparkAWSDroolsHadoopIbm OdmJavaLinuxPythonShell ScriptingSnowflakeSQLVisual StudioVs Code
Reposted 4 Days AgoSaved
Remote
Louisville, KY
Senior level
Senior level
Artificial Intelligence • Information Technology • Machine Learning • Software • Analytics • Consulting • Financial Services
Develop, test, and maintain a complex distributed processing application using Python and Java. Collaborate with product owners, data coaches, analysts, DBAs, and Agile teams to meet backend/frontend requirements. Work with distributed workloads (Spark/Hadoop), SQL/Snowflake, AWS, shell scripting, and job scheduling/process automation. Support delivery under Agile/SAFe practices and ensure alignment with program standards.
Top Skills: AWSBash/Shell ScriptingDroolsHadoopJavaLinux (Cli)OdmPythonSnowflakeSparkSQLVs Code
New

Cut your apply time in half.

Use ourAI Assistantto automatically fill your job applications.

Use For Free
Application Tracker Preview
Reposted 4 Days AgoSaved
Remote
Louisville, KY
4K-5K Hourly
Senior level
4K-5K Hourly
Senior level
Travel
Lead development of Python-based web applications using Django and FastAPI, architect scalable solutions, and establish technical standards while mentoring developers and optimizing infrastructure.
Top Skills: Ai Coding AssistantsAWSDjangoFastapiGitPostgresPythonRailway
Reposted 4 Days AgoSaved
In-Office or Remote
Louisville, KY
Senior level
Senior level
Cloud • Software
The Python Engineer will write maintainable Python software, lead technical initiatives, collaborate globally, and contribute to community engagement at Canonical.
Top Skills: CC++DockerGoKubernetesLinuxNoSQLPythonRustSQL
Reposted 4 Days AgoSaved
In-Office or Remote
Louisville, KY
Senior level
Senior level
Digital Media
Develop and enhance features for EnrollWise, contribute to a scalable software architecture, review code, collaborate on design and technical feasibility, and maintain software quality.
Top Skills: ApolloAWSDjangoDjango OrmGraphQLNextjsPythonReact
Reposted 14 Days AgoSaved
In-Office
Louisville, KY
60K-60K Annually
Senior level
60K-60K Annually
Senior level
Artificial Intelligence • Information Technology • Software • Consulting
Design and develop high-scale, high-performance distributed server applications in Python. Build REST/SOAP/JSON APIs, integrate message buses (RabbitMQ, ActiveMQ, Kafka), use Cassandra and Zookeeper, and apply strong algorithms, data structures, networking, OS knowledge within Agile/Scrum workflows.
Top Skills: ActivemqApache KafkaApache ZookeeperCassandraDjangoFlaskJSONNoSQLPythonRabbitMQRestSoap
5 Days AgoSaved
Remote
Louisville, KY
80K-100K Annually
Senior level
80K-100K Annually
Senior level
Blockchain • Software • Financial Services • Cryptocurrency
Design, build, and scale distributed backend services supporting hundreds of thousands of users. Develop efficient Golang and Python code, optimize infrastructure, make architectural decisions, conduct code reviews, and collaborate with frontend and mobile engineers. The role also involves technical planning, platform innovation, and contributing to product evolution in an autonomous startup environment.
Top Skills: AWSBlockchainCassandraClickhouseDappsDockerGoGrafanaKubernetesMongoDBPostgresPrometheusPythonSentrySmart ContractsTimescaledb
Reposted 6 Days AgoSaved
Remote
Louisville, KY
Senior level
Senior level
Software
Lead the design and development of scalable Python backend services and APIs on AWS, mentor engineers, and manage PostgreSQL databases in a healthcare technology environment.
Top Skills: Api GatewayAWSBitbucketDockerGitJIRAKubernetesLambdaOauth 2PostgresPythonRest ApiSlackTeams
6 Days AgoSaved
Remote
Louisville, KY
Senior level
Senior level
Information Technology • Software • Consulting
Build and maintain full-stack wealth management platform features using Python and Angular or React. Design service-oriented architectures and REST/SOAP APIs, work with relational databases and ORMs, contribute to AWS or Azure cloud architecture, and deploy using container technologies. Collaborate in Agile/Scrum ceremonies, participate in code reviews and demos, and work independently with distributed teams.
Top Skills: AngularAWSAzureConfluenceDjangoDockerEcsFlaskJavaScriptJIRAJSONKubernetesMySQLOracleOrmPostgresPythonReactRestSoapSQLSQL Server
Reposted 6 Days AgoSaved
Remote
Louisville, KY
156K-205K Annually
Senior level
156K-205K Annually
Senior level
eCommerce
Lead design, build, and operate scalable backend services and carrier integrations. Provide technical leadership, mentor engineers, drive architecture and best practices, write and test code, troubleshoot production incidents, and improve monitoring and reliability while collaborating with product and cross-functional teams.
Top Skills: AWSConfluenceDistributed SystemsEnd-To-End TestingIntegration TestingJIRAMicroservicesMonitoring/Observability/AlertingPythonRelational DatabasesRest ApisSQLUnit TestingVersion Control
Reposted 7 Days AgoSaved
Remote
Louisville, KY
388K-619K Annually
Senior level
388K-619K Annually
Senior level
News + Entertainment
Build and maintain internal Python platform libraries and tooling to improve developer experience. Drive runtime, dependency, testing, delivery, monitoring, and performance optimization for Python services (including GPU-enabled workloads). Collaborate cross-functionally to define an opinionated SDLC, support on-call rotations, and balance modern practices with risk-aware change. Enable scalable, low-latency distributed systems and provide AI/ML-facing platform capabilities.
Top Skills: CudaDynamoFastapiFlaskLitserveOnnxPythonPytorch (Torch.Compile)Ray ServeTensorrtTritonVllm
Reposted 8 Days AgoSaved
Remote
Louisville, KY
120K-160K Annually
Senior level
120K-160K Annually
Senior level
Artificial Intelligence • Big Data • Cloud • Information Technology • Machine Learning
Design and build full-stack applications that expose AI/ML insights. Develop backend services in Python, RESTful APIs, and containerized microservices. Build high-performance front-end interfaces with React/Vue/Angular. Implement cloud-native solutions on Google Cloud or Azure, manage relational and NoSQL databases, apply testing and CI/CD, and participate in Agile development and architecture sessions.
Top Skills: AngularAzureCi/CdDockerGCPJavaScriptKubernetesMongoDBMySQLPostgresPythonReactRestful ApisSQL ServerTypescriptVue
Reposted 10 Days AgoSaved
Remote
Louisville, KY
Senior level
Senior level
Software
Senior iOS developer responsible for implementing native iOS features, improving user experience, participating in agile squads, conducting code reviews, troubleshooting customer issues, and helping modernize backend services on AWS. Collaborates with product and UI teams and documents technical knowledge while following best practices.
Top Skills: AWSCocoapodsiOSRestfulSwiftUikitXcode
Reposted 10 Days AgoSaved
In-Office or Remote
Louisville, KY
Senior level
Senior level
Agency • Information Technology
Design, build, test, and maintain backend applications using FastAPI and SQLAlchemy. Implement database schemas, integrate front-end components, optimize for performance and scalability, debug issues, participate in code reviews, and collaborate on feature design. Maintain clean, testable code and stay current with best practices.
Top Skills: FastapiGitMySQLOraclePytestPythonSQLSqlalchemy
12 Days AgoSaved
Remote or Hybrid
Louisville, KY
170K-200K Annually
Senior level
170K-200K Annually
Senior level
eCommerce • Information Technology • Machine Learning • Marketing Tech • Database • Analytics • Big Data Analytics
Design and implement scalable backend and distributed systems for a marketing intelligence platform. Build near-real-time ingestion and processing, scale an incrementality/experimentation product, integrate AI-powered workflows, improve data ingestion/exports and connection-state systems, and contribute frontend components to deliver end-to-end product experiences.
Top Skills: AIAPIsData ProcessingDistributed SystemsMachine LearningMicroservicesPythonRbacReactReal-Time Data IngestionTypescript
All Filters
JobType
New Jobs
Job Category
Experience
Industry
Company Name
Company Size

Sign up now Access later

Create Free Account