Top Senior Software Engineer Jobs in Charleston, SC

The Principal Software Engineer will lead software architecture, design, and development for genetic testing systems, collaborating across teams to deliver robust solutions that enhance patient care.

The Senior Software Engineer will develop reliable systems for IoT fleet management, create user interfaces, and support data engineering tasks.

The Senior Software Engineer will lead the design and development of complex systems, mentor team members, and ensure technical excellence while collaborating with various teams to optimize workflows.

The Senior Software Engineer will design and maintain Microservices in Go, Python, or Java, build cloud-based products, support testing processes, and lead projects in a fast-paced environment.

Design and build services, APIs, frameworks, and UIs; lead development of user interfaces and features; collaborate with teams on core platforms; contribute to backend services and data models.

Build and improve application and developer infrastructure for a FedRAMP-high US environment: support US-specific hosting/on-call, enhance auth/RBAC, feature-flag tooling, CI/CD, monitoring, and developer experience while collaborating across engineering teams.

Responsibilities include modernizing POS and fuel system software, troubleshooting issues, collaborating with team members, and ensuring system reliability in high-transaction environments.

Design and implement solutions for a scalable AI platform. Troubleshoot technical issues and ensure software quality through testing and architecture improvements.

Lead design, architecture, and hands-on implementation of scalable healthcare SaaS systems. Drive interoperability (HL7, FHIR, EDI), mentor engineers, liaise with stakeholders, manage technical risk, and ensure quality, performance, security, and innovation.

Design and build core LLM platform primitives, safety and observability infrastructure, provider abstraction and evaluation systems, prompt lifecycle and Agent-as-a-Service; collaborate with product teams, document reference implementations, and lead technical standards to enable other engineers to build production AI features.

Design and develop software applications for logistics and supply chain operations, collaborating with teams to enhance service offerings and ensure robust functionality.

Lead the architecture of Commerce Hub by defining core domain models, building intricate systems, and mentoring engineers while influencing product strategy.

As a Senior Software Engineer, you will build software for carbon dioxide removal efforts, focusing on full-stack development and optimizing complex workflows.

The role involves leading initiatives for managing federal cloud environments, focusing on DevOps best practices, infrastructure reliability, and mentoring junior engineers.

Build AI/ML-powered features across ClickHouse Cloud, designing scalable APIs, integrating inference systems and vector DBs, implementing frontend interfaces, and ensuring production-grade monitoring, versioning, and observability for model deployments.

The Staff Software Engineer will design and implement user-facing features, architect systems, ensure code quality, and integrate modern tools in a fast-paced environment.

As a Senior Software Engineer, you will develop backend systems for Foodsmart's platform, collaborate with teams, and uphold coding standards.

Lead design and implementation of scalable .NET Core + Angular applications. Communicate with stakeholders, estimate work, drive agile delivery, ensure code quality, mentor engineers, and collaborate across product, QA, and design to deliver client-facing solutions.

Develop and maintain scalable, cloud-based platform services. Enhance reliability and observability, automate infrastructure, provide technical leadership, and improve operational excellence across teams.

The Sr Software Development Engineer will design and maintain scalable cloud-based solutions, lead project technical direction, and ensure high-quality deliverables in a fast-paced Agile environment.

Design, build, and maintain high-scale data ingestion pipelines. Collaborate with product management to define requirements and deploy resources in cloud data providers.

Technical leader designing scalable APIs and agent interfaces for autonomous advertising agents. Build high-throughput real-time systems, evaluate agent protocols, drive architecture, mentor engineers, and integrate external ad platforms.

The Staff Software Engineer will lead technical projects, develop full-stack software, mentor teams, and drive product direction at Propel, focusing on impactful solutions.

As a Senior Software Developer at TherapyNotes, you will design and build features across the tech stack, mentor junior developers, and contribute to architecture decisions while solving complex technical problems.

The Staff Software Engineer leads technical development, designs features, collaborates across teams, and ensures software quality in an agile environment.