Top Senior IT Jobs in Louisville, KY

Administer and secure DOE’s Oracle Fusion Middleware environment, serving as the primary SME for WebCenter, Enterprise Manager, OID/OAM, and SSL/TLS encryption. Responsibilities include installation, configuration, patching, tuning, monitoring, identity and access management, certificate lifecycle management, compliance with NIST and FedRAMP controls, audit support, remediation, and backup support for broader Oracle technologies. The role also requires collaboration with program managers, security teams, and product SMEs.

Plans, prepares, executes, automates, and closes testing for Oracle E-Business Suite applications. Creates test plans, data, cases, and scripts; performs functional, API, regression, load, performance, and end-to-end testing; validates databases with SQL; evaluates testing tools; tracks defects through closure; and conducts root-cause analysis. Collaborates with technical and functional teams in an Agile environment to improve quality and reduce errors.

Develop, enhance, test, deploy, and support clinical applications within the IHS RPMS system. Analyze requirements, translate designs into code, troubleshoot complex software issues, address accessibility and security considerations, support testing and documentation, provide customer support, and report on technical findings and project progress while collaborating with multidisciplinary teams.

Own day-to-day cybersecurity, identity and access hygiene, compliance readiness, and infrastructure security across a multi-site healthcare environment. Administer Microsoft security tools, MFA, Conditional Access, SIEM, email protection, patching, backups, firewalls, and network controls. Lead SOC 2 evidence collection, security reporting, remediation tracking, third-party access reviews, and audit preparation. Direct and verify outsourced IT and offshore resources, enforce SLAs, supervise network work, and communicate risks to nontechnical leaders.

Leads global Workday platform strategy, governance, roadmap, delivery, and operational excellence. Manages Workday technical teams and offshore resources across HCM, talent, recruiting, payroll, integrations, reporting, security, and related modules. Partners with HR, Payroll, and Technology leaders to prioritize investments, oversee enhancements and transformations, manage vendors, budgets, contracts, and business cases, and ensure privacy, compliance, stability, and measurable business value.

Architects, implements, and operates secure, scalable Microsoft Azure solutions supporting generative AI and scientific research. Develops Terraform infrastructure, automation, and CI/CD pipelines; integrates compute, storage, networking, identity, security, monitoring, APIs, and AI services. Troubleshoots performance, reliability, security, and cost issues across application and infrastructure layers. Partners with developers, AI engineers, security teams, and customers to translate requirements into architecture, mentors engineers, evaluates tradeoffs, and supports compliance and authorization activities.

Executes Liquidia’s IT compliance program across SOX, GxP, and 21 CFR Part 11 requirements. Manages IT audits, control evidence, corrective actions, third-party risk assessments, infrastructure qualification, validated systems documentation, cybersecurity framework alignment, AI governance records, and external auditor coordination. Partners with Quality, Procurement, Legal, auditors, and IT stakeholders to maintain policies, assess compliance impacts, support validation activities, and mature the cybersecurity governance roadmap.

Maintain and improve cybersecurity across Azure Cloud and on-premises environments. Monitor and tune security alerts, manage vulnerability scanning and remediation, conduct threat intelligence analysis, support incident response, perform risk assessments and threat modeling, and implement security controls and configurations. The role also supports regulatory compliance, security documentation, cross-functional initiatives, and on-call response to security alerts.

Leads Docker’s global Information Technology organization, overseeing help desk services, application management, device lifecycle logistics, internal productivity tools, service metrics, SLAs, and continual improvement. Develops multi-year IT strategy and technology roadmaps, architects and optimizes the SaaS and cloud application ecosystem, manages technical debt, and partners with executives and technical leaders to support business growth. Builds a metrics-driven, customer-focused team and advances AI- and automation-first practices.

Leads the surveying, design, installation, and implementation of telecommunications rooms and infrastructure at Eielson Air Force Base. Develops rack, cabling, grounding, electrical, cooling, and equipment layouts; manages government, contractor, and subcontractor installation teams; coordinates facility upgrades and network, fiber, ISP, and OSP integration; ensures compliance with DoD, UFC, TIA/EIA, and I3A standards; and supports design reviews and customer briefings.

Serve as primary SIEM/SOC escalation point: investigate and triage network security events, document findings, communicate with stakeholders, tune detections, oversee threat and vulnerability management, implement automations with platform teams, and lead brand collaboration calls. Provide incident response, threat intelligence analysis, and occasional on-call support across a global enterprise.

Leads and supports internal IT operations for a globally distributed workforce. Manages a small IT team, oversees infrastructure and systems, improves identity, device, and SaaS tooling, partners across departments on onboarding and security, supports SOC 2 and ISO 27001 compliance, and establishes scalable processes, SLAs, ticketing workflows, and documentation. This is a hands-on player-coach role focused on reliability, security, efficiency, and employee experience.

Provides senior technical leadership for IT support and operations in a remote healthcare technology environment. Owns complex escalations, incident resolution, root cause analysis, endpoint and identity administration, onboarding and offboarding, vendor escalations, documentation, automation, and reliability improvements. Coaches support staff, develops scalable processes, partners with Security, Compliance, Engineering, Product, and clinical teams, and communicates clearly during high-impact incidents affecting clinical workflows.

Deploys, hardens, troubleshoots, and modernizes Windows and .NET applications across on-premises environments and AWS. Responsibilities include Terraform infrastructure, CI/CD pipelines, SQL Server and Amazon RDS administration, load balancing, WAF configuration, observability, certificate management, automation, migrations, incident response, documentation, and collaboration with application owners. The role is remote but requires weekly onsite availability in Rockville, Maryland, and may involve occasional after-hours maintenance or outage troubleshooting.

Leads enterprise-wide IT and digital transformation strategy, roadmap development, ERP and business application modernization, enterprise architecture, commercial systems, global invoicing, and post-merger technology integration. Oversees transformation portfolios, budgets, vendors, governance, compliance, and value realization across manufacturing, quality, supply chain, finance, human capital, and commercial operations. Builds high-performing technology teams and partners with executives to deliver measurable operational, financial, and customer experience improvements in a regulated environment.

Administer Epic’s corporate identity, access, endpoints, applications, devices, and employee IT support. Manage onboarding and offboarding, access reviews, authentication and device standards, MDM provisioning, asset inventories, procedures, and audit evidence. Support SOC 2 or similar compliance activities, security reviews, and incident response while partnering with infrastructure and people operations. This is a fully remote, US-based role supporting a global engineering team.

Provides global presales technical expertise for IT virtualization and infrastructure modernization solutions. Partners with account executives, engages customers, leads architecture discussions, presents solutions, advises on virtualization and migration strategies, develops service scopes, and supports pricing and delivery alignment. Requires deep virtualization architecture experience across VMware or related platforms, cloud, containers, security, AI, and infrastructure modernization.

Oversee and finalize legal documents governing data sharing between Healthcare Fraud Prevention Partnership members and a trusted third party. Collaborate with CMS, HFPP leadership, partner engagement teams, and private payer partners on agreements, compliance, and negotiations. Present to management, support partner relationships, and ensure legal requirements are met for data governance and sharing.

Lead administration of Microsoft 365, Google Workspace, SaaS applications, Azure identity, and cloud infrastructure in a fully cloud-based organization. Provide Level 2/3 service desk escalation, execute migrations and cybersecurity projects, establish IT service processes, manage assets and vendors, and support onboarding, offboarding, incident response, change management, and M&A initiatives. The role partners with IT leadership and may help build and manage a growing internal technical team.

The Senior Clinical Trials IT Business Analyst bridges Clinical Development and IT, optimizing clinical trial technologies and managing system implementations, validations, and stakeholder engagement.

Leads enterprise architecture for Biogen’s Veeva ecosystem across Development, Quality, Regulatory, Safety, and Commercial functions. Translates business needs into scalable Veeva configurations and integrations, governs target-state architecture and platform standards, reviews solution designs, and oversees implementation and release planning. Mentors configuration teams, drives cross-vault consistency, manages architecture governance, aligns with Veeva product roadmaps, and advises IT leadership on platform strategy, investments, regulatory compliance, and business objectives.

Leads the design, development, integration, deployment, and operation of large-scale Zero Trust security solutions for DoD environments. Creates system architecture blueprints, selects technologies, integrates distributed systems across on-premise and cloud environments, optimizes performance, ensures compliance with DoD requirements, and leads engineering teams. Diagnoses system issues, implements solutions, and produces architecture documentation while supporting installation, migration, and configuration activities across multiple client locations.

Leads the architecture, design, integration, deployment, and operation of large-scale Zero Trust security solutions for DoD environments. Creates system blueprints, selects technologies, integrates distributed systems across on-premises, cloud, and hybrid environments, optimizes performance, resolves system issues, and ensures compliance with DoD requirements. Leads engineering teams, supports installation and migration at multiple locations, and documents architecture and implementation decisions.

Leads complex federal platform, cloud infrastructure, IT services, security, compliance, and disaster recovery initiatives. Coordinates AWS GovCloud infrastructure-as-code, deployment automation, observability, Zero Trust identity programs, FedRAMP High and DoD IL5 readiness, and operational resilience. Partners across Engineering, Security, Compliance, and Product to manage roadmaps, dependencies, risks, milestones, and audit readiness. The role also builds and mentors a Federal Platform Operations team and drives reliable, repeatable delivery practices.

Act as the technical lead for field sales, manage evaluations, deliver on-site and remote demos, prepare SOWs/RFIs/RFPs, respond to security questionnaires, train sales teams, and support sales across U.S. and Canada while maintaining client relationships and achieving technical sales targets.